This document discusses using magnetic nanoparticles (MNPs) for cancer hyperthermia therapy. It describes cancer and current cancer therapies like surgery, chemotherapy, and radiotherapy. It introduces nanomedicine and defines magnetic nanoparticles as nanoparticles that can be manipulated using magnetic fields. The document proposes using MNPs for magnetic hyperthermia cancer treatment, where applying an alternating magnetic field causes the MNPs to heat up. It outlines preparing and characterizing MNPs, then testing their cytotoxicity on cell cultures by exposing cell groups to MNPs, magnetic fields, or both to assess biocompatibility and toxicity.
Study of magnetic and structural and optical properties of Zn doped Fe3O4 nan...Nanomedicine Journal (NMJ)
Objective(s):
This paper describes synthesizing of magnetic nanocomposite with co-precipitation
method.
Materials and Methods:
Magnetic ZnxFe3-xO4 nanoparticles with 0-14% zinc doping (x=0, 0.025, 0.05, 0.075, 0.1 and 0.125) were successfully synthesized by co-precipitation method. The prepared zinc-doped Fe3O4 nanoparticles were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), vibrating sample magnetometer (VSM) and UV-Vis spectroscopy.
Results:
results obtained from X-ray diffraction pattern have revealed the formation of single phase nanoparticles with cubic inverse spinal structures which size varies from 11.13 to 12.81 nm. The prepared nanoparticles have also possessed superparamagnetic properties at room temperature and high level of saturation magnetization with the maximum level of 74.60 emu/g for x=0.075. Ms changing in pure magnetite nanoparticles after impurities addition were explained based on two factors of “particles size” and “exchange interactions”. Optical studies results revealed that band gaps in all Zn-doped NPs are higher than pure Fe3O4. As doping percent increases, band gap value decreases from 1.26 eV to 0.43 eV.
Conclusion:
These magnetic nanocomposite structures since having superparamagnetic property
offer a high potential for biosensing and biomedical application.
Preparation and characterization of nimesulide loaded cellulose acetate hydro...Jing Zang
The aim of this study is to prepare nimesulide loaded cellulose acetate hydrogen phthalate nanoparticles by salting out technique. In this study Cellulose acetate Hydrogen phthalate was taken as polymer. Nimesulide was selected as a model drug. This technique is suitable for drugs and polymers that are soluble in polar solvents such as acetone or ethanol. The effect of drug concentration and polymer concentration on nanoparticle size, shape, uniform size distribution and stability was studied. Nanoparticles were evaluated for particle size, zetapotential and particle size distribution. Size of the particle was measured by SEM.(Scanning electron microscope).Surface charge and stability of the resultant nanoparticles was determined by Zetasizer. Particle size distribution was determined by Photon Correlation Spectroscopy (PCS) with a Malvern Zetasizer Nano-ZS. The cellulose acetate hydrogen phthalate concentration and nimesulide concentration was varied from 5mg/ml to 10 mg/ml. The effect of drug and polymer concentrations on nanoparticle size, shape, particle size distribution was studied. Increased drug concentration has no impact on the particle size. The size of the particle was found to be decreased with increased polymer concentration. Increased polymer concentration has resulted in uniform particle size distribution. Higher the polymer concentrations and lower the drug concentrations resulted in uniform particle size distribution.
THE TREATMENT OF INFECTIONS ON TOOTH SURFACES AND IN ROOT CANALS WITH THREE DIFFERENT LASER MODALITIES: Photodynamic Therapy, Photothermal Therapy, Photoablation
Greener cum chemical synthesis and characterization of Mg doped ZnS nanoparti...IJERA Editor
In the present investigations, high-quality Mg doped ZnS nanoparticles were synthesized by Greener cum
chemical process with the assistance of polyvinyl pyrrolidone (PVP) with two different Mg concentrations.
Doping of Mg metal in nanoparticles were found to be a good technique for tuning the band gap of ZnS
nanoparticles. Simultaneously, Mg doping also inhibited the growth of particle size and it decreased from 33.2
nm to 18.3 nm with the increase in doping concentration from 0% to 5%. Band gap was found to rise from 3.12
eV to 3.38 eV and photoluminescence studies exposed that visible Photoluminescence (PL) emission was
improved with doping concentration. The nanoparticles have been characterized by Field Emission Scanning
Electron Microscopy (FESEM), X-Ray Diffraction (XRD), Fourier Transform Infrared (FTIR) spectroscopy,
Ultra Violet visible (UV–vis) spectroscopy, and Energy Dispersive X-ray Analysis (EDAX).
the branch of technology that deals with dimensions and tolerances of less than 100 nanometres, especially the manipulation of individual atoms and molecules.
Effect of Fe3O4 Nanoparticles on Structure and Activity of Brain MicrotubulesAli Dadras
Microtubules are the most important proteins existing in eukaryotic cells specially neurons in which microtubules array parallel. Microtubules are composed of tubulin dimers which have rather high dipole moment. Probable vibrations in such electric dipoles could lead to electromagnetic field around microtubules. So it is interesting to know the effect of low frequency magnetic field on microtubule structure and activities.
In this paper, it has been tried to use Fe3O4 nanomagnets to investigate microtubules dynamic and function by turbidimetry methods and TEM, therefore analyze probable changes in tubulin structure by the methods of fluorescence spectrophotometer. We found the increase of tubulin activities and conformational changes by the usage of these nanomagnets in vitro. Also microtubule orientation toward nanomagnets has been observed.
Learn how hyperthermia treatments (thermal therapy) can dramatically improve your response to radiation or chemotherapy. There are several mechanisms for action with how this treatment works biologically, and some cancers respond better than others. Contact Cyrus Rafie at (888) 580-5900 or visit http://www.bhthermalmedicine.com
Study of magnetic and structural and optical properties of Zn doped Fe3O4 nan...Nanomedicine Journal (NMJ)
Objective(s):
This paper describes synthesizing of magnetic nanocomposite with co-precipitation
method.
Materials and Methods:
Magnetic ZnxFe3-xO4 nanoparticles with 0-14% zinc doping (x=0, 0.025, 0.05, 0.075, 0.1 and 0.125) were successfully synthesized by co-precipitation method. The prepared zinc-doped Fe3O4 nanoparticles were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), vibrating sample magnetometer (VSM) and UV-Vis spectroscopy.
Results:
results obtained from X-ray diffraction pattern have revealed the formation of single phase nanoparticles with cubic inverse spinal structures which size varies from 11.13 to 12.81 nm. The prepared nanoparticles have also possessed superparamagnetic properties at room temperature and high level of saturation magnetization with the maximum level of 74.60 emu/g for x=0.075. Ms changing in pure magnetite nanoparticles after impurities addition were explained based on two factors of “particles size” and “exchange interactions”. Optical studies results revealed that band gaps in all Zn-doped NPs are higher than pure Fe3O4. As doping percent increases, band gap value decreases from 1.26 eV to 0.43 eV.
Conclusion:
These magnetic nanocomposite structures since having superparamagnetic property
offer a high potential for biosensing and biomedical application.
Preparation and characterization of nimesulide loaded cellulose acetate hydro...Jing Zang
The aim of this study is to prepare nimesulide loaded cellulose acetate hydrogen phthalate nanoparticles by salting out technique. In this study Cellulose acetate Hydrogen phthalate was taken as polymer. Nimesulide was selected as a model drug. This technique is suitable for drugs and polymers that are soluble in polar solvents such as acetone or ethanol. The effect of drug concentration and polymer concentration on nanoparticle size, shape, uniform size distribution and stability was studied. Nanoparticles were evaluated for particle size, zetapotential and particle size distribution. Size of the particle was measured by SEM.(Scanning electron microscope).Surface charge and stability of the resultant nanoparticles was determined by Zetasizer. Particle size distribution was determined by Photon Correlation Spectroscopy (PCS) with a Malvern Zetasizer Nano-ZS. The cellulose acetate hydrogen phthalate concentration and nimesulide concentration was varied from 5mg/ml to 10 mg/ml. The effect of drug and polymer concentrations on nanoparticle size, shape, particle size distribution was studied. Increased drug concentration has no impact on the particle size. The size of the particle was found to be decreased with increased polymer concentration. Increased polymer concentration has resulted in uniform particle size distribution. Higher the polymer concentrations and lower the drug concentrations resulted in uniform particle size distribution.
THE TREATMENT OF INFECTIONS ON TOOTH SURFACES AND IN ROOT CANALS WITH THREE DIFFERENT LASER MODALITIES: Photodynamic Therapy, Photothermal Therapy, Photoablation
Greener cum chemical synthesis and characterization of Mg doped ZnS nanoparti...IJERA Editor
In the present investigations, high-quality Mg doped ZnS nanoparticles were synthesized by Greener cum
chemical process with the assistance of polyvinyl pyrrolidone (PVP) with two different Mg concentrations.
Doping of Mg metal in nanoparticles were found to be a good technique for tuning the band gap of ZnS
nanoparticles. Simultaneously, Mg doping also inhibited the growth of particle size and it decreased from 33.2
nm to 18.3 nm with the increase in doping concentration from 0% to 5%. Band gap was found to rise from 3.12
eV to 3.38 eV and photoluminescence studies exposed that visible Photoluminescence (PL) emission was
improved with doping concentration. The nanoparticles have been characterized by Field Emission Scanning
Electron Microscopy (FESEM), X-Ray Diffraction (XRD), Fourier Transform Infrared (FTIR) spectroscopy,
Ultra Violet visible (UV–vis) spectroscopy, and Energy Dispersive X-ray Analysis (EDAX).
the branch of technology that deals with dimensions and tolerances of less than 100 nanometres, especially the manipulation of individual atoms and molecules.
Effect of Fe3O4 Nanoparticles on Structure and Activity of Brain MicrotubulesAli Dadras
Microtubules are the most important proteins existing in eukaryotic cells specially neurons in which microtubules array parallel. Microtubules are composed of tubulin dimers which have rather high dipole moment. Probable vibrations in such electric dipoles could lead to electromagnetic field around microtubules. So it is interesting to know the effect of low frequency magnetic field on microtubule structure and activities.
In this paper, it has been tried to use Fe3O4 nanomagnets to investigate microtubules dynamic and function by turbidimetry methods and TEM, therefore analyze probable changes in tubulin structure by the methods of fluorescence spectrophotometer. We found the increase of tubulin activities and conformational changes by the usage of these nanomagnets in vitro. Also microtubule orientation toward nanomagnets has been observed.
Learn how hyperthermia treatments (thermal therapy) can dramatically improve your response to radiation or chemotherapy. There are several mechanisms for action with how this treatment works biologically, and some cancers respond better than others. Contact Cyrus Rafie at (888) 580-5900 or visit http://www.bhthermalmedicine.com
Hyperthermia, a non-invasive gentle cancer treatment, raises tumor temperature to approximately 110 degrees Fahrenheit, a temperature similar to a high fever.
The Center for Thermal Oncology 888-580-5900
Cyrus Rafie is a pioneer in the field of hyperthermia for cancer treatment. He has been involved with treatment of more 3000 cancer patients using hyperthermia.
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The Center for Thermal Oncology is cancer treatment center offering thermal therapy heat treatments, also known as hyperthermia, in coordination with the patient’s physician to optimize their outcome. The coupling of thermal heat therapy with traditional cancer healing modalities has scientifically proven to improve treatment efficacy and response by up to 44% - without side effects.
The Center for Thermal Oncology is the only freestanding center to employ hyperthermia cancer treatments, allowing patient’s to keep the physician they love. We are happy to coordinate care with a chosen physician, or recommend one to the patient.
The idea of using heat as a curative modality is not new, and is based on the natural response of the body to disease. In fact, Hippocrates, the “father of medicine” said, “What is not cured by the knife, may be cured by fire.” The ancient Egyptians also recorded using heat for healing in their hieroglyphic texts. And now, 30 years of modern scientific research has determined that the combination of heat treatment with radiation and/or chemotherapy dramatically improves cancer treatment response rates by as much as 44% - without side effects.
Thermal therapy is FDA approved and covered by most insurance, and has proven to be effective on a variety of different types of cancer and has exhibited marked results. In some studies, it has doubled a patient's response rate to radiation therapy: increasing survival, eliminating tumor sites, shrinking tumors and offering palliation. Increased survival and improved response rate has been clinically shown in these areas: Head and neck, thyroid, prostate, breast, axilla, chest, cervical and gynecological, colon, throat, melanoma, base of tongue, among others.
The Center for Thermal Oncology is a unique and innovative cancer treatment clinic that operates with only one goal in mind - positive results. We are uniquely qualified to succeed with each patient’s treatment. Our mission is to help our patients utilize every integrated and traditional method to assist them in regaining health and beating cancer.
Thermo-sensitization of tumor to radiation therapy through a process now as Radio-thermotherapy (hyperthermia and radiation therapy) to treat cancer cells.
Presentation on Nanoparticles Smart Drug Delivery System For Cancer no company
Nano technology is a rapidly expanding field, encompassing the development of a man-made materials in 5-200 nanometer size range. This dimension vastly exceeds that of standard organic molecules.
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Various Approach for the Treatment of Cancer - using Nano-Technologyijsrd.com
the credential part of the paper reviews about the advanced methods for the treatment of cancer using nano devices and nano technology technique. The advanced technology which could be the best to treat cancer is the treatment using nano-technology the molecular scale properties and the interface between the chemical, biological and the physical sciences are the important concerns of nano-technology. The application in the treatment of cancer using nano- technology is promising more than the ordinary treatments. This paper also proposes the use of nano-robots in medical field is the fast, best, and safe method for the treatment of different diseases in the human body. The main stress given in the paper is the comparison of the latest treatment in curing cancer using nano-technology.
7. Magnetic hyperthermia:
Magnetic nanoparticles are used in an experimental
cancer treatment called magnetic hyperthermia in
which the fact that nanoparticles heat when they are
placed in an alternative magnetic field is used.
12. Cytotoxicity (Tissue Culture)
Cell culture assays are used to assess the
biocompatibility of a material or extract through
the use of isolated cells in vitro.
These techniques are useful in evaluating the
toxicity or irritancy potential of materials and
chemicals.
They provide an excellent way to screen
materials prior to in vivo tests.
