This document discusses eicosanoids, which are signaling molecules derived from fatty acids. Eicosanoids are classified into two main groups - prostanoids and leukotrienes/lipoxins. They are produced through the oxidation of fatty acids like arachidonic acid by enzymes like cyclooxygenase and lipoxygenase. Eicosanoids play important roles in inflammation and other bodily processes through their effects on systems like the cardiovascular and respiratory systems.
Eicosanoids is the class of lipids derived from arachidonic acid. Eicosanoids play an important role in the growth and development, cellular signalling, drug response, platelet action and maintenance of body homeostasis.
Eicosanoids is the class of lipids derived from arachidonic acid. Eicosanoids play an important role in the growth and development, cellular signalling, drug response, platelet action and maintenance of body homeostasis.
Describes the different pathways involved in the synthesis of different eicosanoids like prostaglandins, leukotrienes, lipoxins etc along with different enzymes involved.
A catecholamine is a monoamine, an organic compound that has a catechol (benzene with two hydroxyl side groups at carbons 1 and 2) and a side-chain amine. Included among catecholamines are epinephrine (adrenaline), norepinephrine (noradrenaline), and dopamine. Release of the hormones epinephrine and norepinephrine from the adrenal medulla of the adrenal glands is part of the fight-or-flight response.
A Powerpoint presentation on the basics of Eicosanoids which includes Prostaglandins, Leukotrienes (LTs) ad Platelete Activating Factors (PAF) suitable for Undergraduate level Medical students.
Eicosanoids, from the Greek eicosa (“twenty”) are formed from precursor essential fatty acids that contain 20 carbons
Eicosanoids and PAF lipids function as signaling molecules in many biological processes, including the regulation of vascular tone, renal function, hemostasis, parturition, GI mucosal integrity, and stem cell function.
Eicosanoids are the most universally distributed autacoids in the body.Practically every cell and tissue is capable of synthesizing one or more types of PGs or LTs
Describes the different pathways involved in the synthesis of different eicosanoids like prostaglandins, leukotrienes, lipoxins etc along with different enzymes involved.
A catecholamine is a monoamine, an organic compound that has a catechol (benzene with two hydroxyl side groups at carbons 1 and 2) and a side-chain amine. Included among catecholamines are epinephrine (adrenaline), norepinephrine (noradrenaline), and dopamine. Release of the hormones epinephrine and norepinephrine from the adrenal medulla of the adrenal glands is part of the fight-or-flight response.
A Powerpoint presentation on the basics of Eicosanoids which includes Prostaglandins, Leukotrienes (LTs) ad Platelete Activating Factors (PAF) suitable for Undergraduate level Medical students.
Eicosanoids, from the Greek eicosa (“twenty”) are formed from precursor essential fatty acids that contain 20 carbons
Eicosanoids and PAF lipids function as signaling molecules in many biological processes, including the regulation of vascular tone, renal function, hemostasis, parturition, GI mucosal integrity, and stem cell function.
Eicosanoids are the most universally distributed autacoids in the body.Practically every cell and tissue is capable of synthesizing one or more types of PGs or LTs
this file is all about eicosanoids including prostaglandins,prostacyclins and leukutriens with its mechanism of formation and inhibitors of LOX and COX pathways
Eicosanoids are signaling molecules made by the enzymatic or non-enzymatic oxidation of arachidonic acid or other polyunsaturated fatty acids (PUFAs) that are, similar to arachidonic acid, 20 carbon units in length. Eicosanoids are a sub-category of oxylipins, i.e. oxidized fatty acids of diverse carbon units in length, and are distinguished from other oxylipins by their overwhelming importance as cell signaling molecules. Eicosanoids function in diverse physiological systems and pathological processes such as: mounting or inhibiting inflammation, allergy, fever and other immune responses; regulating the abortion of pregnancy and normal childbirth; contributing to the perception of pain; regulating cell growth; controlling blood pressure; and modulating the regional flow of blood to tissues. In performing these roles, eicosanoids most often act as autocrine signaling agents to impact their cells of origin or as paracrine signaling agents to impact cells in the proximity of their cells of origin. Eicosanoids may also act as endocrine agents to control the function of distant cells.
The principal eicosanoids of biological significance to humans are a group of molecules derived from the 20:4 (20 carbons: 4 sites of unsaturation) fatty acid, arachidonic acid.
Preparation of different agro chemical doses for field & pot applicationSupta Sarkar
Preparation of different agro chemical doses for field & pot application:
DIFFERENT AGROCHEMICALS (PESTICIDES) DOSES FOR FIELD APPLICATION:
Cereals:
-rice
-wheat
-maize
Millet:
-ragi
Pulses:
-pigeon pea (Red gram)
-green gram & black gram
-Lentil
-STUDY 1: (Chick pea) /[Bengal gram]
Oilseed crop – Groundnut
Sugar crop – Sugarcane
Fruits – Mango
Vegetables
-Tomato
-Cole crops
FERTILIZERS FOR FIELD APPLICATION
-STUDY 2 :(Optimization & validation of targeted yield equation based fertilizer doses)
GROWTH REGULATORS
DIFFERENT AGROCHEMICAL DOSES FOR POT APPLICATION
-STUDY 3: (Fertilizer management of cabbage)
REFERENCES
Food pattern of East & North East indiaSupta Sarkar
Food pattern of East India & North East India:
FOOD PATTERN OF EAST INDIA:
-WEST BENGAL -BIHAR -JHARKHAND -ORISSA
FOOD PATTERN OF NORTH-EAST INDIA:
-ARUNACHAL PRADESH
-ASSAM
-MANIPUR
-MEGHALAYA
-MIZORAM
-NAGALAND
-SIKKIM
-TRIPURA
Written communication:
Written Communication
Types of written communication
Objectives of written communication
Effective written communication
Media of written communication
Mechanical devices in written communication
Mechanical devices for transmitting written communication
Advantages & Disadvantages
This slide is special for master students (MIBS & MIFB) in UUM. Also useful for readers who are interested in the topic of contemporary Islamic banking.
Macroeconomics- Movie Location
This will be used as part of your Personal Professional Portfolio once graded.
Objective:
Prepare a presentation or a paper using research, basic comparative analysis, data organization and application of economic information. You will make an informed assessment of an economic climate outside of the United States to accomplish an entertainment industry objective.
Normal Labour/ Stages of Labour/ Mechanism of LabourWasim Ak
Normal labor is also termed spontaneous labor, defined as the natural physiological process through which the fetus, placenta, and membranes are expelled from the uterus through the birth canal at term (37 to 42 weeks
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
A Strategic Approach: GenAI in EducationPeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
Biological screening of herbal drugs: Introduction and Need for
Phyto-Pharmacological Screening, New Strategies for evaluating
Natural Products, In vitro evaluation techniques for Antioxidants, Antimicrobial and Anticancer drugs. In vivo evaluation techniques
for Anti-inflammatory, Antiulcer, Anticancer, Wound healing, Antidiabetic, Hepatoprotective, Cardio protective, Diuretics and
Antifertility, Toxicity studies as per OECD guidelines
Unit 8 - Information and Communication Technology (Paper I).pdfThiyagu K
This slides describes the basic concepts of ICT, basics of Email, Emerging Technology and Digital Initiatives in Education. This presentations aligns with the UGC Paper I syllabus.
Synthetic Fiber Construction in lab .pptxPavel ( NSTU)
Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
3. INTRODUCTION
• "Eicosanoid" is derived from a Greek word “eicosa”
meaning "twenty”.
• Eicosanoids is the collective term for the signaling
molecules made by oxidation.
• Eicosanoids are oxygenated derivatives of 3
different 20-carbon fatty acids:
1. Eicosapentanoic acid
2. Arachidonic acid
3. Di-homo-gamma-linolenic acid
4. • Eicosapentaenoic acid (EPA), an ω-3 fatty acid
with 5 double bonds;
• Arachidonic acid (AA), an ω-6 fatty acid, with 4
double bonds;
• Dihomo-gamma-linolenic acid (DGLA), an ω-6,
with 3 double bonds.
Eicosanoids are derived from either omega-3
(ω-3) or omega-6 (ω-6) fatty acids.
5. CLASSIFICATION
• Eicosanoids are classified into two main
groups-
1) Prostanoids
2) Leukotrienes and Lipoxins
• Prostanoids are further sub-classified into
three groups-
a) Prostaglandins(PGs)
b) Prostacyclins(PGIs)
c) Thromboxanes (TXs)
6. BIOSYNTHESIS
• Two families of enzyme catalyze fatty acid
oxygenation to produce the eicosanoids:
• Cyclooxygenase, or COX, generates
the prostanoids.
• Lipoxygenase, or LOX, in several forms.
* 5-lipoxygenase (5-LO) generates the
leukotrienes and via transcellular biosynthesis is
also involved in lipoxin generation.
7. • Eicosanoids are not stored within cells, but
are synthesized as required.
• Derive from the fatty acids that make up the cell
membrane and nuclear membrane.
• Eicosanoid biosynthesis begins when a cell is
activated by mechanical trauma, cytokines, growth
factors or other stimuli. (The stimulus may even be
an eicosanoid from a neighboring cell.)
• This triggers the release of a phospholipase at
the cell membrane.
• The phospholipase travels to the nuclear membrane.
• There, the phospholipase catalyzes
ester hydrolysis of phospholipid or diacylglycerol
(by phospholipase C).
• This frees a 20-carbon fatty acid.
8. • This hydrolysis appears to be the rate-
determining step for eicosanoid formation.
• The fatty acids may be released by any of several
phospholipases.
• Of these, type IV cytosolic phospholipase
A2 (cPLA2) is the key actor, as cells lacking
cPLA2 are, in general, devoid of eicosanoid
synthesis.
• The phospholipase cPLA2 is specific for
phospholipids that contain AA, EPA or GPLA at
the SN2 position.
• Interestingly, cPLA2 may also release the
lysophospholipid that becomes platelet-activating
factor.
9. PROSTANOID PATHWAYS
• Cyclooxygenase (COX) catalyzes the conversion of
the free fatty acids to prostanoids by a two-step
process.
• First, two molecules of O2 are added as two
peroxide linkages, and a 5-member carbon ring is
forged near the middle of the fatty acid chain. This
forms the short-lived, unstable intermediate
Prostaglandin G (PGG).
• Next, one of the peroxide linkages sheds a single
oxygen, forming PGH.
10. • All three classes of prostanoids originate from PGH.
All have distinctive rings in the center of the
molecule. They differ in their structures.
• The derived prostaglandins contain a single,
unsaturated 5-carbon ring.
• In prostacyclins, this ring is conjoined to another
oxygen-containing ring. In thromboxanes the ring
becomes a 6-member ring with one oxygen.
• The leukotrienes do not have rings.
• Several drugs lower inflammation by blocking
prostanoid synthesis
11.
12. LEUKOTRIENE PATHWAYS
• The enzyme 5-lipoxygenase (5-LO) uses 5-
lipoxygenase activating protein (FLAP) to
convert arachidonic acid into 5-
Hydroperoxyeicosatetraenoic acid (5-HPETE),
which spontaneously reduces to 5-
hydroxyeicosatetraenoic acid (5-HETE).
• The enzyme LTA synthase acts on 5-HPETE to
convert it into leukotriene A4 (LTA4), which may be
converted into LTB4 by the enzyme leukotriene A4
epoxide hydrolase.
13. • Eosinophils, mast cells, and alveolar macrophages
use the enzyme leukotriene C4 synthase to
conjugate glutathione with LTA4 to make LTC4,
which is transported outside the cell, where
a glutamic acid moiety is removed from it to
make LTD4.
• The leukotriene LTD4 is then cleaved by
dipeptidases to make LTE4.
• The leukotrienes LTC4, LTD4 and LTE4 all contain
cysteine and are collectively known as the
cysteinyl leukotrienes.
14.
15. FUNCTION
• Eicosanoids exert complex control over many
bodily systems, mainly in inflammation or
immunity, and as messengers in the central
nervous system.
• They are found in most living things.
• In humans, eicosanoids are local hormones that
are released by most cells, act on that same cell
or nearby cells (i.e., they are autocrine and
paracrine mediators), and then are rapidly
inactivated.
16. On the basis of functions eicosanoids
are again said as 2 types:
18. Action of prostanoids
• Prostanoids mediate local symptoms
of inflammation: vasoconstriction or vasodilation,
coagulation, pain and fever.
• COX-2 is responsible for pain and inflammation,
while COX-1 is responsible for platelet clotting
actions.
• Inhibition of cyclooxygenase, specifically the
inducible COX-2 isoform, is the hallmark
of NSAIDs (non-steroidal anti-inflammatory
drugs).
• Prostanoids activate the PPARγ members of the
steroid/thyroid family of nuclear hormone
receptors, directly influencing gene transcription.
19. *Aspirin inhibits the COX pathway and consequently
diverts arachidonic acid metabolites to the LO
pathway.
*This also leads to a decrease in the
levels of PGE2, the anti-inflammatory PG.
*LTC4 synthase overexpression further increases the
number of cysteinyl LTs, tilting the balance toward
inflammation and broncho constriction causing
asthma
Role of Aspirin in Inflammation & Broncho-
constriction
21. Action of leukotrienes
• Leukotrienes play an important role in
inflammation. There is a neuroendocrine role
for LTC4 in luteinizing hormone secretion.
• LTB4 causes adhesion and chemotaxis of
leukocytes and stimulates aggregation,
enzyme release, and generation
of superoxide in neutrophils.
• Blocking leukotriene receptors can play a role
in the management of inflammatory diseases
such as asthma (by the drugs montelukast and
zafirlukast), psoriasis, and rheumatoid
arthritis.
22. • The slow reacting substance of anaphylaxis comprises
the cysteinyl leukotrienes. These have a clear role
in pathophysiological conditions such as
asthma,allergic rhinitis and other nasal allergies, and
have been implicated in atherosclerosis and
inflammatory gastrointestinal diseases.
• They are potent bronchoconstrictors, increase vascular
permeability in postcapillary venules, and
stimulate mucus secretion. They are released from the
lung tissue of asthmatic subjects exposed to specific
allergens and play a pathophysiological role
in immediate hypersensitivity reactions.
• Along with PGD, they function in effector
cell[disambiguation needed] trafficking, antigen presentation,
immune cell activation, matrix deposition, and fibrosis.
23. Eicosanoid
Major site(s) of
synthesis
Major biological activities
PGD2
mast cells,
eosinophils, brain
Induces inflammatory responses principally by
recruiting eosinophils and basophils; induces
bronchoconstriction; involved in androgenetic
alopecia, inhibitors of PGD2 being studied to treat
male pattern baldness
PGE1
Induces vasodilation and inhibits platelet
aggregation
PGE2
kidney, spleen,
heart
Increases vasodilation and camp production,
enhancement of the effects of bradykinin and
histamine, induction of uterine contractions and of
platelet aggregation, maintaining the open
passageway of the fetal ductus arteriosus;
decreases t-cell proliferation and lymphocyte
migration and secretion of il-1α and IL-2
24. Eicosanoid Major site(s) of synthesis Major biological activities
PGF2α kidney, spleen, heart
increases vasoconstriction,
bronchoconstriction and smooth muscle
contraction
PGH2
precursor to thromboxanes A2 and B2,
induction of platelet aggregation and
vasoconstriction
PGI2
heart, vascular
endothelial cells
inhibits platelet and leukocyte aggregation,
decreases T-cell proliferation and
lymphocyte migration and secretion of IL-1α
and IL-2; induces vasodilation and
production of cAMP
TXA1
induces vasodilation and inhibits platelet
aggregation
TXA2 platelets
induces platelet aggregation,
vasoconstriction, lymphocyte proliferation
and bronchoconstriction
TXB2 platelets induces vasoconstriction
25. Eicosanoid Major site(s) of synthesis Major biological activities
LTB4
monocytes, basophils,
neutrophils, eosinophils,
mast cells, epithelial cells
powerful inducer of leukocyte chemotaxis
and aggregation, vascular permeability, T-
cell proliferation and secretion of INF-γ, IL-1
and IL-2
LTC4
monocytes and alveolar
macrophages, basophils,
eosinophils, mast cells,
epithelial cells
component of SRS-A, microvascular
vasoconstrictor, vascular permeability and
bronchoconstriction and secretion of INF-γ,
recruitment of leukocytes to sites of
inflammation, enhance mucus secretions in
gut and airway
LTD4
monocytes and alveolar
macrophages, eosinophils,
mast cells, epithelial cells
same as LTC4
LTE4 mast cells and basophils same as LTC4
**SRS-A = slow-reactive substance of anaphylaxis
26. Pharmacological applications of Eicosanoids
• Cardiovascular uses- pulmonary arterial hypertension,
peripheral vascular disease. For keeping the ductus arteriosus
open until surgery in neonates carrying certain cardiac
malformations and platelet anti-aggregating agents.
• Digestive Uses- indicated in the treatment of gastro duodenal
ulcer and for the prevention of NSAID-induced ulcers.
• Gynecological and obstetrical uses - They induce cervical
dilatation and uterine contractions, particularly in late
pregnancy. Used for medical termination of pregnancy and
induction of labour.
27. • Ophthalmologic Use- lower intraocular pressure.
• Anti- inflammatory use- Inhibitors of cyclo-
oxygenases have anti-inflammatory properties
and include nonsteroidal anti-inflammatory drugs
or NSAID. The useful effects in therapeutics are-
anti-inflammatory effect
analgesic effect
antipyretic effect
inhibition of platelet aggregation and decrease of
thromboembolic risk (well-known with aspirin at
low doses)
28. • Ulcerative Colitis- Mesalamine also called mesalazine
or 5 aminosalicyclic acid has antiinflammatory
properties in the colon and is used in the treatment of
ulcerative colitis (Crohn's disease). Its mechanism of
action is complex and as yet incompletely known: in
addition to cyclo-oxygenases, it also inhibits
lipoxygenases.
• Bronchial Asthma- PGE2 agonists and leukotrienes
receptor antagonists are used for the treatment of
bronchial asthma.
30. CONCLUSION
Eicosanoids are oxygenated derivatives of 3 different 20-
carbon fatty acids
Eicosanoids are classified in to 2 main groups:
Prostanoids, and Leukotrienes & Lipoxins
COX & LOX enzymes catalyze fatty acid oxygenation to
produce the eicosanoids.
Exert complex control over many bodily systems, mainly
in inflammation or immunity, and as messengers in
the CNS.