Development and evaluation of xyloglucan matrix release tabs contaning glipizide

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sukesh

My thesis of B.PHARM... Thanks to batchmates....

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DEVELOPMENT AND EVALUATION OF XYLOGLUCAN MATRIX RELEASE TABLETS CONTAINING GLIPIZIDE Project submitted to Acharya Nagarjuna University, Guntur . DEPARTMENT OF PHARMACEUTICS VICTORIA COLLEGE OF PHARMACY Under the guidance of Mr. P. Arun Kumar , M.Pharm.,

Objective ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],DEPARTMENT OF PHARMACEUTICS VICTORIA COLLEGE OF PHARMACY

Glipizide ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],DEPARTMENT OF PHARMACEUTICS VICTORIA COLLEGE OF PHARMACY

Introduction ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],MATRIX RELEASE TABLETS DEPARTMENT OF PHARMACEUTICS VICTORIA COLLEGE OF PHARMACY

Mechanism of drug release ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Effect of rate limiting parameters ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Extraction of Xyloglucan 20 gm of tamarind kernel powder Added to 200ml of cold distilled water to prepare a slurry Slurry poured into 800 ml of boiled distilled water Solution was boiled for 20 mins in stirred condition Thin clear solution kept over night Centrifuged at 5000 rpm for 20 mins Supernatant liquid was separat ed Poured into excess absolute alcohol and stirred . Precipitate was formed Washed with 200 ml absolute ethanol Dried @ 50 o C

Preparation of matrix tabs FORMULA : XGL 1 XGL2 XGL3 XGL4 XGL5 Glipizide 100 100 100 100 100 Xyloglucan 100 150 150 150 150 Hydroxyl propyl methyl cellulose - - 100 - - Cellulose acetate phthalate - - - 100 - Ethyl cellulose - - - - 100 Lactose 180 130 30 30 30 Magnesium sterate 8 8 8 8 8 Talc 12 12 12 12 12

Procedure ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],.

Preformulation studies FTIR OF GLIPIZIDE

Estimation ,[object Object],Absorbance Concentration (µg/ml) Sl. No Concentration (  g/ml) Absorbance in 0.1N HCl 1. 0 0 2. 1 0.012 3. 2 0.025 4. 3 0.036 5. 4 0.048 6. 5 0.06 7. 6 0.071 8. 7 0.081 9. 8 0.092 10. 9 0.103 11 10 0.116

Dissolution Studies TIME (In Hours) %Drug release F1 fomulation exhibits 99 % drug release for prolonged duration .

COMPARISON OF DISSOLUTION RATES TIME (hr) F1 F2 F3 F4 F5 0 0 0 0 0 0 1 9.321 6.561 9.614 6.514 8.246 2 19.563 13.428 17.328 15.321 15.251 3 30.686 23.324 26.412 23.416 25.143 4 42.414 31.656 34.565 32.162 33.359 5 58.512 39.552 40.591 44.814 41.187 6 73.855 46.124 49.56 52.916 49.237 7 84.661 63.768 55.128 61.123 57.591 8 95.622 79.812 64.325 74.752 66.186

Physical parameters DEPARTMENT OF PHARMACEUTICS VICTORIA COLLEGE OF PHARMACY

Discussion ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],DEPARTMENT OF PHARMACEUTICS VICTORIA COLLEGE OF PHARMACY

Conclusion ,[object Object],[object Object],[object Object]

Bibliography ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],DEPARTMENT OF PHARMACEUTICS VICTORIA COLLEGE OF PHARMACY

THANK YOU !! PROJECT SUBMITTED BY: G. Shanthi Priyanka G. Rajesh J. Vijaya Bhaskar V. Manohar K. Sowjanya P. Sukesh L. V. Kishore U.V. Sudheer GUIDED BY: Mr. P. Arun Kumar, M.Pharm. , Victoria college of pharmacy Nallapadu Guntur

Microencapsulation has been employed to sustain the drug release, reduce or eliminate drug related adverse effects, dose intake and improve the bioavailability inspite drug undergo extensive first pass metabolism ultimately improve the compliance in pharmacotherapy of inflammation and pain. Microencapsulation by ionotropic gelation technique is one of the widely used method for preparation of calcium alginate beads which has ability to form gels reaction with calcium salts . Microencapsulation has been employed to sustain the drug release, reduce or eliminate drug related adverse effects, dose intake and improve the bioavailability inspite drug undergo extensive first pass metabolism ultimately improve the compliance in pharmacotherapy of inflammation and pain. Microencapsulation by ionotropic gelation technique is one of the widely used method for preparation of calcium alginate beads which has ability to form gels reaction with calcium salts .

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RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0). CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.

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Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.

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These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract. Learning objectives: 1. Enlist the non-respiratory functions of the respiratory tract 2. Briefly explain how these functions are carried out 3. Discuss the significance of dead space 4. Differentiate between minute ventilation and alveolar ventilation 5. Describe the cough and sneeze reflexes Study Resources: 1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition 2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition 3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition 4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874

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Development and evaluation of xyloglucan matrix release tabs contaning glipizide

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7. DEVELOPMENT AND EVALUATION OF XYLOGLUCAN MATRIX RELEASE TABLETS CONTAINING GLIPIZIDE Project submitted to Acharya Nagarjuna University, Guntur . DEPARTMENT OF PHARMACEUTICS VICTORIA COLLEGE OF PHARMACY Under the guidance of Mr. P. Arun Kumar , M.Pharm.,

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13. Extraction of Xyloglucan 20 gm of tamarind kernel powder Added to 200ml of cold distilled water to prepare a slurry Slurry poured into 800 ml of boiled distilled water Solution was boiled for 20 mins in stirred condition Thin clear solution kept over night Centrifuged at 5000 rpm for 20 mins Supernatant liquid was separat ed Poured into excess absolute alcohol and stirred . Precipitate was formed Washed with 200 ml absolute ethanol Dried @ 50 o C

14. Preparation of matrix tabs FORMULA : XGL 1 XGL2 XGL3 XGL4 XGL5 Glipizide 100 100 100 100 100 Xyloglucan 100 150 150 150 150 Hydroxyl propyl methyl cellulose - - 100 - - Cellulose acetate phthalate - - - 100 - Ethyl cellulose - - - - 100 Lactose 180 130 30 30 30 Magnesium sterate 8 8 8 8 8 Talc 12 12 12 12 12

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16. Preformulation studies FTIR OF GLIPIZIDE

17. FTIR OF GLIPIZIDE + XYLOGLUCAN

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19. Dissolution Studies TIME (In Hours) %Drug release F1 fomulation exhibits 99 % drug release for prolonged duration .

20. COMPARISON OF DISSOLUTION RATES TIME (hr) F1 F2 F3 F4 F5 0 0 0 0 0 0 1 9.321 6.561 9.614 6.514 8.246 2 19.563 13.428 17.328 15.321 15.251 3 30.686 23.324 26.412 23.416 25.143 4 42.414 31.656 34.565 32.162 33.359 5 58.512 39.552 40.591 44.814 41.187 6 73.855 46.124 49.56 52.916 49.237 7 84.661 63.768 55.128 61.123 57.591 8 95.622 79.812 64.325 74.752 66.186

21. Physical parameters DEPARTMENT OF PHARMACEUTICS VICTORIA COLLEGE OF PHARMACY

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26. THANK YOU !! PROJECT SUBMITTED BY: G. Shanthi Priyanka G. Rajesh J. Vijaya Bhaskar V. Manohar K. Sowjanya P. Sukesh L. V. Kishore U.V. Sudheer GUIDED BY: Mr. P. Arun Kumar, M.Pharm. , Victoria college of pharmacy Nallapadu Guntur

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