This document discusses eight EcoZD research units in Southeast Asia that aim to improve integrative research approaches. It identifies both bridges and barriers to transdisciplinary collaboration. Key barriers include hierarchical structures and rigid reporting processes, while bridges include expanding stakeholder participation, opening information sharing, and securing senior leadership buy-in for long-term collaborative projects. The document provides strategies for research units to implement new structures and incentives, change organizational culture, and mitigate hindering or harness enabling factors to move towards paradigm shifts and better EcoHealth outcomes.