The respiratory system allows organisms to take in oxygen and release carbon dioxide through the process of respiration. Respiration includes ventilation, external respiration where gases are exchanged with the environment, and internal respiration where gases are exchanged at the tissue level. The main respiratory organs are lungs, gills, and in some cases skin or gas bladders. Lungs are found in air-breathing vertebrates like mammals and birds, using an aspiration pump for ventilation. Gills are found in fish and some aquatic amphibians and function via various water pumping mechanisms. Skin respiration also occurs in some amphibians.
Why do animals need to breathe?
Breathing is important to organisms because cells require energy (oxygen) to move, reproduce and function. Breath also expels carbon dioxide, which is a by-product of cellular processes within the bodies of animals.
Respiration is the process of releasing energy from food and this takes place inside the cells of the body.
The process of respiration involves taking in oxygen (of air) into cells, using it for releasing energy by burning food, and then eliminating the waste products (carbon dioxide and water) from the body.
Respiration is essential for life because it provides energy for carrying out all the life processes which are necessary to keep the organisms alive.
The energy produced during respiration is stored in the form of ATP (Adenosine Tri- Phosphate) molecules in the cells of the body and used by the organism as when required.
KEY POINTS
Life started in an anaerobic environment in the so called ‘primodial broth’ (a mixture of organic molecules.
Subsequently, oxygen strangely enough became an crucial factor for aerobic metabolism especially in the higher life forms.
The rise of an oxygenic environment was an important event in the diversification of life.
It evoked a dramatic shift from inefficient to sophisticated oxygen dependent oxidizing ecosystems.
Anaerobic fermentation, the metabolic process that prevailed for the first about 2 billion years of the evolution of life, was a very inefficient way of extracting energy from organic molecules. Ex: A molecule of glucose, e.g., produces only two molecules of ATP (≈ 15 kCal) compared with 36 ATP molecules (≈ 263 kCal) in oxygenic respiration.
Aerobic metabolism must have developed at a critical point when the partial pressure of oxygen rose from an initial level to one adequately high to drive it passively across the cell membrane.
Respiration is a complex and highly integrated biomechanical, physiological, and behavioral processes.
The transfer of O2 occurs through a flow of tissue barriers and compartments by diffusion down a partial pressure gradient, which drops to about zero at the mitochondrial level.
Acquisition of molecular oxygen (O2) from the external fluid media (water and air) and the discharge of carbon dioxide (CO2) into the same milieu is the primary role of respiration.
The respiratory system is a biological system consisting of specific organs and structures.
The primitive blueprint for the heart and circulatory system emerged with the arrival of the third mesodermal germ layer in bilaterians. Since then, hearts in animals have evolved from a single layered tube to a multiple chambered heart in due course of time.
The integumentary system comprises the skin and its appendages. Skin + derivatives= Integument.
It aims to protect the body from various kinds of damage, such as loss of water or damages from outside.
The integumentary system in chordates includes hair, scales, feathers, hooves, and nails.
It may serve to water proof, and protect the deeper tissues.
Excrete wastes, and regulate body temperature.
It is the attachment site for sensory receptors to detect pain, sensation, pressure, and temperature.
Evolutionary change in heart of vertebrates
Heart is situated ventral to the oseophagus in the pericardial section of the coelom.
Heart is a highly muscular pumping organ that pumps blood into arteries and sucks it back through the veins.
In vertebrates it has undergone transformation by twisting from a straight tube to a complex multi-chambered organ.
. There has been an increase in the number of chambers in heart during evolution of vertebrates.
The heart is covered by a transparent protective covering, called pericardium. It is a single layer in fish.
Within pericardium there is a pericardial fluid, protects the heart from the external injury.
The evolution of the heart is based on the separation of oxygenated blood from deoxygenated blood for efficient oxygen transport.
Why do animals need to breathe?
Breathing is important to organisms because cells require energy (oxygen) to move, reproduce and function. Breath also expels carbon dioxide, which is a by-product of cellular processes within the bodies of animals.
Respiration is the process of releasing energy from food and this takes place inside the cells of the body.
The process of respiration involves taking in oxygen (of air) into cells, using it for releasing energy by burning food, and then eliminating the waste products (carbon dioxide and water) from the body.
Respiration is essential for life because it provides energy for carrying out all the life processes which are necessary to keep the organisms alive.
The energy produced during respiration is stored in the form of ATP (Adenosine Tri- Phosphate) molecules in the cells of the body and used by the organism as when required.
KEY POINTS
Life started in an anaerobic environment in the so called ‘primodial broth’ (a mixture of organic molecules.
Subsequently, oxygen strangely enough became an crucial factor for aerobic metabolism especially in the higher life forms.
The rise of an oxygenic environment was an important event in the diversification of life.
It evoked a dramatic shift from inefficient to sophisticated oxygen dependent oxidizing ecosystems.
Anaerobic fermentation, the metabolic process that prevailed for the first about 2 billion years of the evolution of life, was a very inefficient way of extracting energy from organic molecules. Ex: A molecule of glucose, e.g., produces only two molecules of ATP (≈ 15 kCal) compared with 36 ATP molecules (≈ 263 kCal) in oxygenic respiration.
Aerobic metabolism must have developed at a critical point when the partial pressure of oxygen rose from an initial level to one adequately high to drive it passively across the cell membrane.
Respiration is a complex and highly integrated biomechanical, physiological, and behavioral processes.
The transfer of O2 occurs through a flow of tissue barriers and compartments by diffusion down a partial pressure gradient, which drops to about zero at the mitochondrial level.
Acquisition of molecular oxygen (O2) from the external fluid media (water and air) and the discharge of carbon dioxide (CO2) into the same milieu is the primary role of respiration.
The respiratory system is a biological system consisting of specific organs and structures.
The primitive blueprint for the heart and circulatory system emerged with the arrival of the third mesodermal germ layer in bilaterians. Since then, hearts in animals have evolved from a single layered tube to a multiple chambered heart in due course of time.
The integumentary system comprises the skin and its appendages. Skin + derivatives= Integument.
It aims to protect the body from various kinds of damage, such as loss of water or damages from outside.
The integumentary system in chordates includes hair, scales, feathers, hooves, and nails.
It may serve to water proof, and protect the deeper tissues.
Excrete wastes, and regulate body temperature.
It is the attachment site for sensory receptors to detect pain, sensation, pressure, and temperature.
Evolutionary change in heart of vertebrates
Heart is situated ventral to the oseophagus in the pericardial section of the coelom.
Heart is a highly muscular pumping organ that pumps blood into arteries and sucks it back through the veins.
In vertebrates it has undergone transformation by twisting from a straight tube to a complex multi-chambered organ.
. There has been an increase in the number of chambers in heart during evolution of vertebrates.
The heart is covered by a transparent protective covering, called pericardium. It is a single layer in fish.
Within pericardium there is a pericardial fluid, protects the heart from the external injury.
The evolution of the heart is based on the separation of oxygenated blood from deoxygenated blood for efficient oxygen transport.
INTRODUCTION
The term urogenital refers to something that has both urinary and genital origins. The word urogenital is used because the urinary and reproductive systems in males merge.
These are grouped together because of their proximity to each other, their common embryological origin and the use of common pathways (ex. urethra).
Kidneys and urinary ducts form the urinary system.
The Urinary system performs two important homeostatic processes like excretion and osmoregulation. This system is intimately associated both anatomically, and in terms of embryonic origin with the genital system.
The genital system includes the gonads which generate gametes and the genital ducts that serve as passages for the gametes.
Though functionally different the two organ systems the urinary and the genital system are treated together as the urino- genital system, since both develop from the same segmental blocks of trunk mesoderm or adjacent tissues and share many of the ducts.
Thus although the two systems have nothing common functionally they are closely associated in their use of common ducts and are studied under the broad heading of urinogenital system.
The function of the excretory system is crucial in considering the possible environment of the ‘vertebrate life ’. Several main functions can be attributed to all vertebrate excretory systems:
Excretion of nitrogenous waste products.
Maintaining homeostasis with regard to ions (i.e. salt balance).
Regaining valuable substances (glucose, salts, amino acids, etc.)
Maintaining a physiological osmotic value (i.e. water balance).
The excretory system is formed by a series of paired, segmental nephrons that begin with a nephrostome opening into the coelomic cavity.
A pair of glomeruli per segment, supplied by branches from the aorta, projects into the coelomic cavity close to these nephrostomes.
At a later stage of development, the glomerulus/nephrostome area becomes separated from the rest of the coelomic cavity by an epithelial fold.
The nephrons connect to a duct that is formed by caudal growth of the most anterior nephric tubules. These paired urinary ducts open near the anal region.
INTRODUCTION
The jaw (Upper and lower) is any opposable articulated structure at the entrance of the mouth.
It is typically used for grasping and manipulating food.
Jaw suspension means the fusion of upper jaw and lower jaw or skull for efficient biting.
There are different ways in which these attachments are attained depending upon the modifications in visceral arches in vertebrates.
In most vertebrates, the jaws are bony or cartilaginous and oppose vertically.
The vertebrate jaw is derived from the most anterior two pharyngeal arches supporting the gills, and usually bears numerous teeth.
The vertebrate jaw probably originally evolved in the Silurian period and appeared in the Placoderm fish which further diversified in the Devonian.
It is believed that the hyoid system suspends the jaw from the brain case of the skull, permitting great mobility of the jaws.
The original selective advantage offered by the jaw may not be related to feeding, but rather to increased respiration efficiency.
The jaws were used in the buccal pump (observable in modern fish and amphibians) that pumps water across the gills of fish or air into the lungs in the case of amphibians.
Over evolutionary time the more familiar use of jaws (to humans), in feeding, was selected for and became a very important function in vertebrates. Many teleost fish have substantially modified jaws for suction feeding and jaw protrusion, resulting in highly complex jaws with dozens of bones involved.
Jaw Suspension or Suspensoria:
The method by which the upper and lower jaws are suspended or attached from the chondrocranium is known as jaw suspension or suspensorium.
Amongst the visceral arches, the first (mandibular) arch consists of
= a dorsal palato pterygoquadrate bar forming the upper jaw,
= and ventral Meckel’s cartilage forms the lower jaw.
The second (hyoid) arch consists of = a dorsal hyomandibular supporting and suspending the jaws with the cranium, and a ventral hyoid.
The remaining visceral arches support the gills and are, hence, called branchial arches. Thus, splanchnocranium forms the jaws and suspends them with the chondrocranium.
Physiology of Respiration in InvertebratesPRANJAL SHARMA
In physiology, respiration is the movement of oxygen from the outside environment to the cells within tissues, and the removal of carbon dioxide in the opposite direction. In these slides you will get to know about Physiology of Respiration in Invertibrates.
The main function of gills is respiration...In gills, there are many hair like projections called gill filaments..in gill filaments, there are number of lamella, from transfer of gases and water occur..
The vertebrate brain
The vertebrate brain is the main part of the central nervous system. The brain and the spinal cord make up the central nervous system,
In most of the vertebrates the brain is at the front, in the head. It is protected by the skull and close to the main sense organs.
Brains are extremely complex and the part of human and animal body. The brain controls the other organs of the body, either by activating muscles or by causing secretion of chemicals such as hormones and neurotransmitters.
Muscular action allows rapid and coordinated responses to changes in the environment.
The brain of an adult human weights about 1300–1400 grams .
In vertebrates, the spinal cord by itself can cause reflex responses as well as simple movement such as swimming or walking. However, sophisticated control of behaviour requires a centralized brain.
The structure of all vertebrate brains is basically the same.
At the same time, during the course of evolution, the vertebrate brain has undergone changes, and become more effective.
In so-called 'lower' animals, most or all of the brain structure is inherited, and therefore their behaviour is mostly instinctive.
In mammals, and especially in man, the brain is developed further during life by learning. This has the benefit of helping them fit better into their environment. The capacity to learn is seen best in the cerebral cortex.
Three principles
The brain and nervous system is essentially a system which makes connections. It has input from sense organs and output to muscles. It is connected in several ways with the endocrine system, which makes hormones, and the digestive system and sex system. Hormones work slowly, so those changes are gradual.
The brain is a kind of department store. It has, all inter-connected, departments which do different things. They all help each other gather senses.
Much of what the body does is not conscious. Basically, much of the body runs on automatic (breathing, heart beat, hungry, hair growth) adjusted by the autonomic nervous system. The brain, too, does much of its work without a person noticing it. The unconscious mind refers to the brain activities which are hardly ever noticed.
Taxonomic Collections, Preservation and Curating of InsectsKamlesh Patel
Taxonomy: Taxonomy is the science of defining and naming groups of biological organisms on the basis of shared characteristics.
The classification of organisms is according to hierarchal system or in taxonomic ranks (eg; domain, kingdom, phylum class, order, family, genus and species) based on phylogenetic relationship established by genetic analysis.
Taxonomic Collection : Biological collection are typically preserved plant or animals specimens along with specimen documentations such as labels and notations.
Dry Collection - Dry collections consist of those specimens that are preserved in a dry state.
Wet Collection - Wet collections are specimens kept in a liquid preservative to prevent their deterioration.
Air sacs are thin walled non-muscular,non-vascular,non-elastic and bladder like membrane connected to the lungs
Air sacs are only the inflated extensions of the mucous membrane of some blindly ending bronchioles
Some of them extended to bones
In pigeon there are nine major air sacs
One of them is unpaired and others are paired
Unpaired air sac is interclavicular
Paired sac include cervical,anterior thoracic,posterior thoracic and abdominal air sacs
Abdominal and posterior thoracic sacs get filled with fresh air during inspiration.so they are called inspiratory air sacs
Others get filled with fresh air during expiration
Presentation on Organ & Mechanism of Respiration in Pisces And Amphibiansvskgondia
This is Powerpoint presentation helpful for students and teachers. It includes Defination of Respiration & Function of respiratory system. Also contains mechanism of respiration and various repiratory organs of pisces and amphibians, their structures and fuctions.
INTRODUCTION
The term urogenital refers to something that has both urinary and genital origins. The word urogenital is used because the urinary and reproductive systems in males merge.
These are grouped together because of their proximity to each other, their common embryological origin and the use of common pathways (ex. urethra).
Kidneys and urinary ducts form the urinary system.
The Urinary system performs two important homeostatic processes like excretion and osmoregulation. This system is intimately associated both anatomically, and in terms of embryonic origin with the genital system.
The genital system includes the gonads which generate gametes and the genital ducts that serve as passages for the gametes.
Though functionally different the two organ systems the urinary and the genital system are treated together as the urino- genital system, since both develop from the same segmental blocks of trunk mesoderm or adjacent tissues and share many of the ducts.
Thus although the two systems have nothing common functionally they are closely associated in their use of common ducts and are studied under the broad heading of urinogenital system.
The function of the excretory system is crucial in considering the possible environment of the ‘vertebrate life ’. Several main functions can be attributed to all vertebrate excretory systems:
Excretion of nitrogenous waste products.
Maintaining homeostasis with regard to ions (i.e. salt balance).
Regaining valuable substances (glucose, salts, amino acids, etc.)
Maintaining a physiological osmotic value (i.e. water balance).
The excretory system is formed by a series of paired, segmental nephrons that begin with a nephrostome opening into the coelomic cavity.
A pair of glomeruli per segment, supplied by branches from the aorta, projects into the coelomic cavity close to these nephrostomes.
At a later stage of development, the glomerulus/nephrostome area becomes separated from the rest of the coelomic cavity by an epithelial fold.
The nephrons connect to a duct that is formed by caudal growth of the most anterior nephric tubules. These paired urinary ducts open near the anal region.
INTRODUCTION
The jaw (Upper and lower) is any opposable articulated structure at the entrance of the mouth.
It is typically used for grasping and manipulating food.
Jaw suspension means the fusion of upper jaw and lower jaw or skull for efficient biting.
There are different ways in which these attachments are attained depending upon the modifications in visceral arches in vertebrates.
In most vertebrates, the jaws are bony or cartilaginous and oppose vertically.
The vertebrate jaw is derived from the most anterior two pharyngeal arches supporting the gills, and usually bears numerous teeth.
The vertebrate jaw probably originally evolved in the Silurian period and appeared in the Placoderm fish which further diversified in the Devonian.
It is believed that the hyoid system suspends the jaw from the brain case of the skull, permitting great mobility of the jaws.
The original selective advantage offered by the jaw may not be related to feeding, but rather to increased respiration efficiency.
The jaws were used in the buccal pump (observable in modern fish and amphibians) that pumps water across the gills of fish or air into the lungs in the case of amphibians.
Over evolutionary time the more familiar use of jaws (to humans), in feeding, was selected for and became a very important function in vertebrates. Many teleost fish have substantially modified jaws for suction feeding and jaw protrusion, resulting in highly complex jaws with dozens of bones involved.
Jaw Suspension or Suspensoria:
The method by which the upper and lower jaws are suspended or attached from the chondrocranium is known as jaw suspension or suspensorium.
Amongst the visceral arches, the first (mandibular) arch consists of
= a dorsal palato pterygoquadrate bar forming the upper jaw,
= and ventral Meckel’s cartilage forms the lower jaw.
The second (hyoid) arch consists of = a dorsal hyomandibular supporting and suspending the jaws with the cranium, and a ventral hyoid.
The remaining visceral arches support the gills and are, hence, called branchial arches. Thus, splanchnocranium forms the jaws and suspends them with the chondrocranium.
Physiology of Respiration in InvertebratesPRANJAL SHARMA
In physiology, respiration is the movement of oxygen from the outside environment to the cells within tissues, and the removal of carbon dioxide in the opposite direction. In these slides you will get to know about Physiology of Respiration in Invertibrates.
The main function of gills is respiration...In gills, there are many hair like projections called gill filaments..in gill filaments, there are number of lamella, from transfer of gases and water occur..
The vertebrate brain
The vertebrate brain is the main part of the central nervous system. The brain and the spinal cord make up the central nervous system,
In most of the vertebrates the brain is at the front, in the head. It is protected by the skull and close to the main sense organs.
Brains are extremely complex and the part of human and animal body. The brain controls the other organs of the body, either by activating muscles or by causing secretion of chemicals such as hormones and neurotransmitters.
Muscular action allows rapid and coordinated responses to changes in the environment.
The brain of an adult human weights about 1300–1400 grams .
In vertebrates, the spinal cord by itself can cause reflex responses as well as simple movement such as swimming or walking. However, sophisticated control of behaviour requires a centralized brain.
The structure of all vertebrate brains is basically the same.
At the same time, during the course of evolution, the vertebrate brain has undergone changes, and become more effective.
In so-called 'lower' animals, most or all of the brain structure is inherited, and therefore their behaviour is mostly instinctive.
In mammals, and especially in man, the brain is developed further during life by learning. This has the benefit of helping them fit better into their environment. The capacity to learn is seen best in the cerebral cortex.
Three principles
The brain and nervous system is essentially a system which makes connections. It has input from sense organs and output to muscles. It is connected in several ways with the endocrine system, which makes hormones, and the digestive system and sex system. Hormones work slowly, so those changes are gradual.
The brain is a kind of department store. It has, all inter-connected, departments which do different things. They all help each other gather senses.
Much of what the body does is not conscious. Basically, much of the body runs on automatic (breathing, heart beat, hungry, hair growth) adjusted by the autonomic nervous system. The brain, too, does much of its work without a person noticing it. The unconscious mind refers to the brain activities which are hardly ever noticed.
Taxonomic Collections, Preservation and Curating of InsectsKamlesh Patel
Taxonomy: Taxonomy is the science of defining and naming groups of biological organisms on the basis of shared characteristics.
The classification of organisms is according to hierarchal system or in taxonomic ranks (eg; domain, kingdom, phylum class, order, family, genus and species) based on phylogenetic relationship established by genetic analysis.
Taxonomic Collection : Biological collection are typically preserved plant or animals specimens along with specimen documentations such as labels and notations.
Dry Collection - Dry collections consist of those specimens that are preserved in a dry state.
Wet Collection - Wet collections are specimens kept in a liquid preservative to prevent their deterioration.
Air sacs are thin walled non-muscular,non-vascular,non-elastic and bladder like membrane connected to the lungs
Air sacs are only the inflated extensions of the mucous membrane of some blindly ending bronchioles
Some of them extended to bones
In pigeon there are nine major air sacs
One of them is unpaired and others are paired
Unpaired air sac is interclavicular
Paired sac include cervical,anterior thoracic,posterior thoracic and abdominal air sacs
Abdominal and posterior thoracic sacs get filled with fresh air during inspiration.so they are called inspiratory air sacs
Others get filled with fresh air during expiration
Presentation on Organ & Mechanism of Respiration in Pisces And Amphibiansvskgondia
This is Powerpoint presentation helpful for students and teachers. It includes Defination of Respiration & Function of respiratory system. Also contains mechanism of respiration and various repiratory organs of pisces and amphibians, their structures and fuctions.
Accssory respiratiory organs in fishesaadiihussain
Gills are primary respiratory organs in fishes, Extra branchial respiration is highly useful for survival when oxygen supplied by gills is not sufficient.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
2. Respiratory system -is a system consisting of specific
organs and structures used for the process of
respiration in an organism.
General Function
Respiration-the act or process of inhaling or exhaling
Respiration includes:
- Ventilation is the pumping of water in gills and of
air in lungs
-External Respiration- exchange of gases with the
environment
-Internal Respiration- essential gases are then
exchange with the tissues in the respective
capillary beds
3. GILLS
Vertebrate gills are designed for water
breathing
Mechanism of ventilation depends on
whether the gills are located internally or
externally
1. INTERNAL GILLS
2. EXTERNAL GILLS
4. LUNGS
Designed for air breathing
Elastic bags that lie within the body
Volume expands when air is inhaled and
decreases when air is exhaled
GAS BLADDERS
Are air filled with the air
Swim bladders are used to control the
buoyancy of a fish
5.
6. Gas bladders differ in lungs in two ways
1. Gas bladders are usually situated dorsal to the
digestive tracts
2. Gas bladders are not paired
Oxygen is released into the bladder
Gas in the swim bladder is mainly oxygen
CUTANEOUS RESPIRATION
Respiration through the skin
Amphibians rely heavily in cutaneous
respiration
7. BREATHING EMBRYOS
Chorioallantois in birds acts as respiratory
organs in birds
It sustains the respiratory needs of the chicken
embryo for most of its time in the egg
VENTILATORY MECHANISM
CILIA lines the routes along which water
current flows
8. MUSCULAR MECHANISM
Ventilation on vertebrates usually depends
much on muscle action
Ram ventilation is a technique by which the
fish’s own forward locomotion contributes to
gill ventilation
1. Water Ventilation: Dual pump
2. Air ventilation: Pulse pump
3. Air ventilation: Aspiration pump
9.
10. Gills
External Gills-develop from surface ectoderm
and extend beyond the head
Internal Gills- lie within the head
Comprised of gill arches with gill
filamentslined with rows of lamellae
(increase surface area)
11. Utilize countercurrent exchange(except for
cartilaginous fishes)
blood flows oppposite to the direction of
water movementg against gills
12. INTERNAL GILLS
- develop from the pharynx as evaginations called
pharyngeal pouches
Visceral grooves (opposite to the pouches)
Closing plates (separates pouches and grooves)
- The general structure of a mature gill is
composed of several parts:
Gill bars (support the gills)
Gill rakers (prevents food particles from entering)
Gill rays
Gill filaments and Gill lamellae
13.
14. 3 TYPES OF GILL BARS
Holobranch
Hemibranch
Pseudobranch
AGNATHAN
Pouched gills
6-15 pairs of gill pouches
No gill Slits
Hagfishes and lampreys
20. Serves as an hydrostatic organ
Oxygen and carbon dioxide are exchanged
between the bladder and the blood
Also important in hearing and sound
production
21.
22. AMPHIBIANS
They are cold blooded, meaning they don’t
need much oxygen
2 simple sacs
Lungs
- don’t have diaphragms and they force air into
their lungs by moving their mouth (like
swallowing) Buccal pumping
23. Four stages of lung ventilation
1.) Buccal cavity expands to draw fresh air in
through the open nares
2.) Glottis opens rapidly, releasing spent air from
the elastic lungs
3.( Nares close, floor the buccal cavity rises
forcing the fresh air held in this cavity into the
lung through the open glottis
4.) Glottis closes, retaining the air that has just
filled the lungs and nares open again
24.
25. Skin
- Highly vascularized and moist
- Very thin nd allows water to go through it
- Aquatic Amphibians and anurans Cutaneous
respiration
- The short trachea divides into 2 short bronchi
leading to the apex of each lung
- The opening from the trachea to pharynx is called the
glottis supported by the larynx
26. Gills ( aquatic salamanders and tadpoles)
- Made up of very thin blood vessels surrounded
by water channe;s
- When amphibians undergo metamorphosis
into adult, gills are lost
27.
28. REPTILES
-Lungs are large and varied
-Rely largely on LUNGS for gas exchange
-Have large lung volumes (10xmore volume
compared to mammals)
-Trachea and bronchi are larger than for
amphibians and are supported by cartilaginous
rings
29. -Supplemental cutaneous respiration is
significant, but for the most part, paired lungs
meet their respiratory needs
-Filling of the lungs in all the reptiles is based on
an aspiration pump
- Exhalation of passive
CROCODALIANS
- Use diaphragm muscle for lung ventilation
30.
31. -Contraction of the diaphragmatic muscles draws
the liver back, increasing the volume of the
lung cavity and dropping pressure within the
lungs
- In caimans and other crocodiles, ribs rotate
forward and outward, expanding the cavity
around the lungs during inhalation
SQUAMATES (Snakes and Lizards )
-Don’t have diaphragm muscles for lung
ventilation
32. -The muscle s used for locomotion are the same
used for their respiratory systems
-Contracting and flexing body muscles move
their ribs and lungs
In most snakes , there are usually two regions of
the lung:
1. Anterior respiratory portion or faveoli
2. Posterior saccular portion or avascular
-Submergence in water- have large lungs for large
amount of oxygen for long dives
(Hydrophinae and Arochordidae)
33. TESTUDINES (Turtles)
-Having shells makes lung expansion more
difficult
-Must use their limbs for lung ventilation
expels air from the lungs and pushing their
limbs out of their shells expands the lungs
-Have complex lungs w/ large surface areas and
volumes
34.
35. 4.) Mammals
- The chief organ in mammalian respiration is the
lungs (located in the pleural cavities in the thorax)
- More finely, homogenously divided and more
efficient
- Aspiration pumps ventilates the lungs of
mammals
- Breathing is dependent to the rib muscles and
diaphragm
36.
37. SUCTION-PUMP MECAHNISM OF
INHALATION AND EXHALATION
inhalationwhen the rib cage opens up and
the diaphragm flattens and moves downward;
air rush inside
lungs expandsdecrease in air pressure
exhalation the diaphragm and rib muscles
relax to their neutral state that causes the lungs
to contract; air flow out
squashing of lungs increase in air pressure
38.
39. AIR FLOW IS BIODIRECTIONAL:
Trachea primary bronchi secondary
bronchi tertiary bronchi alveoli
Trachea is a long structure of soft tissue;
supported by rings of hyaline or fibrous
cartilages; elastic connective tissue joins the
ring and completes the tube where cartilage is
absent
Splits into two bronchi branches, each enters its lung
anterior and dorsal to the center
Divides into numerous membranous bronchioles
Alveolus- tiny air sacs; increase surface area; where
actual gas exchange occurs
40. The trachea, bronchi and bronchioles that
transport gas to and from the alveoli is called
the respiratory tree
No gas exchange occurs along the conducting
passageway of the respiratory tree until air
reaches the alveoli
Epiglottis
Glottis
41.
42. 5.) Birds
- Have one way flow of air in their lungs
-Lungs are small but compact, rigid and have a
fixed volume
-Have two lungs connected to trachea and
ventilated by an aspiration pump
-Birds have air sacs that collect air and then force
the air through their lungs
-Large air sacs joined the lungs and serve to
ventilate them in crosscurrent circulation
-Gas exchange in the blood actually occurs in the
air capillaries
-Bones contain air, not marrow
43.
44. -Lungs receive fresh air during inhalation and
exhalation
-Air is pulled by a suction type pull and gas
exchange are in the capillaries
-Trachea is divided into two primary bronchi,
termed mesobronchi, that do not enter the lung
but extend posteriorly to reach the posterior air
sacs
-Gases diffuse between the lumen of the
parabronchus and the connecting, blind-ended air
capillaries
45. -Oxygen diffuses in turn from the air capillaries
into the adjacent blood capillaries that give up
carbon dioxide to the air capillaries
-Walls of air and blood capillaries constitute the
site of gas exchange
-Air sacs function to lighten the birds like helium
balloon, but air sacs provide no lift, and it is not
the prerequisite for flight
46.
47. When bird inhales, air is brought into the
posterior air sacs, which expand. Upon
exhalation, air is forced from the posterior sacs
into the lungs; second inhalation will move the
air from the lungs to the anterior air sac and
second exhalation will push the air out
Advantages of one-way flow:
1.)No residual volume; all old air leaves w/ each
breath
2.)Cross-current blood flow through the lungs
48. Pattern of Gas Transfer
- Respiratory organ couples blood flow with
ventilation
Rates of Gas transfer
- Respiratory organs must also be designed to
match the ventilation rate with perfusion rate
- Breathing that is too fast or too slow is inefficient
- Ratio of perfusion to ventilation depends on the
species
49. Breathing in Water
- Water is considerably denser than air
50. Cartilaginous Fishes Bony Fishes(Teleost) Agnathans
Septal Gills Opercular Gills Pouched Gills
5 “naked” gill slits Usually have 5 gill slits 6 to 15 pairs of gill
pouches
Sharks and Rays Eels, milkfish, salmon Hagfishes and Lampreys
51. Reptiles Amphibians Birds Mammals
No vocal cords Simple saclike lungs Most of the birds has
nine sacs and these are:
anterior and posterior
sacs
Human breathe through
lungs
No True Diahragms Some amphibians have
no lungs like
Salamander
The typical bird trachea
is 2.7 times longer and
1.29 wider than that of
similarly-sized animals.
Alveoli- spongy and has
a little sac
Reptile lungs composed
of three and these are:
Unicameral,
Multicameral and
Paucicameral
Skin- Cutaneous
Respiration
Avian lungs Trachea
Reptiles are capable of
surviving for long
periods without
breathing.
Many amphibians used
gills at least when they
are young.
Bronchi- structure
similar to trachea,
flexible tubes with
stiffening walls of
hyaline cartilage
Bronchioles
52. BIRD FISH MAMMAL REPTILE AMPHIBIAN
•Unidirectional
•Lungs
•Aspiration
pump
•Longer and
wider trachea
compared to
mammals
•Air sacs
•Unidirectional
•Gills
•Dual pump
•5 to 7 pairs of
gills
•Bidirectional
•Lungs
•Aspiration
pump
•Muscles are
used
•Air are filtered
•Bidirectional
•Lungs
•Aspiration
pump
•Much larger
lungs than
mammals
•Can survive
for long
periods
without
breathing
•Muscles are
used
•Bidirectional
•Lungs and
skin
•Pulse pump
•Simple saclike
lungs