Omeprazole is a prescription-only drug used to treat gastric and duodenal ulcers, GERD, NSAID-associated ulcers, H. pylori infection, and Zollinger-Ellison syndrome. It is available as capsules and infusions in 20mg and 40mg strengths from manufacturers like Getz Pharma, Sami Pharmaceutical, and Ferozsons Laboratories. Omeprazole is absorbed in the small intestine and has a bioavailability of 35% initially and 60% with repeated daily doses. It is metabolized in the liver by CYP2C19 and CYP3A4 and excreted primarily in urine. Recommended dosage regimens

1. MUHAMMAD USAMA
45-E 7TH SEMESTER
IPS-UVAS LAHORE
DRUG PROFILE OF
OMEPRAZOLE

2. General Detail
Generic: Omeprazole
Drug category: Prescription only drug
Included in WHO Essential Drug List: Yes

3. Product Description
Popular Brands

4. Manufacturer name:
GETZ PHARMA
 Dosage form available:
Infusion,Capsules
Strength: 20mg,40mg
Price: Rs.260
Risek

5. Manufacturer name:
SAMI PHARMACEUTICAL
 Dosage form available:
Infusion,Capsules
Strength: 20mg,40mg
Price: Rs.258
Teph

6. Manufacturer name:
FEROZSONS lABORTRIES
 Dosage form available:
Infusion,Capsules
Strength: 20mg,40mg
Price: Rs.258
Omega

7. Storage Conditions/Considerations
Store below 30℃
protect from sun light

8. Pharmacokinetics of the Drug

9. Absorption
Absorbed at Small intestine(weakly basic)
Bioavailability:
35% At first dose
60% After Repeated once daily Dose
Protein Binding : 95%
Cross Placental Barrier
Do not cross Blood Brain Barrier
Secreted in Breast milk

10. Distribution
Distributed in (Vd): 0.3 l/kg
Time for onset of action: 1Hr
Duration of Action: 73 hr

11. Metabolism
Half Life: 0.5- 3 Hr
Site of Metabolism: Liver
Liver Enzymes Used:
CYP2C19 (Primarily)
CYP3A4 (Small extent)

12. Excretion
77% through Urine
To a lesser extent through Bile

13. Pharmacology
Pharmacological Class Anti ulcer
Indications Gastric and Duodenal ulcer,GERD,NSAID associated Ulcer,H.pylori`
infection,Zollinger-Ellison syndrome,Prophylaxis of acid aspiration
Mechanism of Action Omeprazole is a selective and irreversible proton pump inhibitor.
It suppresses stomach acid secretion by specific inhibition of the
H+/K+-ATPase system found at the secretory surface of gastric
parietal cells.
Contraindications In renal failure,Hypersensitivity to any component of drug
Precautions/warning Atrophic gastritis has been noted occasionally in gastric corpus
biopsies from patients treated long-term with omeprazole
Avoid use in pregnancy
Avoid use in liver failure
FDA Pregnancy Class C

14. Recommended Dosage Regimen
For which
Indication
Route of Administration Recommended
Dose
Duration of Treatment
Duodenal Ulcer Oral
20mg
4-8 weeks
H.Pylori Infection
(Triplet therapy)
Oral
20mg
10 Days
Gastric Ulcer Oral
40mg
8 weeks

15. For which
Indication
Route of Administration Recommended
Dose
Duration of Treatment
Errosive esophagitis Oral
20mg
4-8 weeks
Oral
20mg
10 Days
Oral
40mg
8 weeks