Up to 60% of the general population experiences epistaxis in their lifetime. Epistaxis can be classified as anterior or posterior depending on the bleeding source. Anterior bleeds are more common and often self-limiting, while posterior bleeds can cause significant hemorrhage and require prompt medical attention. Treatment involves identifying the bleeding site, applying pressure, cauterization or nasal packing to achieve hemostasis. Persistent or severe bleeding may require hospitalization, endoscopic surgery, or angiographic embolization.
Slides prepared and compiled by highly experienced ENT teacher, Dr. Krishna Koirala from Nepal, for teaching undergraduate and postgraduate ENT students in the field of otorhinolaryngology.
A clear and concise explanation of the basic concepts in the subject matter concerned.
He is the Head of department with a sound knowledge in the field of ENT to teach both undergraduate and postgraduate ENT students
Slides prepared and compiled by highly experienced ENT teacher, Dr. Krishna Koirala from Nepal, for teaching undergraduate and postgraduate ENT students in the field of otorhinolaryngology.
A clear and concise explanation of the basic concepts in the subject matter concerned.
He is the Head of department with a sound knowledge in the field of ENT to teach both undergraduate and postgraduate ENT students
“An ENT disease with an ophthalmic manifestation”
Orbital cellulitis (OC) is an inflammatory process that involves the tissues located posterior to the orbital septum within the bony orbit, but the term generally is used to describe infectious inflammation.
It manifests with erythema and edema of the eyelids, vision loss, fever, headache, proptosis, chemosis, and diplopia.
OC usually originates from sinus infection, infection of the eyelids or face, and even hematogenous spread from distant locations.
OC is an uncommon condition that can affect all age groups but is more frequent in the pediatric population.
“An ENT disease with an ophthalmic manifestation”
Orbital cellulitis (OC) is an inflammatory process that involves the tissues located posterior to the orbital septum within the bony orbit, but the term generally is used to describe infectious inflammation.
It manifests with erythema and edema of the eyelids, vision loss, fever, headache, proptosis, chemosis, and diplopia.
OC usually originates from sinus infection, infection of the eyelids or face, and even hematogenous spread from distant locations.
OC is an uncommon condition that can affect all age groups but is more frequent in the pediatric population.
it is bleeding disorder of upper respiratory tract , it can cause by the weather change ,nose crusting etc . if minor bleeding have to manage at home ,and sever we can manage in hospital .
Bleeding from inside the nose is called epistaxis
Fairly common and is seen in all age groups.
“Epistaxis refers to nose bleed or hemorrhage from the nose”.
It‘s mostly commonly originates in the anterior portion of the nasal cavity.
A hemorrhage from the nose, referred to as epistaxis, is caused by the rupture of tiny, distended vessels in the mucous membrane of any area of the nose.
Most commonly, the site is the anterior septum, where three major blood vessels enter the nasal cavity:
(1) the anterior ethmoidal artery on the forward part of the roof (Kesselbach’s plexus)
(2) the sphenopalatine artery in the posterosuperior region, and
(3) the internal maxillary branches (the plexus of veins located at the back of the lateral wall under the inferior turbinate).
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
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Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
3. EPIDEMIOLOGY
• Up to 60% of the general population.
• only 10% or fewer seek medical attention.
• Bimodal age distribution, before age 10 or between 45 and 65 years of age.
• Seasonal variation, with predominance in winter months.
5. ANATOMY
• Epistaxis may be classified as anterior or posterior, depending upon the source
of bleeding.
6. ANATOMY
• Anterior bleeds — the most common.
• A large proportion is self-limited and can be
managed definitively in the primary care
setting.
• Up to 90% occur within Kiesselbach's plexus.
7. • Posterior bleeds:
• Can result in significant hemorrhage.
• Most patients require prompt referral to an
emergency department.
8. COMMON CAUSES OF EPISTAXIS
LOCAL CAUSES
• Epistaxis digitorum (nose picking)
• Trauma
• Dryness
• Chronic sinusitis, Rhinitis
• Foreign bodies
• Irritants (e.g., cigarette smoke)
• Medications (e.g., topical
corticosteroids)
• Septal deviation, perforation
• Vascular malformation or
telangiectasia
• Intranasal neoplasm or polyps
• Aneurysm of the carotid artery.
10. EVALUATION
• Initial assessment:
• Should focus on ABC.
• Airway intervention, fluid resuscitation, and emergent otolaryngologic
consultation can be necessary in severe epistaxis.
11. INITIAL TAMPONADE
• Properly instructed patients may achieve hemostasis unassisted while the
evaluation gets underway. The following approach may be helpful:
Patient blows their nose to remove blood and clots.
Clinician sprays the nares with oxymetazoline.
Patient pinches the alae tightly against the septum and holds continuously for 10
minutes.
12.
13. HISTORY
• Interduce yourself
• Establish rapport
• C/O: duration, site, onset, timing, severity, previous episodes.
• Any trauma, exposure to extreme weather or altitude changes.
• Any ongoing problems: rhinitis, sinusitis, hypertension, bleeding disorder, liver
disease.
• Any medications: nasal steroids, aspirin, warfarin, clopidogrel.
14. HISTORY
• ICEE
• Family and social history:
bleeding disorders, abuse or domestic violence, smoking, cocaine, alcohol
15. PHYSICAL EXAMINATION
• General examination
• vital signs, mental status, and airway of any patient with significant bleeding.
• looking for signs of airway compromise or hypovolemic shock.
• signs of coagulopathy (eg, ecchymoses, petechiae, telangiectatic lesions).
16. PHYSICAL EXAMINATION
Before examining the nose:
The nasal cavity should be anesthetized.
cotton swabs soaked in an anesthetic and vasoconstrictive agent e.g:
• 2% lidocaine, lidocaine with epinephrine.
• Oxymetazoline nasal preparation, can provide vasoconstriction.
17. EXAMINATION OF THE NOSE
• Head of an examination table to upright so the patient can sit
comfortably while head movement is restricted.
• Ask the patient to look directly ahead and attempt the sniffing position.
• Use nasal speculum. with good light.
• Clots may be cleared either with suction or by asking the patient to
gently blow his or her nose.
18. EXAMINATION OF THE NOSE
• Inspect the area of Kiesselbach's plexus first
• Look closely for bleeding, ulceration, or erosion.
• Also inspect the nasal vestibule, septum, and turbinates for sources of bleeding.
• If bleeding site cannot be identified. In such cases, bleeding may be from a
posterior source or minor injury that already resolved.
19.
20. INVESTIGATIONS
• CBC
• PT, PTT, INR
• Coagulation factors.
• crossmatch should be obtained in the setting of massive or prolonged
hemorrhage.
• LFT if indicated
22. BLEEDING STOPS WITH CONSERVATIVE
MEASURES
• If no anterior source is evident and bleeding has stopped.
• It is reasonable to observe the patient for approximately 30 minutes for
recurrent bleeding. Such patients should be discharged with antibiotic ointment.
• The nose should be packed only if bleeding recurs rapidly.
23. CAUTERY
• If an anterior bleeding source is visualized, first-line treatment consists of chemical
or electrical cautery. After applying anesthetic.
• Chemical cautery is usually performed with silver nitrate sticks.
• Cautery is applied for a few seconds (no longer than 10 seconds), until a white
precipitate forms.
• antibiotic ointment with a fingertip or cotton swab three times daily for three days.
24.
25. NASAL TAMPONS
• Nasal packing is most easily accomplished with a
nasal tampon.
• Coat the tampon with bacitracin ointment to
facilitate placement, and possibly decrease the risk
of toxic-shock syndrome.
28. THROMBOGENIC FOAMS AND GELS
• As effective as cautery and packing.
• caution in patients in whom the potential dangers of systemic thrombosis are
high
(eg, known coronary or cerebrovascular disease).
34. PERSISTENT BLEEDING
• the contralateral naris may be packed, thereby providing a counterforce to
promote tamponade.
• If bilateral anterior packing fails to produce hemostasis, the odds of a posterior
source increase greatly.
35. ANTIBIOTICS AND TOXIC SHOCK SYNDROME
• 16 per 100,000 packings.
• Be alert for signs of toxic shock syndrome (fever, hypotension, desquamation, and mucosal
hyperemia).
• Abs should not be given routinely for prophylaxis.
• It may be reasonable to treat patients at greater risk of infection, such as those with diabetes,
advanced age, or immunosuppression.
• If prescribed, an antibiotic with staphylococcal coverage should be selected, such
as amoxicillin-clavulanate or a second-generation cephalosporin; topical mupirocin may also
be used.
36. FOLLOW-UP
• If vital signs and respiratory function remain normal after packing.
• the patient may be safely referred for specialist follow-up in 24 to 48 hours, with
advice to present to an emergency department sooner if bleeding recurs.
37. PREVENTION
• Sleep in a humidified environment.
• A topical antibacterial (eg, mupirocin) or bacteriostatic (eg, bacitracin) ointment
may be gently applied to the nasal mucosa with a cotton-tipped swab in an
attempt to prevent recurrence.
• Directing nasal medication sprays away from the septum may decrease the risk
of epistaxis.
38. TREATMENT OF POSTERIOR BLEEDING
• Prefer balloon catheters.
• If balloon catheters are not available, alternatives include a Foley catheter and
cotton packing.
41. HOSPITALIZATION
• Most patients with a suspected posterior source of bleeding.
• Patients with anterior packing who cannot be reasonably expected to return for
prompt follow-up or who have serious comorbidities or concerning symptoms.
• Prolonged retention of nasal packing (greater than 72 hours) - necrosis, TSS,
sinus or nasolacrimal infections, and dislodgment.
43. TREATMENT FAILURES
• Surgical treatment is often performed endoscopically and can include ligation of
the sphenopalatine or anterior ethmoid artery.
44. • Angiographic embolization is increasingly common, The rate of severe
complications (eg, stroke, blindness) with embolization is approximately 4%.