Sarah Bodell and Jackie Taylor, OT educators from the University of Salford, discuss feedback from a social networking project with clinicians from the Lancashire Care Foundation Trust. COT Annual Conference 2010 (22-25 June 2010)
These slides are from a 4 hour workshop I gave on how to collaborate in science. They are taken from a Professional Development series of lectures I give at the University of California San Diego and are in turn taken from the Ten Simple Rules series which I have published in PLoS Computational Biology. Most of the rules are general and apply to all branches of science.
Collaboration on the Intranet: Keynote at Interaction 2013 Conference in Lond...Michael Sampson
My keynote speech at the Interaction 2013 conference, in London in late September 2013. I talked about why the intranet needs to support collaborative activities, outlined some core concepts (culture, governance, adoption), and then talked about the journey ahead.
People are more complex than computers - Mairead O'Connor Equal ExpertsMairead O'Connor
Equal Experts is a consultancy founded and run by software people. We try to take the principles we use when building products and apply them to building a company. In just over a decade we’ve grown to a 1500 person network with many great clients. We’ve learned that there are some cultural challenges you can successfully apply an engineering mindset to, but some things are harder than they first appear! Join me to learn about how we’re trying to be a different sort of company. We’re challenging traditional ways of working; we question the standard practices of hierarchical management, performance appraisals, approvals, annual budgets, etc. Instead, we’re using concepts like iterative, user-centred design, microservices, ‘devops’, monitoring and alerting and plenty of other buzzwords du jour to try to create a better place to work.
From QCON London March 2019
These slides are from a 4 hour workshop I gave on how to collaborate in science. They are taken from a Professional Development series of lectures I give at the University of California San Diego and are in turn taken from the Ten Simple Rules series which I have published in PLoS Computational Biology. Most of the rules are general and apply to all branches of science.
Collaboration on the Intranet: Keynote at Interaction 2013 Conference in Lond...Michael Sampson
My keynote speech at the Interaction 2013 conference, in London in late September 2013. I talked about why the intranet needs to support collaborative activities, outlined some core concepts (culture, governance, adoption), and then talked about the journey ahead.
People are more complex than computers - Mairead O'Connor Equal ExpertsMairead O'Connor
Equal Experts is a consultancy founded and run by software people. We try to take the principles we use when building products and apply them to building a company. In just over a decade we’ve grown to a 1500 person network with many great clients. We’ve learned that there are some cultural challenges you can successfully apply an engineering mindset to, but some things are harder than they first appear! Join me to learn about how we’re trying to be a different sort of company. We’re challenging traditional ways of working; we question the standard practices of hierarchical management, performance appraisals, approvals, annual budgets, etc. Instead, we’re using concepts like iterative, user-centred design, microservices, ‘devops’, monitoring and alerting and plenty of other buzzwords du jour to try to create a better place to work.
From QCON London March 2019
A look at the underlying ethos of collaboration, and a series of strategies and approaches to encourage the development of collaborative human behaviours.
Reflecting on The Children’s Society learning journey through the pandemicNoel Hatch
Discover how the Children's Society has navigated the pandemic and using its learning to improve what it does and how it is tackling new issues
Discover how to use learning to help reinvent and renew services & ways of working in this new environment
Speaking will be Nerys Anthony – Director of National Operation and Adam Groves, The Children’s Society’s Design Lead.
Leading from a Distance: Practical Tips for Successful Virtual LeadershipHRDQ-U
As technology advances, organizations are moving away from the traditional workplace setting to embrace the possibility—and the benefits—of “going virtual.” However, leading a geographically dispersed team is radically different from traditional face-to-face leadership, and it comes with a unique set of challenges, such as how to collaborate, manage accountability, inspire motivation, and build trust. Thankfully, help is here.
President of OnPoint Consulting and virtual team expert, Rick Lepsinger will present Leading from a Distance: Practical Tips for Successful Virtual Leadership. Based on the groundbreaking research study explored in his book Virtual Team Success, Rick will explore four critical areas that affect virtual leadership with practical strategies for effectively managing others from a distance. Register today—you
won’t want to miss this powerful hour of learning.
https://www.hrdqu.com/webinars/leading-distance/
SharePoint "Moneyball" - The Art and Science of Winning the SharePoint Metric...Susan Hanley
Measurement is not just about looking for a bottom-line result to justify investments. It’s also a tool to provide feedback about where the organization is along the road to successfully leveraging investments in SharePoint and the business outcomes it provides. At every stage in the development of your solution, metrics provide a valuable means for focusing attention on desired behaviors and results. This presentation showcases a practical and realistic framework for SharePoint metrics based on real world examples and successes.
This talk to the IPAC annual conference on August 21 2012 addresses the question why, if collaboration is so good and beneficial, then why do we not do it more often or more successfully?
Ask anyone to list the biggest challenges in their ITSM migration project and chances are ‘the people’ will feature in the top three. It’s one of the biggest factors in successfully effecting change in ITSM, and yet good practical guidance is hard to find.
WINTalk Project Connect Keynote "Designing Organisations To Be More Human"Phoebe Tickell
"Organisations are generally the place we manifest our potential and action in the world. With roughly 80,000 hours spent in work and a critically challenged planet with 7.7 billion people, we have to re-think the way we think about work.
A new generation is rising up, looking for work that has meaning, purpose, flexibility and agency. An existing workforce is living and working amidst uncertainty and increasing levels of change. The future is de-centralised — and yet we need to stick together more than ever before.
In our technological and networked future, instead of fearing our fate, let’s ask ourselves: What are the things that make it worth being a human for the next 100 years? How can we design organisations that enable humans to thrive, and continue to attract the best talent to have a real and positive impact on the world?
We’re hearing about smart contracts, collective intelligence, self-driving cars and robotic warehouses. As we automate more of what we do, and gain access to tools that unlock new ways of organising, where does this leave the humans?"
This talk was given on the 26th March 2019 for the Project Connect Keynote (https://the-project.co.nz/home#about).
The WINTalk Project Connect Event Series is a collaboration between AUT (Auckland University of Technology), Wynyard Innovation Neighbourhood and the US Embassy of New Zealand, bringing together the respective successes of AUT’s Project Connect event programme and Wynyard Innovation Neighbourhood’s WINTalk events.
To subscribe to stay updated on upcoming talks and trainings on more horizontal and human practices for work, please subscribe here: http://www.phoebetickell.com/subscribe.
Starting With Today, Inc. 2014 Impact Report.
STARTING WITH TODAY, INC. IS A 501(C)(3) NON-PROFIT ORGANIZATION THAT IGNITES FRESH STARTS WITH INDIVIDUALS IN THEIR PROFESSIONAL, MENTAL, AND FINANCIAL LIVES.
CU Berkeley Workshop #2: Making it work, Effective Facilitation of Clicker Q...Stephanie Chasteen
So now you’ve got some great questions to use with clickers, but that’s no magic bullet. What might go wrong, and how do we avoid common pitfalls? How do we avoid just giving students the answer, or what if students are reluctant to discuss the questions? In this interactive workshop, we’ll explore research-based tips and ideas for questioning in a way that allow us to achieve the full benefit of clickers and peer instruction. We’ll discuss common challenges, share tips on getting students to productively argue and reason through the questions, and ways to encourage all students to speak up in response to questions. Time-depending, participants will also get a chance to practice aspects of teaching through questioning.
A look at the underlying ethos of collaboration, and a series of strategies and approaches to encourage the development of collaborative human behaviours.
Reflecting on The Children’s Society learning journey through the pandemicNoel Hatch
Discover how the Children's Society has navigated the pandemic and using its learning to improve what it does and how it is tackling new issues
Discover how to use learning to help reinvent and renew services & ways of working in this new environment
Speaking will be Nerys Anthony – Director of National Operation and Adam Groves, The Children’s Society’s Design Lead.
Leading from a Distance: Practical Tips for Successful Virtual LeadershipHRDQ-U
As technology advances, organizations are moving away from the traditional workplace setting to embrace the possibility—and the benefits—of “going virtual.” However, leading a geographically dispersed team is radically different from traditional face-to-face leadership, and it comes with a unique set of challenges, such as how to collaborate, manage accountability, inspire motivation, and build trust. Thankfully, help is here.
President of OnPoint Consulting and virtual team expert, Rick Lepsinger will present Leading from a Distance: Practical Tips for Successful Virtual Leadership. Based on the groundbreaking research study explored in his book Virtual Team Success, Rick will explore four critical areas that affect virtual leadership with practical strategies for effectively managing others from a distance. Register today—you
won’t want to miss this powerful hour of learning.
https://www.hrdqu.com/webinars/leading-distance/
SharePoint "Moneyball" - The Art and Science of Winning the SharePoint Metric...Susan Hanley
Measurement is not just about looking for a bottom-line result to justify investments. It’s also a tool to provide feedback about where the organization is along the road to successfully leveraging investments in SharePoint and the business outcomes it provides. At every stage in the development of your solution, metrics provide a valuable means for focusing attention on desired behaviors and results. This presentation showcases a practical and realistic framework for SharePoint metrics based on real world examples and successes.
This talk to the IPAC annual conference on August 21 2012 addresses the question why, if collaboration is so good and beneficial, then why do we not do it more often or more successfully?
Ask anyone to list the biggest challenges in their ITSM migration project and chances are ‘the people’ will feature in the top three. It’s one of the biggest factors in successfully effecting change in ITSM, and yet good practical guidance is hard to find.
WINTalk Project Connect Keynote "Designing Organisations To Be More Human"Phoebe Tickell
"Organisations are generally the place we manifest our potential and action in the world. With roughly 80,000 hours spent in work and a critically challenged planet with 7.7 billion people, we have to re-think the way we think about work.
A new generation is rising up, looking for work that has meaning, purpose, flexibility and agency. An existing workforce is living and working amidst uncertainty and increasing levels of change. The future is de-centralised — and yet we need to stick together more than ever before.
In our technological and networked future, instead of fearing our fate, let’s ask ourselves: What are the things that make it worth being a human for the next 100 years? How can we design organisations that enable humans to thrive, and continue to attract the best talent to have a real and positive impact on the world?
We’re hearing about smart contracts, collective intelligence, self-driving cars and robotic warehouses. As we automate more of what we do, and gain access to tools that unlock new ways of organising, where does this leave the humans?"
This talk was given on the 26th March 2019 for the Project Connect Keynote (https://the-project.co.nz/home#about).
The WINTalk Project Connect Event Series is a collaboration between AUT (Auckland University of Technology), Wynyard Innovation Neighbourhood and the US Embassy of New Zealand, bringing together the respective successes of AUT’s Project Connect event programme and Wynyard Innovation Neighbourhood’s WINTalk events.
To subscribe to stay updated on upcoming talks and trainings on more horizontal and human practices for work, please subscribe here: http://www.phoebetickell.com/subscribe.
Starting With Today, Inc. 2014 Impact Report.
STARTING WITH TODAY, INC. IS A 501(C)(3) NON-PROFIT ORGANIZATION THAT IGNITES FRESH STARTS WITH INDIVIDUALS IN THEIR PROFESSIONAL, MENTAL, AND FINANCIAL LIVES.
CU Berkeley Workshop #2: Making it work, Effective Facilitation of Clicker Q...Stephanie Chasteen
So now you’ve got some great questions to use with clickers, but that’s no magic bullet. What might go wrong, and how do we avoid common pitfalls? How do we avoid just giving students the answer, or what if students are reluctant to discuss the questions? In this interactive workshop, we’ll explore research-based tips and ideas for questioning in a way that allow us to achieve the full benefit of clickers and peer instruction. We’ll discuss common challenges, share tips on getting students to productively argue and reason through the questions, and ways to encourage all students to speak up in response to questions. Time-depending, participants will also get a chance to practice aspects of teaching through questioning.
A brief intrioduction of team facilitation and the importance of team work is described. Role of facilitator and the skills which are required by the facilitaor for encourging the team are elaborated here
groupVision was established in the early 90s and has acquired a unique expertise in leading products for collaboration. Our in-depth understanding of group processes is based on a distilled experience of more than 15 years in computer support for cooperative learning with MeetingSphere. No matter your unique challenge, we can advise on a cost efficient solution for every group collaboration need and implement it with you.
A review of the technical and cultural benefits and barriers to adopting social media inside the organization to aid in collaboration, knowledge management.
Promoting Exchange, Enhancing Resources: How Connecting Organizations Improve...BCCPA
Improving workplace safety in continuing care often means undertaking significant culture change. Organizations often find themselves re-creating the same programs as neighbouring organizations, with similar outcomes. The PEER Resource Network was initiated by SafeCare BC to address two key issues raised by the continuing care sector:
1. Managers lack the resources to support the development of a safety culture within their organizations;
2. Continuing care organizations largely face the same root workplace safety issues.
In this workshop, participants will:
1. Learn about PEER’s innovative model and the preliminary results of the initiative (both quantitative and qualitative data).
2. Understand how PEER’s structure contributes to collaborative learning – and how this supports organizational excellence in workplace safety.
3. Engage with fellow participants in PEER-like exercises to glean insight into solutions for their organization’s own safety challenges.
4.Develop new connections to support the implementation of those solutions.
Presented by:
- Jennifer Lyle, Executive Director, SafeCare BC
- Saleema Dhalla, Workplace Health and Safety Programs Director, SafeCare BC
Outlining lessons learned from experience running a Young Professionals Network in the public sector. Professional Networks can help static organizations overcome bureaucracy and get things done faster.
Developing a PLN and open co-learning opportunities #UoRsocialmediaSue Beckingham
Developing your academic online presence with social media
Workshop at the University of Reading led by Sue Beckingham SFHEA, Senior Lecturer in Information Systems and LEAD Associate at Sheffield Hallam University, this workshop will provide an opportunity to learn about new approaches and practical examples of using social media in higher education; and as co-learners share examples of effective practice and consider how these might be applied in your own contexts. The session will also provide participants some time and space to network and potentially make new connections.
The workshop aims to provide participants with an opportunity to:
Gain a better understanding of how social media can be used in a scholarly context
Appreciate the value of developing a rich professional online presence
Learn about opportunities for social and open informal learning through social media
Appreciate five elements of ‘working out loud’ (Stepper 2015) and how these can be of value to both yourself and others
Using the 5C Framework (Nerantzi and Beckingham 2014, 2015) as a lens we will consider how social media can be used to connect, communicate, curate, collaborate and create. In doing so consider the value of:
Developing a digital professional persona to share scholarly achievements
Cultivating your own personal learning network and co-learning communities
Sharing learning journeys through working out loud
Programme
Tuesday 26 April 2016
10.45-11.00 Networking and registration
11.00-12.30 Becoming a Digital Scholar using social media
12.30-13.15 Lunch
13.15 -14.30 Developing a PLN and open co-learning opportunities
The following webinar will provide insight into the ways in which educational designers (and those with similar titles) have been impacted by COVID-19, are dealing with various issues, are providing support to academic staff, and are contributing solutions in response to COVID-19.
The Home-Based Memory Rehabilitation Programme (for persons with mild Alzheimer’s disease and other dementias)
Mary McGrath, Advanced Clinical Specialist Occupational Therapist
Memory Clinic, Belfast City Hospital
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Team working has significant benefits in relation to service development (Borrill et al 2000) however effective team working can be difficult to achieve (Hall, 2005). NHS organizations are therefore being encouraged to consider the use of online social networking sites as potential fertile breeding ground for the development of innovative services (NHS Faculty of Health Informatics 2008). Mason and Rennie (2008) suggest that any group of individuals who have a relationship with each other can be described as a social network. Lancashire Care Foundation Trust Adult Network meets this criteria as it is comprised of 150 mental health occupational therapists spread over a large geographical area. who share a common goal of service development. During a band & training initiative it was noted that team working could be improved, and may enhance job satisfaction and also impact positively on th development and delivery of care. Whilst the Trust was keen to embrace online networking, in collaboration with the University of Salford, a number of "readiness" factors were considered including cultural, legal, managerial and technical issues (NHS Faculty of Health Informatics 2008).
In order to progress the project expediently it was decided to adopt a prototyping approach (Dziag 2009) of do, evaluate and refine. The advantages of this approach are that projects can be initiated expediently, and can be considered a work in progress, however the disadvantages are that for those involved, there may be many bumps and frustrations along the way. The challenge is to measure the risk of this against the cost of attempting to generate a ‘perfect product’ prior to beginning a project. Given that this initiative in an innovation, and does not have an extensive body of knowledge to guide us, we decided that this approach would allow us to test a model for future development. The risks were minimised by using a small number of therapists who volunteered knowing that it was a work in progress. Once we had a model that seemed reasonable it would be opened to a second select group, albeit staff who has not expressed a specific interest. Feedback would be gained from the 4 ‘early adopters. 1 expert networker and 3 novices.
When I received the initial e mail the project sounded beneficial and somewhat pioneering. Reading about the NING project was really quite refreshing and I felt the potential was unlimited. It’s not often you receive e-mails requesting support to promote and establish a social networking site within an NHS environment. I was very excited to firstly know that this project was underway and how it’s existence could possible help me in my working practice, but also the fact that Sarah and Jackie had requested support to make this happen excited me more since I had the opportunity to contribute to what I felt was a new innovation in our service. On receiving the invitation to join the Ning project it was something that I immediately felt quite excited about. I was drawn by the chance firstly to be involved in a research project and secondly to be part of being at the fore front of a new technical development.
I made my decision to volunteer for a number of reasons. Firstly, i enjoy the challenge of participating in new projects and being a novice to social networking I knew this would be so I decide to volunteer for two reasons; firstly, the NING project was a very achievable project that could alter the working practices for myself and many of my colleagues due to the often numerous amounts of meetings we may need to attend at any given time. Secondly, I wanted to be involved in contributing to a project that put occupational therapy in a spot light that showed we are forward thinking and willing to make that happen. As an occupational therapist I pride my profession as being skilled individuals in thinking around problem and I felt this was a fantastic opportunity for our services to demonstrate that. By volunteering in the project I hoped to gain some personal and professional development through the experience and learning the processes for planning, implementing and completing such a great and challenging project. But most of all I believed the project was new, sharp, forward thinking and suited my mind set, all things that excite me in my professional practice. I was drawn by the chance firstly to be involved in a research project and secondly to be part of being at the fore front of a new technical development. Not being terribly IT literate the latter was also a chance to introduce myself to new skills and being pragmatic in nature the opportunity to learn something through experience was very attractive. I also thought that it would be interesting to be part of the beginning of something which I thought could � be big � in the future and embarrassingly, a slightly competitive part of my personality wanted to say � oh yes I was part of that system being set up � in the years to come!
I hoped my exposure would allow me to demonstrate my working knowledge if needed. Luckily for me Sarah and Jackie agreed and ask for my input to be at an expert level. Having being given the choice of identifying myself as a novice or expert it I instinctively choice the former. This was based on mostly my lack of confidence and self belief that I can use a pc and the fact that I didn’t really understand the terminology that phrases such as � social networking � meant. In truth I was more adept than I believed myself to be having had previous experience using a music festival network site – I just hadn’t considered this to be the same kind of thing.
Professionally I hoped that Ning would offer me an opportunity to create links with other OTs within the Trust. I also was optimistic that it would create networking opportunities with not only colleagues but the University as well. I had/have high hopes that it would/will give opportunities to share knowledge, debate issues, answer queries and brain storm problems. It also sounded like fun and could potentially provide support at times when immediate colleagues are not in a position to offer it. The networking site I believed would allow us the opportunity to still maintain the level of communication required but without having to spend as much travelling to various venues. I also felt that the project would be of great benefit to me in my working life i.e. reduced time spent travelling to and attending meetings and access to a plethora of knowledge and opinions from my peers.
Once the network was up and running my involvement was more as an active promoter to ensure my colleagues joined/accessed the network and through constant reinforcement of the strengths of our network in our work place. I believe my level of involvement was a result of my confidence and keen interest to make this project happen. As time progressed I became more involved, but this varied depending on how co-operative the IT system was being, how busy I was and if I could get access to a pc (being somewhat short of these within the department). I also think that as this point I couldn’t completely give myself permission to spend time on Ning which felt more like play than work. The number of false starts and difficulty accessing the site was particularly frustrating and impacted upon my initial motivation to participate in the project. My level of involvement was (lower) due to the wider group also having difficulty with access. This meant that a full discussion of topics was not possible and it did not seem worthwhile starting discussions that were then going to be discussed at meetings anyway. The initial teething problem experienced settings up the network were at times frustrating and disappointing since most of our initial false starts were due to IT problems. On commencing Ning I found it frustrating, difficult and time consuming due to the Trust network being particularly awkward. It also felt � naughty � somehow using work time to � mess about on the computer to contact my buddies in West Lancs. � If anyone saw what I was doing I was very keen to point out to them exactly what was going on as if to justify my actions. No one really commented except to ask when it would be available Trust wide or to say that they wished their profession had such a forum. Still, with all these factors I decided to set up my account at home first. As I have mentioned earlier I am a bit nosey and enjoy the social stories of my friend on other social networking sites, so accessing our network was kind of second nature. However this was not the case for everyone else in our service. I noticed that forum topics were not having the response or input we had expected and when this question was asked it did appear that people were cautious of participating in the unknown. Once people took that first step activity increased and the project was up and running.
It gave me the opportunity to work with people I may never have met in my normal role and it also allowed my colleagues and myself the facility to engage in discussions (through the network) that have altered my ways of thinking both personally and professionally. My involvement in the NING project to date was an experience that has helped me to take that next step forward to being involved with a larger project, increased my communication skills and thought me to be forward thinking in my ideas and not give in if I fall at the first hurdle but jump higher. Communicating online was great fun! I had many laughs reading others messages and particularly enjoyed my interactions with one of the university staff who had misinterpreted one of my comments! – It taught me to be careful how I phrase things in future, luckily that proved to be a positive and enjoyable learning experience on this occasion. One of the more surreal moments was meeting Sarah in person – we said hello and chatted for about five minutes as if we knew each other already before acknowledging that we had never actually met and probably should have introduced ourselves. This I think proves the usefulness of networking on line – we had got over all the awkward introductions prior to our meeting and could move to the next stage of social interaction. What I have gained from Ning is the excitement from being involved in something new and novel. I have gained insight into how we can use technology and how we under use the facilities and resources available. I have been pleasantly surprised that despite the practical set backs that the system is not too difficult to use and that even someone who is technically limited can quickly become adept in social networking. I have gained some new practical skills in uploading and inputting. I have also made new contacts with people I would not have normally had opportunity to be in touch with. It has helped forge the way for future clinicians to set up similar projects which can draw from our experiences both positive and negative.
I still feel that this way of working would be of significant benefit, particularly so in a trust like ours that is spread over such a large geographical area. A project such as this offers great value in promoting team working. I would feel very confident justifying others using the site because I genuinely believe it to be something that could be of immense value. I feel positive that if promoted correctly that this could be something that will be of help in the future when developing locally and nationally the profile and quality of Occupational Therapy in the ever changing and developing world of Healthcare As occupational therapist we are all too often a single practitioner within a team and support both clinical and social is essential to helping the individual maintain role identity. Within a large Trust such as Lancashire Care there are issues in disseminating ideas about systems, best practice and local developments. A project such as this can help reduce distance between OTs so that a clear Trust wide identity can be achieved which is consistent wherever the person works. I can also see this as a valuable tool to assist new members of staff to the Trust, as described earlier social networking can speed up the formation of relationships and this could help improve communication between different teams. Whilst the � fun, socialising � element of the project may seem a little trivial I believe that having this type of contact with other individuals in the Trust can aid working relationships which are all too often limited by prejudices created by unfamiliarity. As a manager of a team it is useful to have a drop in forum that I can get queries answered or debated. The information received can then be quickly disseminated locally. In relation to this point it would be helpful if senior managers used Ning so they could contribute their views or directives.
In short I think it is a valuable way of working but requires commitment from the service to be effective rather than just a few clinicians. I feel the experience of Ning may have been improved by the IT systems being tried and tested prior to the project beginning although I did learn from this process. It would have also been helpful if line managers had been briefed about the project which may have helped reduce the guilty feelings, this may have also pushed me a bit more into making rather that grabbing time to work on the Ning project. I think I did feel a level of irritation that others involved in the project were as inconsistent as me accessing the site and therefore the activity peaked and troughed which did not really inspire me to keep Ning in the forefront of my mind. Perhaps it would have been good for us to sign up to some kind of agreement when commencing the project stating that we would allocate so much time each week to going online and inputting onto the forum. It would also have been productive to spend more time establishing serious clinical discussions rather than the fun but limited chit chat that we only really seemed to get as far as. Maybe this too may have been resolved by a pre-project agreement for the participants. I think that should this progress from a project to an established part of my job role then I would need to make a concerted effort to timetable Ning into my daily routine. The project may have worked better if more importance had been placed on it by management and it was used as a time efficient way to replace other commitments.