This document summarizes research on crop rotations in Iowa. A 2-year corn-soybean rotation is compared to 3-year and 4-year rotations that include oats, red clover, and alfalfa. The longer rotations require more labor but use 86-96% less nitrogen fertilizer and 97% less herbicide. Soil quality improves with longer rotations, which also have similar or higher yields compared to the 2-year system. Integrating livestock through manure application provides nitrogen to the crops and improves the economics and environmental sustainability of the farming system.