Ascending Cholangitis - case presentationRobert Ferris
Diagnosis, differentials, treatment of ascending cholangitis. Slides compiled as part of medical school studies.
Sources for all imagery and sources listed in references section where possible. I do not claim ownership of any images or graphics. Slides for educational purposes only, and should not replace clinical judgement. No monetary gain was made for this work.
Abdominal pain is one of common problems
encountered by doctors, either in primary or
secondary health care (specialists). It may be
mild, but it may also a life-threatening sign. It
has been estimated that almost 50% adults have
experienced abdominal pain. In general, abdominal pain is categorized
based on the onset as acute or chronic pain.
Sudden onset of abdominal pain that lasts for less
than 24 hours is considered as acute abdominal
pain.
The problems of a surgeon
If 'I' operate 'and 'the' problem 'is' not 'surgical, Pt
exposed 'to' unnecessary 'risk ,'anesthetic,'etc.'
Risks 'greater' with 'concomitant 'illness,'older 'age'
If 'I' do 'not' operate 'and' problem 'is' surgical, 'patient 'at'
risk 'because' of 'wrong' therapy.'
Again 'the' older 'patient 'is' under 'greater' burden.'
Ascending Cholangitis - case presentationRobert Ferris
Diagnosis, differentials, treatment of ascending cholangitis. Slides compiled as part of medical school studies.
Sources for all imagery and sources listed in references section where possible. I do not claim ownership of any images or graphics. Slides for educational purposes only, and should not replace clinical judgement. No monetary gain was made for this work.
Abdominal pain is one of common problems
encountered by doctors, either in primary or
secondary health care (specialists). It may be
mild, but it may also a life-threatening sign. It
has been estimated that almost 50% adults have
experienced abdominal pain. In general, abdominal pain is categorized
based on the onset as acute or chronic pain.
Sudden onset of abdominal pain that lasts for less
than 24 hours is considered as acute abdominal
pain.
The problems of a surgeon
If 'I' operate 'and 'the' problem 'is' not 'surgical, Pt
exposed 'to' unnecessary 'risk ,'anesthetic,'etc.'
Risks 'greater' with 'concomitant 'illness,'older 'age'
If 'I' do 'not' operate 'and' problem 'is' surgical, 'patient 'at'
risk 'because' of 'wrong' therapy.'
Again 'the' older 'patient 'is' under 'greater' burden.'
Describes the concept of a surgical abdomen, acute abdominal pain, emergency intervention and approach to management, including the controversial use of analgesic and antibiotics in emergency room.
Measuring and Enhancing Your Academic Medical ImpactMarion Sills
Overview of measuring and enhancing the impact of your scholarly work in academic medicine. The talk reviews how impact is defined and measured, how to improve your own impact metrics and how to describe the impact of your scholarly contributions to science.
Stakeholder Engagement in a Patient-Reported Outcomes Implementation by a Pra...Marion Sills
Kwan BM, Sills MR, Graham D, Hamer MK, Fairclough DL, Hammermeister KE, Kaiser A, Diaz-Perez MJ, Schilling LM. Stakeholder Engagement in a Patient-Reported Outcomes Implementation by a Practice-Based Research Network. JABFM. In Press.
Practice Variability in and Correlates of Patient-Centered Medical Home Chara...Marion Sills
Schilling LM, Sills MR, Fairclough D, Kwan MB. Practice Variability in and Correlates of Patient-Centered Medical Home Characteristics. SAFTINet Convocation. Aurora, Colorado. 13 Feb 2013.
Sills MR. Inpatient capacity margin at children's hospitals during the fall 2009 H1N1 influenza pandemic. Presentation to the Colorado Emergency Medicine Research Center. 14 June 2010.
Sills MR. Overview of the SAFTINet Program. Presented to the Emergency Department Research Committee, Department of Pediatrics, University of Colorado School of Medicine. 6 January 2015.
Patient-reported outcomes for asthma in children and adultsMarion Sills
Patient-reported outcomes for asthma in children and adults. Guided Discussion to Facilitate SAFTINet Stakeholders' Selection of an Asthma PROM. Teleconference. 1 April 2011
Sills MR. Cardiovascular Cohorts PROM Measures Updates and Action Items. Slides for teleconference to facilitate discussion of Cardiovascular PRO Measure Selection by SAFTINet Stakeholder Community. 21 March 2012.
Sills MR. Evolution of PRO Measure for Cardiovascular Cohorts in SAFTINet. Slides for teleconference to facilitate discussion of Cardiovascular PRO Measure Selection by SAFTINet Stakeholders. 2 May 2012.
Sills MR. Medication Adherence PROM Measures Updates and Pilot Results. Slides for teleconference to facilitate discussion of Cardiovascular PRO Measure Selection and Refinement by SAFTINet Stakeholders. 2 July 2012.
Sills MR. Medication Adherence PROM Measures and Self Efficacy. Slides for teleconference to facilitate discussion of Cardiovascular PRO Measure Selection by SAFTINet Stakeholders. 21 May 2012.
Cer safti net overview edrc 1 feb 2011Marion Sills
Sills MR. Overview of Comparative Effectiveness Research Using SAFTINet as an Example. Methods Talk presented to the Emergency Department Research Conference, Department of Pediatrics, 1 February 2011.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
1. The ED Patient with
Abdominal Pain
Marion R. Sills, MD, MPH
Medical Student Lecture
2. Overview of ED Abdominal
Pain
• Epidemiology
• Extensive differential
• Timely identification of the acute abdomen is key
• Approach
• Manage pain first
• H&P is key (again!)
3. Epidemiology
• Common: 5% of all emergency department (ED) visits
• Varied presentations
• acute exacerbations of chronic problems (e.g., peptic disease,
pancreatitis in alcoholics, inflammatory bowel disease)
• acute surgical abdomens (e.g., appendicitis, ruptured bowel,
acute volvulus)
• also includes trauma (e.g., splenic rupture, hepatic laceration, small
bowel rupture)
• nonsurgical abdominal emergencies (e.g., gastritis, biliary colic,
gastroenteritis)
• Differential is extensive
4. Epidemiology: Age, Sex
• Most Common Diagnoses pts > 50
• Cholecystitis (21%)
• Nonspecific abdominal pain (16%)
• Appendicitis (15%)
• SBO (12%)
• Everything else (diverticulitis, hernia, cancer, vascular)
• Most Common Diagnoses pts < 50:
• Nonspecific Abdominal Pain ( ~40% )
• Appendicits (32%)
• Cholecystitis (6%)
• SBO and Pancreatitis (each ~ 2%)
5. Other Common Diagnoses
• Gastroenteritis*
• GERD
• Cholecystitis
• Appendicitis
• Obstruction
• Constipation*
• UTI*
• PID*
• Renal stones
• Intussusception
*often misdiagnosed in patients with another, more
significant abdominal pathology
6. H&P
• H&P are key
• guide workup
• narrow the extensive differential
• Labs and imaging are used to either support/refute your
suspected diagnosis
• More helpful in generating a diagnosis when the H&P is
suboptimal (altered, confused patient)
7. H&P: Key Considerations
• Essential to rule out the life-threatening causes
• AAA
• Perforation
• Obstruction
• Ischemia
• Ectopic pregnancy
• identify patterns that place a person at risk for life-threatening
causes and rule out/in those causes
8. H&P: Initial approach
• If on initial assessment the patient is in obvious pain, give
analgesia immediately
• Severe pain: parenteral administration
• Usually morphine sulfate
• If probable renal colic, consider ketorolac
• if low/borderline BP, consider shorter acting opioid: fentanyl
• Milder pain: oral medication may be OK
• Medications will not interfere with the exam
• If the vital signs are abnormal have low threshold for
obtaining vascular access
9. Abdominal Pain History
• HPI
• Onset
• Palliates/Provokes
• Quality
• Radiation
• Severity
• Time course
• Undo (what have they
done to “undo” their
pain)
• PMH
• PMHx
• Surgical Hx
• Allergies
• Meds
• Social Hx
• EtOH
10. History: Characterizing Pain
• Onset and pattern
• Location and radiation
• Alleviating and aggravating factors
• Severity
• Quality
11. History: Characterizing Pain
• Onset
• Abrupt or gradual onset (abrupt is worse)
• Duration (< 48 hours is worse)
• Trend and pattern: constant or intermittent (constant pain is
worse)
• Timing in relation to other symptoms (e.g., pain that precedes
vomiting is worse)
• Tip:
• Constant pain that began abruptly suggests renal colic,
perforated viscus, ischemia (myocardial infarction, testicular or
ovarian torsion) or hemorrhage
12. History: Characterizing Pain
• Location
• Ask where the pain is and how this has changed
• 6 anatomic locations: RUQ, epigastrium, LUQ, RLQ, suprapubic,
and LLQ
• Tips:
• The more midline the pain, the more likely it is bowel based
• Pain that starts centrally and migrates to the RLQ has a high
specificity for appendicitis
• Pain that localizes (in children, to somewhere other than umbilicus)
is of higher concern
• Radiation
• Can be helpful when present
• Tips:
• Radiating into back or groin suggests renal colic
• Radiating into right shoulder suggests biliary disease
14. History: Characterizing Pain
• Alleviating and aggravating factors
• Include eating, movement, medication
• Tips:
• Worsened by eating: often related to pancreas or gall bladder
• Relieved by eating: often peptic disease.
15. History: Characterizing Pain
• Severity
• Evaluate with 1-10 scale
• Allows assessment of trends and response to therapy
• Quality
• Sometimes helpful, but some patients are highly suggestible, or
unable to describe pain very precisely.
• Tip: Ask if the patient had pain like this before. If yes, consider
peptic disease, biliary disease, IBD, hepatitis, and pancreatitis. (A
report of no prior episodes is worse)
16. History: Pain
Characterization and
Differential Diagnosis• Sudden onset of severe pain which does not diminish
• renal colic
• perforated viscous (e.g., ulcer)
• myocardial infarction, intestinal infarction
• torsion (ovary, testicle)
• hemorrhage (e.g., dissecting AAA)
• Crampy pain
• biliary colic
• renal colic
• intestinal obstruction
• gastroenteritis
• ectopic pregnancy
• Referred pain
• myocardial infarction may present as epigastric pain
• pneumonia
• strep tonsillitis
17. History: ROS
• General: Fever and chills point to an acute inflammatory
condition
• Respiratory: cough or dyspnea may point to pneumonia with
upper quadrant radiation
• GI:
• Anorexia: absence rules against an acute inflammatory condition
• Diarrhea suggests gastroenteritis but may be present with 20% of
acute appendicitis (be careful diagnosing gastroenteritis without
diarrhea)
• Ask about BMs, melena, hematochezia, straining
• GYN: ask about pregnancy, vaginal bleeding and discharge,
STDs and LMP
• GU: symptoms of UTIs—dysuria, frequency, and back pain
18. History: PMH
• PSH:
• Ask about prior abdominal surgeries
• Tip: Abdominal pain with vomiting, no flatus or BM, and a midline
abdominal scar suggests an SBO
• PMH:
• Ask about prior bowel problems
• History of vascular or heart disease, HTN or atrial fib increases
risk of mesenteric ischemia and abdominal aneurysm
• If history of cancer, diverticulosis, pancreatitis, kidney stones,
gallstones, or inflammatory bowel disease, consider recurrence
• In elderly/frail, DM and ESRD increase risk for ischemic bowel
• HIV increases risk for serious etiology (consider occult infection
or drug- related pancreatitis)
19. History: PMH
• Meds:
• consider iatrogenic causes of abdominal pain (e.g., erythromycin
at 500 mg BID causes abdominal pain in 50%)
• consider medications that may mask infection, such as antibiotics
or steroids
• Habits:
• Ask about alcohol and quantity of consumption, IV drug use,
cocaine/amphetamine
• Tip: Most alcoholics have some component of pancreatitis,
hepatitis and gastritis
20. History: Age
• Abdominal pain in the elderly:“an M&M waiting to happen”
• Mortality & misdiagnosis rise exponentially w/each decade >50
yrs.
• For those > 65 years, ~ 60-70% get admitted, 40-50% go to the
OR and 10% die (this is higher than mortality of acute MI at 6-8%)
• Elderly patients frequently get more testing
21. Physical Exam
• General characteristics
• overall appearance (key)
• level of distress (and response to analgesia)
• diaphoresis (concerning)
• VS (persistent fever, tachycardia, tachypnea, or hypotension are
concerning)
• body posture:
• writhing (suggests renal, biliary or intestinal colic)
• prefers to sit, leaning forward a little (suggests pericarditis or
pancreatitis)
• lying very quietly, often with hips and knees flexed, and does not like
to move (suggests peritonitis)
23. Physical Exam: Abdomen
• Peritoneal irritation (heel tap, jump, rock the bed, ask patient
to cough)
• Inspect abdomen for distention, ascites, contusions, incisions
• Auscultate for the presence and quality of bowel sounds
• Percuss to determine
• presence of percussion tenderness
• liver span
• Palpate to determine
• location of maximal tenderness
• presence or absence of guarding and/or rebound tenderness
• presence of masses, organomegaly and/or hernias
• start gently, away from the area of pain, distract the patient, and
then palpate more deeply
24. Physical Exam: Signs
• Murphy’s Sign
• arrest of inspiration with examiner’s palpating fingers in the RUQ
• suggests irritation in the RUQ
• always present in cholecystitis: may also occur with pancreatitis,
hepatitis and peptic disease
• Psoas Sign (extend patient’s leg at hip with patient in lateral
decubitus position (to move psoas muscle)
• Obturator sign (flex and externally and internally rotate hip)
• Rovsings Sign
• palpation in LLQ causes pain in RLQ
• suggests appendicitis
25. Rectal Exam
• Generally indicated only in those with symptoms referable to
the rectal/anal area or suspected GI bleeding, otherwise rarely
useful in generalized abdominal pain workup
• Prostatitis
• GI bleeding: upper or lower
• Hemorrhoids
• Constipation: possible impaction?
• Bloody diarrhea (enteritis)
26. Physical Exam: Down There
• Women (especially if they’ve had a pelvic exam before):
• at least a bimanual pelvic examination of women
• evaluate for cervical motion tenderness (PID) and adnexal masses
• Males: examine the testicles, scrotum, groin and prostate as
indicated
27. Diagnostic Testing
• Obtain tests
• if the diagnosis is not clinically apparent
• if the patient is sick
• if there is a suspected complication of a known diagnosis
(e.g.,rectal bleeding in IBD, fever in diverticulitis)
• Knowing that studies will only aid what you already suspect,
identify needed treatments and start them empirically as
indicated
28. Laboratory Studies
• CBC
• 10-60% of patients with appendicitis have a normal WBC count
• Elevated WBC count detects 53% of severe abdominal pathology
• WBC > 15K with abdominal pain raises risk. If a benign diagnosis
(gastroenteritis, renal colic) is not clear, consider imaging.
• Electrolytes, anion gap, BUN/Cr
• Lipase
• UA
• LFTs (transaminases, bilirubin, albumin, alk phos)
• Pregnancy Test!
• ECG (especially if > 40 years, in patients with DM and/or those with
epigastric pain)
• ABGs are indicated in patients who are elderly and in severe pain.
Acidosis suggests bowel ischemia.
30. Radiographic Studies: Plain
Film
• Mostly helpful in ED for:
– Free air (suspected perforation)
– Pneumatosis (typhlitis)
– Dilated loops of bowel with air fluid levels (obstruction)
– Foreign body
• Free air seen in only 30-50% of bowel perforation
34. Radiography: Ultrasound
• Excellent for biliary tract disease (90+% sensitive for
gallstones)
• AAA- can rapidly assess size at bedside
• Ectopic pregnancy- look for intrauterine yolk sac, assess
adnexa, assess for free fluid
• Appendicitis- 75%-90% sensitive (in experienced hands, best
in thin patients)
• Pelvic structures, testicles
• Can also assess intussusception, obstructive kidney stone
37. Radiology- CT Scan
• Detect leaking AAA (in stable patient)
• Evaluate for renal calculi, appendicitis, perforation (free air),
diverticulitis, abscess, mesenteric ischemia, masses, obstruction
• Sensitivity and specificity vary
• Not a place for unstable patients
• Contrast
• PO and IV contrast in most patients
• sometimes rectal contrast is helpful to look for large bowel problems
(appendicitis)
• In patients with renal insufficiency
• give IV contrast judiciously in patients
• consider ultrasound as an alternative if possible
• a creatinine > 1.5 usually requires bicarbonate and fluid hydration to
minimize contrast nephropathy
43. Radiographic Studies: Other
• CXR—useful in upper quadrant pain
• ERCP—essential for common duct obstruction (gallstones,
sludge, compression, stricture)
44. General Management
• Fluids
• Most patients with serious abdominal pain are dehydrated
• Unless there is concern for fluid overload, give a bolus and then a
rapid infusion rate
• Analgesia—give ongoing pain relief with morphine in most
cases.
• Antibiotics for acute inflammatory processes (cholecystitis,
diverticulitis, appendicitis)
• NG tube—decompress the stomach for SBOs, ischemic bowel
or any serious condition with ileus
• Blood transfusion—Use in any symptomatic hemorrhagic
event, such as a ruptured AAA or GI bleed from an active ulcer
• Surgical consultation—obtain in patients with peritonitis,
hemorrhage, ischemia; consider with uncertain etiology
45. Case #1- Presentation
• 23 yo female
• acute onset LLQ pain 2 hours ago
• Constant, no radiation, no N/V/D
• No exacerbating, alleviating factors
• No vaginal discharge
46. Case #1 -PMH
• No medical problems
• No medications, No allergies
• Surg Hx: S/P Elective Abortion 1 year ago
• No history of STDs, Sexually Active
• LMP 4 weeks ago
47. Case #1- Exam
• Vitals: P105 R20 T37.7 BP 103/58
• Abd: soft, tender LLQ with guarding, no rebound pain
detected
• Pelvic: No cervical motion tenderness, L adnexal
tenderness/fullness
• Rectal: No masses, guaiac negative
50. Case#1- Intervention/Diagnosis
• Pregnancy Test - Negative
• IV Fluids - 500 cc bolus ( repeat P 90, BP110/65 )
• U/S- L ovary with absent blood flow, multiple cysts
• Diagnosis: Ovarian Torsion
• Disposition: To OR by GYN
51. Case #2- Presentation
• 47 yo male with sudden onset abd pain
• Epigastric pain, vomited x2
• Pain 10/10
• Better if holds still, worse on car ride into hospital
• Never had pain like this before
52. Case #2- Past Medical History
• Medical Hx: Arthritis, Chronic Low Back Pain
• Surgical Hx: L knee meniscus repair
• Meds: No prescribed meds, OTC ibuprofen
• Allergies: NKDA
• SH: 2 beers/night
53. Case #2- Exam
• Vitals: P95 R22 T37.4 BP 124/75 O2 100%
• Gen: Anxious, Mild distress/diaphoretic, Remaining still
• Abd: Decreased BS, Severe epigastric tenderness with
guarding and rebound
• Rectal: Guaiac positive
54. Case #2- Actions
• Large bore IV x2, Type and Screen, CBC, CMP, Lipase, Fluid
bolus,ECG
• Acute Abdominal Series
• Orthostatic Vitals
55.
56. Case #2 -
Interventions/Diagnosis
• CXR reveals intra-abdominal free air
• Diagnosis: Perforation, likely duodenal or gastric ulcer
• Disposition: To OR for identification and repair
57. Multiple Life Threatening Causes
of Abdominal Pain
• Identify the potential life threatening cause of the following
cases.
• Differential diagnosis is large but consider an acute event and
test your intuition
59. Rapid Cases #2
• Healthy 17 yo male, football player
• L shoulder pain, not reproducible on exam
• lightheaded, weak
• U/S with free intraperitoneal fluid
• Diagnosis: Splenic Lac
60. Rapid Cases #3
• 16 yo female
• Nausea, diffuse discomfort starting yesterday
• Now worse RLQ
• Abd exam: pain RLQ, +guarding
• Diagnosis: Appendicitis
61.
62. Rapid Case #4
• 65 yo male
• Hx of HTN, Renal Colic x3 episodes
• Low back pain- ?new pain
• Abd: obese, soft, no masses palpated
• U/S shows 7cm AAA
63.
64. Rapid Case #5
• 56 yo female
• H/O Alcoholic Cirrhosis
• Diffuse abd pain, gradual onset
• Distended abdomen, febrile
• U/S: ascites
• Peritoneal tap >500 WBC/cc
• Spontaneous Bacterial Peritonitis
65. Rapid Case #6
• 32 yo female, S/P Tubal ligation 2 weeks ago
• Gradual onset diffuse pain
• N/V/D, fever
• Diffusely tender, guarding, + rebound
• CXR with free air
• Bowel perforation
69. Rapid Case #8
• 16 yo male
• sudden onset lower abd, scrotal pain
• No hx of trauma
• Tender L testicle to exam
• U/S: No vascular flow to L testicle
• Acute Testicular Torsion
70. Rapid Case #9
• 30 yo female, G3P3 IUD in place
• LLQ pain, gradually worsening today
• No fever, Tender L Adnexa
• + UPT
• U/S with L Adnexal Gestational Sac
• Ectopic Pregnancy
71. Rapid Case #10
• 4 yo male
• Crampy abdominal pain- crying
• Tender diffusely to exam, afebrile
• Guaiac positive stool
• Complete relief with enema
• Intussusception
77. Rapid Case #14
• 78 yo male
• H/O HTN, DM
• Acute onset nausea, diaphoresis, epigastric discomfort,
• Exam: Mild epigastric discomfort to palpation
• ECG ST elevation 3mm leads II, III aVF
• Dx: Inferior MI
82. Rapid Case #16
• 52 yo alcoholic male
• Diffuse abd pain, gradually worsening, vomiting recurrently
• Exam: soft abdomen, minimal tenderness
• Labs: Increased lipase
• Dx: Pancreatitis
83. Rapid Case #17
• 14 yo healthy male
• Acute crampy abd pain past day
• Vomiting, Diaphoretic
• Exam: Diffuse mildly tender abdomen with palpable firm mass
in R groin
• Dx: Incarcerated inguinal hernia
85. Rapid Case #18
• 28 yo post-partum healthy female
• Acute R flank pain radiating to groin
• Exam: Abd soft, non-tender without CVA tenderness
• UA with 2+ RBC, no WBCs
• CT with R Ureteral Calculi
• Dx: Renal Colic
90. Rapid Case #19
• 72 yo female c/o RUQ pain & cough
• PMHx: HTN, COPD on home O2
• Vitals: T38.5 HR 105 RR 26 BP 140/90 SpO2 88% on 2L
• Physical: dry mucous membranes, decreased breath sounds,
non-tender abdomen
• CXR: RLL infiltrate
• Diagnosis: RLL pneumonia
91.
92.
93. Summary
• The Differential Diagnosis of Abdominal Pain is extensive.
Large. Massive even.
• You need to identify patterns that place a person at risk for
serious causes of their pain and rule out/in those causes
• History and Physical are the key to narrowing the ddx
• Labs and Radiology support/refute your diagnosis
94. Summary Continued
• Always get Pregnancy Test (doesn’t matter if they are on
OCP’s, had a tubal ligation, or swear they can’t be pregnant
due to saintly behavior-OK, no, if hysterectomy or elderly)
• If discharging a patient, always alert patient of symptoms they
should watch for and when to return
• If dx is “abdominal pain NOS” (unknown etiology), consider
f/u, even in ED, for re-evaluation