Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect multiple organ systems. It is more prevalent in women and in African Americans. The exact causes are unknown but genetic and environmental factors are thought to play a role. SLE is diagnosed based on clinical criteria including symptoms such as rashes, joint pain, and organ inflammation or damage. Treatment involves managing symptoms with medications like NSAIDs, antimalarials, corticosteroids, and immunosuppressants to prevent flares and organ damage. Research is ongoing to better understand the disease mechanisms and develop new targeted therapies.