The document discusses interventions for recurrent ischemia after coronary artery bypass grafting, describing the typical causes of early and late ischemia, techniques for intervening on saphenous vein grafts including thrombectomy and aspiration devices to remove thrombus, and the use of distal protection devices during stenting to prevent embolization. It compares rheolytic thrombectomy, aspiration thrombectomy, and various distal protection devices. The role of glycoprotein IIb/IIIa inhibitors during saphenous vein graft interventions is also discussed.
rotablation is procedure used in complex pci with heavily calcified lesion for adequate expansion of stent.if used in indicated case and well aware of contraindication is necessary for achieving good results.
Significant, defined as a greater than 50 percent narrowing, left main coronary artery disease is found in 4 to 6 percent of all patients who undergo coronary arteriography. When present, it is associated with multivessel coronary artery disease about 70 percent of the time
rotablation is procedure used in complex pci with heavily calcified lesion for adequate expansion of stent.if used in indicated case and well aware of contraindication is necessary for achieving good results.
Significant, defined as a greater than 50 percent narrowing, left main coronary artery disease is found in 4 to 6 percent of all patients who undergo coronary arteriography. When present, it is associated with multivessel coronary artery disease about 70 percent of the time
A stent is a small, expandable tube. During a procedure called angioplasty, the stent is inserted into a coronary artery and expanded using a small balloon. A stent is used to open a narrowed or clotted artery.
This is a comprehensive description of coronay lesion assessment from routinely used angiography to advanced imaging modalities like IVUS/OCT including their functional significance by FFR
Based on the principle that the distal coronary pressure measured during vasodilation is directly proportional to maximum vasodilated perfusion.
FFR is defined as the ratio of maximum blood flow in a stenotic artery to maximum blood flow in the same artery if there were no stenosis.
FFR is simply calculated as a ratio of mean pressure distal to a stenosis (Pd) to the mean pressure proximal stenosis, that is the mean pressure in the aorta (Pa), during maximal hyperaemia.
A stent is a small, expandable tube. During a procedure called angioplasty, the stent is inserted into a coronary artery and expanded using a small balloon. A stent is used to open a narrowed or clotted artery.
This is a comprehensive description of coronay lesion assessment from routinely used angiography to advanced imaging modalities like IVUS/OCT including their functional significance by FFR
Based on the principle that the distal coronary pressure measured during vasodilation is directly proportional to maximum vasodilated perfusion.
FFR is defined as the ratio of maximum blood flow in a stenotic artery to maximum blood flow in the same artery if there were no stenosis.
FFR is simply calculated as a ratio of mean pressure distal to a stenosis (Pd) to the mean pressure proximal stenosis, that is the mean pressure in the aorta (Pa), during maximal hyperaemia.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
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micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
2. • Svg pathology.
• Natural course.
• Problems in interventions.
• Techniques.
• Procedure related complications.
• Role of stents and supportive medications.
3.
4.
5.
6.
7.
8.
9.
10.
11. Patients who experience recurrence of
ischemia after CABG
lesions in
– saphenous vein graft (SVG).
– native arteries.
– internal mammary.
– Radial.
– gastroepiploic graft.
– proximal subclavian artery.
12. Early postoperative ischemia (<1
month):
• acute vein graft thrombosis (60%).
• incomplete surgical revascularization (10%).
• kinked grafts.
• focal stenoses distal to the insertion site and
at the proximal or distal anastomotic sites.
• spasm or injury.
• insertion of graft to a vein causing AV fistula.
• bypass of the wrong vessel.
• all above cxs are common after minimally invasive and “off-bypass” techniques)
13. Early postoperative ischemia (1
month–1 year):
• peri-anastomotic stenosis.
• graft occlusion.
• mid-SVG stenosis from fibrous intimal
hyperplasia.
• Recurrence of angina at about three months
postoperatively is highly suggestive of a distal
graft anastomotic lesion and in most cases,
lead to evaluation for PCI
14. Late postoperative ischemia (>3
years after surgery):
• the most common cause of ischemia is the formation of new
atherosclerotic plaques which contain
– foam cells,
– cholesterol crystals,
– blood elements,
– necrotic debris as in native vessels.
• However, these plaque have less fibrocollagenous tissue and
calcifi cation, so they are softer, more friable, of larger size,
and frequently associated with thrombus.
15.
16.
17. • The status of the LAD and its graft significantly
influences the selection process.( because lack of
survival benefit of repeat surgery to treat non-LAD
ischemia.)
18. Interventions within hours of C.A.B.G:
• urgent coronary angiography may reveal a
compromised graft.
• Once a graft is thrombosed-------opening of
the native vessel is preferable.
• if the native vessel is not a reasonable
target------------- balloon interventions
(thrombectomy device) on the graft are also
effective if thrombus formation is not
extensive.
19. • ? Intracoronary thrombolytic therapy-1/3rd
requiring mediastinal drainage due to
bleeding.
20. Native coronary interventions
• One year after C.A.B.G,
– patients begin to develop new atherosclerotic
plaques in the graft conduits
or
– show atherosclerotic progression in the native
coronary arteries.
21. Approaches to native vessel sites in post-bypass patients
• Treatment of protected left main disease.
• recanalization of old total occlusion
or
• native artery via venous or arterial grafts.
22. Intervention of the aorto-ostial lesion
• there is a question about need of prior debulking
followed by stenting or stenting alone of the aorto-
ostial lesion.
• In a study by Ahmed et al. for both groups of patients
with or without prior debulking, the TLR rate after one
year was similar at 19%.
• The technical concern during PCI of large and bulky
aorto-ostial lesion is the antegrade and retrograde
embolization.
• There is distal protective device for antegrade
embolization but there is none for retrograde
embolization
23. Saphenous vein graft interventions
• 1-3yrafter surgery, patients begin to develop atherosclerotic
plaques in the SVG.
• after 3 years, these plaques appear with increased frequency.
• At the early stage, dilation of the distal anastomosis can be
accomplished with little morbidity and good long-term
patency (80–90%).
• Dilation of the proximal and mid-segment of the vein graft
was highly successful at 90%, with a low rate of mortality
(1%), Q-wave MI, and CABG(2%).
• The rate of non-Q-wave MI was 13%.
24. Intervention in degenerated
saphenous vein grafts:
• The lesions that are bulky or associated with thrombus are
considered to be high-risk.
• The complications include distal embolization, no-refl ow,
abrupt closure, and perforation.
• So different approaches were devised because there is much
to lose from the standpoint of distal embolization causing
non-Q MI and increasing long-term mortality.
• In the case of perforation of SVG, usually there is contained
perforation rather than cardiac tamponade due to the
extrapericardial course of the grafts and extensive post-
pericardiotomy fi brosis
25.
26.
27.
28. Rheolytic thrombectomy
Dissolution and removal of Hypo tube
clots from coronary and
peripheral arteries is achieved
by the creation of a flow-
mediated vacuum in the Water
vicinity of the treated lesion. jets
Exhaust lumen
High speed injection of saline
fluid into an aspiration catheter
forms a low pressure zone at
its orifice (the Bernoulli effect).
29. The pressure gradient between the thrombus
and the catheter tip draws clot particles into the
lumen of the device, where they are further
fragmented by the high speed saline jets and
then aspirated.
The double lumen device allows both saline
injection and aspiration of particulate matter into
its collection system.
30. In the VeGAS 2 trial, the 40%
Angiojet device was compared 30% 33.1%
with urokinase prior to Angiojet
30.8%
percutaneous treatment of 346 20%
Urokinase
patients with thrombus-rich
lesions in native coronary 13.9% 15.0%
10%
arteries or SVG’s. 1.7%
3.0%
0%
Death MI MACE
In this high risk population, 20.0%
Angiojet
procedural success and Urokinase
hospital course without a major 15.0%
adverse cardiac event were 13.6%
achieved with the Angiojet 10.0%
11.8%
catheter in 86% of cases,
significantly more frequently 5.0%
than with urokinase (66%, P = 3.3%
0.01) 0.0%
3.3% 0.6% 3.0%
Any Surgical Repair Transfusion
31. Aspiration thrombectomy
The X-Sizer (EndicCOR
Medical, Inc.,) is a
thromboatherectomy catheter
of varying dimensions.
Rotation of a distal helical
cutter results in thrombus
maceration and extraction into
a distal vacuum collection
bottle.
Experience in several hundred
pts has shown this catheter to
be effective in debulking
thrombus and degenerating
SVG lesions .
32. The X-TRACT trial
demonstrated that the X- X-SIZER Control
Sizer may be safely used as an 25
adjunct to PCI of diseased
SVGs and thrombus-laden 20
native coronary arteries. 16.9 17.0 17.4
15.8
15
Less need for GP IIb/IIIa
Incidence (%)
inhibitor bail-out in patients 10
treated with the X-Sizer,
suggesting a reduction in
periprocedural complications. 5
1.0 0.3 1.8 1.5
MACE rates at 30 days were 0
similar in both groups Cardiac MI TVR MACE
death
There was a significantly lower
incidence of large
postprocedural MI at 30-day
follow-up among patients
treated with the X-Sizer device.
33. • In general, the X-Sizer system is more
effective in removing thrombus and
atheromatous debris .
• while the AngioJet system was effective only
in the removal of fresh thrombus, and not the
friable, grumous vein graft material or older
organized thrombi
37. SAFER Trial – Comparison of
PercuSurge to Routine Stenting in SVG’s
801 Patients Randomized
20 30 Day MACE
16.5%
Reduced 42%
P<0.001
9.6%
%
0
Routine PercuSurge
Baim et al. Circulation 2002; 105: 1285.
38. The 800 patient multicenter randomized SAFER
trial demonstrated a 50% reduction in in-hospital
adverse events with PercuSurge distal
protection during SVG stenting, when compared
to stenting without protection
Preliminary experiences with the PercuSurge
in AMI patients undergoing percutaneous
intervention suggest that normal myocardial
blush may be achieved in more than 60%
39. PercuSurge System
Advantages Disadvantages
Captures smaller Transient occlusion
particles and Long “parking”
“humoral” mediators segment
Frequently applicable Side branches
unprotected
Two operators
42. In Filter wire-type devices, An emboli entrapment net is
mounted on a 0.014" guidewire and expanded distally to
the lesion.
Intervention is then performed over the guidewire.
Filters do not block distal blood flow when first deployed
unlike occlusive devices.
Dislodged material is caught by the distal filter, which is
then closed and retracted only at the end of the
procedure.
43. Fire Trial: Randomized BSC/EPI
Filter vs. PercuSurge in SVGPCI
650 patients in 65 sites
FW GW
TIMI 3 Flow 95.7% 97.7%
Device Success 95.5% 97.2%
Death 0.9% 0.9%
MI 9.0% 10.0%
QMI 0.9% 0.6%
30 day MACE 9.9% 11.6%
Conclusion: FW not inferior to GW
Stone et al. J Am Coll Cardiol 2003; 41: 43A
44.
45.
46.
47.
48.
49. PROXIMAL OCCULUSION
DEVICES
These devices occlude flow into the
vessel using a balloon on the tip of or just
the tip of catheter
Two proximal occulusion catheters are in
use:
Proxis catheter
Kerberos embolic protection system
50. Proxis In Vessel
With inflow occlusion ,
retrograde flow generated by
distal collaterals or infusion
through a ”rinsing “ catheter
can propel any liberated debris
back into the lumen of the
guiding catheter
These have potential
advantage of providing
embolic protection even before
the first wire crosses the
lesion.
51.
52. Benefits to Proximal Protection
Nothing crosses the lesion prior to
protection
Protection of main vessel and side
branches
Captures large and small particles
Can handle large embolic loads
53. • Is there a role for 2b3a inhibitors in SVG
interventions ?