1) The acute abdomen refers to a clinical situation requiring immediate diagnosis and treatment for an acute change in the intraabdominal organs, usually related to inflammation or infection.
2) A history, physical exam, and serial exams are more important for diagnosis than tests. Common causes include appendicitis, cholecystitis, pancreatitis, diverticulitis, perforated ulcer, and inflammatory bowel disease.
3) CT scans accurately diagnose many conditions like appendicitis, diverticulitis, and pancreatitis but should only be used after developing a working diagnosis, as treatment may involve antibiotics, drainage, or surgery.
Describes the concept of a surgical abdomen, acute abdominal pain, emergency intervention and approach to management, including the controversial use of analgesic and antibiotics in emergency room.
Physical exam of an acute surgical abdomen. Using detailed descriptions of pain along with onset and physical exam tests including peritoneal signs and more advanced physical exam maneuvers in order to formulate a diagnosis and severity of illness.
Describes the concept of a surgical abdomen, acute abdominal pain, emergency intervention and approach to management, including the controversial use of analgesic and antibiotics in emergency room.
Physical exam of an acute surgical abdomen. Using detailed descriptions of pain along with onset and physical exam tests including peritoneal signs and more advanced physical exam maneuvers in order to formulate a diagnosis and severity of illness.
writes I have a good salary, am married, and have two children. My whole life I've been drawn to prescription and have always enjoyed it. However, I have a unattached in English literature, so I've always put it as unattainable to become a doctor. Now, once again, I'm bearing in mind doing one of the post bac premed programs out there and going for it.
acute abdomen conditions in radiology and their evaluation
acute pancreatitis, cholicystitis, pelvic pathology, mri evaluation , intra abdominal abcess, plain radiography evaluation of acute abdomen, vascular causes of acute abdomen, causes of acute abdomen.
Abdominal pain is one of common problems
encountered by doctors, either in primary or
secondary health care (specialists). It may be
mild, but it may also a life-threatening sign. It
has been estimated that almost 50% adults have
experienced abdominal pain. In general, abdominal pain is categorized
based on the onset as acute or chronic pain.
Sudden onset of abdominal pain that lasts for less
than 24 hours is considered as acute abdominal
pain.
The problems of a surgeon
If 'I' operate 'and 'the' problem 'is' not 'surgical, Pt
exposed 'to' unnecessary 'risk ,'anesthetic,'etc.'
Risks 'greater' with 'concomitant 'illness,'older 'age'
If 'I' do 'not' operate 'and' problem 'is' surgical, 'patient 'at'
risk 'because' of 'wrong' therapy.'
Again 'the' older 'patient 'is' under 'greater' burden.'
writes I have a good salary, am married, and have two children. My whole life I've been drawn to prescription and have always enjoyed it. However, I have a unattached in English literature, so I've always put it as unattainable to become a doctor. Now, once again, I'm bearing in mind doing one of the post bac premed programs out there and going for it.
acute abdomen conditions in radiology and their evaluation
acute pancreatitis, cholicystitis, pelvic pathology, mri evaluation , intra abdominal abcess, plain radiography evaluation of acute abdomen, vascular causes of acute abdomen, causes of acute abdomen.
Abdominal pain is one of common problems
encountered by doctors, either in primary or
secondary health care (specialists). It may be
mild, but it may also a life-threatening sign. It
has been estimated that almost 50% adults have
experienced abdominal pain. In general, abdominal pain is categorized
based on the onset as acute or chronic pain.
Sudden onset of abdominal pain that lasts for less
than 24 hours is considered as acute abdominal
pain.
The problems of a surgeon
If 'I' operate 'and 'the' problem 'is' not 'surgical, Pt
exposed 'to' unnecessary 'risk ,'anesthetic,'etc.'
Risks 'greater' with 'concomitant 'illness,'older 'age'
If 'I' do 'not' operate 'and' problem 'is' surgical, 'patient 'at'
risk 'because' of 'wrong' therapy.'
Again 'the' older 'patient 'is' under 'greater' burden.'
This is a lucid presentation on the management of abdominal trauma/injury in children of paediatric age. Even though it focused on paediatric trauma, the information is also relevant to adult trauma. It went ahead to discuss the definition, causes, and initial management of abdominal trauma. It further went to highlight the management algorithms and outcomes of management. Finally, the presentation ended with management of abdominal compartment syndrome
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Antimicrobial stewardship to prevent antimicrobial resistanceGovindRankawat1
India is among the nations with the highest burden of bacterial infections.
India is one of the largest consumers of antibiotics worldwide.
India carries one of the largest burdens of drug‑resistant pathogens worldwide.
Highest burden of multidrug‑resistant tuberculosis,
Alarmingly high resistance among Gram‑negative and Gram‑positive bacteria even to newer antimicrobials such as carbapenems.
NDM‑1 ( New Delhi Metallo Beta lactamase 1, an enzyme which inactivates majority of Beta lactam antibiotics including carbapenems) was reported in 2008
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
DISSERTATION on NEW DRUG DISCOVERY AND DEVELOPMENT STAGES OF DRUG DISCOVERYNEHA GUPTA
The process of drug discovery and development is a complex and multi-step endeavor aimed at bringing new pharmaceutical drugs to market. It begins with identifying and validating a biological target, such as a protein, gene, or RNA, that is associated with a disease. This step involves understanding the target's role in the disease and confirming that modulating it can have therapeutic effects. The next stage, hit identification, employs high-throughput screening (HTS) and other methods to find compounds that interact with the target. Computational techniques may also be used to identify potential hits from large compound libraries.
Following hit identification, the hits are optimized to improve their efficacy, selectivity, and pharmacokinetic properties, resulting in lead compounds. These leads undergo further refinement to enhance their potency, reduce toxicity, and improve drug-like characteristics, creating drug candidates suitable for preclinical testing. In the preclinical development phase, drug candidates are tested in vitro (in cell cultures) and in vivo (in animal models) to evaluate their safety, efficacy, pharmacokinetics, and pharmacodynamics. Toxicology studies are conducted to assess potential risks.
Before clinical trials can begin, an Investigational New Drug (IND) application must be submitted to regulatory authorities. This application includes data from preclinical studies and plans for clinical trials. Clinical development involves human trials in three phases: Phase I tests the drug's safety and dosage in a small group of healthy volunteers, Phase II assesses the drug's efficacy and side effects in a larger group of patients with the target disease, and Phase III confirms the drug's efficacy and monitors adverse reactions in a large population, often compared to existing treatments.
After successful clinical trials, a New Drug Application (NDA) is submitted to regulatory authorities for approval, including all data from preclinical and clinical studies, as well as proposed labeling and manufacturing information. Regulatory authorities then review the NDA to ensure the drug is safe, effective, and of high quality, potentially requiring additional studies. Finally, after a drug is approved and marketed, it undergoes post-marketing surveillance, which includes continuous monitoring for long-term safety and effectiveness, pharmacovigilance, and reporting of any adverse effects.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
share - Lions, tigers, AI and health misinformation, oh my!.pptxTina Purnat
• Pitfalls and pivots needed to use AI effectively in public health
• Evidence-based strategies to address health misinformation effectively
• Building trust with communities online and offline
• Equipping health professionals to address questions, concerns and health misinformation
• Assessing risk and mitigating harm from adverse health narratives in communities, health workforce and health system
ABDOMINAL TRAUMA in pediatrics part one.drhasanrajab
Abdominal trauma in pediatrics refers to injuries or damage to the abdominal organs in children. It can occur due to various causes such as falls, motor vehicle accidents, sports-related injuries, and physical abuse. Children are more vulnerable to abdominal trauma due to their unique anatomical and physiological characteristics. Signs and symptoms include abdominal pain, tenderness, distension, vomiting, and signs of shock. Diagnosis involves physical examination, imaging studies, and laboratory tests. Management depends on the severity and may involve conservative treatment or surgical intervention. Prevention is crucial in reducing the incidence of abdominal trauma in children.
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
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1. The Surgical Approach to the
Acute Abdomen
General Doctor
Gamal A. M. Antar
Consultant surgeon
2. The acute abdomen refers to the clinical
situation in which an acute change in the
condition of the intraabdominal organs,
usually related to inflammation or
infection, demands immediate and
accurate diagnosis.
3. “The term “acute abdomen” should never be
equated with the invariable need for
operation.”
Zachary Cope, MD, 1927
4. The Acute Abdomen
• Abdominal pain is one of the most frequent
reasons to visit physician offices and emergency
rooms
• Most patients are found to have self limited
conditions
• A subset of patients harbor serious intraabdominal
disease that requires urgent surgical or medical
intervention
5. The Acute Abdomen
• Early diagnosis is the key to improving outcomes
• An accurate history and complete physical
examination are more important than any
diagnostic test
• The history should be obtained with the abdomen
bare, with attention to how the patient positions
himself and moves
6. The Acute Abdomen
• Early evaluation by experienced physicians is
important, as once the initial evaluation is done
analgesia may be given
• Antibiotics should not be given until a working
diagnosis is made
• Serial examinations by the same physician during
the patient’s work up determines disease
progression or resolution
7. Peritoneal Signs
• Palpation and Percussion – BE GENTLE
• Rebound – please do not perform this test
– Causes unexpected and unnecessary pain
– Does not add information to an examination
after percussion
• Rigidity
– not present in pelvic inflammation or
obstruction, unreliable
8. The Acute Abdomen
• Review anatomy and physiology of
abdominal pain
• Review some common causes of the acute
abdomen
9. Abdominal Pain
• Acute abdominal pain is the hallmark of an
acute abdomen
• It may originate from any organ in the
abdominal cavity
• Understanding the mechanisms of pain
production and the physiology of pain
perception allow for more accurate
diagnoses
10.
11. Abdominal Pain
• Pain may be visceral, somatic or referred
• Visceral pain is characterized by dullness,
poor localization, cramping, burning or
gnawing
• Visceral pain is mediated by autonomic
(sympathetic and parasympathetic) nerves
• The location of the pain corresponds to the
dermatomes of the organs involved
12.
13. Abdominal Pain
• Sensory neuroreceptors for visceral pain are
located in the mucosa or muscularis of hollow
viscera, on the visceral peritoneum and within the
mesentery
• These receptors respond to mechanical and
chemical stimuli
• Stretch is the primary mechanical signal for pain
14. Abdominal Pain
• The parietal peritoneum has an entirely somatic
innervation
• Somatic pain is more intense and well localized
• Somatic innervation is mediated by the spinal
nerves
• A transition from visceral to somatic pain
indicates extension of the underlying process
15. Abdominal Pain
• Referred pain is perceived as pain distant from the
involved organ
• It is due to a convergence of visceral afferent
neurons with somatic afferent neurons from
different anatomic regions
• Referred pain is well localized
20. Appendicitis
• 1 in 15 people will develop appendicitis in
their lifetime
• It’s the most common cause of the acute
abdomen
• Peak incidence is from 10 – 30 years
21. Appendicitis
• History may be classic – if you’re lucky
• Vague peri-umbilical pain is the most
common symptom
• McBurney’s Point
• Hyperesthesia of the abdominal wall
• Rovsing’s, psoas and obturator signs
22. Appendicitis
• Retrocecal appendix occurs 64% of the time
• Ultrasound or CT Scan may be used
• CT Scan with triple contrast and 5mm cuts
through the level of the appendix is 98%
sensitive for appendicitis
• A retrocecal or pelvic appendix or abscess
will NOT cause peritoneal signs
23. Appendicitis in Pregnancy
• Appendicitis is the most common extrauterine
surgical emergency
• 1 in 6000 pregnancies
• Signs and symptoms are unreliable
• Derangements in GI physiology include decreased
gastric acid secretion, increased reflux, delayed
gastric emptying and decreased peristalsis
• CT scans in the third trimester are safe
26. Acute Cholecystitis
• Biliary colic is the most common symptom
• Pain may radiate to the right shoulder or scapula
• The pain is colicky and is associated with nausea
and vomiting
• Murphy’s sign/acute abdomen
• Ultrasound/HIDA/DISIDA Scans
28. Acute Acalculous Cholecystitis
• Rare, 3% of all biliary procedures
• Life threatening – patients have comorbidities
• Mortality approaches 60%
• Late diagnosis = bad outcome
• Ultrasound/HIDA/DISIDA with CCK stimulation
• Percutaneous drainage vs OR
30. Acute Pancreatitis
• Onset is acute
• Abdomen is tender, but rarely has true peritoneal
signs
• Grey Turner’s sign, Cullen’s sign and Fox’s sign
are infrequently seen
• Serum amylase and lipase are the biochemical
hallmarks
• Ranson’s criteria is used to torture surgical
housestaff – APACHE Score
31. Acute Pancreatitis
• Chest x-rays may show segmental atelectasis,
pleural effusions and an elevated left
hemidiaphragm
• KUB may show the sentinel loop and loss of the
psoas shadow
• CT scan with double contrast will show pancreatic
edema, retroperitoneal inflammation, and areas of
pancreatic necrosis
33. Perforated Ulcer
• Perforated ulcer requires immediate operative
therapy
• Anterior gastric perforations cause peritonitis
• Posterior gastric and duodenal perforations may
not cause peritonitis, and after the acute episode of
pain, the leak may wall off, giving the impression
that the patient is improving
• Tympany over the liver at the mid-axillary line is
almost always a perforated ulcer
34. Perforated Ulcer
• Free air (80% of perforated ulcers)
– Go to OR
• No free air, no peritonitis
– Go to CT scan with gastrograffin
• Subhepatic fluid collection
• Fluid in the lesser sac
36. Diverticulitis
• Patients may have antecedent history of thinning
bowel movements
• Patients may know they have “pockets”
• All colonic pain is hypogastric – so bandlike pain
across the lower abdomen is common
• Differential includes perforated colon cancer
• No endoscopy or contrast enemas in the acute
phase – CT Scan
40. Diverticulitis
• Patients with peri-diverticular pain and no
peritoneal signs may be managed as outpatients
• Patients with localized peritonitis and no abscess
may be given a trial of IV Abx
• Abscesses should be percutaneously drained trans-
abdominally
• Generalized peritonitis is rare (2-24%), but requires
laparotomy
Gordon 1999
43. Inflammatory Bowel Disease
• Crohn’s Disease
– Acute exacerbation in patients with
undiagnosed ileocolic Crohn’s may be confused
with appendicitis
– Laparoscopy may help determine the diagnosis
– Isolated Crohn’s colitis accounts for 25% of all
Crohn’s disease
44. Crohn’s Disease
Operative Indications
• Colitis refractory to
medical therapy is the
most common cause for
urgent operation
• Persistent hemorrhage and
free perforation are rare
51. Pelvic Pouch
Quality of Life
• SF 36: Comparable to general population
• HRQOL: Comparable to patients in remission
with mild disease
• HRQOL: Comparable to general population
Fazio 1998, Martin 1998, Thirlby 1998
52. Pelvic Pouch
Early complications
• Small bowel obstruction: 13%
• Pelvic sepsis: 5%
• Wound infection: 3%
• Sexual dysfunction: 2%
Pemberton 1991, Fazio 1995
55. Small Bowel Obstruction
• History
– Prior surgery
– Hernias
• Signs and Symptoms
– Colicky abdominal pain
– Nausea and vomiting
– Abdominal distension
– Rectal exam
• No peritoneal signs
56. Small Bowel Obstruction
• Diagnosis
– KUB and upright abdominal films
– 3cm is upper limit of small bowel diameter
• Partial SBO
– Colonic gas
– Small bowel series if needed
• Complete bowel obstruction
– Immediate laparotomy
58. Large Bowel Obstruction
• Greater than 50% are malignant
– Colorectal cancer is usually the primary
– Volvulus and intussuception are other causes
• Signs and Symptoms
– Gradual onset
– Pain is not colicky
– Vomiting is rare
• Patients with competent ileocecal valves are at
highest risk of perforation
59. Large Bowel Obstruction
• Diagnostic x-rays
– Obstruction vs ileus
• Rectal exam and rigid proctoscopy
– Rigid proctoscopy will detorse sigmoid volvulus
• Gastrograffin enema
• Cecal volvulus requires laparotomy
61. Vascular Emergencies
• Acute Mesenteric Occlusion
– Embolic vs thrombotic
– Look for embolic source
– Acute onset of pain
– Pain out of proportion to exam
– High index of suspicion
– A-gram
62. Vascular Emergencies
• Nonocclusive Mesenteric Ischemia
– Arterial constriction secondary to low cardiac
output, hypovolemia, vasoconstrictors
– Usually ICU patients
– Usually no peritonitis
– Flexible sigmoidoscopy is the first test
– Angiography may be diagnostic and therapeutic
63. Vascular Emergencies
• Abdominal Aortic Aneurysms
– Acute onset of back/flank/abdominal pain
– Palpable pulsatile mass
– Not associated with nausea or vomiting
– Rupture with hemodynamic instability - -OR
– No shock, unclear etiology – CT scan
64. Gynecologic Diseases
• Menstrual and sexual histories are mandatory
• Pregnancy test is mandatory
• Pelvic pain often mimics appendicitis
– Mittelschmerz
– Pelvic Inflammatory Disease
– Ruptured ectopic pregnancy
– Adnexal torsion
65. Urinary Tract Disease
• Renal colic
– Patients are often writhing in pain and cannot get
comfortable
• Diagnostic Tests
– UA
– KUB
– IVP
– CT
66. Other Causes
• Sickle Cell Anemia
– Acute onset of abdominal pain
– Diffuse pain
– Unremarkable physical exam
– May have peritoneal signs
• Acute Porphyria
– Noninflamed blisters and erosions
– Crampy abdominal pain with projectile vomiting
– Migrating pain
– Mimics peritonitis