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Introduction to Neuroanesthesia
Edward B. Fohrman M.D.
Department of Anesthesiology
Regulation of 

Cerebral Blood Flow
Normal Cerebral Physiology
CBF   
– Global 45–55 mL/100 g/min  
– Cortical (mostly gray matter)75–80 mL/100 g/min  
– Subcortical (mostly white matter)∼20 mL/100 g/min
CMRO2 = 3 - 3.5 mL/100 g/min
CVR = 1.5–2.1 mmHg/100 g/min/mL
Cerebral venous PO2 32 – 44 mmHg
Cerebral venous SPO2 55%–70%
ICP (supine) 8–12 mmHg
Tight Brain Checklist
1. Are the relevant
pressures controlled?   
– Jugular venous pressure
(CVP)     
Extreme head rotation or neck
flexion?     
Direct jugular compression?     
Head-up posture?   
– Airway pressure:
Airway obstruction?
Bronchospasm?
Straining
coughing
adequately relaxed?
Pneumothorax?   
– Partial pressure of CO2 and O2
(PaCO2, PaO2)
– Mean arterial pressure (MAP)
2. Is the metabolic rate
(CMRO2) controlled?   
– Pain/arousal?   
– Seizures?
– Fever?
– Consider burst supression
3. Are any potential
vasodilators in use?   
– N2O
– volatile anesthetics
– NTP
– CCB’s
4. Are there any
unrecognized mass
lesions?   
– Blood, air ± N2O

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Edward Fohrman | Introduction to Neuroanesthesia

  • 1. Introduction to Neuroanesthesia Edward B. Fohrman M.D. Department of Anesthesiology
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  • 4. Normal Cerebral Physiology CBF    – Global 45–55 mL/100 g/min   – Cortical (mostly gray matter)75–80 mL/100 g/min   – Subcortical (mostly white matter)∼20 mL/100 g/min CMRO2 = 3 - 3.5 mL/100 g/min CVR = 1.5–2.1 mmHg/100 g/min/mL Cerebral venous PO2 32 – 44 mmHg Cerebral venous SPO2 55%–70% ICP (supine) 8–12 mmHg
  • 5. Tight Brain Checklist 1. Are the relevant pressures controlled?    – Jugular venous pressure (CVP)      Extreme head rotation or neck flexion?      Direct jugular compression?      Head-up posture?    – Airway pressure: Airway obstruction? Bronchospasm? Straining coughing adequately relaxed? Pneumothorax?    – Partial pressure of CO2 and O2 (PaCO2, PaO2) – Mean arterial pressure (MAP) 2. Is the metabolic rate (CMRO2) controlled?    – Pain/arousal?    – Seizures? – Fever? – Consider burst supression 3. Are any potential vasodilators in use?    – N2O – volatile anesthetics – NTP – CCB’s 4. Are there any unrecognized mass lesions?    – Blood, air ± N2O