The document describes the anatomy and physiology of the human eye. It discusses the three layers that make up the eyeball - outer fibrous tunic, middle vascular tunic, and inner retinal layer. It also describes the structures within each layer, including the cornea, iris, choroid, and retina. In addition, the document explains how visual information is transmitted through the retina and optic nerve to the visual cortex of the brain. Key functions like image formation, accommodation, phototransduction, and visual pathway are summarized as well.
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these slide are modified or upgraded from the slid belonging to this website.i had added some of the content.hope that it will be more helpful to you all.
Special Senses: Eye | Physiology and Anatomy | Assignment Md. Shakil Sarker
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy | Assignment
Special Senses: Eye | Physiology and Anatomy
The eye is our organ of sight. The eye has a number of components which include but are not limited to the cornea, iris, pupil, lens, retina, macula, optic nerve, choroid and vitreous.
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
1. 1
DAWN V TOMY M.Pharm., Asst. Professor, Dept. of Pharmacology, ST.JOSEPH’S COLLEGE OF PHARMACY, CHERTHALA.
Eye
Half the sensory receptors in body is present in the eye. Large part of cerebrum devoted to
process visual information.
Structure consists of the eye ball & accessory structures.
Eye Ball:
Approximately 2.5 cm in diameter made up of 3 layers:
Outer fibrous tunic – consists of cornea and sclera.
Middle vascular tunic – consists of choroid and ciliary body.
Inner retinal layer – consists of 2 neural layer i.e. outer pigmented and inner neural layer.
2. 2
DAWN V TOMY M.Pharm., Asst. Professor, Dept. of Pharmacology, ST.JOSEPH’S COLLEGE OF PHARMACY, CHERTHALA.
1. Fibrous tunic: Outermost layer consists of:
• Cornea is a transparent coat over the iris.
– Curved, helps focusing light to retina.
– Non-keratinized, stratified squamous outside.
– Collagen fibers and fibroblasts in the middle.
– Simple squamous in the innerside.
• Sclera is the hard white of eye.
– Gives shape & rigidity to the eye ball formed of dense connective tissue and
collagen fibers.
– Covers entire eye ball except cornea
• Canal of schlemm (scleral venous sinus) is the opening at junction of cornea and
sclera through which the fluid aqueous humor drains.
2. Vascular tunic (uvea): Middle layer consists of 3 parts:
• Choroid is the posterior part, internal to sclera, with blood vessels and melanocytes
forms melanin which gives dark brown color to the eye and also absorb stray light
rays.
• Ciliary body – anterior part of choroid. Dark brown due to melanin.
– Ciliary process is the protrusions on internal surface of ciliary body and its
function is to secrete aqueous humor.
– Zonular fibers and suspensory ligaments are attached to the lens and ciliary
muscles.
– Ciliary muscles are circular band of smooth muscle; contraction and
relaxation affects zonular fibers and thus lens widening and flattening.
• Iris is the colored portion of eye ball between cornea and lens.
– Circular and radial muscles forms the aperture which regulate the amount of
light falling on to the retina.
– Pupil is the hole at the center of the iris.
3. 3
DAWN V TOMY M.Pharm., Asst. Professor, Dept. of Pharmacology, ST.JOSEPH’S COLLEGE OF PHARMACY, CHERTHALA.
3. Retina: 3rd
and interior layer where optic nerve II end and the visual pathway begin.
– Optic disc or blind spot - where optic nerve exits eye ball visually inactive
area in the retina.
Retina has 2 layers:
• Outer pigmented layer is between choroid and neural layer. Melanin absorbs the
stray light.
• Neural layer is the multilayered outgrowth of brain, process visual data and have 3
layers:
– Photoreceptor cell layer with rods activated at dim light (120 million) and
cones for color vision (blue, red and green cones).
– Bipolar cell layer with bipolar, horizontal and amacrine nerve cells.
– Ganglion cell layer with neurons.
• Macula lutea is the center of posterior portion of retina.
• Central fovea is a depression at macula lutea has the highest area of visual acuity
(sharpness).
4. 4
DAWN V TOMY M.Pharm., Asst. Professor, Dept. of Pharmacology, ST.JOSEPH’S COLLEGE OF PHARMACY, CHERTHALA.
Lens – behind the iris and pupil, made of a proteins called crystalline.
Interior of eye ball. Outside lens – anterior cavity - 2 chambers:
Anterior chamber – b/w cornea and iris.
Posterior chamber – behind iris and front of lens – filled with aqueous humor, nourishment
for lens and cornea.
Aqueous humor – produced from ciliary process, reaches posterior chamber between iris and
lens, flow through pupil reaches anterior chamber between pupil and cornea, drains through canal
of schlemn to blood.
Function is nourishment (replaced every 90 min) maintains Intra ocular pressure (16 mm of hg)
by aqueous humor and partly vitreous humor. Gives shape and prevents collapsing.
Vitreous chamber between lens and retina. Vitreous body is a jelly like substance contain water,
collagen, hyaluronic acid, phagocytic cells. Hyloid canal posterior to optic disc drains vitreous
humor.
ACCESSORY STRUCTURES:
Eyelids (palpebrae) – lower palpebra and upper palpebra (more movable).
Function - protection, lubrication.
Muscles - superioris muscle, levator palpebrae.
Palpebral fissure is the space between upper and lower eyelids.
Lateral (near temporal angle) and medial commissure (near nasal bone).
Lacrimal caruncle – small reddish elevation at medial commissure secrets sebaceous oil and
contains sudoriferous sweat glands.
Tarsal plate is thick connective tissue which gives form and support to eyelids.
Tarsal or meibomian glands secretes fluid which keeps eyelids from adhering.
Conjunctiva is a thin mucus membrane above (bulbar) eyeball and inside palpebra (palpebral).
Eye lashes – project from border of eyelid.
Eye brows – arch transversely above upper eyelid gives protection from foreign objects, direct
rays of sun.
Sebaceous ciliary glands secrets lubricating fluid.
Lacrimal apparatus involved in the secretion of tear, flow of tears from lacrimal gland (almond
shaped) through excretory lacrimal duct (6-12 ducts) – superior and inferior lacrimal canal –
lacrimal sac – nasolacrimal duct to nasal cavity. One gland secrets 1 ml/day, facial nerve VII
control the secretion.
Contents of Tear – water, mucus, lysozyme.
Extrinsic eye muscles –
– Rectus – superior, inferior, lateral, medial.
– Oblique – superior, inferior.
Nerves – III, IV, VI.
5. 5
DAWN V TOMY M.Pharm., Asst. Professor, Dept. of Pharmacology, ST.JOSEPH’S COLLEGE OF PHARMACY, CHERTHALA.
IMAGE FORMATION:
Reflected light enters the eye by refraction, 75% light refracted by cornea and 25% by lens. Lens
is convex in form and helps in the convergence of light (more convex more convergence and
focusing power). The lens increase or decrease curvature according to the need for distant object
less curvature flat lens relaxing ciliary muscle. Near object more spherical contracting ciliary
muscle. This power of lens to adjust itself according to need is called power of accommodation.
Near point of vision is the minimum distance from eye to be clearly focused i.e.15 cm.
Abnormalities of vision:
Myopia – near sightedness - eyeball too long or thick lens – image in front of retina –
use concave lens.
Hyperopia – hypermetropia - farsightedness - eyeball short or lens thinner –image
behind retina- use convex lens.
Presbyopia - lens loses its elasticity, after age of 40 – near point of vision. Increases –
use bifocal lens.
Astigmatism – cornea or lens has irregular curvature.
6. 6
DAWN V TOMY M.Pharm., Asst. Professor, Dept. of Pharmacology, ST.JOSEPH’S COLLEGE OF PHARMACY, CHERTHALA.
PHYSIOLOGY OF VISION:
Photoreceptor layer of retina contains rods & cones with photo pigments.
Rods: Rod shaped, for dim vision, plasma membrane pleats form discs (10000 discs), 1-3 disc
replaced every hour.
Cones: Plasma membrane fold in pleats and cone shaped for color vision.
Photo-pigments:
Glycoprotein – Opsin - 3 opsin in one cone.
Rhodopsin – in rods. Retinal a Vitamin-A derivative, is the light absorbing part. When light reaches
pigments, light is absorbed by pigment and pigment protein undergoes structural changes like
Isomerization, bleaching & regeneration. When light reaches, cis retinal in the opsin isomerizes to
trans-retinal - called isomerization. Trans-retinal separates from opsin to form colorless opsin
called bleaching. Retinal isomerizes convert Trans to cis, and cis gets attached to opsin back called
regeneration, occurs half to 5 minutes and full 30-40 minutes. These chemical changes produce
receptor potential.
7. 7
DAWN V TOMY M.Pharm., Asst. Professor, Dept. of Pharmacology, ST.JOSEPH’S COLLEGE OF PHARMACY, CHERTHALA.
1. Increased darkness – glutamate release inhibits bipolar cell layer.
2. Light – no cGMP, no inflow of sodium, no glutamate release and bipolar layer excitation.
• Adaptation – adjustment of visual system to environment.
• Light – quick, dark – slow due to difference in regeneration and bleaching.
VISUAL PATHWAY
• From retina – axons of retinal ganglion cells, exit the eye ball at optic disc form optic nerve.
• Reaches – optic chiasm – crossing over.
– Right side visual field to left side of brain.
– Left side visual field to right side of eye.
– Objects in binocular field in both eyes.
8. 8
DAWN V TOMY M.Pharm., Asst. Professor, Dept. of Pharmacology, ST.JOSEPH’S COLLEGE OF PHARMACY, CHERTHALA.
– Temporal half – do not cross – go same side of eye and thalamus.
– Nasal half cross opposite side of the eye and to thalamus.
• Thalamus – crossed and not crossed at lateral geniculate nuclease of thalamus as optic
tract.
• Some to supra chiasma nuclease of hypothalamus – involve in sleep.
• Optic radiations – thalamic neuron form optic radiations project to visual area of cortex
on same side area 17.
9. 9
DAWN V TOMY M.Pharm., Asst. Professor, Dept. of Pharmacology, ST.JOSEPH’S COLLEGE OF PHARMACY, CHERTHALA.