Glycosides are plant-derived compounds formed by the linkage of a sugar molecule to a non-sugar molecule. They have both toxic and beneficial properties. Glycosides contain an active aglycone portion and a sugar portion that helps solubilize the aglycone. Many important drugs are derived from plant glycosides, including cardiac glycosides and laxatives. Alkaloids are another class of nitrogen-containing plant compounds that include many drugs and poisons. They are derived from amino acids and have pronounced physiological effects in humans. Over 3,000 types of alkaloids have been identified in plants.
Occurrence and classification and function of alkaloidsJasmineJuliet
Alkaloids introduction, Alkaloids classification, Alkaloids function, pharmaceutical applications of alkaloids, Examples of alkaloids, Some review questions related to alkaloids.
Cinchona is a genus of flowering plants in the family Rubiaceae containing at least 23 species of trees and shrubs. They are native to the tropical Andean forests of western South America. A few species are reportedly naturalized in Central America, Jamaica, French Polynesia, Sulawesi, Saint Helena in the South Atlantic,The coast of tropical Africa. Several species were sought after for their medicinal value and cultivated in India and Java where they also formed hybrids. The barks of several species yield quinine and other alkaloids that were the only effective treatments against malaria during the height of colonialism which made them of great economic and political importance. The synthesis of quinine in 1944, an increase in resistant forms of malaria, and alternate therapies ended the large-scale economic interest in their cultivation. Academic interest continues as cinchona alkaloids show promise in treating falciparum malaria which has evolved resistance to synthetic drugs.
Alkaloids are basic (alkali-like), nitrogen-containing organic constituents found in some plants.Alkaloids are normally classified according to the heterocyclic ring system they possess, but some authors prefer a classification based on their biosynthetic origins from amino acids, e.g. phenylalanine, tyrosine or tryptophan. (Justin et al.) Many individual names are formed by adding the suffix "-ine" to the species or generic alkaloids. For example, atropine is isolated from the plant Atropa belladonna, strychnine is obtained from the seed of Strychnine tree. Alkaloids are important chemical compounds that serve as a rich reservoir for drug discovery. Several alkaloids isolated from natural herbs exhibit antiproliferation and antimetastasis effects on various types of cancers both in vitro and in vivo. Alkaloids, such as camptothecin and vinblastine, have already been successfully developed into anticancer drugs.
Occurrence and classification and function of alkaloidsJasmineJuliet
Alkaloids introduction, Alkaloids classification, Alkaloids function, pharmaceutical applications of alkaloids, Examples of alkaloids, Some review questions related to alkaloids.
Cinchona is a genus of flowering plants in the family Rubiaceae containing at least 23 species of trees and shrubs. They are native to the tropical Andean forests of western South America. A few species are reportedly naturalized in Central America, Jamaica, French Polynesia, Sulawesi, Saint Helena in the South Atlantic,The coast of tropical Africa. Several species were sought after for their medicinal value and cultivated in India and Java where they also formed hybrids. The barks of several species yield quinine and other alkaloids that were the only effective treatments against malaria during the height of colonialism which made them of great economic and political importance. The synthesis of quinine in 1944, an increase in resistant forms of malaria, and alternate therapies ended the large-scale economic interest in their cultivation. Academic interest continues as cinchona alkaloids show promise in treating falciparum malaria which has evolved resistance to synthetic drugs.
Alkaloids are basic (alkali-like), nitrogen-containing organic constituents found in some plants.Alkaloids are normally classified according to the heterocyclic ring system they possess, but some authors prefer a classification based on their biosynthetic origins from amino acids, e.g. phenylalanine, tyrosine or tryptophan. (Justin et al.) Many individual names are formed by adding the suffix "-ine" to the species or generic alkaloids. For example, atropine is isolated from the plant Atropa belladonna, strychnine is obtained from the seed of Strychnine tree. Alkaloids are important chemical compounds that serve as a rich reservoir for drug discovery. Several alkaloids isolated from natural herbs exhibit antiproliferation and antimetastasis effects on various types of cancers both in vitro and in vivo. Alkaloids, such as camptothecin and vinblastine, have already been successfully developed into anticancer drugs.
HALDI BIOLOGICALLY KNOWN AS CURCUMA LONGA AND COMMONLY TURMERIC ITS PHARMACOGNOSY IS DISCUSSED HERE ALSO WHERE IT IS GROW AT HIGHER AND ITS MEDICINAL USES AND FORMULATION AVAILABLE IN MARKET.
Commonly known as its anionic form shikimate, is a cyclohexene, a cyclitol and a cyclohexanecarboxylic acid.
It is an important biochemical metabolite in plants and microorganisms.
Its name comes from the Japanese flower shikimi the Japanese star anise, Illicium anisatum), from which it was first isolated in 1885 by Johan Fredrik Eykman.
The elucidation of its structure was made nearly 50 years later.
Shikimic acid is also the glycoside part of some hydrolysable tannins.
The shikimate pathway is a seven step metabolic route used by bacteria, fungi, algae, parasites, and plants for the biosynthesis of aromatic amino acids (phenylalanine, tyrosine, and tryptophan).
This pathway is not found in animals; therefore, phenylalanine and tryptophan represent essential amino acids that must be obtained from the animal's diet
Animals can synthesize tyrosine from phenylalanine, and therefore is not an essential amino acid except for individuals unable to hydroxylate phenylalanine to tyrosine).
Resins are amorphous products of complex chemical nature. They are transparent or translucent solids, semi-solids or liquid substances containing large number of carbon atoms. They are hard, electrically non-conductive and combustible masses. They are usually formed in schizogenous or schizolysigenous cavities or ducts as end products of metabolism.
Most of the resins are heavier than water. They are insoluble in water, but soluble in alcohol, volatile oils, fixed oils, chloral hydrate and non-polar organic solvents like benzene and ether.
the topic tannins include their introductory part, definition, physical properties, uses, importance, classification of tannins, identification test for tannins, and the drug containing tannins
Flavonoids classification, isolation and identificationMona Ismail
Flavonoids are groups of polyphenolic compounds which are found in fruits, flowers, seeds & vegetable.
(named from the Latin word flavus meaning yellow, their colour in nature)
Sources of drug for Undergraduate MBBS studentsSarju Zilate
--> Drugs are obtained from 8 major sources
.Plant sources
.Animal sources
.Mineral/ Earth sources
.Microbiological sources
.Synthetic sources
.Semi synthetic sources
.Human sources
.Genetically engineered
Almost all parts of the plants are used i.e. leaves, flowers, fruits, seeds, roots, bark and stem.
Leaves
Digitoxin and Digoxin
Hyoscine
Nicotine
Atropine
Oil of Eucalyptus
Animal source
Heparin - Leech
Pepsin - stomach of cow
Human source
HCG - Pregnant women
Urokinase - human kidney cell
Pharmacognosy B.Pharm final year 2021
A glycoside is a molecule within which a sugar is absolute to another functional group through a glycoside bond. Glycosides play various vital roles in living organisms. Several plants store chemicals within the kind of inactive glycosides.
Slide covers the introduction , classification of glycosides , moreover covers the anthracene glycosides with examples like aloes,senna,rhubarb,rubia,st.john;s wort furthermore slide covers isothiocyanate and cyanogenic glycosides with examples
HALDI BIOLOGICALLY KNOWN AS CURCUMA LONGA AND COMMONLY TURMERIC ITS PHARMACOGNOSY IS DISCUSSED HERE ALSO WHERE IT IS GROW AT HIGHER AND ITS MEDICINAL USES AND FORMULATION AVAILABLE IN MARKET.
Commonly known as its anionic form shikimate, is a cyclohexene, a cyclitol and a cyclohexanecarboxylic acid.
It is an important biochemical metabolite in plants and microorganisms.
Its name comes from the Japanese flower shikimi the Japanese star anise, Illicium anisatum), from which it was first isolated in 1885 by Johan Fredrik Eykman.
The elucidation of its structure was made nearly 50 years later.
Shikimic acid is also the glycoside part of some hydrolysable tannins.
The shikimate pathway is a seven step metabolic route used by bacteria, fungi, algae, parasites, and plants for the biosynthesis of aromatic amino acids (phenylalanine, tyrosine, and tryptophan).
This pathway is not found in animals; therefore, phenylalanine and tryptophan represent essential amino acids that must be obtained from the animal's diet
Animals can synthesize tyrosine from phenylalanine, and therefore is not an essential amino acid except for individuals unable to hydroxylate phenylalanine to tyrosine).
Resins are amorphous products of complex chemical nature. They are transparent or translucent solids, semi-solids or liquid substances containing large number of carbon atoms. They are hard, electrically non-conductive and combustible masses. They are usually formed in schizogenous or schizolysigenous cavities or ducts as end products of metabolism.
Most of the resins are heavier than water. They are insoluble in water, but soluble in alcohol, volatile oils, fixed oils, chloral hydrate and non-polar organic solvents like benzene and ether.
the topic tannins include their introductory part, definition, physical properties, uses, importance, classification of tannins, identification test for tannins, and the drug containing tannins
Flavonoids classification, isolation and identificationMona Ismail
Flavonoids are groups of polyphenolic compounds which are found in fruits, flowers, seeds & vegetable.
(named from the Latin word flavus meaning yellow, their colour in nature)
Sources of drug for Undergraduate MBBS studentsSarju Zilate
--> Drugs are obtained from 8 major sources
.Plant sources
.Animal sources
.Mineral/ Earth sources
.Microbiological sources
.Synthetic sources
.Semi synthetic sources
.Human sources
.Genetically engineered
Almost all parts of the plants are used i.e. leaves, flowers, fruits, seeds, roots, bark and stem.
Leaves
Digitoxin and Digoxin
Hyoscine
Nicotine
Atropine
Oil of Eucalyptus
Animal source
Heparin - Leech
Pepsin - stomach of cow
Human source
HCG - Pregnant women
Urokinase - human kidney cell
Pharmacognosy B.Pharm final year 2021
A glycoside is a molecule within which a sugar is absolute to another functional group through a glycoside bond. Glycosides play various vital roles in living organisms. Several plants store chemicals within the kind of inactive glycosides.
Slide covers the introduction , classification of glycosides , moreover covers the anthracene glycosides with examples like aloes,senna,rhubarb,rubia,st.john;s wort furthermore slide covers isothiocyanate and cyanogenic glycosides with examples
this presentation was done by a final year biochemistry student at northern Caribbean university in Jamaica. It focuses on several popular Jamaican botanical foods and toxins present and the biochemistry of the effect of these toxins.
Glycosides play numerous important roles in living organisms. Many plants store chemicals in the form of inactive glycosides. These can be activated by enzyme hydrolysis, which causes the sugar part to be broken off, making the chemical available for use. Many such plant glycosides are used as medications. In animals and humans, poisons are often bound to sugar molecules as part of their elimination from the body.A glycoside is a molecule consisting of a sugar and a non-sugar group, called an aglycone. The sugar group is known as the glycone and can consist of a single sugar group or several sugar groups. The sugars is in its cyclic form and is covalently attached to the aglycon through the hydroxyl group of the hemiactal function.
There are many different kinds of aglycones. It can be a terpene, a flavonoid, a coumarin or practically any other natural occurring product (se figure 1)
The glycone can be attached to the aglycon in many different ways. The most common bridging atom is oxygen (O-glycoside), but it can also be sulphur (S-glycoside), nitrogen (N-glycoside) or carbon (C-glycoside). In general, one distinguishes between α-Glycosides and β-glycosides, depending on the configuration of the hemiactal hydroxyl group. The majority of the naturally occurring glycosides are β-glycosidesGenerally glycosides are more polar than the aglycones and as a result glycoside formation usually increases water solubility. This may allow the producing organism to transport and store the glycoside more efficiently
Many biologically active compounds are glycosides. The pharmacological effects are largely determined by the structure of the aglycone.
Glycosides comprise several important classes of compounds such as hormones, sweeteners, alkaloids, flavonoids and antibiotics
1. Definition, Classification, Properties and Qualitative Chemical tests of Alkaloids
2. Definition, Classification, Properties and Qualitative Chemical tests of Glycosides
3. Definition, Classification, Properties and Qualitative Chemical tests Flavonoids
4. Definition, Classification, Properties and Qualitative Chemical tests of Tannins
5. Definition, Classification, Properties and Qualitative Chemical tests of Volatile oils
6. Definition, Classification, Properties and Qualitative Chemical tests Resins
Structural elucidation and isolation of glycoside, purine and flavanoidsSana Raza
Unit three of chemistry of natural products, consist of the method of extraction, isolation and structure elucidation of Glycoside(digoxin), Flavanoids( quercetin), Lignans( Podophyllotoxin), Purines (caffeine)
presentation includes chemistry, classification of carbohydrates, monosaccharides, oligosaccharides and polysaccharides. It also includes properties of carbohydrates such as epimerism, cyclization of sugars, anomerism and mutarotation. Numerous biochemical, industrial and medical functions of various carbohydrates have been described.
content
Flavonoids (importance, Physiological role and Therapeutic uses).
Flavonoids biosynthesis, General Properties and Tests for identity.
Flavone Glycosides (Diosmin and Apiin)
Flavonol Glycosides (rutin and Quercetrin)
Flavanone Glycosides (Hesperidin)
Silymarin (flavonolignans)
Isoflavonoids (Genistein)
Coumarin Glycosides
a molecule in which a sugar is bound to another functional group via a glycosidic bond.
anthraquinone, coumarin, cyanogens (cyanohydrin), flavonoids, glucosinolates (or thioglycosides), phenols, steroidal, terpenoids, and saponins.
Digoxin (Lanoxicaps, Lanoxin, Digibind)
Digitoxin (Crystodigin)
Cardiac glycosides are medicines for treating heart failure and certain irregular heartbeats. They are one of several classes of drugs used to treat the heart and related conditions.
lycosides and glycoside containing drugs.
Biosynthesis of glycosides: The details of the followings:
i) Cyanogenic: Wild Cherry
ii)Isothiocyanate-Mustard (Black mustard and white mustard).
iii) Cardiac: Digitalis, strophanthus, squill.
B.Pharm Syllabus
Northern University Bangladesh
De ve loped b y: Ma hab ur R a hma n She i kh & M ahm ud ur R ahman
Assistant Professors, Department of Pharmacy, Northern University Bangladesh
30
iv) Saponins: Sarsaparilla, glycyrrhiza, dioscorea.
v)
Anthraquinone glycosides: Cascara sagrada, aloe, senna, rhubarb.
vi) Other glycosides and neutral principles: Gentian, quassia, saffron.
Definition
Glycosides are non-reducing organic compounds that on hydrolysis with acids or enzymes yield:
1- A sugar part (or glycone, formed of one or more sugar units).
2- A non-sugar part (or aglycone, also called genin).
Antimicrobial stewardship to prevent antimicrobial resistanceGovindRankawat1
India is among the nations with the highest burden of bacterial infections.
India is one of the largest consumers of antibiotics worldwide.
India carries one of the largest burdens of drug‑resistant pathogens worldwide.
Highest burden of multidrug‑resistant tuberculosis,
Alarmingly high resistance among Gram‑negative and Gram‑positive bacteria even to newer antimicrobials such as carbapenems.
NDM‑1 ( New Delhi Metallo Beta lactamase 1, an enzyme which inactivates majority of Beta lactam antibiotics including carbapenems) was reported in 2008
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
DISSERTATION on NEW DRUG DISCOVERY AND DEVELOPMENT STAGES OF DRUG DISCOVERYNEHA GUPTA
The process of drug discovery and development is a complex and multi-step endeavor aimed at bringing new pharmaceutical drugs to market. It begins with identifying and validating a biological target, such as a protein, gene, or RNA, that is associated with a disease. This step involves understanding the target's role in the disease and confirming that modulating it can have therapeutic effects. The next stage, hit identification, employs high-throughput screening (HTS) and other methods to find compounds that interact with the target. Computational techniques may also be used to identify potential hits from large compound libraries.
Following hit identification, the hits are optimized to improve their efficacy, selectivity, and pharmacokinetic properties, resulting in lead compounds. These leads undergo further refinement to enhance their potency, reduce toxicity, and improve drug-like characteristics, creating drug candidates suitable for preclinical testing. In the preclinical development phase, drug candidates are tested in vitro (in cell cultures) and in vivo (in animal models) to evaluate their safety, efficacy, pharmacokinetics, and pharmacodynamics. Toxicology studies are conducted to assess potential risks.
Before clinical trials can begin, an Investigational New Drug (IND) application must be submitted to regulatory authorities. This application includes data from preclinical studies and plans for clinical trials. Clinical development involves human trials in three phases: Phase I tests the drug's safety and dosage in a small group of healthy volunteers, Phase II assesses the drug's efficacy and side effects in a larger group of patients with the target disease, and Phase III confirms the drug's efficacy and monitors adverse reactions in a large population, often compared to existing treatments.
After successful clinical trials, a New Drug Application (NDA) is submitted to regulatory authorities for approval, including all data from preclinical and clinical studies, as well as proposed labeling and manufacturing information. Regulatory authorities then review the NDA to ensure the drug is safe, effective, and of high quality, potentially requiring additional studies. Finally, after a drug is approved and marketed, it undergoes post-marketing surveillance, which includes continuous monitoring for long-term safety and effectiveness, pharmacovigilance, and reporting of any adverse effects.
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Novas diretrizes da OMS para os cuidados perinatais de mais qualidade
Drugs obtained from Plants
1. Drugs obtained from Plant
Md. Nafizur Rahman
Dept. of Genetic Engineering & Biotechnology,
Shahjalal University of Science & Technology, Sylhet.
2. Glycosides
Glycosides are substances produced in plants by metabolic processes which are formed by
the ether linkage or an oxygen bridge between a sugar and a non-sugar compound by
replacement of a hydroxyl group in the sugar molecule. They are important in human and
animal nutrition and they have both toxic and beneficial properties. Many plants store
chemicals in the form of inactive glycosides. These can be activated by enzyme hydrolysis,
which causes the sugar part to be broken off.The glycosyl group of a glycoside is replaced
by a hydrogen atom making the aglycone part.
Glycoside is composed of two parts-
a) Sugar part is known as glycone. The glycone can consist of a single sugar group
(monosaccharide) or several sugar groups (oligosaccharide). Glycone part confers on the
molecule solubility properties.
b) Non-sugar part is known as aglycone. It is the active part of glycoside. Sugar helps in the
solubilization of non-sugar, for increasing the bioavailability of the drug. The aglycone part
is responsible for the pharmacological activity.
3. Characteristics of Glycosides
Glycoside contains sugar but still the physical, chemical and therapeutic activity is based
on aglycon portion. Sugar facilitates the absorption of the glycoside helping it to reach
the site of action.
Glycoside are crystalline, amorphous substance which are soluble in water, and dilute
alcohol but in soluble in the CHCl3 and ether. The aglycon moiety is insoluble in non-
polar solvent like C6H6.
Glycosides are easily hydrolyzed by mineral acids, water and enzyme. They show optical
activity normally they are levorotatory.
Glycoside cannot reduce fehling’s solution until they are hydrolyzed.
They are believed to facilitates growth and protection of plant.
Glycosides are water soluble compounds and insoluble in the organic solvents.
4. Classification of Glycosides
1. Based on the chemical nature of non-sugar half:
i) Alcoholic glycosides
An example of an alcoholic glycoside is salicin, which is found in the genus salix. Salicin is
converted in the body into salicylic acid, which is closely related to aspirin and has
analgesic, antipyretic, and anti-inflammatory effects.
ii) Anthraquinone glycosides
These glycosides contain an aglycone group that is a derivative of anthraquinone. They
have a laxative effect. They are mainly found in dicot plants except the Liliaceae family
which are monocots. They are present in senna, rhubarb and Aloe species. Antron and
anthranol are reduced forms of anthraquinone.
iii) Coumarin glycosides
Here, the aglycone is coumarin or a derivative. An example is apterin which is reported to
dilate the coronary arteries as well as block calcium channels. Other coumarin glycosides
are obtained from dried leaves of Psoralea corylifolia.
5. iv) Cyanogenic glycosides
In this case, the aglycone contains a cyanide group. An example of these is amygdalin from
bitter almonds (but not sweet almonds). Cyanogenic glycosides can also be found in the
fruit seeds (and wilting leaves) of many members of the rose family (including cherries,
apples, plums, bitter almonds, peaches, apricots, raspberries, and crabapples).
v) Phenolic glycosides
Here, the aglycone is a simple phenolic structure. An example is arbutin found in the
Common Bearberry Arctostaphylos uva-ursi. It has a urinary antiseptic effect.
vi) Steroidal glycosides or cardiac glycosides
Here the aglycone part is a steroidal nucleus. These glycosides are found in the plant
genera Digitalis, Scilla, and Strophanthus. They are used in the treatment of heart diseases,
e.g., congestive heart failure (historically as now recognized does not improve survivability;
other agents are now preferred) and arrhythmia.
6. 2.Based on the nature of sugar half:
i) Glucoside: sugar portion is glucose
ii) Rhamnoside: sugar portion is rhamnose
iii) Pentoside: sugar portion is pentose
iv) Fructoside: sugar portion is fructose
v) Arabinoside: sugar portion is arabinose
3. Based on therapeutic nature of glycoside:
i) Cardiac glycoside Ex: Digitalis
ii) Laxative glycoside Ex: Senna
iii) Anti-ulcer glycoside Ex: Liquorice
iv) Bitter glycoside Ex: quassia wood
4. Based on linkage between glycon and aglycon portion:
7. a) C-glycoside:-
Glycon-OH + HC –aglycon --> glycone-c-aglycon +H2O
Some of the anthraquinone glycoside like cascaroside in cascara, aloin in aloes shows the
particular linkage. C-glycosides are called aloin type glycoside present in aloes. They do not
hydrolyze by heating with diluted acid or alkalis. Cochical contains c-glycoside in the form
of coloring matter called carminoic acid.
b) O-glycoside
They are common in higher in plants Ex senna, rhubarb
They are hydrolyzed by treatment with acid or alkali into glycon and aglycon portion.
c) S-glycoside
They occurrence of this glycoside is restricted to isothiacyanate glycoside like sinigirin in
black mustard formed by the condensation of sulphohydryl group aglycon to OH group of
glycon.
d) N-glycoside
They most typical representation of this is nucleoside where the amino group reacts with
OH group of ribose or deoxyribose resulting into N-glycoside.
8. Biosynthesis of Glycosides
1. Starting point of the synthesis is a sugar, such as glucose is phosphorylated by ATP.
2. Transfer of a uridylyl group from uridine triphosphate (UTP) to a sugar-1-phosphate
forming UDP-sugar & inorganic pyrophosphate. Enzyme catalyzing this reaction are
referred to as uridylyl transferases.
3. Transfer of the sugar from UDP-sugar to a suitable acceptor (aglycone), mediated by
enzyme glycosyl transferases, thus forming the glycoside.
9. Application of glycosides
Many glycosides are used in production of various types of drugs and therapeutic agents.
The main therapeutic applications are:
Cardiac drugs (cardiotonic glycosides; e.g., strophanthus, squill)
Anti-inflammatories (e.g., naringin, naringenin)
Antipyretics (e.g., salicin), Antivirals (e.g., glycyrrhizin, prunin)
Antirheumatics, analgesics (e.g., methylsalicylate)
Demulcent, Expectorant, Antispasmodic action
Laxatives (e.g., anthraquinone glycosides of senna, aloes)
Counter-irritants (e.g., thioglycosides)
In cardiac failure glycosides increase the force of myocardial contractions, slow heart rate,
and slow the conduction of electrical impulses. This increased force of contractions
improves the efficiency of the heart without increasing oxygen consumption. As a result,
more blood is pumped from the heart, decreasing congestion. Normal blood circulation is
restored and kidney function is increased.
10. Alkaloids
Alkaloidsany of a class of nitrogenous organic compounds of plant origin that have
pronounced physiological actions on humans. They often have pharmacological effects and
are used as medications, as recreational drugs, or in entheogenic rituals. They include
many drugs (morphine, quinine) and poisons (atropine, strychnine). More than 3,000
different types of alkaloids have been identified in a total of more than 4,000 flowering
plant species.
Alkaloids in plants
About 10-25% of higher plants contain alkaloids. Alkaloids generally abound in the
following parts of plants-
Leaf-Tobacco (Nicotiana tabacum), tea (Camellia sinensis)
Seed-caffeine that appears in coffee (Arabian coffea)
Root-Pokeweed (Phytolacca americana)
Fruit-Hemlock (Conium maculatum)
Sometimes alkaloid appear in whole plant such as Yew (Texus bacata)
Furthermore, different tissues of same plant contain different alkaloids.
11. Properties of Alkaloids
Derived from amino acid and its derivatives
Toxic, bitter in taste, some contain O2
Low molecular weight and High melting point
Most are crystalline solids although few are amorphous
Usually insoluble or sparingly soluble in water
Classification of Alkaloids
1. Non-heterocyclic Alkaloids:
Non-heterocyclic alkaloids are alkaloids having non-heterocyclic nucleus. They are also
known as Proto alkaloids or Biological alkaloids. They are less commonly found in nature.
Table below shows the chemical structure and example of such compounds-
Types of Alkaloid Structure Example
Phenyl ethylamine
Ephedrine, Narceine
Pseudoephedrine
Capsaicin, Mescalin
12. 2. Heterocyclic Alkaloids:
Heterocyclic alkaloids are alkaloids having heterocyclic nucleus. They are also known as
typical alkaloids. They are more commonly found in nature. Heterocyclic alkaloids are
further subdivided into 14 groups. Table below shows the chemical structure and example
Types of Alkaloid Structure Example
Pyridine Lobeline
Steroidal
Conessine
Veratramine
Purine
Caffeine
Theobromine
13. Biosynthesis of Alkaloids
Amino acids are the biosynthetic precursor of most Alkaloids. They are-
Tyrosine (e.g. morphine, codeine)
Tryptophan (e.g. quinin)
Glumate (e.g. cocaine, nicotine, senecionine)
Aspartate (e.g. nicotine)
Xanthine (e.g. caffeine, theobromine)
Biosynthetic Pathway
Some of the general reactions that are of particular importance includes decarboxylation
(removal of carboxyl group or carbon dioxide) and transamination (transfer of an amino
group from one molecule to another without the formation of ammonia) of the amino
acids to yield a corresponding amine or aldehyde. These can react to form a Schiff base
which, in turn can react with carbanion in a Mannich-type condensation.
Synthesis of Schiff bases: Schiff bases can be obtained by reacting amines with ketones or
aldehydes. These reactions are a common method of producing C=N bonds.
14. Fig: Synthesis of Schiff base
In the biosynthesis of alkaloids, such reactions may take place within a molecule, such as
in the synthesis of Piperidine-
Fig: Biosynthesis of Piperidine
Mannich reaction: An integral component of the Mannich reaction, in addition to an
amine and a carbonyl compound, is a carbanion, which plays the role of the nucleophile in
the nucleophilic addition to the ion formed by the reaction of the amine and the carbonyl.
15. Fig: Mannich reaction
The Mannich reaction can proceed both intermolecularly and intramolecularly.
Fig: Overview of alkaloids synthesis pathway
16. Application of Alkaloids
Alkaloids have important role in plant, animal and human life. These have role in plant-
plant interaction, plant-herbivore interaction and plant-microorganism interaction.
Alkaloids either activate or inhibit the central process at cellular and organ level in
animals. They also affect the digestive process and influence the reproductive system of
animals. Many alkaloids, though poisonous, have physiological effect as valuable medicine
against various diseases in human including malaria, diabetics, cancer, cardiac dysfunction
etc. Alkaloids are used as-
As medicines
As insect repellents
As biofertilizers
As psychoactive drug
For research and scientific study
As medicine: Medical use of alkaloid-containing plants has a long history since 19th
century. At present, many alkaloids are being used in medicine, usually in the form of
salts, including the following-
17. Alkaloid Action
Caffeine Stimulant
Digoxin Improves heart function
Ephidrine Blood pressure
Morphin Analgesic
Quinine Antimalarial
Theobromine Treatment of asthma
Vincristine Anti-tumor
As insect repellents: Alkaloids can be toxic in varying concentrations. Alkaloid pyrethrin
is used as insect repellent in mosquito coils, mosquito repellents and even in agriculture.
These insecticides are less toxic to humans but affect mosquitoes to leave the vicinity.
As biofertilizers: The use of Lupinex (contains quinolizidine alkaloids, minerals and
carbohydrates) increased yields of cereals, legumes, oil plants, tubers and vegetable crop.
Moreover, later research confirmed that the increase in yield have also been observed in
sunflowers, soybeans and Chinese cabbage.
18. As euphoric & addicting drugs: Many psychotropic substances like marijuna, cannabis,
opium sort if substances are alkaloids. They have been used since ancient period as an
instruments for mental excitement and euphoria. They are considered harmful as per
modern medicine.
For research and scientific study: Due to their specific effects on body, they are used in
research and scientific study. For example, atropine an alkaloid can cause dilation of pupil.
To test if a new substance is having similar effects or opposite effects, it is compared with
atropine. So here atropine is used as standard for comparison in research.
Function of Alkaloids in plants:
Alkaloids are Poisonous agents which protect plants against insects and herbivores
Act as regulatory growth factors and considered as reserve substance which is
capable of supplying nitrogen or other elements necessary to the plant’s economy.
The presence of alkaloids in the plant prevents insects and chordate animals from
eating it. For example, aporphine alkaloid liriodenine produced by the tulip tree
protects it from parasitic mushrooms.
Alkaloids are also known to regulate plant growth.
19. Volatile Oils
Volatile (unstable) oil is a concentrated hydrophobic liquid containing rapidly evaporating
aroma compounds from plants. Volatile oils are mixture of hydrocarbon terpenes,
sesquiterpenes and polyterpenes and their oxygenated derivatives obtained from various
parts of the plant. Volatile oils evaporate on exposure to air at ordinary’ temperature and
are the odorous constituents. As volatile oil oils are responsible for the essence or odor of
the plant they are also known as essential oils.
Basic Features:
Mobile liquid at ambient temperature
Possess very pleasant and characteristic odor which vary considerably from one
specimen to another.
Colorless liquids with the exception of chamomile oil (violet in color)
Insoluble in water but soluble in common organic solvent and liposoluble (lipophilic)
Practically all volatile oils consist of chemical mixers that are often quite complex
Density is lower than water, with the exception clove or cinnamon
A large number of volatile oils exhibit optical activity by virtue of the chemical
constitution of the oil(s) or its constitution.
20. Classification of Volatile Oils
The most acceptable classification whereby volatile oils and volatile-oil containing drugs
may be grouped together are as follows, namely:
i. Hydrocarbon volatile oils, E.g. Bitter orange, Turpentine, Juniper, etc.
ii. Alcohol volatile oils, E.g. Mentha, Coriander, Rose, etc.
iii. Aldehyde volatile oils, E.g. Cinnamon Bark, Cassia Bark, Lemon, etc.
iv. Ketone volatile oils, E.g. Caraway, Dill, Spearmint, etc.
v. Phenol volatile oils, E.g. Cinnamon Leaf, Clove, Horsemint, etc.
vi. Ester volatile oils, E.g. Lavender, Rosemary, Sweet Orange, etc.
vii. Phenolic ether volatile oils, E.g. fennel, anise, myristica, etc.
viii. Oxide volatile oils, E.g. eucalyptus, chenopodium, etc.
Volatile oils mainly divided into two broad classes based on their biosynthetic origin:
i. Terpene derivatives
ii. Aromatic derivatives
Many volatile oils consist largely of terpenes.Terpenes are defined as natural products
whose structure may be divided into isoprene units (hemi-terpenes).
21. Biosynthesis of volatile oils
In aromatic plants species, biosynthesis of essential oils occurs through two complex
natural biochemical pathways involving different enzymatic reactions.
They are produced by
i. Cytosolic enzymatic MVA (mevalonic acid) pathway
ii. Plastidic and enzymatic 1-deoxy-D-xylolose-5-phosphate (DOXP), also called the
2-C-methylerythritol 4-phosphate (MEP) pathway
The mevalonate pathway begins with Acetyl-CoA and ends with the production of two
five-carbon building blocks called isopentenyl pyrophosphate (IPP) and dimethylallyl
pyrophosphate (DMAPP), which are used to make isoprenoids. It is best known as the
target of statins, a class of cholesterol lowering drugs.
The non-mevalonate pathway, also known as the 2-C-Methyl-D-erythritol 4-phosphate/
1-deoxy-D-xylulose 5-phosphate (MEP/DOXP) pathway—is an alternative metabolic
pathway for isoprenoid biosynthesis that forms isopentenyl pyrophosphate (IPP) and
dimethylallyl pyrophosphate (DMAPP).
22. Steps for volatile oil production in MVA pathway is:
Firstly, acetyl CoA is produced from pyruvate which is derived from glyceraldehyde-3-
phosphate and glucose-6-phosphate by a series of reactions in glycolysis pathway.
Acetyl CoA is again transformed into Acetoacetyl CoA by thiolase enzyme.
Acetoacetyl-CoA produces HMG-CoA (3-hydroxy-3- methyl-glutaryl-CoA) which is
transformed into Mevalonate.
Mevalonate is transformed into mevalonate 5-phosphate and resulting metabolite,
mevalonate-3,5-bisphosphate, is decarboxylated to IP, and finally phosphorylated to
yield IPP.
Isopentenyl diphosphate(IPP) can be transformed intoDMAPP by isomerase enzyme.
DMAPP & IPP are linked in a head to tail fashion resulting in monoterpene which is in
terpenoid group.
Essential oils are final terpenoid products and are formed by a huge group of enzymes
known as terpene synthases (TPS).
Classical MVA pathway is given below….
25. Uses of volatile oils
As insect repellent to prevent the destruction of the flowers and leaves
Help in the cross fertilization of different species of plants
Can be used as a flavoring agent
Used in perfume industries and in cosmetics
Used in food industries and as preservatives
As starting material for synthesis of other compounds
As anti-spasmodic and antiseptic due to high phenols
Used as a therapeutic agent (oil of eucalyptus)
Therapeutic uses of volatile oils
As a counter irritant and inhalant
As carminative, shows anti-spasmodic
Thymol is used in mouth washes and gargles
Reduce secretion of lungs in cough and asthma
Antiseptic, anti-bacterial, anti-fungal and anti-helminthes
Also used in aroma therapy (e.g. lavander, rosemary)
26. Phenolic compounds
Phenolics are a class of chemical compounds consisting of a hydroxyl group (—OH)
bonded directly to an aromatic hydrocarbon group. They are also called as arenols or
aryl alcohols. These are secondary natural metabolites produced in plants biogenetically
from either the shikimate/phenylpropanoid pathway which directly provide
phenylpropanoids and which fulfill a very broad physiological role in plants
Natural phenolic compoundsfrom medicinal herbs and dietary plants include phenolic
acids, flavonoids, tannins, stilbenes, curcuminoids, coumarins, lignans, quinones etc.
play an important role in various disease prevention and treatment.
Properties of arenols
Plant phenolics are a chemically heterogenous group
Some are soluble only in organic solvents
some are water soluble carboxylic acids and glycosides.
Another group of phenolics are insoluble polymers
27. Biosynthesis of phenolics
In plants species, biosynthesis of phenolics occurs through two complex natural
biochemical pathways. They are produced by
i. Shikimic acid pathway
ii. Malonic acid pathway
The shikimate pathway (shikimic acid pathway) is a seven step metabolic route for the
biosynthesis of folates and aromatic amino acids (phenylalanine, tyrosine, and
tryptophan).
The first key step in the shikimic acid pathway is the condensation of erythrose-4-
phosphate from the pentose phosphate pathway.
Phenylalanine, tyrosine and tryptophan are the primary metabolites which serve as
precursors for many natural (secondary) products such as flavonoids, phenolic acids,
coumarins, alkaloids, glucosinolates and cyanogenic glycosides.
Phenylalanine ammonia-lyase (PAL) is a key gateway enzyme in the secondary metabolic
pathway leading to the synthesis of phenolic compounds.
28. Fig: Outline of phenolic compound production by shikimic acid pathway.
29. Therapeutic uses of phenols
Various bioactivities of phenolic compounds are responsible for their chemo preventive
properties (e.g., antioxidant, anticarcinogenic, or antimutagenic and anti-inflammatory
effects) and also contribute to their inducing apoptosis by arresting cell cycle, regulating
carcinogen metabolism and ontogenesis expression, inhibiting DNA binding and cell
adhesion, migration, proliferation or differentiation, and blocking signaling pathways.
As antioxidant:
Antioxidant action of phenolic compounds is because of their high tendency to chelate
metals with heavy metals like iron and copper. In human body as well as in plant system,
free radicals are main component which can easily damage cell due to the presence of
free electrons.
Proteins, green vegetables have releases some compounds which can neutralize free
radicals and help to repair the damage occur in cell due to free radicals. Generally,
antioxidants can rapidly lose electron to a free radical and get paired. The pairing of
electron with free radical makes it less harmful.Some phenolic compounds like vitamin-
e, vitamin-c (ascorbic acid) and polyphenols are good antioxidants.
30. Some other uses and applications of phenolic compounds are….
Phenolic compounds have strong antiseptic and antibacterial properties and act as
nerve stimulants and immunostimulants.
Phenols sprays are anesthetic and analgesic combinations that work in the painful
and irritating areas.
Phenols used to relieve pain caused by sore throat.
Phenolic compounds have potential against oxidative damages diseases, therefore
play a protective role through ingestion of fruits and vegetables.
These compounds are very much essential for the growth of plant and involve in
reproduction process of plants.
It is used in insulating materials, paints, rubber, inks, dyes, etc.
It is used in illuminating gasses, perfumes, soaps and toys.
31. Flavonoids
Flavonoids are group of plant metabolites (polyphenols) thought to provide health
benefits through cell signaling pathways and antioxidant effects. These molecules are
found in a variety of fruits and vegetables in the form of glycosides and sometimes as
acylglycosides, while acylated, methylated and sulfate molecules are less frequent and
in lower concentrations.They are water-soluble and accumulate in cell vacuoles.
Uses of flavonoids
In plants:
Flavonoids are the most important plant pigments for flower coloration,producing
yellow or red/blue pigmentation in petals designed to attract pollinator animals.
In higher plants, flavonoids are involved in UV filtration, symbiotic nitrogen fixation
and floral pigmentation.
Flavonoids secreted by the root of the host plant are sensed by Rhizobia which
triggers the secretion of Nod factors and control root nodule formation.
Some flavonoids have inhibitory activity against organisms that cause plant
diseases, e.g. Fusarium oxysporum.
32. In humans:
Flavonoids have antioxidant powers that may provide important health benefits. Diets
rich in flavonoids have been associated with reduced risk of a variety of diseases.
Flavonoid-rich foods include cocoa, apples, onions, cranberries, tea and red wine.
Antioxidant effect: Antioxidants may protect the body’s cells from harmful free
radicals from cigarette smoke and other environmental contaminants.
Anti-inflammatory effect: Cocoa and chocolate contain a type of flavonoid called
flavonols that may reduce dangerous inflammation in the arteries.
Anti-cardiovascular disease effect: Flavonols in cocoa may help lower blood
pressure and cholesterol, helping to reduce the risk for heart disease. Flavonoid-
rich foods that may help reduce heart disease risk include apples, onions and black
tea. Cocoa and dark chocolate may also have positive effects on blood clotting,
coronary artery function and insulin sensitivity.
Anti-Cancer effect: Studies have found that flavonoids inhibit a variety of cancers
in animals. Extracts from flavonoid-rich onions provided strong anti-proliferation
effects against liver and colon cancer cells.
33. Tannins
Tannins (commonly referred to as tannic acid) are water-soluble polyphenols, is an
astringent biomolecule that binds to and precipitates proteins and various other organic
compounds including amino acids and alkaloids. The tannin compounds are widely
distributed in many species of plants, particularly prevalent in a variety of vascular
plants, including fruits (especially grapes), teas, legumes, and grasseswhere they play a
role in protection from predation, and perhaps also as pesticides, and in plant growth
regulation.
Properties of tannins
Tannins are found as shapeless yellowish or light brown masses like powder, flakes or
sponge.Their taste is quite sharp or caustic, providing the distinctive astringency that
humans associate with red wines, teas, and unripe fruits. In their condensed, secondary-
metabolite form, tannins are highly toxic and insoluble compounds, and they bind to
proteins and enzymes. Tannins are usually found in large quantities in the bark of trees
where they act as a barrier for micro-organisms like bacteria and fungi and protect the
tree.
34. Classification of tannins
Hydrolyzable tannins: A hydrolyzable tannin is a type of tannin that, on heating
with hydrochloric or sulfuric acids, yields gallic or ellagic acids. They are hydrolyzed
by weak acids or weak bases to produce carbohydrate and phenolic acids. They can
be extracted from different vegetable plants, such as chestnut wood, oak wood etc.
Non-Hydrolyzable or condensed tannins: Condensed tannins are polymers formed
by the condensation of flavans. They do not contain sugar residues. They are called
proanthocyanidins as they yield anthocyanidins when depolymerized under
oxidative conditions. Different types of condensed tannins exist, such as the
procyanidins, propelargonidins, prodelphinidins, profisetinidins etc.
Phlorotannins:Phlorotannins are a type of tannins found in brown algae and in a
lower amount also in some red algae. Contrary to hydrolysable or condensed
tannins, these compounds are oligomers of phloroglucinol. These phenolic
compounds are integral structural components of cell walls in brown algae, but
they also seem to play many other secondary ecological roles such as protection
from UV radiation and defense against grazing.
35. Application of Tannins:
Tannins are an important ingredient in the process of tanning leather. Tanbark
from oak, mimosa and chestnut tree has traditionally been the primary source of
tannery tannin.
Tannin is a component in a type of industrial particleboard adhesive. Pinus radiata
tannins have been investigated for the production of wood adhesives.
Tannins can be used for production of anti-corrosive primer for treatment of rusted
steel surfaces prior to painting, rust converter to transform oxidized steel into a
smooth sealed surface and rust inhibitor.
Tannins in folk medicine are used to combat diarrhoea, hemorrhoids, heal wounds,
as bactericides, other poisons and antidotes.
The tannins in cranberries have been medically proven to help prevent urinary tract
infections in women by reducing the ability of the bacteria E. coli from adhering to
cells lining the urinary tract.
Similarly, this anti-adhesive property may reduce the ability of H. pylori to cause
stomach ulcers.
Recent medical research has also shown that these polyphenolic compounds can
also reduce LDL cholesterol and improve cardiac health.
36. Resins
Resin is amorphous mixtures of essential oils, oxygenated products of terpene and
carboxylic acids. They can be found as exudations from trunk of various trees. In
polymer chemistry, resin is a "solid or highly viscous substance" of plant or synthetic
origin that is typically convertible into polymers. The resins produce in response to
injury and acts as a bandage protecting the plant from invading insects and pathogens.
Notable examples of plant resins include amber, balm of gilead, balsam, dammar gum,
kauri gum etc.
Properties of Resins
Hard, transparent or translucent brittle materials.
Resins are bad conductors of electricity and heavier than water.
On being heated at a relatively low temperature resins first get softened and
ultimately melt down thereby forming either an adhesive or a sticky massive fluid.
Resins are complex mixtures of resin acids, resin alcohols, resinotannols, esters,
and resenes.
Can dissolve in alcohol or other organic solvents but insoluble in water.
Resins do not contain N2 elements and when boiled with alkalis, it yields soaps.
37. Application of resins
Pharmaceutical application
Resins are local irritant and hence act as local cathartics. (e.g. Jalap and Ipomea)
Also used in bronchial asthma (e.g. Cannabis)
Used externally as mild antiseptic in the form of tinctures (Benzoin), ointment and
plasters (Turpentine and Colophony)
Used in the preparation of emulsion and sustained released formulations.
Resins have medicinal purposes because of their antihypertensive, analgesic, and
cardioactive properties.
Podophyllotoxin, from resins in the roots and rhizomes of Podophyllum, is the
starting material for semi synthesis of anticancer compounds.
Other application
It protects the flower by reflecting light.
Production of varnishes, adhesives, and food glazing agents.
Provide constituents of incense and perfume.
Solid resenes are available as adhesives.