This document outlines the principles of Good Laboratory Practices (GLP). GLP provides a framework for conducting laboratory studies and ensuring quality and integrity of data. The key points covered include defining GLP and its purpose of certifying valid study steps. Ten GLP principles are described relating to laboratory organization, facilities, equipment, test systems, methods, and record keeping. Maintaining proper documentation, conducting quality assurance inspections, and retaining records and materials are emphasized. In conclusion, following GLP guidelines helps produce high quality data and ensures proper laboratory management.
Global Manager Group has prepared presentation to provide information about Medical Laboratory Accreditation Standard - ISO 15189 and about Documentation kit. All the documents like quality manual, procedures, SOPs, audit checklist, etc that required for the ISO 15189 Certification process. are described in details in this presentation.
How medical/clinical laboratory staff should behave. Their relationship with their regulatory body, their clients, their colleagues and other professionals.
Global Manager Group has prepared presentation to provide information about Medical Laboratory Accreditation Standard - ISO 15189 and about Documentation kit. All the documents like quality manual, procedures, SOPs, audit checklist, etc that required for the ISO 15189 Certification process. are described in details in this presentation.
How medical/clinical laboratory staff should behave. Their relationship with their regulatory body, their clients, their colleagues and other professionals.
In the continuous quality journey, Controlling laboratory Errors is an integral part & focusing on analytical, post-analytical process is the first step. Developing a reporting culture followed by thorough analysis and implementation of appropriate corrective, preventive actions is required.
Biochemistry is a basic science which deals with chemical nature and chemical behaviour of living matter and with the reactions and processes they undergo.
Biochemistry involves the study of:
Chemical constituents of living matter.
Chemical changes which occur in the organism during digestion, absorption and excretion.
Chemical changes which occur during growth and multiplication of the organism.
Transformation of one form of chemical constituent to the other.
Energy changes involved in such transformation.
Note:- The term “Biochemistry” was first introduced by German chemist Carl Neuberg in 1903 from Greek word “bios” means “life”.
It is mainly deals with the biochemical aspects that are involved in several conditions.
The results of qualitative and quantitative analysis of body fluids assist the clinicians in the diagnosis, treatment and prevention of the disease and drug monitoring, tissue and organ transplantation, forensic investigations and so on.
Various biological fluids subjected to chemical tests and assays include blood, plasma, serum, urine, cerebrospinal fluid (CSF), ascetic fluid, pleural fluid, faeces, calculi and tissues.
Note:- Modern day medical practice is highly dependent on the laboratory analysis of body fluids, especially the blood. The disease manifestations are reflected in the composition of blood and other tissues.
Hence, the demarcation of abnormal from normal constituents of the body is another aim of the study of clinical biochemistry.
In the era of modern technology, health care delivery system involves so many different personnel and specialties that the caregiver must have an understanding and working knowledge of other professional endeavors, including the role of diagnostic evaluation.
Basically, laboratory and diagnostic tests are tools by and of themselves, they are not therapeutic.
In conjunction with a pertinent history and physical examination, these tests can confirm a diagnosis or provide valuable information about a patient status and response to therapy.
In addition to these, laboratory findings are essential for epidemiological surveillance and research purposes.
If the entire network of a laboratory service is to be effectively utilized and contribute to health care and disease prevention, every member of its work force need to:
Understand the role of the laboratory and its contribution to the nation’s health service;
Appreciate the need to involve all members in the provision of health service;
Follow professional ethics and code of conduct;
Experience job satisfaction and have professional loyalty.
Medical laboratory science is a complex field embracing a number of different disciplines such as
Microbiology,
Hematology,
Clinical Chemistry,
Urinalysis,
Immunology,
Serology,
Histopathology,
Immunohematology and
Molecular biology and others
Responsibilities of Clinical Laboratory Scientist and TechniciansBest care Lab
Laboratory science, being the vital element of the medical industry, a medical laboratory and its technicians play a great role in it. In general medical laboratory scientists and medical laboratory technicians collect samples and perform the tests to analyze body fluids, tissue, and other substances.
In the continuous quality journey, Controlling laboratory Errors is an integral part & focusing on analytical, post-analytical process is the first step. Developing a reporting culture followed by thorough analysis and implementation of appropriate corrective, preventive actions is required.
Biochemistry is a basic science which deals with chemical nature and chemical behaviour of living matter and with the reactions and processes they undergo.
Biochemistry involves the study of:
Chemical constituents of living matter.
Chemical changes which occur in the organism during digestion, absorption and excretion.
Chemical changes which occur during growth and multiplication of the organism.
Transformation of one form of chemical constituent to the other.
Energy changes involved in such transformation.
Note:- The term “Biochemistry” was first introduced by German chemist Carl Neuberg in 1903 from Greek word “bios” means “life”.
It is mainly deals with the biochemical aspects that are involved in several conditions.
The results of qualitative and quantitative analysis of body fluids assist the clinicians in the diagnosis, treatment and prevention of the disease and drug monitoring, tissue and organ transplantation, forensic investigations and so on.
Various biological fluids subjected to chemical tests and assays include blood, plasma, serum, urine, cerebrospinal fluid (CSF), ascetic fluid, pleural fluid, faeces, calculi and tissues.
Note:- Modern day medical practice is highly dependent on the laboratory analysis of body fluids, especially the blood. The disease manifestations are reflected in the composition of blood and other tissues.
Hence, the demarcation of abnormal from normal constituents of the body is another aim of the study of clinical biochemistry.
In the era of modern technology, health care delivery system involves so many different personnel and specialties that the caregiver must have an understanding and working knowledge of other professional endeavors, including the role of diagnostic evaluation.
Basically, laboratory and diagnostic tests are tools by and of themselves, they are not therapeutic.
In conjunction with a pertinent history and physical examination, these tests can confirm a diagnosis or provide valuable information about a patient status and response to therapy.
In addition to these, laboratory findings are essential for epidemiological surveillance and research purposes.
If the entire network of a laboratory service is to be effectively utilized and contribute to health care and disease prevention, every member of its work force need to:
Understand the role of the laboratory and its contribution to the nation’s health service;
Appreciate the need to involve all members in the provision of health service;
Follow professional ethics and code of conduct;
Experience job satisfaction and have professional loyalty.
Medical laboratory science is a complex field embracing a number of different disciplines such as
Microbiology,
Hematology,
Clinical Chemistry,
Urinalysis,
Immunology,
Serology,
Histopathology,
Immunohematology and
Molecular biology and others
Responsibilities of Clinical Laboratory Scientist and TechniciansBest care Lab
Laboratory science, being the vital element of the medical industry, a medical laboratory and its technicians play a great role in it. In general medical laboratory scientists and medical laboratory technicians collect samples and perform the tests to analyze body fluids, tissue, and other substances.
GLP applies to nonclinical studies conducted for the assessment of the safety or efficacy of chemicals (including pharmaceuticals).
GLP helps assure regulatory authorities that the data submitted are a true.
OECD principles of Good laboratory practice. this ppt include the basic and necessary information required for OECD GLP guideline . Content is taken from official site
Good Laboratory Practice (GLP) regulations are applied to non-clinical safety of study items contained in pharmaceutical products, cosmetic products, veterinary drugs, devices as well as food additives. The purpose of testing these items is to obtain information on their safety with respect to human health and environment. GLP is also required for registration purpose and licensing of pharmaceuticals, pesticides, food additives, veterinary drug products and some bio-products.
The Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA) was established under Section 15(1) of the Prevention of Cruelty to Animals Act 1960.
GLP is a quality system concerned with the organizational process and conditions under which non-clinical health and environmental safety studies are planned, performed, monitored, recorded, archived and reported. GLP principles include. Organization and Personnel. Management-Responsibilities.
A bioassay is an analytical method to determine the concentration or potency of a substance by its effect on living animals or plants, or on living cells or tissues. A bioassay can be either quantal or quantitative, direct or indirect.
Study Material for Applications of Stem Cells In Health CareVamsi kumar
Explore the cutting-edge field of stem cell therapies and their pivotal role in treating autoimmune disorders with our comprehensive textbook. This essential resource covers the latest advances in the use of stem cells, including mesenchymal stem cells, induced pluripotent stem cells, and hematopoietic stem cell transplantation, in managing conditions such as rheumatoid arthritis, multiple sclerosis, type 1 diabetes, and systemic lupus erythematosus. Gain insights into innovative treatments, ethical considerations, and case studies showcasing successful patient outcomes. Whether you're a medical lab technology student, researcher, or healthcare professional, this textbook equips you with the knowledge and expertise to navigate the exciting world of stem cell-based therapies for autoimmune disorders.
By Atuluri Vamsi Kumar
Future of Embryology by Attuluri Vamsi KumarVamsi kumar
This comprehensive PowerPoint presentation offers a detailed exploration of the dynamic field of embryology and its significant role in medical science. Titled "Navigating the Future of Embryology: Innovations and Ethical Considerations," it delves into the history, current practices, and future prospects of embryology. It covers the evolution of embryological studies, the vital role of the Indian Council of Medical Research (ICMR) in shaping guidelines, and the impact of technological advancements on the discipline. With a focus on predictions and trends, the presentation also contemplates potential future amendments to guidelines in response to evolving technologies and ethical considerations. This resource is invaluable for medical professionals, researchers, and students keen on understanding the trajectory of embryology and its implications for future medical practices.
I am Attuluri Vamsi Kumar, Academician in Medical Laboratory Sciences of highly successful job experience and a strong desire to improve OBE structured MLT education. I am constantly focusing on building an academic atmosphere that is set high standards with strong multi blended teaching pedagogy models. Contact me at 7416660584.
Notes of Shape and Size of RBCs, Structure of RBCs, Life Cycle of RBCs, Funct...Vamsi kumar
Red Blood Cells (RBCs) possess unique attributes essential for their function in the circulatory system. Their distinctive biconcave shape maximizes surface area for efficient gas exchange. Structurally, mature RBCs lack a nucleus, making room for hemoglobin, a molecule vital for oxygen and carbon dioxide transport. These cells undergo a lifecycle that lasts about 120 days, originating from the bone marrow and eventually being removed by the spleen. Their primary role involves ferrying oxygen to body tissues and removing carbon dioxide. Additionally, changes in RBC size, shape, or hemoglobin content can signify various medical conditions, and there are specific disorders, like anemia or sickle cell disease, that directly impact RBCs.
What is Medical Lab Technology, Difference between Treatment, Prognosis and Diagnosis, Role of Doctor or Physician and Medical Lab Technologist, Vital Signs, Significance of Vital Signs Assessment, Difference Between Signs and Symptoms in Patient Assessment, Example Case Study on Signs and Symptoms, Definition of Disease, Definition of Illness, Definition of Infection, Factors Contributing to Disease, Introduction to Factors Contributing to Disease, Types of Samples that Can be Collected from Patients for Clinical Diagnosis, Additional Types of Samples for Clinical Diagnosis.
Created by: Mr. Attuluri Vamsi Kumar, Assistant Professor, Department of MLT, UIAHS, Chandigarh University, Mohali, Punjab. For more details website: https://www.mltmaster.com
Welcome to the Hematology Laboratory Practical Manual, an essential tool in your journey as a Medical Laboratory Technology student. This manual has been meticulously curated to provide an effective foundation for your practical skills in hematology and enhance your understanding of the human blood system's dynamics.
Hematology, a branch of medicine, focuses on the study of blood, blood-forming organs, and blood diseases. It includes the study of etiology, diagnosis, treatment, prognosis, and prevention of blood diseases. The manual bridges the gap between theoretical knowledge and practical application, intending to prepare you to perform and interpret various laboratory tests related to blood.
The manual introduces you to laboratory practices, standard operating procedures, and safety protocols. It explores a wide range of topics from the basic blood collection techniques, preparation of blood smears, and staining techniques to complex tests like complete blood count (CBC), coagulation tests, bone marrow examination, hemoglobinopathies, and blood group typing, to name a few.
Understanding the principles and methods used in hematology laboratory tests is crucial for any Medical Laboratory Technologist (MLT). You will find this manual to be instrumental in developing the necessary skillset and cultivating the meticulous approach required in laboratory practice. Each practical in this manual is supplemented with objectives, materials required, procedures, observations, precautions, and viva questions to enrich your learning experience.
The laboratory is a place where the theories you learn in the classroom come alive. Here, you will understand the importance of accuracy, precision, and repeatability. You will learn to calibrate equipment, handle samples, observe reactions, record data, analyze results, and generate reports. You will become acquainted with the microscope, centrifuge, pipettes, hemocytometers, reagents, and other laboratory tools.
To further enhance your learning experience, case studies and clinical correlation sections are incorporated, connecting the dots between laboratory findings and clinical symptoms. You will be challenged to interpret results and provide a plausible explanation for various hematological conditions.
This manual is designed to stimulate your curiosity, encourage critical thinking, and prepare you for your future role as a Medical Laboratory Technologist. It is not merely a collection of laboratory procedures but a practical guide to understanding the human blood system and its associated disorders.
The path to becoming a competent MLT involves understanding and respecting the significance of laboratory practices. It's about knowing that each sample represents a person awaiting diagnosis, treatment, or confirmation of health stat
This course provides an in-depth exploration of blood bank laboratory practices and procedures, introducing students to the core concepts and technical skills involved in blood banking. The program uses a case-based approach to facilitate the application of theoretical knowledge to practical scenarios, encouraging problem-solving skills and clinical reasoning. The curriculum spans from basic principles and safety considerations to advanced testing techniques and current trends in blood banking, providing comprehensive coverage of this essential area of medical lab technology.
Created by: Mr. Attuluri Vamsi Kumar, Assistant Professor, Department of MLT, UIAHS, Chandigarh University, Mohali, Punjab. For more details website: https://www.mltmaster.com
This course provides an extensive study of research methodologies in the field of Medical Lab Technology. Students will learn the fundamentals of research, how to design their research, and methods of data collection. Further, they will gain insights into data analysis, interpretation of results, and the essentials of writing a research report. The course integrates theoretical learning with practical case studies to facilitate a comprehensive understanding of the subject.
Created by: Mr. Attuluri Vamsi Kumar, Assistant Professor, Department of MLT, UIAHS, Chandigarh University, Mohali, Punjab. For more details website: https://www.mltmaster.com
51_Introduction to Artificial Intelligence and its applications.pdfVamsi kumar
This course provides an in-depth understanding of the fundamentals, applications, and future trends of artificial intelligence (AI) in the field of medical lab technology. It covers the role of AI in clinical lab diagnostics, predictive analysis, big data interpretation, precision medicine, and ethical considerations in AI deployment. Through case studies, students will gain practical insights into the use of AI in healthcare.
Created by: Mr. Attuluri Vamsi Kumar, Assistant Professor, Department of MLT, UIAHS, Chandigarh University, Mohali, Punjab. For more details website: https://www.mltmaster.com
This Medical Lab Technology Internship syllabus is intended to provide students with the opportunity to apply and enhance their knowledge and skills in the context of real-world laboratory settings. Over the course of six months, interns will gain hands-on experience in essential and advanced laboratory techniques, laboratory safety practices, quality assurance processes, and professional and ethical considerations in the field. Through practical learning and critical examination of case studies, students will emerge better prepared for their careers as Medical Lab Technologists.
Created by: Mr. Attuluri Vamsi Kumar, Assistant Professor, Department of MLT, UIAHS, Chandigarh University, Mohali, Punjab. For more details website: https://www.mltmaster.com
This course aims to provide students with an in-depth understanding of blood banking, including the concepts of blood grouping, compatibility testing for transfusion, and the management of blood resources. It also delves into the fundamental principles of genetics, focusing on inheritance patterns, chromosomal basis of inheritance, and the role of DNA and RNA in protein synthesis. Through practical exercises, students will gain hands-on experience on various techniques used in blood banking and genetics.
Created by: Mr. Attuluri Vamsi Kumar, Assistant Professor, Department of MLT, UIAHS, Chandigarh University, Mohali, Punjab. For more details website: https://www.mltmaster.com
This course in "Virology and Mycology" (701) is designed to provide a comprehensive understanding of the medically important fungi and viruses. The content includes an introduction, general characteristics, life cycle, laboratory diagnosis, and the various techniques used in the identification and study of these microbes. This course will also equip students with practical skills, from preparing culture media to processing clinical samples for diagnosis.
Created by: Mr. Attuluri Vamsi Kumar, Assistant Professor, Department of MLT, UIAHS, Chandigarh University, Mohali, Punjab. For more details website: https://www.mltmaster.com
50_Research methodology and Biostatistics.pdfVamsi kumar
This syllabus covers the foundational aspects of Research Methodology and Biostatistics. The course is designed to equip students with the necessary understanding and skills to formulate research problems, address ethical considerations, design research studies, comprehend the basic concepts of Biostatistics, and understand the relationship between data and variables. The aim is to enhance the students' ability to construct, summarize, and analyze data in biostatistics effectively.
Created by: Mr. Attuluri Vamsi Kumar, Assistant Professor, Department of MLT, UIAHS, Chandigarh University, Mohali, Punjab. For more details website: https://www.mltmaster.com
This course is designed to provide Medical Lab Technology students with a comprehensive understanding of the medical microbiology laboratory's operation. It starts with foundational knowledge in laboratory safety, equipment, and microbial classification and then advances to diagnostic microbiology techniques, immunology, and serology. Lastly, it explores more sophisticated lab procedures such as molecular diagnostics, virology, and recent trends in the field. Each unit comes with real-life case studies to further reinforce the application of theoretical knowledge.
Created by: Mr. Attuluri Vamsi Kumar, Assistant Professor, Department of MLT, UIAHS, Chandigarh University, Mohali, Punjab. For more details website: https://www.mltmaster.com
44_Program Elective course - III (Introduction to NABL).pdfVamsi kumar
This course provides an in-depth understanding of the National Accreditation Board for Testing and Calibration Laboratories (NABL) accreditation process, its quality management system (QMS), and the practical aspects of implementing the NABL standards. The course includes an analysis of case studies to enhance the understanding of real-world applications of the NABL accreditation process.
Created by: Mr. Attuluri Vamsi Kumar, Assistant Professor, Department of MLT, UIAHS, Chandigarh University, Mohali, Punjab. For more details website: https://www.mltmaster.com
49_Immunopathology and Molecular Biology.pdfVamsi kumar
This course aims to provide students with an in-depth understanding of Immunopathology and Molecular Biology, with a focus on the immune system's role in health and disease, transplantation immunology, hypersensitivity, autoimmunity, and immune tolerance. Additionally, it introduces molecular biology, DNA structure, and replication, with practical applications of molecular techniques such as PCR, gel electrophoresis, and western blotting.
Created by: Mr. Attuluri Vamsi Kumar, Assistant Professor, Department of MLT, UIAHS, Chandigarh University, Mohali, Punjab. For more details website: https://www.mltmaster.com
This course, Applied Clinical Biochemistry- II, is designed to impart in-depth knowledge about the techniques and methods used in clinical biochemistry. The curriculum focuses on automation in clinical biochemistry, methods of estimation and assessment, enzyme principles and estimation, gastric analysis, renal function tests, qualitative tests, and chemical examination. The students will engage in practical applications of these concepts through hands-on experimentation.
Created by: Mr. Attuluri Vamsi Kumar, Assistant Professor, Department of MLT, UIAHS, Chandigarh University, Mohali, Punjab. For more details website: https://www.mltmaster.com
45_Program Elective course - III (Laboratory and Hospital information syste...Vamsi kumar
The elective course "Hospital Information System and Laboratory Information System" aims to provide medical lab technology students with a comprehensive understanding of the design, implementation, and usage of health and laboratory information systems in the healthcare sector. It emphasizes the significance of these systems in ensuring effective patient care, data interoperability, and the integration of various systems for optimized healthcare delivery.
Created by: Mr. Attuluri Vamsi Kumar, Assistant Professor, Department of MLT, UIAHS, Chandigarh University, Mohali, Punjab. For more details website: https://www.mltmaster.com
43_Program Elective course - III (Community medicine).pdfVamsi kumar
This syllabus covers the principles and applications of Community Medicine and Epidemiology. Students will gain a comprehensive understanding of community health, disease control, health promotion, and the role of medical social work. They will apply knowledge to real-world case studies, fostering skills in critical analysis, problem-solving, and ethical decision-making.
Created by: Mr. Attuluri Vamsi Kumar, Assistant Professor, Department of MLT, UIAHS, Chandigarh University, Mohali, Punjab. For more details website: https://www.mltmaster.com
This course aims to provide a comprehensive understanding of the field of Cytopathology. It begins with the basics of cryostat sectioning and enzyme cytochemistry, proceeding towards an in-depth study of cytological investigations, including vital staining and aspiration cytology. The course then focuses on advanced topics like exfoliative cytology, automation in cytology, liquid-based cytology, and immune-cytochemistry. Finally, it allows students to apply their theoretical knowledge to practical applications and master various techniques and staining methods used in a Cytology lab.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
2. Course outcomes
• On completion of course student will be able to:
1. Perform estimation of Haemoglobin
2. Perform total RBC and WBC Count, Differential WBC ount
and Calculate blood indices.
3. Determination of Blood Group.
4. Perform Erythrocyte sedimentation rate [ESR] And PCV
5. Determination of Clotting Time and Bleeding time
6. Perform Auscultation for Heart Sounds and Blood
pressure
7. Perform Electrocardiogram and Determination of vital
capacity.
3. Learning outcomes
• Upon completion of this lecture, the students will be
able to:
1. Understand the principles of GLP and its regulatory
basis
2. Understand the structure of GLP as compared to ISO
3. Understand the requirements of a laboratory facility
4. Understand the QA programs documentations, such as
Standard Operating Procedures, protocols, study plans,
data quality and integrity, auditing, archival, etc.
5. Understand the regulatory inspections
4. Objective
To provide the knowledge in the principles of
Good Laboratory Practices (GLP) and
understanding in the requirements and its
regulations.
5. Contents
• Definition of GCLP
• Purpose of GCLP
• Scope of GCLP
• Principles of GCLP
i. 1. Test Facility Organisation and Personnel.
ii. 2. Quality Assurance Programme(QAP).
iii. 3. Facilities.
iv. 4. Apparatus, Material and Reagents.
v. 5. Test systems.
vi. 6. Test and Reference Substances.
vii. 7. Standard Operating Procedures(SOP).
viii. 8. Performance of The Study.
ix. 9. Reporting of Study Results.
x. 10. Storage and Retention of Records and materials.
6. Definition of GLP
• GLP embodies a set of principles that provides
a frame work within which laboratory studies
are planned performed, monitored, and
archived and reported.
7. Purpose of GLPs:
• GLP is to certify that every step of the analysis
is valid or Not.
• Assure the quality & integrity of data
submitted to FDA in support of the safety of
regulated products.
• GLPs have heavy emphasis on data recording,
record & specimen retention.
8.
9. GCLP PRINCIPLES.
• 1. Test Facility Organisation and Personnel.
• 2. Quality Assurance Programme(QAP).
• 3. Facilities.
• 4. Apparatus, Material and Reagents.
• 5. Test systems.
• 6. Test and Reference Substances.
• 7. Standard Operating Procedures(SOP).
• 8. Performance of The Study.
• 9. Reporting of Study Results.
• 10. Storage and Retention of Records and
materials.
10. 1. Test Facility Organization and
Personnel Responsibilities
1. • Should have the Knowledge of the GLP
principles.
2. • Access to the study plan and appropriate
SOP’s.
3. • Comply with the instructions of the SOP’s.
4. • Record raw data.
5. • Study personnel are responsible for the quality
of their data.
6. • Exercise health precautions to minimize risk.
7. • Ensure the integrity of the study
11. 2.Quality Assurance Program
Responsibilities of the QA Personnel
1. • Access to the updated study plans and SOP’s.
2. • Documented verification of the compliance of study
plan to the GLP principles.
3. • Inspections to determine compliance of the study
with GLP principles.
4. • Three types of inspection. – Study-based inspections.
– Facility-based inspections. – Process-based
inspections.
5. • Inspection of the final reports for accurate and full
description.
6. • Report the inspection results to the management
7. Statements.
12. 3. Facilities
1. • Suitable size, construction and location.
2. • Adequate degree of separation of the
different activities.
3. • Isolation of test systems and individual
projects to protect from biological hazards.
4. • Suitable rooms for the diagnosis, treatment
and control of diseases.
5. • Storage rooms.
13. 4. Apparatus, Materials and Reagents
1. • Apparatus of appropriate design and
adequate capacity.
2. • Documented Inspection, cleaning,
maintenance and calibration of apparatus.
3. • Apparatus and materials not to interfere
with the test systems.
4. • Chemicals, reagent and solutions should be
labeled to indicate identity, expiry and
specific storage instructions.
14. 5. Test Systems
1. • Physical and chemical test systems.
2. • Biological test systems.
3. • Records of source, date of arrival, and
arrival conditions of test systems.
4. • Proper identification of test systems in
their container or when removed.
5. • Cleaning and sanitization of containers.
6. • Pest control agents to be documented.
15. 6. Test and Reference Items
• Receipt, handling, sampling and storage
• Characterization.
• Known stability of test and reference items.
• Stability of the test item in its vehicle (container).
• Experiments to determine stability in tank mixers
used in the field studies.
• Samples for analytical purposes for each batch.
16. 7.Standard Operating Procedures
(SOP)
1. Written procedures for a laboratories
program.
2. They define how to carry out protocol-
specified activities.
3. Most often written in a chronological listing
of action steps.
4. They are written to explain how the
procedures are suppose to work.
17. SOP’s continue
• Routine inspection, cleaning, maintenance,
testing and calibration.
• Actions to be taken in response to equipment
failure.
• Keeping records, reporting, storage, mixing,
and retrieval of data.
• Definition of raw data.
• Analytical methods.
18. 8. Performance of the Study
• • Prepare the Study plan.
• • Content of the study plan.
• › Identification of the study.
• › Records.
• › Dates.
• ›Reference to test methods.
• › Information concerning the sponsor and facility.
• • Conduct of the study.
19. Reporting of Study Results
• • Information on sponsor and test facility.
• • Experimental starting and completion dates.
• A Quality Assurance Program Statement.
• • Description of materials and test methods.
• • Results.
• • Storage (samples, reference items, raw data,
final reports) etc.
20. 10. Storage and Retention of Records
and Materials –
• The study plan, raw data, samples.
• – Inspection data and master schedules.
• – SOPs. – Maintenance and calibration data. –
• If any study material is disposed of before
expiry the reason to be justified and
documented.
• – Index of materials retained.
21. What Good Laboratory Must
Contain.?
1. • Area should be free from smoke, smell, dust etc.
2. • Ensure good ventilation, proper illumination and prefer natural
light.
3. • Air conditioned the lab with humidity control.
4. • Enough space for measuring and testing instrument.
5. • Proper arrangement of testing.
6. • Take care of all safety points including proper earthing as well as
fire safety.
7. • Avoid uncleanable spots in floors, walls, ceiling.
8. Establish proper areas for storage of incoming samples as well as
test–completed samples.
9. • Also provide sample collection place as well as packing and
disposal of tested samples.
22. Benefits of good laboratory practices.
• • It will give better image of company as a Quality
producer in Global market.
• • Provide hot tips on analysis of data as well as
measure uncertainty and perfect record keeping.
• • Provide guideline for doing testing and
measurement in detail.
• • Provide guidelines and better control for
maintenance of instruments, environment
control, preservation of test records etc
23. CONCLUSION
• Gives better image of company as a Quality
producer in Global market Provide hot tips on
analysis of data as well as measure uncertainty
and perfect record keeping & guideline for doing
testing and measurement in detail.
• Finally GLP Provide guidelines and better
control for maintenance of instruments,
environment control, preservation of test
records etc.