Cataracts are a major cause of blindness in diabetic patients. The pathogenesis involves the polyol pathway where high glucose levels increase aldose reductase and lead to accumulation of sorbitol in the lens, causing osmotic stress. This induces apoptosis in lens epithelial cells and development of cataracts. Diabetic patients have higher risks of complications after cataract surgery compared to nondiabetics. Aldose reductase inhibitors and antioxidants from plants like ocimum sanctum have been shown to help prevent or treat cataracts.