This document discusses single molecule detection using localized surface plasmon resonance of gold nanoparticles. It notes that single molecule detection is needed for early disease detection but current labeling techniques are destructive, not real-time, and don't allow virus information extraction. Label-free detection monitors inherent optical and dielectric properties but has sensitivity and specificity issues. Localized surface plasmon resonance exploits the resonant oscillation of conduction electrons in gold nanoparticles stimulated by light, producing a shift in resonant frequency when the refractive index changes due to molecule binding. This enables label-free single molecule protein detection using a single plasmonic nanoparticle sensor.