This document discusses various diseases that can affect the lips and tongue. It outlines conditions like swelling of the lips, angular chelitis, lip fissures, and perioral dermatitis that involve the lips. For the tongue, it describes abnormalities, infections like hairy tongue, traumatic injuries, geographic tongue, and median rhomboid glossitis. It provides details on symptoms, causes, and treatment approaches for many of these oral diseases.
At the End oF this Discussion we will be able to Describe
Which are the Diseases Of the Lips??
Swelling?
Generalized
Localized
Angular Cheilitis?
Lip Fissures?
Allergic Cheilitis?
Actinic cheilitis?
Exfoliative
Perioral Dermatitis?
Lick Eczema?
Cheilocandidiosis
Dr. ShahzaD Hussain
BDS, FCPS(r)
Oral & Maxillofacial Surgery
Nishtar Institute Of Dentistry, Multan
SNDENTALCARE.CO
At the End oF this Discussion we will be able to Describe
Which are the Diseases Of the Lips??
Swelling?
Generalized
Localized
Angular Cheilitis?
Lip Fissures?
Allergic Cheilitis?
Actinic cheilitis?
Exfoliative
Perioral Dermatitis?
Lick Eczema?
Cheilocandidiosis
Dr. ShahzaD Hussain
BDS, FCPS(r)
Oral & Maxillofacial Surgery
Nishtar Institute Of Dentistry, Multan
SNDENTALCARE.CO
Gingivitis is a form of gum disease characterised by reversible gingival inflammation without destruction of tooth-supporting tissues, periodontal ligament or bone
The longer plaque and tartar are on teeth, the more harmful they
become. The bacteria cause inflammation of the gums that is called
“gingivitis.” In gingivitis, the gums become red, swollen and can bleed
easily. Gingivitis is a mild form of gum disease that can usually be
reversed with daily brushing and flossing, and regular cleaning by a
dentist or dental hygienist. This form of gum disease does not include
any loss of bone and tissue that hold teeth in place.
All about gingivitis
*definition
*classification
*Signs and Symptoms: Increased GCF, Gingival Bleeding, Color change, Consistency, Surface texture (STIPPLING), Position of Gingiva, Gingival Contour, Size.
Treatment consisits of scaling and root planing. The more inflamed a gingival unit appears clinically, the better the chances of therapeutic measures resulting in a return to normal gingival health
Tongue Release by Co2 Laser under Local or General Anesthesia is the easiest way to correct this problem.It is painless, no bleeding, no sutures and can be done as Day case procedure.
Presented By Dr.K.O.Paulose FRCS DLO Consultant ENT Surgeon Jubilee Hospital, Trivandrum, South India. www.drpaulose.com, www.snorefreesleep.com
Gingivitis is a form of gum disease characterised by reversible gingival inflammation without destruction of tooth-supporting tissues, periodontal ligament or bone
The longer plaque and tartar are on teeth, the more harmful they
become. The bacteria cause inflammation of the gums that is called
“gingivitis.” In gingivitis, the gums become red, swollen and can bleed
easily. Gingivitis is a mild form of gum disease that can usually be
reversed with daily brushing and flossing, and regular cleaning by a
dentist or dental hygienist. This form of gum disease does not include
any loss of bone and tissue that hold teeth in place.
All about gingivitis
*definition
*classification
*Signs and Symptoms: Increased GCF, Gingival Bleeding, Color change, Consistency, Surface texture (STIPPLING), Position of Gingiva, Gingival Contour, Size.
Treatment consisits of scaling and root planing. The more inflamed a gingival unit appears clinically, the better the chances of therapeutic measures resulting in a return to normal gingival health
Tongue Release by Co2 Laser under Local or General Anesthesia is the easiest way to correct this problem.It is painless, no bleeding, no sutures and can be done as Day case procedure.
Presented By Dr.K.O.Paulose FRCS DLO Consultant ENT Surgeon Jubilee Hospital, Trivandrum, South India. www.drpaulose.com, www.snorefreesleep.com
Aesthetics is a major topic in modern dentistry. majority of patients presenting to the dental clinic today are concerned about their smile. A holistic dental care must encompass restoring function, anatomy and a confident smile.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
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6. Marker of Systemic Diseases
Anemia
Iron, B 12, Folate deficiency
OFG
HIV Infection
DM
Sjogren Syndrome
7. Management
Elimination of local factors
Denture Hygiene
Instruct patient to leave denture at night
Referral to medical specialist for underlying medical cause
Provision of antimicrobial therapy
Local
Systemic
9. Allergic Chelitis
Irritation and scaling of lips caused by allergy
Lipsticks
Ointments
Foods
Moisturizes
Tooth pastes
Lipstick allergy may also be caused by straw
sharing and kissing
11. Actinic Chelitis (Solar keratosis)
Prolonged exposure to sunlight either occupational or
recreational may result this
Long exposure to sunlight
Lower lip more effected
Crusting and induration of the vermilion margin
May progress to carcinoma
13. Exfoliative Chelitis
Production of excess amount of keratin
Involves vermilion border
Histology is simply hyperparakeratosis
Not a malignant condition
May be related to stress
14. Exfoliative Chelitis (Treatment)
Local or systemic steroids
Tranquilizers
Cautery
Cryosurgery
Skin must be peeled off before applying gel
15. Lick eczema
Sharply circumscribed zone
of irritable scaly skin around
the mouth
Children and specially young
patients are effected
It’s the result of licking habit
16. Lick eczema (Treatment)
Remove the causative factor
Removable appliance with a sharp edge to touch the tongue is
beneficial.
17. Cheilocandidosis
Heavy candidal infection of lower lip.
Bilaterally spreading
Secondary candidal infection
Antifungals may be used
19. Diseases of the Tongue
Neoplasms of the tongue are of great significance because they
may grow to a considerable size before presentation of
symptoms (Pain & Paresthesia)
21. Diseases of the Tongue
Tongue fissure
Coated tongue
Hairy tongue
Atrophy of the lingual
epithelium
Traumatic irritation of
tongue
Enlargement of foliate
papillae
Geographic tongue
Median rhomboid glossitis
22. Tongue fissure
Normal structure showing
variation in depth, number &
arrangements.
Fissures may be exaggerated
during some conditions like CMC
Cholorhexidine mouthwash is the
treatment of choice for
symptomatic cases
23. Scrotal Tongue
Normal morphological variation
Multiple fissures on dorsum of
tongue
Irregular border of the tongue
resembling ‘’Pie Crust’’ is called
‘’Crenated Tongue’’.
25. Coated Tongue
Coating consists of mucus, desquamated
epithelial cells, microorganisms and
debris.
Normal mobility of the tongue and
salivary flow help in cleaning the tongue
When the balance is upset, coating starts
26. Coated Tongue
Lack of mobility
Painful lesions
↓ salivary flow
↑ tobacco or alcohol use
Gastric or respiratory upset
Build up of coating on dorsal surface
of tongue
Color depends on tobacco / dietary
habits
28. Hairy Tongue
Elongation of filiform papillae
Dark brown and black color is
common
May be due to long antibiotic
course
Resolves with time on completion
of drug course
Candidal infection may be
common
29. Hairy Tongue (Treatment)
Resolves with completion of
antibiotic therapy
Mucous solvent
mouthwashes
Chemical cauterization
Sucking a dry peach stone
(not much effective)
30. Atrophy of the lingual epithelium
Opposite to hairy tongue
May be due to hematological & nutritional deficiencies
Iron deficiency
Megaloblastic anemia
Vitamin deficiency
31. Atrophy of the lingual epithelium
Surface appears shiny, red &
painful
Investigations
Serum Ferritin
SerumFolate
B12
Glucose
32. Atrophy of the lingual epithelium
May be associated with following generalized condition
Anemias
Salivary gland hypofunction
Rhematoid arthritis
Sjogren syndrome
Burning Mouth Syndrome (BMS)
33. Traumatic Irritation of the Tongue
Acute (fracture of the tooth)
Chronic (continuous rubbing of tongue on denture or anterior
teeth)
Superficial traumatic lesions leads to inflammation and ulcers
with surrounding white borders
It gives suspicion of malignancy but are always benign
They relieves within a week after removal of irritant
If not relieves then biopsy must be taken and sent to lab
34. Traumatic Irritation of the Tongue
Most difficult cases are of
tongue biting
Hematological investigations
must be carried out to rule out
systemic cause
Mild erythema of tip of the
tongue and mucosa of lower lips
is sign of trauma
35. Geographic Tongue
Depapillation of tongue
Red patches surrounded by
white borders
Distributed in a map like
fashion & tend to vary their
position with time
Involves palate and lingual
mucosa
36. Geographic Tongue
Etiology is unknown
Hematinic deficiency may be
associated
If tongue is symptomatic then
hematinic investigation must be
carried out
Biopsy is rarely indicated
Simple analgesic mouthwash provides
symptomatic relief
37. Median Rhomboid Glossitis
Candidal pseudo membrane +
fissuring and fibrosis of tongue
Diabetes or iron deficiency may
be associated
May vary from immediately in
front of vallate papillae towards
anterior surface
38. Median Rhomboid Glossitis
Short term use of systemic
antifungal drugs
(Nystatin Pastilles)
Long term use of topical
antifungal drugs
(fluconazole)
Seen associated with HIV
39. Disturbance of taste
A neurological disturbance that is due to surgical trauma to the
chorda tympani following middle ear surgeries
Bells palsy may have the same situation