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ACCESSORY GLANDS

Pancreas, Liver, and gallbladder

Copyright © 2011 Pearson Education, Inc.
Pancreas
• Location
• Inferior to stomach
• Retroperitoneal
• Head is encircled by the
duodenum; tail abuts the
spleen

Copyright © 2011 Pearson Education, Inc.
Pancreas
• Soft triangular gland
• Endocrine function – secretes hormones
• Pancreatic islet cells
• Insulin / glucagon : blood sugar regulation

• Exocrine function – secretes enzymes
• Pancreatic juice : neutralizes stomach acid

Copyright © 2011 Pearson Education, Inc.
Pancreatic Juice
• Alkaline solution (pH 8), neutralizes chyme
• Enzymes
• Breakdown of sugars, proteins and fats
• Amylase, lipases and proteases
• Activated in the duodenum

Copyright © 2011 Pearson Education, Inc.
Stomach

Pancreas
Epithelial
cells
Membrane-bound
enteropeptidase
Trypsinogen
Trypsin
(inactive)
Chymotrypsin
Chymotrypsinogen
(inactive)
Carboxypeptidase
Procarboxypeptidase
(inactive)

Copyright © 2011 Pearson Education, Inc.

Figure 22.27
LIVER AND GALLBLADDER

Copyright © 2011 Pearson Education, Inc.
Liver
• Largest gland in the body
• Produces bile

• Four lobes—right, left, caudate, and quadrate

Copyright © 2011 Pearson Education, Inc.
Parts of the Liver
• Falciform ligament
• Separates the right and left lobes
• Suspends liver from the diaphragm

• Round ligament (ligamentum teres)
• Remnant of fetal umbilical vein

Copyright © 2011 Pearson Education, Inc.
Sternum

Bare area

Liver

Falciform
ligament
Left lobe of liver

Right lobe
of liver

Gallbladder
(a)

Copyright © 2011 Pearson Education, Inc.

Round ligament
(ligamentum
teres)

Figure 22.24a
Liver: Associated Structures
• Lesser omentum anchors liver to stomach
• Hepatic artery and vein at the porta hepatis
• Bile ducts
• Common hepatic duct leaves the liver
• Cystic duct connects to gallbladder
• Bile duct joining of common and cystic ducts

Copyright © 2011 Pearson Education, Inc.
Right and left
hepatic ducts
of liver
Cystic duct
Common hepatic duct
Bile duct and sphincter
Accessory pancreatic duct

Mucosa
with folds
Gallbladder
Major duodenal
papilla
Hepatopancreatic
ampulla and sphincter
Copyright © 2011 Pearson Education, Inc.

Tail of pancreas
Pancreas
Jejunum

Duodenum

Main pancreatic duct
and sphincter
Head of pancreas
Figure 22.21
Liver: Function
• Liver lobules
• Functional units of liver
• Hexagonal shape
• Filter nutrient-rich blood
• Composed of hepatocytes (liver cells)
• Longitudinal central vein

Copyright © 2011 Pearson Education, Inc.
(a)

Lobule

Copyright © 2011 Pearson Education, Inc.

(b)

Central vein

Connective
tissue septum
Figure 22.25a, b
Liver: Microscopic Anatomy
• Hepatocyte functions
• Process bloodborne nutrients
• Store fat-soluble vitamins
• Store glycogen
• Perform detoxification
• Produce bile
• Kupffer cells (hepatic macrophages) in liver
sinusoids
Copyright © 2011 Pearson Education, Inc.
Bile
• Yellow-green, alkaline solution containing
• Bile salts
• Bilirubin: pigment formed from heme
• Cholesterol, neutral fats, phospholipids, and
electrolytes

Copyright © 2011 Pearson Education, Inc.
Bile
• Enterohepatic circulation
• Recycles bile salts
• Bile salts → duodenum → reabsorbed from
ileum → hepatic portal blood → liver →
secreted into bile

Copyright © 2011 Pearson Education, Inc.
The Gallbladder
• Muscular sac on the ventral surface of the
liver
• Stores bile
• Releases bile via the cystic duct,
• flows into bile duct

• Bile secretion is stimulated by
• Exposure to HCl and fatty chyme

Copyright © 2011 Pearson Education, Inc.
Organ Coverings of the Abdominal Cavity
All abdominal organs are supported by coverings

• Parietal peritonium
• Contacts abdominal
wall

• Greater omentum
• Fatty sheet draped over
organs

• Visceral peritonium

• Lesser omentum

• Contacts abcominal
organs

• Connects liver to
stomach

• Mesentary
• Double-layered tissue
supporting organs
Copyright © 2011 Pearson Education, Inc.
Copyright © 2011 Pearson Education, Inc.
Organ Coverings of the Abdominal Cavity
Liver
Lesser omentum
Pancreas
Stomach
Transverse
mesocolon

Duodenum
Transverse colon
Mesentery
Greater omentum
Jejunum
Ileum
Visceral peritoneum
Parietal peritoneum
(d)
Copyright © 2011 Pearson Education, Inc.

Urinary bladder
Rectum
Figure 22.30d
Bacterial Flora
• Help to breakdown food
• Found in the colon
• Release irritating acids and gases
• Synthesize B complex vitamins and vitamin K

Copyright © 2011 Pearson Education, Inc.

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Digest ii online

  • 1. ACCESSORY GLANDS Pancreas, Liver, and gallbladder Copyright © 2011 Pearson Education, Inc.
  • 2. Pancreas • Location • Inferior to stomach • Retroperitoneal • Head is encircled by the duodenum; tail abuts the spleen Copyright © 2011 Pearson Education, Inc.
  • 3. Pancreas • Soft triangular gland • Endocrine function – secretes hormones • Pancreatic islet cells • Insulin / glucagon : blood sugar regulation • Exocrine function – secretes enzymes • Pancreatic juice : neutralizes stomach acid Copyright © 2011 Pearson Education, Inc.
  • 4. Pancreatic Juice • Alkaline solution (pH 8), neutralizes chyme • Enzymes • Breakdown of sugars, proteins and fats • Amylase, lipases and proteases • Activated in the duodenum Copyright © 2011 Pearson Education, Inc.
  • 6. LIVER AND GALLBLADDER Copyright © 2011 Pearson Education, Inc.
  • 7. Liver • Largest gland in the body • Produces bile • Four lobes—right, left, caudate, and quadrate Copyright © 2011 Pearson Education, Inc.
  • 8. Parts of the Liver • Falciform ligament • Separates the right and left lobes • Suspends liver from the diaphragm • Round ligament (ligamentum teres) • Remnant of fetal umbilical vein Copyright © 2011 Pearson Education, Inc.
  • 9. Sternum Bare area Liver Falciform ligament Left lobe of liver Right lobe of liver Gallbladder (a) Copyright © 2011 Pearson Education, Inc. Round ligament (ligamentum teres) Figure 22.24a
  • 10. Liver: Associated Structures • Lesser omentum anchors liver to stomach • Hepatic artery and vein at the porta hepatis • Bile ducts • Common hepatic duct leaves the liver • Cystic duct connects to gallbladder • Bile duct joining of common and cystic ducts Copyright © 2011 Pearson Education, Inc.
  • 11. Right and left hepatic ducts of liver Cystic duct Common hepatic duct Bile duct and sphincter Accessory pancreatic duct Mucosa with folds Gallbladder Major duodenal papilla Hepatopancreatic ampulla and sphincter Copyright © 2011 Pearson Education, Inc. Tail of pancreas Pancreas Jejunum Duodenum Main pancreatic duct and sphincter Head of pancreas Figure 22.21
  • 12. Liver: Function • Liver lobules • Functional units of liver • Hexagonal shape • Filter nutrient-rich blood • Composed of hepatocytes (liver cells) • Longitudinal central vein Copyright © 2011 Pearson Education, Inc.
  • 13. (a) Lobule Copyright © 2011 Pearson Education, Inc. (b) Central vein Connective tissue septum Figure 22.25a, b
  • 14. Liver: Microscopic Anatomy • Hepatocyte functions • Process bloodborne nutrients • Store fat-soluble vitamins • Store glycogen • Perform detoxification • Produce bile • Kupffer cells (hepatic macrophages) in liver sinusoids Copyright © 2011 Pearson Education, Inc.
  • 15. Bile • Yellow-green, alkaline solution containing • Bile salts • Bilirubin: pigment formed from heme • Cholesterol, neutral fats, phospholipids, and electrolytes Copyright © 2011 Pearson Education, Inc.
  • 16. Bile • Enterohepatic circulation • Recycles bile salts • Bile salts → duodenum → reabsorbed from ileum → hepatic portal blood → liver → secreted into bile Copyright © 2011 Pearson Education, Inc.
  • 17. The Gallbladder • Muscular sac on the ventral surface of the liver • Stores bile • Releases bile via the cystic duct, • flows into bile duct • Bile secretion is stimulated by • Exposure to HCl and fatty chyme Copyright © 2011 Pearson Education, Inc.
  • 18. Organ Coverings of the Abdominal Cavity All abdominal organs are supported by coverings • Parietal peritonium • Contacts abdominal wall • Greater omentum • Fatty sheet draped over organs • Visceral peritonium • Lesser omentum • Contacts abcominal organs • Connects liver to stomach • Mesentary • Double-layered tissue supporting organs Copyright © 2011 Pearson Education, Inc.
  • 19. Copyright © 2011 Pearson Education, Inc.
  • 20. Organ Coverings of the Abdominal Cavity Liver Lesser omentum Pancreas Stomach Transverse mesocolon Duodenum Transverse colon Mesentery Greater omentum Jejunum Ileum Visceral peritoneum Parietal peritoneum (d) Copyright © 2011 Pearson Education, Inc. Urinary bladder Rectum Figure 22.30d
  • 21. Bacterial Flora • Help to breakdown food • Found in the colon • Release irritating acids and gases • Synthesize B complex vitamins and vitamin K Copyright © 2011 Pearson Education, Inc.