This document discusses dissolution, which is the process by which a solid substance solubilizes in a solvent to form a solution. It is affected by various factors related to the chemical properties of the drug and formulation, as well as the testing conditions. The rate of dissolution can be modeled using theories like the diffusion layer model. Dissolution testing is important for optimization, quality control, and showing bioequivalence between batches. Common techniques to increase dissolution rate include reducing particle size, forming salts, selecting appropriate excipients, and processing methods like wet granulation.
Dissolution, factors affecting drug dissolution, methods to evaluate dissolution, advantages and disadvantages, recent approaches--these are the topics covered in this presentation.
An in-vitro in-vivo correlation (IVIVC) has been defined by the U.S. Food and Drug Administration (FDA) as "a predictive mathematical model describing the relationship between an in-vitro property of a dosage form and an in-vivo response".
FORMULATION FACTORS EFFECTING BIOAVAILABILITY OF DRUGSN Anusha
Bioavailability means the rate and extent to which the active ingredient is absorbed from a drug product and becomes available at the site of action.
When the drug is given orally, only part of the administered dose appears in the plasma.
By plotting plasma concentrations of the drug versus time, one can measure the area under the curve (AUC).
This curve reflects the extent of absorption of the drug.
In this slide contains introduction, copmpression, consolidation, compaction, heckel plots and equation, interpretation and application.
Presented by: NARAYAN SINGH UDIT (Department of pharmaceutics).
RIPER, anantapur
Dissolution, factors affecting drug dissolution, methods to evaluate dissolution, advantages and disadvantages, recent approaches--these are the topics covered in this presentation.
An in-vitro in-vivo correlation (IVIVC) has been defined by the U.S. Food and Drug Administration (FDA) as "a predictive mathematical model describing the relationship between an in-vitro property of a dosage form and an in-vivo response".
FORMULATION FACTORS EFFECTING BIOAVAILABILITY OF DRUGSN Anusha
Bioavailability means the rate and extent to which the active ingredient is absorbed from a drug product and becomes available at the site of action.
When the drug is given orally, only part of the administered dose appears in the plasma.
By plotting plasma concentrations of the drug versus time, one can measure the area under the curve (AUC).
This curve reflects the extent of absorption of the drug.
In this slide contains introduction, copmpression, consolidation, compaction, heckel plots and equation, interpretation and application.
Presented by: NARAYAN SINGH UDIT (Department of pharmaceutics).
RIPER, anantapur
Dissolution : Official and Non official methods, Alternative methods of dissolution testing and transport models, Drug release testing, Invitro drug release testing
Physics of Tablet compression is very useful during study of the tablet. It contains the mechanism of tablet compression. It also contains the process of tablet compression.
It includes Introductory part about what is Dissolution...then Mechanism of Dissolution is elaborated...Theories of Dissolution also given..It also includes Factors affecting Dissolution profile..Along with References given below for easily searching..
WHAT IS COMPRESSION ?
Compression means reduction of bulk volume of material as a result of the removal of gaseous phase (air) by applied pressure
WHAT IS CONSOLIDATION?
Consolidation is an increase in mechanical strength of material resulting from particle - particle interactions.
It is defined as “the predictive mathematical model that describes the relationship between in vitro property (such as rate & extent of dissolution) of a dosage form and in vivo response (such as plasma drug concentration or amount of drug absorbed)”.
United State Pharmacopoeia (USP)The establishment of a rational relationship between a biological property, or a parameter derived from a biological property produced by a dosage form, and a physicochemical property or characteristic of the same dosage form.
Food and Drug Administration (FDA) definitionIVIVC is a predictive mathematical model describing the relationship between an in vitro property of a dosage form and a relevant in vivo response. Generally, the in vitro property is the rate or extent of drug dissolution or release while the in vivo response is the plasma drug concentration or amount of drug absorbed.
DISSOLUTION
Dissolution is defined as a process in which a solid substance solubilises in a given solvent.
(i.e. mass transfer from the solid surface to the liquid phase.)
Three Theories:
Diffusion layer model / Film theory
Danckwert’s model / Penetration or Surface renewal theory
Interfacial barrier model / Double barrier or Limited solvation theory
Dissolution : Official and Non official methods, Alternative methods of dissolution testing and transport models, Drug release testing, Invitro drug release testing
Physics of Tablet compression is very useful during study of the tablet. It contains the mechanism of tablet compression. It also contains the process of tablet compression.
It includes Introductory part about what is Dissolution...then Mechanism of Dissolution is elaborated...Theories of Dissolution also given..It also includes Factors affecting Dissolution profile..Along with References given below for easily searching..
WHAT IS COMPRESSION ?
Compression means reduction of bulk volume of material as a result of the removal of gaseous phase (air) by applied pressure
WHAT IS CONSOLIDATION?
Consolidation is an increase in mechanical strength of material resulting from particle - particle interactions.
It is defined as “the predictive mathematical model that describes the relationship between in vitro property (such as rate & extent of dissolution) of a dosage form and in vivo response (such as plasma drug concentration or amount of drug absorbed)”.
United State Pharmacopoeia (USP)The establishment of a rational relationship between a biological property, or a parameter derived from a biological property produced by a dosage form, and a physicochemical property or characteristic of the same dosage form.
Food and Drug Administration (FDA) definitionIVIVC is a predictive mathematical model describing the relationship between an in vitro property of a dosage form and a relevant in vivo response. Generally, the in vitro property is the rate or extent of drug dissolution or release while the in vivo response is the plasma drug concentration or amount of drug absorbed.
DISSOLUTION
Dissolution is defined as a process in which a solid substance solubilises in a given solvent.
(i.e. mass transfer from the solid surface to the liquid phase.)
Three Theories:
Diffusion layer model / Film theory
Danckwert’s model / Penetration or Surface renewal theory
Interfacial barrier model / Double barrier or Limited solvation theory
Dissolution apparatus, invivo-invitro corelation, factor affecting,BCS classification ..
Complete dissolution topic in this slide & easy way to write..
Cheak it now and give feedback
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
2. *What is dissolution?
- Dissolution is a process in which a solid substance
solubilizes in a given solvent to yield a solution i.e. mass
transfer from the solid surface to the liquid phase.
- It depends on the affinity between the
solid substance and solvent.
Dissolution 2
3. - It quantifies the speed
of the dissolution process.
- It depends on
chemical natures of the solvent and solute,
temperature (and possibly to a small degree, the
pressure),
degree of undersaturation,
presence of a means of mixing,
interfacial surface area, and
the presence of "inhibitors" (e.g., substances adsorbed on
the surface).
It is defined as the amount of drug substance that goes in
solution per unit time under standardized conditions of
temperature, pH and solvent composition and constant
surface area.
* Rate of dissolution
Dissolution 3
4. * Need of dissolution
Drug in the blood
and the body
Dissolution 4
5. - Initial mechanical lag.
- Wetting of dosage form.
- Penetration of dissolution
medium.
- Disintegration.
- De-aggregation.
- Dissolution.
- Occlusion of some particles.
* Mechanism of dissolution
The S-Shaped dissolution curve of solid dosage form
Dissolution 5
6. - For optimization of formulation and quality control.
- To identify the manufacturing variable, like the binding
agent effect, mixing effects, granulation procedure,
coating parameters and comparative profile studies.
- To show that the release of drug from the tablet is close to
100%.
- To show that the rate of drug release is uniform batch to
batch.
- And to show that release is equivalent to those batches
proven to be bioavailable and clinically effective.
* Application of dissolution
studies
Dissolution 6
7. *Theories of dissolution
1. Diffusion layer model
2. Danckwert’s model
3. Interfacial barrier model
Dissolution 7
8. - Also called ‘film theory’.
- 2 steps are involved:
1. Interaction of solvent with drug
surface to form a saturated drug
layer , called stagnant layer.
2. Diffusion of drug molecules from
stagnant layer into bulk of the
system.
* 1. Diffusion layer model
Dissolution 8
9. Noyes- Whitney’s equation:
where,
dC/ dt = dissolution rate of the drug,
k = dissolution rate constant,
Cs = concentration of drug in the
stagnant layer, and
Cb = concentration of drug in the
bulk of the solution at time
t.
Diffusion layer Model
Dissolution 9
10. Where,
D = diffusion coefficient (diffusivity) of the
drug
A = surface area of the dissolving solid
Kw/o = water/oil partition coefficient of the drug.
V = volume of dissolution medium
h = thickness of the stagnant layer
(Cs – Cb)= concentration gradient for diffusion of
drug.
Dissolution 10
11. - Noyes- Whitney’s equation represents first order kinetics, for
which the driving force is concentration gradient.
- This is true for in- vitro dissolution which is characterized by
non sink condition.
- The in- vivo dissolution is rapid as sink conditions are
maintained by absorption of drug in systemic circulation I.e.
Cb = 0 .
- Under sink condition,
dissolution rate follows
zero order kinetics.
Dissolution rate under sink and non- sink conditions
Dissolution
11
12. *The Hixson-Crowell Cube Root
Law
- Major assumptions in Noyes-Whitney relationship is that the
surface area remains constant throughout dissolution process.
- However, size of drug particles will decrease as drug dissolves.
and thus changes the effective surface area.
- Thus, Hixson & Crowell modified the equation to represent rate of
appearance of solute by weight in solution.
where,
M0 = initial mass of powder
M = mass of powder dissolved in time, t
k = cube root dissolution rate constant
Dissolution 12
13. *2. Danckwert’s Model
-Also called “Penetration or Surface Renewal Theory”.
-Danckwert’s takes into account the eddies or
packets that are present in the agitated fluid
which reach the solid- liquid interface, absorb the
solute by diffusion and carry it into the bulk of
solution.
-These packets get continuously replaced by new
ones and expose to new solid surface each time,
thus the theory is called as surface renewal
theory.
Dissolution 13
14. Where,
m = mass of solid dissolved,
and
γ = rate of surface renewal
(or the interfacial tension)
Danckwert’s Model
Dissolution 14
15. *3. Interfacial Barrier Model
-Drug dissolution is a function of solubility rather
than diffusion.
-Intermediate concentration exist at the interface
as a result of solvation.
-Dissolution rate per unit area, G is given by,
where,
Ki = effective interfacial transport
constant.
Dissolution 15
16. *Factors affecting dissolution
rate
1. Factors related to Physicochemical
Properties of Drug
2. Factors related to Drug Product
Formulation
3. Processing Factor
4. Factors Relating Dissolution Apparatus
5. Factors Relating Dissolution Test
Parameters
Dissolution 16
17. *Factor related to
physicochemical properties
of drug
1. Particle size of drug
- There is a direct relationship between surface area of drug and its
dissolution rate. Since, surface area increases with decrease in particle
size, higher dissolution rates may be achieved through reduction of
particle size.
- E.g. Micronisation of non-hydrophobic drug like griseofulvin leads to
increase in dissolution rate.
- Micronisation of hydrophobic powders can lead to aggregation and
floatation, when powder is dispersed into dissolution medium.
- E.g. hydrophobic drugs like aspirin, phenacetin and phenobarbital
shows decrease in dissolution rate, as they tend to adsorb air at the
surface and inhibit their wettability.
Dissolution 17
18. 2. DRUG SOLUBILITY
- Solubility of drug plays a prime role in
controlling its dissolution from dosage
form. Aqueous solubility of drug is a
major factor that determines its
dissolution rate.
- E.g. Poorly soluble drug :griseofulvin,
spironolactone
Hydrophilic drug :neomycin
Solubility
Dissolution 18
19. 3. Solid state characteristics
- Solid phase characteristics of drug, such as amorphicity,
crystallinity, state of hydration and polymorphic structures
have significant influence on dissolution rate.
- Anhydrous forms dissolve faster than hydrated form because
they are thermodynamically more active than hydrates. E.g.
Ampicillin anhydrate faster dissolution rate than trihydrate.
- Amorphous forms of drug tend to dissolve faster than
crystalline materials. E.g. Novobiocin suspension, Griseofulvin.
- Metastable(high activation energy)
polymorphic form have better
dissolution than stable form.
Dissolution 19
20. 4. Salt formation
- It is one of the common approaches used to increase drug
solubility and dissolution rate. E.g. sodium and potassium salts of
Penicillin G, phenytoin, barbiturates etc.
- While in case of Phenobarbital, dissolution of sodium salt was
slower than that of weak acid.
Dissolution and absorption of an acidic drug administered in salt form
Dissolution
20
21. *Factors related to drug
product formulation
1. Binders and granulating agents:
- In general, the hydrophilic ( aqueous) binders show
better dissolution profile with poorly wettable drugs
like phenacetin by imparting hydrophilic properties
to the granule surface.
- Large amounts of such binders increase hardness
and decrease disintegration / dissolution rates of
tablets.
Dissolution 21
22. .
Rate of dissolution of phenacetin from ▲powder, ●
granules, and ○ tablet in diluted gastric juice.
Dissolution 22
23. 2. Disintegrants
- Disintegrating agent added before & after the granulation
affects the dissolution rate.
- E.g. Phenobarbital tablet showed that when copagel (low
viscosity grade of Na CMC) added before granulation
decreased dissolution rate but if added after did not had any
effect on dissolution rate.
- Microcrystalline cellulose is a very good disintegrating agent
but at high compression force, it may retard drug dissolution.
- Starch is not only an excellent diluent but also superior
disintegrant due to its hydrophilicity and swelling property.
Dissolution 23
24. Effect of starch content on dissolution rate of salicylic
acid tablet, ○ 5 %, ● 10 % and × 20 % starch in granules.
Dissolution 24
25. 3. Effect of lubricants / anti-frictional agents
- The nature, quantity, and quality of lubricants added can
affect the dissolution rate.
- Lubricants are hydrophobic in nature (several metallic stearate
& waxes) which inhibit wettability, penetration of water into
tablet so decrease in disintegration and dissolution.
- The use of soluble lubricants like SLS and Carbowaxes promote
drug dissolution.
- E.g. Magnesium stearate, a hydrophobic lubricant, tend to
retard the dissolution rate of salicylic acid tablet, whereas
sodium lauryl sulfate enhances its dissolution, due to its
hydrophobic but surface activity, which increases wetting and
better solvent penetration into tablet.
Dissolution 25
26. (A) Effect of magnesium stearate on
dissolution rate of salicylic acid from
rotating disc made from fine salicylic
acid powder, ○ 3 % Mg. Stearate, ● no
lubricant added.
(B) Effect of lubricant on dissolution
rate of salicylic acid contained in
compressed tablet, × 3 % Mg. Stearate
, ● no lubricant, and ○ 3 % Sodium
lauryl sulphate.
Dissolution 26
27. 4. Coatings
- In general, the deleterious effect of various coatings on drug
dissolution from a tablet dosage form is in the following order:
Enteric coat > Sugar coat > Non- enteric film coat.
5. Buffers
- Buffers are sometimes useful in creating the right atmosphere for
drug dissolution, e.g. buffered aspirin tablets.
6. Complexing agents
- A complexed drug may have altered stability, solubility, molecular
size, partition coefficient and diffusion coefficient.
- E.g. Enhanced dissolution through formation of a soluble complex of
ergotamine tartarate-caffeine complex and hydroquinone-digoxin
complex.
Dissolution 27
28. *Processing factors
1. Method of granulation
- Wet granulation has been shown to improve the
dissolution rate of poorly soluble drugs by
imparting hydrophilic properties to the surface of
granules.
- A newer technology called as APOC
“Agglomerative Phase of Comminution” was
found to produce mechanically stronger tablets
with higher dissolution rates than those made by
wet granulation. A possible mechanism is
increased internal surface area of granules
produced by APOC method.
Dissolution 28
29. 2. Compression force
- The compression process influence density, porosity,
hardness, disintegration time & dissolution of tablet.
- The curve obtained by plotting compression force versus
rate of dissolution can take one of the 4 possible shapes
1. tighter bonding increases hardness
2 . higher compression force cause
deformation crushing or fracture of
drug particle or convert a
spherical granules into disc Shaped
particle
3.& 4. both condition
Dissolution
29
1 2
3 4
30. *Factors related to
dissolution apparatus
1. AGITATION
-Rate of dissolution depends on type of agitation used, the
degree of laminar and turbulent flow in system, the shape and
design of stirrer.
- Speed of agitation should be such that it prevent turbulence
and sustain a reproducible laminar flow, which is essential for
obtaining reliable results.
- So, agitation should be maintained at a relatively low rate.
Dissolution 30
31. 2. SAMPLING PROBE POSITION & FILTER
- Sampling probe can affect the hydrodynamic of the system.
- USP states that sample should be removed at approximately
half the distance from the upper surface of basket or paddle
and surface of dissolution medium and not closer than 1 cm to
the side of the flask.
3. STIRRING ELEMENT ALIGNMENT
- The USP / NF states that the axis of the stirring element
must not deviate more than 0.2 mm from the axis of the
dissolution vessel.
Dissolution 31
32. *Factors related to
dissolution test parameters
1. Vibration
- The excessive vibration of dissolution apparatus
increases dissolution rates.
2. Vessel design and construction
- Plastic vessels provide more perfect hemisphere
than glass vessels.
3. Temperature control
- Should be maintained at 37 ± 0.5 º C
4. Dissolution medium parameters
- Surface tension, pH, Viscosity, De-aeration
Dissolution 32
33. *Dissolution apparatus
Based on the absence or presence of sink conditions, there
are two principal types of apparatus:
1 . Closed- compartment apparatus:
It is basically a limited volume apparatus operating under non-
sink conditions. e.g. beaker type apparatuses such as the rotating basket
and the rotating paddle apparatus.
2 . Open- compartment ( continuous flow- through ) apparatus:
It is the one in which the dosage form is contained in a column
which is brought in continuous contact with fresh, flowing dissolution
medium ( perfect sink condition ).
3 . A third type called as dialysis systems are used for very poorly
aqueous soluble drugs for which maintenance of sink conditions would
otherwise require large volume of dissolution fluid.
Dissolution 33
34. *USP compendial apparatus
1. Basket type (USP apparatus 1)
2. Paddle type (USP apparatus 2)
3. Reciprocating cylinder type (USP
apparatus 3)
4. Flow - through cell type (USP apparatus 4)
5. Paddle over disc type (USP apparatus 5)
6. Cylinder type (USP apparatus 6)
7. Reciprocating holder type (USP apparatus
7)
Dissolution 34
35. *Basket type (USP apparatus 1)
Design:
Vessel:- Made up of transparent, inert material
(borosilicate glass)
Semi hemispherical bottom
Capacity: 1000ml
Shaft:- Stainless steel 316
Rotates smoothly without significance wobble
Basket:- Stainless steel 316
Gold coatings up to 0.0001 inch (2.5 µm)
Water bath:- Maintained at 37± 0.5˚c
Dissolution
35
36. - Dosage form contained within
basket
- Dissolution should occur within
Basket
- pH change by media exchange
Uses:- Capsules, tablets,
delayed release dosage form,
suppositories, floating dosage
forms.
Agitation:- Rotating stirrer
Usual speed: 50 to 100 rpm
Disadvantage:- Formulation
may clog to 40 mesh screen
Dissolution 36
Fig. Basket stirring element
37. *Paddle type (USP apparatus 2)
Design:
Vessel:- Made up of transparent, inert material
(borosilicate glass)
Semi hemispherical bottom
Capacity: 1000ml
Shaft:- The blade passes through shaft so that
bottom of blade fuses with bottom of shaft.
Stirring elements:- Made of Teflon for laboratory purpose
Stainless steel 316
Water bath:- Maintain at 37± 0.5˚c.
Sinkers:- Small loose wire helix used to prevent
capsule/tablet from floating.
Dissolution 37
38. - Dosage form should remain at the bottom
center of the vessel.
- pH change by media change.
Useful for:- Tablets
Capsules
Agitation:- Rotating stirrer
Usual speed: 25 to 100 rpm
Advantages:- Easy to use and robust
pH change possible
Can be easily adapted to apparatus 5
Disadvantages:- Floating dosage forms require sinker
Positioning of tablet.
Dissolution 38
Fig. Paddle stirring element
40. *Reciprocating cylinder type
(USP apparatus 3)
Design:
Vessel:- Cylindrical flat bottom glass vessel.
Agitation:- Reciprocating
Generally 6-35 cycles/min
Volume of dissolution fluids:- 200-250 ml
Water bath:- Maintain at 37 ± 0.5˚C
Use:- Extended release
Dissolution 40
41. - The apparatus consist of a set of cylindrical flat– bottomed glass
vessel equipped with reciprocating cylinders.
- The vessels are partially immersed in a suitable water
bath of any convenient size that permits holding the
temperature at 37 º C ± 0.5 º C during the test.
- The dosage unit is placed in reciprocating cylinder
& the cylinder is allowed to move in upward and
downward direction constantly.
Total distance it travels during stroke is 9.9- 10.1 cm.
Useful for:- Tablets, Beads, controlled release
Formulations.
Advantages:- Easy to change the pH-profiles
Hydrodynamics can be directly influenced by
varying the dip rate.
Disadvantages:- Small volume (max. 250 ml)
Dissolution
41
Fig. Reciprocating cylinder
42. *Flow-through cell type
(USP apparatus 4)
The apparatus consist of a reservoir for the dissolution medium
and a pump that forces medium through the cell holding the test
sample.
Dissolution fluid is collected in separate reservoir.
Temperature is maintained at 37 º C ± 0.5 º C.
Useful for:- Low solubility drugs, powders and granules,
micro particles, implants.
Advantages:- Easy to maintain sink
condition.
Easy to change media pH
Disadvantages:-De-aeration necessary
High volumes of media
Labor intensiveDissolution 42
Fig. Flow through cell
44. *Paddle over disc type
(USP apparatus 5)
This uses the paddle apparatus 2 with a
stainless steel disk designed for holding
transdermal system at the bottom of the
vessel.
The disk holds the system flat and is
positioned such that the release surface
is parallel with the bottom of the paddle
blade.
Media volume used is 900 ml which is
maintained at 37 º C ± 0.5 º C.
Useful for transdermal patches.
Disadvantages:- Disk assembly restrict
the size of patch.
Transdermal patch retainer ( Hanson style)
Dissolution 44
Fig. Paddle over disc
45. * Cylinder type
(USP apparatus 6)
This is a modification of Basket
apparatus 1, in which the basket is replaced
with a stainless steel cylinder as a stirring
element.
Sample is mounted to cuprophan (inner porous
cellulosic material) and entire system is adhere to
cylinder.
The dosage unit is placed on the cylinder with
release side out.
Useful for testing of transdermal patches.
Dissolution 45
Fig. Cylinder type
Cylinder stirring element
46. *Reciprocating holder type
(USP apparatus 7)
The assembly consist of a set of calibrated solution containers,
a motor and drive assembly to reciprocate the system vertically.
The sample holder may take the form of disc,
cylinder or a spring or acrylic rod,
or it may simply be the rod alone.
Capacity is 50– 200 ml.
Reciprocating frequency is 30 cycles/ min.
Useful for transdermal patches and
solid dosage forms.
Dissolution
46
48. *IVIVC
(In vitro- in vivo correlation)
IVIVC is an approach to describe the relationship
between an in-vitro property of dosage form ( rate and
extent of drug release) and a relevant in- vivo response
( plasma drug conc. or amount of drug absorbed )
Dissolution 48
49. *Purpose of IVIVC
- Serves as a surrogate for in- vivo bioavailability and to
support biowaiver.
- Used in optimization of formulation.
- To reduce the number of human studies during
formulation development.
Dissolution 49
51. *Level A correlation
- The % of drug dissolved at a given time is correlated to %
absorbed.
- Highest category of correlation.
- Represents point to point correlation between in vitro
dissolution time course and in vivo response time course.
- Utilizes all the dissolution and plasma level data available to
develop correlation.
Dissolution 51
52. *Level B correlation
- The mean in vitro dissolution time (MDT) is compared either
to the mean residence time (MRT) or to the mean in vivo
dissolution time.
- Is not a point-to-point correlation.
- Does not reflects the actual shape of in- vivo plasma level
curve.
- Level B correlations are rarely seen in NDAs.
Dissolution 52
53. *Level C correlation
- One dissolution time point (t50% t90% etc.) is compared to
one mean pharmacokinetic parameter such as AUC, Tmax ,
Cmax .
- A single point estimation and does not reflect the entire
shape of plasma drug concentration curve.
- Weakest level of correlation.
- Can be useful in early stages of formulation development
when pilot formulations are being selected.
Dissolution 53
54. *References
* D.M. Brahmankar, Sunil B. Jaiswal. pg. no. 29- 59 and 328- 335.
* The science and practice of of pharmacy by Remington 21st edition Pg. no. 673- 688.
* United states of pharmacopoeia, 2009. pg. no. 263- 276
* Principles and Application of Biopharmaceutics and Pharmacokinetics by H.P. Tipnis and Amrita
Bajaj. Pg. no. 332- 350.
* The theory and the practice of Industrial pharmacy by Lachman L, Liberman HA, Indian edition
2009. Pg. no. 302- 303.
* Article on Dissolution testing of various dosage forms by TK Indira.
(http://www.pharmainfo.net/Dissolution/dissolution-testing-various-dosage-forms)
* http://apps.who.int/phint/en/p/docf/
* www.wikipedia.com
* www.ei-instrument.com for images
* https://www.google.co.in/search?q=theory+of+dissolution&espv=2&biw=1600&bih=799&site=we
bhp&source=lnms&tbm=isch&sa=X&sqi=2&ved=0CAgQ_AUoA2oVChMIjf-
ckKuXyAIVUEiOCh2mUQ5i#imgrc=_
* http://www.pharmainfo.net/dissolution-test
* https://www.youtube.com/watch?v=CTxc9CCXurk
* https://www.youtube.com/watch?v=cG2IHw7S3nw
* https://www.youtube.com/watch?v=vmohYJn89NA
* https://www.youtube.com/watch?v=b40PbkbLP_M
* https://www.youtube.com/watch?v=nFShFBlzT5k
Dissolution
54