The male and female reproductive systems develop initially embryonically "indifferent", it is the product of the Y chromosome SRY gene that makes the "difference".
♂ - Male ♀ - Female
The reproductive organs are developed from the intermediate mesoderm.
The permanent organs of the adult are preceded by a set of structures which are purely embryonic, and which with the exception of the ducts disappear almost entirely before the end of fetal life.
These embryonic structures are the mesonephric ducts (also known as Wolffian ducts) and the paramesonephric ducts, (also known as Müllerian ducts). The mesonephric duct remains as the duct in males which gives rise to seminal vesical, epididymes and vas deferens, and the paramesonephric duct as that of the female.
Importantly its sex chromosome dependence, late embryonic/fetal differential development, complex morphogenic changes, long time-course, hormonal sensitivity and hormonal influences make it a system prone to many different abnormalities.
Gonads:
Gonads Produce eggs and sperm cells, transport and sustain egg and sperm cells, nurture developing offspring, and produce hormones.
The gonads, ovary or testis, also develop in the intermediate mesoderm.
They originally form as swellings that lie just ventral to the anterior mesonephric kidney.
A mullarian duct also develops in the intermediate mesoderm near the mesonephric duct.
Due to fusion or failure of 1st ridge to differentiate, some vertebrates (agnathans, some female lizards & crocodilians, & most female birds) have a single testis or ovary.
Hormones cause differentiation of early gonads into either testes or ovaries.
As males develop the mesonephric duct makes connection with the testis as the primary sperm conducting duct, and the mullerian duct is lost.
INTRODUCTION
The term urogenital refers to something that has both urinary and genital origins. The word urogenital is used because the urinary and reproductive systems in males merge.
These are grouped together because of their proximity to each other, their common embryological origin and the use of common pathways (ex. urethra).
Kidneys and urinary ducts form the urinary system.
The Urinary system performs two important homeostatic processes like excretion and osmoregulation. This system is intimately associated both anatomically, and in terms of embryonic origin with the genital system.
The genital system includes the gonads which generate gametes and the genital ducts that serve as passages for the gametes.
Though functionally different the two organ systems the urinary and the genital system are treated together as the urino- genital system, since both develop from the same segmental blocks of trunk mesoderm or adjacent tissues and share many of the ducts.
Thus although the two systems have nothing common functionally they are closely associated in their use of common ducts and are studied under the broad heading of urinogenital system.
The function of the excretory system is crucial in considering the possible environment of the ‘vertebrate life ’. Several main functions can be attributed to all vertebrate excretory systems:
Excretion of nitrogenous waste products.
Maintaining homeostasis with regard to ions (i.e. salt balance).
Regaining valuable substances (glucose, salts, amino acids, etc.)
Maintaining a physiological osmotic value (i.e. water balance).
The excretory system is formed by a series of paired, segmental nephrons that begin with a nephrostome opening into the coelomic cavity.
A pair of glomeruli per segment, supplied by branches from the aorta, projects into the coelomic cavity close to these nephrostomes.
At a later stage of development, the glomerulus/nephrostome area becomes separated from the rest of the coelomic cavity by an epithelial fold.
The nephrons connect to a duct that is formed by caudal growth of the most anterior nephric tubules. These paired urinary ducts open near the anal region.
Development of gonads (Gonad differentiation)male gonad and female gonadshallu kotwal
The development of the gonads is part of the prenatal development of the reproductive system and ultimately forms the testes in males and the ovaries in females. The gonads initially develop from the mesothelial layer of the peritoneum.
INTRODUCTION
The term urogenital refers to something that has both urinary and genital origins. The word urogenital is used because the urinary and reproductive systems in males merge.
These are grouped together because of their proximity to each other, their common embryological origin and the use of common pathways (ex. urethra).
Kidneys and urinary ducts form the urinary system.
The Urinary system performs two important homeostatic processes like excretion and osmoregulation. This system is intimately associated both anatomically, and in terms of embryonic origin with the genital system.
The genital system includes the gonads which generate gametes and the genital ducts that serve as passages for the gametes.
Though functionally different the two organ systems the urinary and the genital system are treated together as the urino- genital system, since both develop from the same segmental blocks of trunk mesoderm or adjacent tissues and share many of the ducts.
Thus although the two systems have nothing common functionally they are closely associated in their use of common ducts and are studied under the broad heading of urinogenital system.
The function of the excretory system is crucial in considering the possible environment of the ‘vertebrate life ’. Several main functions can be attributed to all vertebrate excretory systems:
Excretion of nitrogenous waste products.
Maintaining homeostasis with regard to ions (i.e. salt balance).
Regaining valuable substances (glucose, salts, amino acids, etc.)
Maintaining a physiological osmotic value (i.e. water balance).
The excretory system is formed by a series of paired, segmental nephrons that begin with a nephrostome opening into the coelomic cavity.
A pair of glomeruli per segment, supplied by branches from the aorta, projects into the coelomic cavity close to these nephrostomes.
At a later stage of development, the glomerulus/nephrostome area becomes separated from the rest of the coelomic cavity by an epithelial fold.
The nephrons connect to a duct that is formed by caudal growth of the most anterior nephric tubules. These paired urinary ducts open near the anal region.
Development of gonads (Gonad differentiation)male gonad and female gonadshallu kotwal
The development of the gonads is part of the prenatal development of the reproductive system and ultimately forms the testes in males and the ovaries in females. The gonads initially develop from the mesothelial layer of the peritoneum.
Evolutionary change in heart of vertebrates
Heart is situated ventral to the oseophagus in the pericardial section of the coelom.
Heart is a highly muscular pumping organ that pumps blood into arteries and sucks it back through the veins.
In vertebrates it has undergone transformation by twisting from a straight tube to a complex multi-chambered organ.
. There has been an increase in the number of chambers in heart during evolution of vertebrates.
The heart is covered by a transparent protective covering, called pericardium. It is a single layer in fish.
Within pericardium there is a pericardial fluid, protects the heart from the external injury.
The evolution of the heart is based on the separation of oxygenated blood from deoxygenated blood for efficient oxygen transport.
Vittelogenesis is a word developed from Latin vitellus-yolk, and genero-produce
Vitellogenesis (also known as yolk deposition) is the process of yolk formation via nutrients being deposited in the oocyte, or female germ cell involved in reproduction of lecithotrophic organisms. In insects, it starts when the fat body stimulates the release of juvenile hormones and produces vitellogenin protein.
Yolks is the most usual form of food storage in the egg.
Yolks appear in the oocyte in the secondary period of their growth called vittelogenesis.
Thus,the formation and deposition of yolks is known as vittelogenesis
Characteristic
Yolks is a complex variable assembled component.
The principle component are protein,phospholipid and fats in different combination.
Depending upon these component yolks is distinguished into protein yolks and fatty acid
For eg- the avian contain 48.19% water , 16.6 % protein, 32.6% phospholipids and fats and 1% carbohydrates.
It discusses basic information regarding a hemichordate animal called Balanoglossus or Acorn worm, which is also a good connecting link between the non-chordates and chordates.
The vertebrate brain
The vertebrate brain is the main part of the central nervous system. The brain and the spinal cord make up the central nervous system,
In most of the vertebrates the brain is at the front, in the head. It is protected by the skull and close to the main sense organs.
Brains are extremely complex and the part of human and animal body. The brain controls the other organs of the body, either by activating muscles or by causing secretion of chemicals such as hormones and neurotransmitters.
Muscular action allows rapid and coordinated responses to changes in the environment.
The brain of an adult human weights about 1300–1400 grams .
In vertebrates, the spinal cord by itself can cause reflex responses as well as simple movement such as swimming or walking. However, sophisticated control of behaviour requires a centralized brain.
The structure of all vertebrate brains is basically the same.
At the same time, during the course of evolution, the vertebrate brain has undergone changes, and become more effective.
In so-called 'lower' animals, most or all of the brain structure is inherited, and therefore their behaviour is mostly instinctive.
In mammals, and especially in man, the brain is developed further during life by learning. This has the benefit of helping them fit better into their environment. The capacity to learn is seen best in the cerebral cortex.
Three principles
The brain and nervous system is essentially a system which makes connections. It has input from sense organs and output to muscles. It is connected in several ways with the endocrine system, which makes hormones, and the digestive system and sex system. Hormones work slowly, so those changes are gradual.
The brain is a kind of department store. It has, all inter-connected, departments which do different things. They all help each other gather senses.
Much of what the body does is not conscious. Basically, much of the body runs on automatic (breathing, heart beat, hungry, hair growth) adjusted by the autonomic nervous system. The brain, too, does much of its work without a person noticing it. The unconscious mind refers to the brain activities which are hardly ever noticed.
INTRODUCTION
The jaw (Upper and lower) is any opposable articulated structure at the entrance of the mouth.
It is typically used for grasping and manipulating food.
Jaw suspension means the fusion of upper jaw and lower jaw or skull for efficient biting.
There are different ways in which these attachments are attained depending upon the modifications in visceral arches in vertebrates.
In most vertebrates, the jaws are bony or cartilaginous and oppose vertically.
The vertebrate jaw is derived from the most anterior two pharyngeal arches supporting the gills, and usually bears numerous teeth.
The vertebrate jaw probably originally evolved in the Silurian period and appeared in the Placoderm fish which further diversified in the Devonian.
It is believed that the hyoid system suspends the jaw from the brain case of the skull, permitting great mobility of the jaws.
The original selective advantage offered by the jaw may not be related to feeding, but rather to increased respiration efficiency.
The jaws were used in the buccal pump (observable in modern fish and amphibians) that pumps water across the gills of fish or air into the lungs in the case of amphibians.
Over evolutionary time the more familiar use of jaws (to humans), in feeding, was selected for and became a very important function in vertebrates. Many teleost fish have substantially modified jaws for suction feeding and jaw protrusion, resulting in highly complex jaws with dozens of bones involved.
Jaw Suspension or Suspensoria:
The method by which the upper and lower jaws are suspended or attached from the chondrocranium is known as jaw suspension or suspensorium.
Amongst the visceral arches, the first (mandibular) arch consists of
= a dorsal palato pterygoquadrate bar forming the upper jaw,
= and ventral Meckel’s cartilage forms the lower jaw.
The second (hyoid) arch consists of = a dorsal hyomandibular supporting and suspending the jaws with the cranium, and a ventral hyoid.
The remaining visceral arches support the gills and are, hence, called branchial arches. Thus, splanchnocranium forms the jaws and suspends them with the chondrocranium.
The integumentary system comprises the skin and its appendages. Skin + derivatives= Integument.
It aims to protect the body from various kinds of damage, such as loss of water or damages from outside.
The integumentary system in chordates includes hair, scales, feathers, hooves, and nails.
It may serve to water proof, and protect the deeper tissues.
Excrete wastes, and regulate body temperature.
It is the attachment site for sensory receptors to detect pain, sensation, pressure, and temperature.
ORIGIN OF CHORDATES
Animal kingdom is basically divided into two sub kingdoms:
Non-chordata- including animals without notochord.
Chordata- This comprising animals having notochord or chorda dorsalis.
Chordates were evolved sometime 500 million years ago during Cambrian period (invertebrates were also began to evolve in this period) .
Chamberlain (1900) pointed out that all modern chordates possess glomerular kidneys that are designed to remove excess water from body.
It is believed that Chordates have originated from invertebrates.
It is difficult to determine from which invertebrate group the chordates were developed.
Chordate ancestors were soft bodied animals. Hence they were not preserved as Fossils.
However, early fossils of chordates have all been recovered from marine sediments and even modern protochordates are all marine forms.
Also glomerular kidneys are also found in some marine forms such as myxinoids and sharks. That makes the marine origin of chordates more believable.
Chordates evolved from some deuterostome ancestor (echinoderms, hemichordates, pogonophorans etc.) as they have similarities in embryonic development, type of coelom and larval stages.
Many theories infers origin of chordates, hemichordates and echinoderms from a common ancestor.
The urinary system includes the kidneys and the ducts that carry away their product, urine. The genital system includes the gonads and their ducts that carry away the products they form, sperm or eggs. Embryologically, urinary and reproductive organs arise from the same or
adjacent tissues and maintain close anatomical association
throughout the organism’s life.
Evolutionary change in heart of vertebrates
Heart is situated ventral to the oseophagus in the pericardial section of the coelom.
Heart is a highly muscular pumping organ that pumps blood into arteries and sucks it back through the veins.
In vertebrates it has undergone transformation by twisting from a straight tube to a complex multi-chambered organ.
. There has been an increase in the number of chambers in heart during evolution of vertebrates.
The heart is covered by a transparent protective covering, called pericardium. It is a single layer in fish.
Within pericardium there is a pericardial fluid, protects the heart from the external injury.
The evolution of the heart is based on the separation of oxygenated blood from deoxygenated blood for efficient oxygen transport.
Vittelogenesis is a word developed from Latin vitellus-yolk, and genero-produce
Vitellogenesis (also known as yolk deposition) is the process of yolk formation via nutrients being deposited in the oocyte, or female germ cell involved in reproduction of lecithotrophic organisms. In insects, it starts when the fat body stimulates the release of juvenile hormones and produces vitellogenin protein.
Yolks is the most usual form of food storage in the egg.
Yolks appear in the oocyte in the secondary period of their growth called vittelogenesis.
Thus,the formation and deposition of yolks is known as vittelogenesis
Characteristic
Yolks is a complex variable assembled component.
The principle component are protein,phospholipid and fats in different combination.
Depending upon these component yolks is distinguished into protein yolks and fatty acid
For eg- the avian contain 48.19% water , 16.6 % protein, 32.6% phospholipids and fats and 1% carbohydrates.
It discusses basic information regarding a hemichordate animal called Balanoglossus or Acorn worm, which is also a good connecting link between the non-chordates and chordates.
The vertebrate brain
The vertebrate brain is the main part of the central nervous system. The brain and the spinal cord make up the central nervous system,
In most of the vertebrates the brain is at the front, in the head. It is protected by the skull and close to the main sense organs.
Brains are extremely complex and the part of human and animal body. The brain controls the other organs of the body, either by activating muscles or by causing secretion of chemicals such as hormones and neurotransmitters.
Muscular action allows rapid and coordinated responses to changes in the environment.
The brain of an adult human weights about 1300–1400 grams .
In vertebrates, the spinal cord by itself can cause reflex responses as well as simple movement such as swimming or walking. However, sophisticated control of behaviour requires a centralized brain.
The structure of all vertebrate brains is basically the same.
At the same time, during the course of evolution, the vertebrate brain has undergone changes, and become more effective.
In so-called 'lower' animals, most or all of the brain structure is inherited, and therefore their behaviour is mostly instinctive.
In mammals, and especially in man, the brain is developed further during life by learning. This has the benefit of helping them fit better into their environment. The capacity to learn is seen best in the cerebral cortex.
Three principles
The brain and nervous system is essentially a system which makes connections. It has input from sense organs and output to muscles. It is connected in several ways with the endocrine system, which makes hormones, and the digestive system and sex system. Hormones work slowly, so those changes are gradual.
The brain is a kind of department store. It has, all inter-connected, departments which do different things. They all help each other gather senses.
Much of what the body does is not conscious. Basically, much of the body runs on automatic (breathing, heart beat, hungry, hair growth) adjusted by the autonomic nervous system. The brain, too, does much of its work without a person noticing it. The unconscious mind refers to the brain activities which are hardly ever noticed.
INTRODUCTION
The jaw (Upper and lower) is any opposable articulated structure at the entrance of the mouth.
It is typically used for grasping and manipulating food.
Jaw suspension means the fusion of upper jaw and lower jaw or skull for efficient biting.
There are different ways in which these attachments are attained depending upon the modifications in visceral arches in vertebrates.
In most vertebrates, the jaws are bony or cartilaginous and oppose vertically.
The vertebrate jaw is derived from the most anterior two pharyngeal arches supporting the gills, and usually bears numerous teeth.
The vertebrate jaw probably originally evolved in the Silurian period and appeared in the Placoderm fish which further diversified in the Devonian.
It is believed that the hyoid system suspends the jaw from the brain case of the skull, permitting great mobility of the jaws.
The original selective advantage offered by the jaw may not be related to feeding, but rather to increased respiration efficiency.
The jaws were used in the buccal pump (observable in modern fish and amphibians) that pumps water across the gills of fish or air into the lungs in the case of amphibians.
Over evolutionary time the more familiar use of jaws (to humans), in feeding, was selected for and became a very important function in vertebrates. Many teleost fish have substantially modified jaws for suction feeding and jaw protrusion, resulting in highly complex jaws with dozens of bones involved.
Jaw Suspension or Suspensoria:
The method by which the upper and lower jaws are suspended or attached from the chondrocranium is known as jaw suspension or suspensorium.
Amongst the visceral arches, the first (mandibular) arch consists of
= a dorsal palato pterygoquadrate bar forming the upper jaw,
= and ventral Meckel’s cartilage forms the lower jaw.
The second (hyoid) arch consists of = a dorsal hyomandibular supporting and suspending the jaws with the cranium, and a ventral hyoid.
The remaining visceral arches support the gills and are, hence, called branchial arches. Thus, splanchnocranium forms the jaws and suspends them with the chondrocranium.
The integumentary system comprises the skin and its appendages. Skin + derivatives= Integument.
It aims to protect the body from various kinds of damage, such as loss of water or damages from outside.
The integumentary system in chordates includes hair, scales, feathers, hooves, and nails.
It may serve to water proof, and protect the deeper tissues.
Excrete wastes, and regulate body temperature.
It is the attachment site for sensory receptors to detect pain, sensation, pressure, and temperature.
ORIGIN OF CHORDATES
Animal kingdom is basically divided into two sub kingdoms:
Non-chordata- including animals without notochord.
Chordata- This comprising animals having notochord or chorda dorsalis.
Chordates were evolved sometime 500 million years ago during Cambrian period (invertebrates were also began to evolve in this period) .
Chamberlain (1900) pointed out that all modern chordates possess glomerular kidneys that are designed to remove excess water from body.
It is believed that Chordates have originated from invertebrates.
It is difficult to determine from which invertebrate group the chordates were developed.
Chordate ancestors were soft bodied animals. Hence they were not preserved as Fossils.
However, early fossils of chordates have all been recovered from marine sediments and even modern protochordates are all marine forms.
Also glomerular kidneys are also found in some marine forms such as myxinoids and sharks. That makes the marine origin of chordates more believable.
Chordates evolved from some deuterostome ancestor (echinoderms, hemichordates, pogonophorans etc.) as they have similarities in embryonic development, type of coelom and larval stages.
Many theories infers origin of chordates, hemichordates and echinoderms from a common ancestor.
The urinary system includes the kidneys and the ducts that carry away their product, urine. The genital system includes the gonads and their ducts that carry away the products they form, sperm or eggs. Embryologically, urinary and reproductive organs arise from the same or
adjacent tissues and maintain close anatomical association
throughout the organism’s life.
A concise class lecture for veterinary students, practitioners, and researchers covering the functional anatomy of reproductive organs of domestic animals and pet animals.
This lecture explains anatomy of the reproductive organs of domestic animals. This would be useful for veterinary students, practitioners and researchers
The anatomy of female reproductive organs of domestic animals is described in this lecture useful for students, practitioners and aspirants of examinations
Water pollution is a threat to aquatic organisms, including fish, and is a global concern for aquatic biodiversity and ecosystem integrity. This study evaluates the effect of waterborne pollutants on Gangetic Mystus (Mystus cavasius) collected from Chambal River at Nagda, Ujjain. Mystus appeared to be a useful biomarker to assess the impact of toxicity of water pollution.
Zooplankton are the animal component of the plankton community. They are heterotrophic, meaning they can't make their own food and must eat other organisms. In particular, they eat phytoplankton, which are generally smaller than zooplankton.11 species of zooplankton were found in the Shivna River. The most abundant species were copepods Oithona similis, Paracalanus sp., and Calanus sinicus.The species composition of zooplankton varies by season. The highest number of species were found in winter, followed by autumn, summer, and spring. The highest abundance of zooplankton was found in summer, and the lowest in post-monsoon.
This presentation explores how climate change alters the pursuit of economic development: the transformation of poor economies and their people into prosperous ones.
This is hardly the first attempt to reconcile the climate agenda with that of economic development. The United Nations’ Sustainable Development Goals are significant for defining a dual agenda where development targets for people and planet sit alongside each other in a unifying framework.1 Much commentary focuses on the compatibility of the two agendas. A radical and specious view pits progress on climate change and economic development as strict substitutes and calls for no less than the unravelling of economic development to save the planet.2 Cooler heads point instead to their complementarity: the critical role of economic development in supporting adaptation and the recognition that investments in the green transition will propel economies rather than sacrifice living standards.3
In contrast, this essay takes as its starting point that the goals and salience of economic development are immutable. The question posed here is how the quest for economic development changes in a world gripped by a changing climate. The essay argues that climate change will force three major changes: a reappraisal of the causes of and prospects for development, the rebirth of the economics of transition, and a reformulation of the problem development is trying to solve. In a final section, it asks what these changes could mean for international security and for the community of national and global actors who set policy and strategy in this field.
Climate change refers to long-term shifts in temperatures and weather patterns. Such shifts can be natural, due to changes in the sun’s activity or large volcanic eruptions. But since the 1800s, human activities have been the main driver of climate change, primarily due to the burning of fossil fuels like coal, oil and gas.
Burning fossil fuels generates greenhouse gas emissions that act like a blanket wrapped around the Earth, trapping the sun’s heat and raising temperatures.
The main greenhouse gases that are causing climate change include carbon dioxide and methane. These come from using gasoline for driving a car or coal for heating a building, for example. Clearing land and cutting down forests can also release carbon dioxide. Agriculture, oil and gas operations are major sources of methane emissions. Energy, industry, transport, buildings, agriculture and land use are among the main sectors causing greenhouse gases.
In India, bacteria that cause common infections, such as urinary tract and bloodstream infections, are becoming resistant to nearly all antibiotics. This resistance is due to a combination of factors: uncontrolled access to antibiotics, gaps in infection prevention and control (IPC) practices, and high rates of communicable diseases. Antibiotic resistance, or AR, is a serious problem throughout the country, and threatens to reduce the usefulness of antibiotics both in India and around the world.
Because of this emerging threat, India is committed to slowing the spread of AR. Two institutions within India’s Ministry of Health – the Indian Council of Medical Research and National Centre for Disease Control – each developed national networks of public and private hospitals to measure AR trends, prevent healthcare-associated infections (HAIs), and enhance appropriate use of antibiotics. The All India Institute of Medical Sciences is coordinating HAI measurement and prevention efforts in both networks. In addition, efforts in the state of Tamil Nadu focus on building district-level IPC capacity to prevent HAIs, focusing on maternal and neonatal patients.
The Indian Governamnet is is working closely with partners at the national and state level to:
Detect AR pathogens, including novel strains, by developing lab networks and lab expertise.
Use standardized surveillance to monitor and track AR infections in healthcare to learn how often these infections occur and to help develop strategies to prevent them.
Implement focused IPC activities and training.
Optimize use and reduce misuse of critical antibiotics through antibiotic stewardship programs.
Physiological and histopathological effects of Bisphenol A .Bisphenol A is less soluble in water. For that reason, dimethyl sulfoxide (DMSO) was used as a medium to obtain proper distribution in the test solution (Chen, J., et al, 2015). Working solution of commercial grade Bisphenol A (97% pure) was prepared by dilution of stock solution double distilled water immediately prior to experimental use. Serial dilutions of the stock solution were prepared using previously aerated, copper free and stored tap water. The water was continuously aerated. This was prepared by dissolving BPA (50mg) in 100ml of DMSO and the desired concentrations of BPA in tap water were prepared by adding appropriate volumes of this stock solution into test aquarium. A static non-renewable bioassay was conducted in triplicate for each concentration with four animals in each tub. No water exchange was done and the fishes were not fed during the period of the experiment. Percentage mortality was recorded at 12, 24, 48, 72 and 96 h interval. Control group was subjected to acetone at the maximum acetone volume used in the dilution of the dose concentrations. The range of LC50 for H.fossilis (mean wt. 36.78 g) under given conditions was determined to lie between 5 and 10 mg/L for BPA. Hence, for the definitive test, concentrations such as 2, 4, 6, 8, 10, 12, and 14 mg/L of BPA concentration were selected. The test was conducted in triplicate for each concentration with 10 fishes in each tank. At the end of 96 h, the fishes that had survived were anesthetized with clove oil at 100 mg/L, sampled for blood, and processed for hematological analysis. The data obtained from the experiment was processed by probit analysis using a Microsoft Excel computer program.
When pollutants are discharged from a specific location such as a drain pipe carrying industrial effluents discharged directly into a water body it represents point source pollution.
In contrast, non-point sources include discharge of pollutants from diffused sources or from a larger area such as runoff from agricultural fields, grazing lands, construction sites, abandoned mines and pits, etc.
Targets of Sustainable Development Goal 3
WHO Framework Convention on Tobacco Control; support research, development and universal access to affordable vaccines and medicines; increase health financing and support health workforce in developing countries
INTRODUCTION
Toxicology is the science of the poisons. It also studies the nature, effects, detection, assessment and treatment of their effects on biological material.
Toxicology is a multidisciplinary science. The ultimate objective of the combined research is to determine how an organism is affected by exposure to an agent.
This includes an understanding of:
How the agent moves and interact with living cells and tissues of the organism;
What parts of the organism are affected by its presence and health outcomes of this exposure.
Evaluation of the toxicity of substances whose biological effects may not have been well characterized.
The influence of chemical toxicity is mainly
determined by the dosage, duration of exposure,
route of exposure, species, age, sex, and environment.
The goal of toxicology is to contribute to the
general knowledge and harmful actions of
chemical substances.
2. to study their mechanisms of action,
3. and to estimate their possible risks to humans
HISTORY
Dioscorides, a Greek physician in the court of the Roman emperor Nero, made the first attempt to classify plants according to their toxic and therapeutic effect. Poisonous plants and animals were recognized and their extracts used for hunting or in warfare.
In 1500 BC people used hemlock, opium, arrow poisons, and certain metals to poison enemies or for state executions.
Theophrastus Phillipus Auroleus Bombastus von Hohenheim (1493–1541) (also referred to as Paracelsus, a Roman physician from the first century) is considered "the father" of toxicology.
He stated that "All things are poisonous and nothing is without poison; only the dose makes a thing not poisonous.“
Mathieu Orfila (1813) is considered the modern father of toxicology.
In 1850, Jean Stas became the first person to successfully isolate plant poisons from human tissue.
Hippolyte Visart de Bocarmé used nicotine to kill his brother-in-law. He extracted nicotine from tobacco leaves.
The 20th and 21st Centuries have marked by great advancements in the level of understanding of toxicology. DNA and various biochemicals that maintain body functions have been discovered. Our level of knowledge of toxic effects on organs and cells has expanded to the molecular level.
Introduction
Gnathostomata are the jawed vertebrates. (gnathos= "jaw" + (stoma)="mouth".
It comprises roughly 60,000 species. (99% of all living vertebrates).
Living gnathostomes have teeth, and paired appendages.
A horizontal semicircular canal is present in the inner ear.
Myelin sheaths is present on the neurons.
Adaptive immune system uses V(D) J recombination ( it is the mechanism of somatic recombination that occurs only in developing lymphocytes during the early stages of T and B cell maturation. VDJ recombination is the process by which T cells and B cells randomly assemble different gene segments – known as variable (V), diversity (D) and joining (J) genes – in order to generate unique receptors (known as antigen receptors) that can collectively recognize many different types of molecule. While Agnatha (petromyzon and hagfish) use genetic recombination in the variable lymphocyte receptor gene.
It is now assumed that Gnathostomata evolved from ancestors that already possessed a pair of both pectoral and pelvic fins.
In addition to this, some placoderms were shown to have a third pair of paired appendages, that had been modified to claspers in males and basal plates in females—a pattern not seen in any other vertebrate group.
It is believed that the jaws evolved from anterior gill support arches that had acquired a new role, being modified to pump water over the gills by opening and closing the mouth more effectively – the buccal pump mechanism.
Presence of Calcified, bony skull and vertebra are the characteristic features of Gnathostomata (fishes, amphibians, reptiles, birds and mammals).
Pelvic fins are situated just in front of the anus.
Interventrals and basiventrals present in the backbone. These are the elements of the backbone which lie under the notochord, and match the basidorsals and interdorsals respectively.
Gill arches which lie internally to the gills and branchial blood vessels, contrary to the gill arches of all jawless craniates, which are external to the gills and blood vessels.
A horizontal semicircular canal in the inner ear.
Paired nasal sacs which are independent from the hypophysial tube.
There are numerous other characteristics of the soft anatomy and physiology (e.g. myelinated nerve fibres, sperms passing through urinary ducts, etc.), which are unique to the gnathostomes among extant craniates, but cannot by observed in fossils.
Introduction
Ostracoderms (shell-skinned) are of several groups of extinct, primitive, jawless fishes that were covered in an armour of bony plates.
They appeared in the Cambrian, about 510 million years ago, and became extinct towards the end of the Devonian, about 377 million years ago. They were quite abundant during the upper Silurian and Devonian periods. Most of fossils of Ostracodermi were preserved in the bottom sediments of freshwater streams.
However, the opinion is sharply divided as to whether their habitat was freshwater or marine.
The first fossil fishes that were discovered were ostracoderms.
The Swiss anatomist Louis Agassiz received some fossils of bony armored fish from Scotland in the 1830s.
The ostracoderms resembled the present day cyclostomes (lampreys and hagfishes) in many respects and together with them constitute a special group of jawless vertebrates, the Agnatha.
Characteristics: They use gills exclusively for respiration but not for feeding . Earlier chordates with gills used them for both respiration and feeding. Ostracoderms had separate pharyngeal gill pouches along the side of the head, which were permanently open with no protective operculum. mostly small to medium-sized fishes, protected by a heavy, bony dermal (derived from skin) armor. bottom-dwellers; filter-feeders or grazers. no paired fins, but many with stabilizing paired flaps on either side of head.
(1) Ostracoderms were the first vertebrates.
(2) They were popularly called armoured fishes.
(4) They lived in freshwater.
(5) They were bottom dwellers.
(6) Their body was fish-like and did not exceed 30 cm in size.
(7) Paired fins were absent.
(8) Median and caudal fins were present.
(9) The caudal fin was of heterocercal type.
(10) The head and thorax were covered by heavy armour of bones. It protected ostracoderms from the giant scorpion like arthropods, eurypterids.
(11) Bony skull was well developed.
(12) Mouth was mostly present on the ventral side.
(13) They were having large number of gill slits.
(14) The nervous system had 10 pairs of cranial nerves.
(15) The head had a pair of lateral eyes, and a median pineal eye.
(16) They were filter feeders, feeding like a vacuum cleaner.
(17) The endoskeleton was either bony or cartilaginous.
Introduction:
Adaptation to environment is one of the basic characteristics of the living organisms. Living organisms are plastic and posses the inherent properties to respond to a particular environment.
It is a facet of evolution and involve structural diversities amongst living organisms that are heritable. Organisms exhibit numerous structural and functional adaptations that help them to survive as species and to overcome the tremendous competition in nature.
All classes of vertebrates have their representatives leading to partial or total aquatic life.
Water is a homogenous medium for animals.
As a medium, it is heavy in concentration than air.
Stable gaseous and osmotic concentration in a specific region.
Temperature fluctuation is minimum for a particular region.
Water bodies generally have very rich food resources.
Characters of an Aquatic Animal:
An aquatic animal should have the ability to swim to overcome the resistance of the surrounding medium.
Therefore, it should have a streamlined body with an organ or ability to float.
The animal should also have to overcome the problem of osmoregulation.
There are two types of animals living in the present day water, which have undergone aquatic adaptation.
According to their origin, they are primary and secondary aquatic animals.
Adaptations to water habitat are of two types:
Primary aquatic adaptations which includes primitive gill-breathing vertebrates (fishes); Those animals, whose ancestors and themselves are living in the water from the very beginning of their evolution, are called primary aquatic animals. In other words, primary aquatic animals never had a terrestrial ancestry. They exhibit perfect aquatic adaptations. All fishes are primary aquatic animals.
Secondary aquatic adaptations which are acquired as in reptiles, birds and mammals. Those animals whose ancestors were lung breathing land animals, migrated to the water for some reason and ultimately got adapted to live in aquatic habitat, are called secondary aquatic animals. Some of them live partially while others live totally in the water. All aquatic reptiles, aves and mammals are representatives of secondary aquatic animals. Amphibians are in a transitional form between primary and secondary aquatic life.
Sensory adaptations like, electroreception for electrolocation and electro communication, olfaction (vomeronasal system), balance (spatial orientation, movement perception), vision (cornea curvature, retinal topography), and hearing (acoustics, ear anatomy) under the underwater sound reception mechanisms in various aquatic amniotes are well developed.
Origin of the Lateral Line System
Lateral line is a canal along the side of a fish containing pores that open into tubes supplied with sense organs sensitive to low vibrations.
Robert H. Denison explained the origin of the lateral line system. He explained that early vertebrates had a pore-canal system in the dermis which functioned as a primitive sensory system in detecting water movement.
Through the evidences from fossils, embryology and comparative anatomy, Denison (1966) established that the inner ear is closely related to the lateral line system. He found a distinct relationship between the pore canal system and the lateral line in Osteotraci.
The inner ear and the lateral line are developed from ectodermal thickenings, called dorso-lateral placodes. These have a number of similarities, including receptors with sensory hairs, and are both innervated by fibers in the acoustico-lateral area of the brain.
The pore canal system is present and developed in Osteostraci (ostracoderm).
It is also present in Heterostraci which is another group of ostracoderms and includes early vertebrates such as lungfishes and crossopterygians.
As its presence is extensive, it is reasonable to suggest that the pore canal system was a primitive character in early vertebrates .
In transverse sections also , it is very difficult to differentiate the pore canal system from a lateral line canal.
Structure of the Lateral Line System
Epidermal structures called neuromasts form the peripheral area of the lateral line.
Neuromasts consist of two types of cells, hair cells and supporting cells.
Hair cells have an epidermal origin and each hair cell has one high kynocyle (5-10 μm) and 30 to 150 short stereocilia (2-3 μm).
The number of hair cells in each neuromast depends on its size, and they can range from dozens to thousands.
Hair cells can be oriented in two opposite directions with each hair cell surrounded by supporting cells.
At the basal part of each hair cell, there are synaptic contacts with afferent and efferent nerve fibers. Afferent fibers, transmit signals to the neural centres of the lateral line and expand at the neuromast base. The regulation of hair cells is achieved by the action of efferent fibers.
Stereocilia and kinocilium of hair cells are immersed into a cupula and are located above the surface of the sensory epithelium.
The cupula is created by a gel-like media, which is secreted by non-receptor cells of the neuromast.
Central nervous system: The central nervous system consists of the brain and spinal cord. The brain plays a central role in the control of most bodily functions, including awareness, movements, sensations, thoughts, speech, and memory. Some reflex movements can occur via spinal cord pathways without the participation of brain structures. The spinal cord is connected to a section of the brain called the brainstem and runs through the spinal canal.
Peripheral Nervous System: Nerve fibers that exit the brainstem and spinal cord become part of the peripheral nervous system. Cranial nerves exit the brainstem and function as peripheral nervous system mediators of many functions, including eye movements, facial strength and sensation, hearing, and taste.
The autonomic nervous system: The autonomic nervous system is a control system that acts largely unconsciously and regulates bodily functions, such as the heart rate, digestion, respiratory rate, pupillary response, urination, and sexual arousal. This system is the primary mechanism in control of the fight-or-flight response.
The autonomic nervous system comprises two antagonistic sets of nerves, the sympathetic and parasympathetic nervous systems. The hypothalamus is the key brain site for central control of the autonomic nervous system, and the paraventricular nucleus is the key hypothalamic site for this control.
Divisions of Nervous System:
The vertebrate nervous system has three divisions:
(i) A central nervous system comprising the brain and spinal cord. Its function is to receive the stimulus from the receptors and transmit its response to the effectors. Thus, it coordinates all the functions of the body.
(ii) A peripheral nervous system consisting of cranial and spinal nerves arising from the brain and spinal cord respectively. It forms a connecting link between the receptors, central nervous system (CNS) and effectors.
(iii) An autonomic nervous system made of two ganglionated sympathetic nerves, ganglia in the head and viscera, and their connecting nerves. The autonomic nervous system is often regarded as a part of the peripheral nervous system because the two are connected. But all the three divisions of the nervous system are connected intimately both structurally and functionally.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
In silico drugs analogue design: novobiocin analogues.pptx
Gonadal system
1. Genital system in vertebrates
(Vertebrate Kidneys and Ducts)
Dr. P.B.Reddy
M.Sc,M.Phil,Ph.D, FIMRF,FICER,FSLSc,FISZS,FISQEM
PG DEPARTMENT OF ZOOLOGY
GOVERTNAMENT PG COLLEGE, RATLAM.M.P
reddysirr@gmail.com
2.
3. Introduction: The male and female reproductive systems develop initially
embryonically "indifferent", it is the product of the Y chromosome SRY gene
that makes the "difference".
♂ - Male ♀ - Female
The reproductive organs are developed from the intermediate
mesoderm.
The permanent organs of the adult are preceded by a set of
structures which are purely embryonic, and which with the exception
of the ducts disappear almost entirely before the end of fetal life.
These embryonic structures are the mesonephric ducts (also
known as Wolffian ducts) and the paramesonephric ducts, (also
known as Müllerian ducts). The mesonephric duct remains as the
duct in males which gives rise to seminal vesical, epididymes and vas
deferens, and the paramesonephric duct as that of the female.
Importantly its sex chromosome dependence, late embryonic/fetal
differential development, complex morphogenic changes, long time-course,
hormonal sensitivity and hormonal influences make it a system prone to
many different abnormalities.
4. Gonads:
Gonads Produce eggs and sperm cells,
transport and sustain egg and sperm cells, nurture
developing offspring, and produce hormones.
The gonads, ovary or testis, also develop in the
intermediate mesoderm.
They originally form as swellings that lie just
ventral to the anterior mesonephric kidney.
A mullarian duct also develops in the
intermediate mesoderm near the mesonephric
duct.
Due to fusion or failure of 1st ridge to
differentiate, some vertebrates (agnathans, some
female lizards & crocodilians, & most female birds)
have a single testis or ovary.
Hormones cause differentiation of early gonads
into either testes or ovaries.
As males develop the mesonephric duct makes
connection with the testis as the primary sperm
conducting duct, and the mullerian duct is lost.
5. Ovaries:
•In some teleosts, ovaries are hollow sacs,
either because the ovary develops around
coelom or the ovary becomes hollow at
ovulation (eggs are discharged into cavity
which is continuous with the oviduct).
•In other teleosts plus agnathans, the
ovaries are compact & eggs are discharged
into coelom.
•Amphibians - ovaries are hollow & eggs are
discharged into the coelom.
•Reptiles, birds, & monotremes - ovaries
solid but develop irregular, fluid-filled
lacunae (cavities); eggs discharged into
coelom.
•Mammals - ovaries compact; no large
chambers or lacunae.
6. Testes:
•Usually smaller than ovaries because sperm are much smaller than
eggs (especially eggs with yolk).
•In mammals, testes are larger than ovaries.
Translocation of testes in mammals:
•Testes descend permanently into scrotal sacs in many mammals.
•Some mammals - testes lowered into scrotal sacs & retracted at will.
•Inguinal canal - passage between abdominal cavity & scrotum.
•Scrotal sacs - do not develop in some mammals; testes remain in
abdomen.
7. Male genital ducts:
•Some fishes (e.g., gar & sturgeon) & amphibians - mesonephric duct
transmits sperm & urine.
•Some amphibians - mesonephric duct transports only sperm; new
accessory urinary duct drains the kidney.
•Sharks - mesonephric duct is used primarily for sperm transport;
accessory urinary duct develops.
•Teleosts - mesonephric duct drains kidney; separate sperm duct
develops.
•Amniotes - embryonic mesonephric ducts transport sperm in adults.
8. Intromittent organs:
Useful when fertilization is internal; introduce sperm into female
reproductive tract.
Found in some fish, some birds, reptiles, & mammals.
Cartilaginous fish - appendages of pelvic fins called claspers direct
sperm into female reproductive tract.
Snakes & lizards - have pair of HEMIPENES (pocket like diverticula of
wall of cloaca).
Turtles, crocodilians, a few birds, & mammals - exhibit an unpaired
erectile penis.
Penis - usually a thickening of floor of cloaca consisting of spongy
erectile tissue (corpus spongiosum) with grooves to direct sperm &
ending in a glans penis (sensory endings that reflexly stimulate
ejaculation).
Mammals (except monotremes) - penis extends beyond body. The
embryonic corpus spongiosum becomes a tube with urethra inside & 2
additional erectile masses develop (corpus cavernosa).
9. Female genital ducts:
Consists of a pair of
gonoducts (or oviducts) that
extend from ostia to the cloaca.
Different segments of ducts
perform special functions.
When internal, fertilization
occurs near beginning of ducts,
the mullerian duct becomes the
passage for eggs.
The females of fish and
amphibians retain the
mesonephric duct as a urinary
duct.
In reptiles, birds, and
mammals (amniotes) the
metanephric kidney replaces the
mesonephric kidney.
10. Anatomy in various vertebrate groups:
Cartilaginous fish - 2 ostia fuse to form single
ostium (or osteum); shell gland secretes albumen &
a shell; uterus holds eggs until laying.
Teleosts - ducts are continuous with cavity of the
ovary.
Lungfish & amphibians - oviducts long &
convoluted; lining secretes jelly-like material around
each egg.
Crocodilians, some lizards, & nearly all birds
(diagram below) - 1 coiled oviduct lined with glands
that add albumen, shells, &, sometimes, pigment
Monotremes - tract is reptilian; caudal end
secretes a shell before egg passes into the cloaca.
Placental mammals - embryonic ducts give rise to
oviducts, uteri, & vaginas. Adult tract is paired
anteriorly & unpaired posteriorly (typically
terminating as an unpaired vagina). oviducts
(fallopian tubes) are relatively short, small in
diameter, convoluted, & lined with cilia; begin at
ostium bordered with fimbria.
Uterus:
Marsupials - no fusion of embryonic ducts
so there are 2 tracts (DUPLEX UTERUS)
11. Other placental mammals - varying degrees of
fusion:
Bipartite uterus - 2 uterine horns, a uterine body
(with 2 lumens), & a single vagina.
Bicornuate uterus - 2 uterine horns, a uterine body
(with a single lumen), & a single vagina.
Simplex uterus - no uterine horns & oviducts open
directly into body of uterus.
Vagina - fused terminal portion of oviducts that
opens either into urogenital sinus or to the
exterior; receives male intromittent organ.
12.
13. Both Müllerian and Wolffian
ducts are present at the bipotential
stage.
In males, the Müllerian ducts
degenerate under the influence of
Anti-Müllerian hormone (AMH)
secreted by the testicular Sertoli
cells.
Wolffian ducts differentiate into
epididymides, vasa deferentia, and
seminal vesicles under the control
of androgens produced by Leydig
cells.
In females, the Wolffian duct
regresses and the Müllerian duct
differentiates into oviduct, uterus,
and upper vagina.
14. Fish male FROG -MALE - URENOGENITAL SYSTEM
L. Testes are very long and ribbon like. 1. Testes are small and rod-like.
2. Testes are attached to the kidneys
anteriorly.
2. Testes are attached to the kidneys
above the middle region with
mesorchium.
3. Testes are connected with the rectal
gland by epigonal organs.
3. The epigonal organs are absent.
4. Vasa efferentia leave the testis at its
anterior end.
4. Vasa efferentia leave the testis alone
its inner border.
5. These open into the wolffian duct.
5. open into .the Bidder's canal which
drains into the wolffian duct.
6. Wolffian duct is differentiated into an
anterior narrow closely convoluted
epididymis and the posterior wide less
convoluted vesiculus seminalis.
6.Wolffian duct is not differentiated into
the parts except having a small seminal
vesicle near its beginning.
7. Wolffian ducts act only as genital
ducts.
7. Wolffian ducts act as both urinary
and genital duct. Hence they are known
as urinogenital ducts.
8. A pair of club-shaped sperm sac open
into the urinogenital sinus
8. Sperm sacs are absent
9. The copulatory apparatus comprising
siphons and claspers.
9. Copulatory apparatus is absent.
10. Sperms are released into the genita
iuct of female, hence fertilization is
internal.
10. Sperms are released over the eggs
tithe fresh water, hence fertilization is
external. Sperms are released as milt'
11. There are no fat bodies attachec to
the testes.
11. There is a large branched fai-bodv
attached to the anterior end of ead
testis.
12. There is a single urino-genital
12. Urino-genital papillae are paired.
SHARK -FEMALE -
REPRODUCTIVE SYSTEM
FROG -FEMALE - REPRODUCTIVE
SYSTEM
1. Ovaries are small, tabulated
bodies
1. Ovaries are large, hollow,
lobed sacs
2. connected with rectal glands
by long epigonal organs.
2. Epigonal organs are absent.
3. Oviducts (Mullerian ducts) are
long but not convoluted.
3. Oviducts (Mullerian ducts) are
very long and greatly convoluted.
4. Oviducts converge and unite in
front of the ovaries leaving a slit
'ostium tubae! The oviducal
funnels are on either side of
ostium tubae.
4. Oviducts converge infront of
the ovaries but do not unite.
Each oviduct has its own ostium
at the lip of oviducal funnel.
5. shell glands are present. 5. There is no shell gland
6. The oviducts are expanded to
form large uteri in the region of
renal part of kidneys
6. The oviducts are expanded to
form small ovisacs behind the
kidneys.
7. The oviducts join to form a
median sac-'vagina' which opens
into the cloaca.
7. The oviducts independently
open into the cloaca. The vagina
is absent.
8. There are no fat bodies.
8, There is a large fat body
attached to the anterior end of
each ovary.
9 Since the fertilization in
internal, there is no question of
releasing the egg out side the
body
9. The mass of eggs is called
"spawn* which is released
outside the body Fertilization is
external.
15. FEMALE-CALOTES FEMALE-PEGION FEMALE-RABBIT
1, Two ovaries are present. 1. Only left ovary is present. 1. A pair of ovaries are present on the left and
right sides. They are small and compact bodies.
2. Ovaries are irregular bodies situated
asymmetrically and hanging from the dorsal wall
of the body cavity by mesovaria.
2. The single left ovary is attached to anterior
lobe of the left kidney by mesovarium.
2. The ovaries lie behind the kidneys and
attached to dorsal wall of the abdominal cavity
by mesovaria.
3. Right ovaiy is a little anterior to the left one. 3. Right ovary is absent. 3. Right and left ovaries are at the same level.
4. Oviducts are paired. 4. Only left oviduct is developed. 4. Oviducts are paired.
5. Oviducts give striated appearance over
greater part of their length.
5. Oviduct doesnot give striated appearance. 5: Striated appearance is absent.
6. Oviducts extend well ahead of ovaries and
follow straight course.
6. Oviduct starts'just behind the ovary and
follow a convoluted course.
6. Oviducts start just outside the ovaries and
follow convoluted course.
7. Oviducal funnel are large and have externally
directed Ostia with the entire margin.
7. Single Left oviducal funnel is very large and
membranous. It has fimbricated margins it lies
close to the ovary with it; ostium.
7. Oviducal funnel are small and have internally
directed ostia with fimbricated margin.
8. Each oviduct dilates to form an oval shell
gland along the ventral surface of the kidney
uteri are not demarcated. Oviducts are enlarged
into small ovisacs. These are two vaginae.
Vaginae open into the urodaeum.
8. The oviduct is divided into anterior oviducal
funnel, behind it magnum which is thick walled
& secretes albumen. The posterior most part is
the thick walled and muscular vagina.
8. The oviducal funnel leads distally in a narrow
and convoluted tube - Fallopian tube. The
posterior most parts of the two oviducts form
uteri. The paired uteri open into median and
highly muscular chamber-vagina. Associated
with urethra, the vagina forms the urino-genital
canal or vestibule.
9. Urodaeum opens outside by a cloaca 9. Urodaeum opens out by a cloaca. 9. Urino - genital canal opens outside by a
longitudinal aperture - vulva in front of the
anus.
10. There are no special glands associated with
female reproductive system.
10. Same as in calotes. 10. Cowper's and perineal glands are associated
with female reproductive system.
11. Milk glands are absent. 11. Milk Glands are absent. 11. On the ventral surface of trunk region 4 or 5
pairs of milk glands open through their tears.
12. Fertilization is internal oviparous animal. 12. Same as in calotes. Oviparous animal 12. Same as in calotes and columba. Viviparous
animal
16. MALE-CALOTES (GARDENLIZARD) MALE- (PIGEON) MALE (RABBIT)
1. Testes are white ovoid bodies. 1. Testis white ovoid bodies. 1. Testes are pink, ovoid bodies.
2. Testes lie in the abdominal cavity much ahead
of kidneys. Inguinal canal is absent.
2. Testes lie in the abdominal cavity under the
anterior parts of kidneys. Inguinal canal is
absent.
2. Testes are extra abdominal and lie in the
scrotal sacs which are the folds of the skin.
They are connected with perivisceral cavity by
inguinal canals.
3 Right testis is a little ahead of the left one. 3. Left testis is a little bigger than the right one. 3. Right and left testes are symmetrical.
4. Spermatic cord is not formed. 4. Same as in calotes. 4. A spermatic cord extends from each testis to
a little behind the kidney of its side.
5. Each testis is attached to the dorsal body wall
by a double fold of peritoneum the mesorchium.
5. Each testis is attached to the kidney of its
side by mesorchium.
5. Each testis is attached to the wall of scrotal
sac by a short, thick, elastic cord
'gubernaculum'.
6. From the inner end of each testis arises a
much convoluted tube-epididymis.
6. Epididymis is absent. 6. Epididymis is present.
7. Caput and cauda epididymis are not found 7. Same as in calotes. 7 Caput epididymis and cauda epididymes are
the extensions of epididymis in front and
behind the testis
8. Epididymis is continued behind as long,
narrow, coiled and delicate vas deferens. It
passes backwards along the ventral surface of
the kidney of its side and joins with the ureter to
form urino-genital sinus which opens into the
cloaca.
8 The vas deferens arises directly from the
inner border of the kidney in the form of a
narrow convoluted tube. It runs backwards
outside the ureter parallel to it and both open
dorsally by separate aperture in urodaeum of
the cloaca.
8. The vas deferens passes through the
inguinal canal and runs forward and enters into
the abdominal cavity. So that a loop around
the ureter of its side to open into sac-uterus
masculinus' which is present in the dorsal wall
of the urinary bladder.
9. Seminal vesicles are absent. 9. Posterior end of each vas deferens enlarges
to form seminal vesicle.
9. Seminal vesicles are absent.
10. There are no special glands associated with
male genital system.
10. Same as in calotes. 10. There are prostate, couper's and perineal
glands are associated with the male genital
system.
11. In male a pair of eversible copulatory organs
'hemipenis' lie under the skin behind cloacal
aperture
11. Copulatory organs are absent. 11. The copulatory organ in male is in the form
of a thick muscular 'Penis'. It is covered by skin
loose fold prepuce or foreskin penis is made
up of a spongy tissue containing blood vessels
and it is erectile.