Children with epilepsy are at risk for cognitive difficulties like lower IQ, learning problems, and academic underachievement due to factors like underlying brain abnormalities, seizures, and medication side effects. While half of children with epilepsy develop normally, certain epilepsy syndromes carry a higher risk of intellectual disability or unfavorable cognitive outcomes. Autism also commonly co-occurs with epilepsy, especially among those with intellectual disabilities, suggesting shared neurological mechanisms. Anti-seizure medications can cause mild to moderate cognitive impairments involving slowed processing, reduced working memory, and decreased mental flexibility, with effects varying between medications.
Epilepsy awareness training innovations slidesharePatrick Doyle
This Epilepsy Awareness training course is aimed at raising awareness of the importance of the safe care and management of epilepsy. The course explores some of the common misconceptions about epilepsy and to care for someone who experiences seizures. On completion of this course staff will be aware of the clinical features of epilepsy and contribute to the care and wellbeing of patients who experience epileptic seizures.
Duration: 2 hours
Experience: None required.
This course is suitable for all staff currently working within health and social care settings in the United Kingdom who may come into contact with patients who experience epileptic seizures.
Number of Trainees: 16 maximum
Course Standard: Certificate of attendance
Equipment Needed: Hand-outs will be provided
Candidates will cover:
•Definitions, diagnosis and symptoms of epilepsy, including the nature and incidence of epilepsy
•Seizures and seizure types
•Care and treatment of epilepsy, including basic first aid and emergency care
•What to do when caring for a patient experiencing an epileptic seizure
•Care and management of patients who experience epileptic seizures
•Living with epilepsy
By the end of the course Candidates will be able to:
•Describe the diagnosis, symptoms and different types of epilepsy
•Understand and demonstrate the care and treatment of patients with epilepsy
•Understand the impact of epileptic seizures
•Contribute to the care-planning and safe management and care of patients who experience epileptic seizures, including basic first aid for epileptic sufferers
Through this project, we created a helpful resource for children diagnosed with epilepsy to bring with them to sleepovers or in instances where they are surrounded by people who are unfamiliar with epilepsy. We also covered the background of epilepsy as well as treatments and prognosis for this disorder.
The epilepsies are a spectrum of brain disorders ranging from severe,
life-threatening and disabling, to ones that are much
more benign. In epilepsy, the normal
pattern of neuronal activity becomes disturbed, causing strange
sensations, emotions,
and behavior or sometimes convulsions,
muscle spasms, and loss of consciousness. The epilepsies have many
possible causes
and there are several types of seizures.
Anything that disturbs the normal pattern of neuron activity—from
illness to brain
damage to abnormal brain development—can
lead to seizures.
Epilepsy may develop because of an abnormality in
brain wiring,
an imbalance of nerve signaling chemicals
called neurotransmitters, changes in important features of brain cells
called channels,
or some combination of these and other
factors. Having a single seizure as the result of a high fever (called
febrile seizure)
or head injury does not necessarily mean
that a person has epilepsy. Only when a person has had two or more
seizures is he
or she considered to have epilepsy. A
measurement of electrical activity in the brain and brain scans such as
magnetic resonance
imaging or computed tomography are common
diagnostic tests for epilepsy.
More than 10 million people suffer from epilepsy in India.Seizures impact the lives of people with epilepsy and their family in many ways including creating barriers to employment and education and facing a sense of discrimination and isolation from their peers who donʼt understand what happens when they see a seizure occur. In India, epilepsy is still thought of as mental illness mainly due to lack of information on the condition among the general public.
This presentation touches every aspect of epilepsy
1. Overview of Epilepsy;
2. Type of Seizures;
3. Diagnosis and Management;
4. Psychological Issues; and
5. Social Perspectives.
Epilepsy: A Neurological Condition Affecting the Nervous System. Epilepsy is also known as a seizure disorder. Here is a quick who, what, where, when, why, and how about epilepsy.
Epilepsy awareness training innovations slidesharePatrick Doyle
This Epilepsy Awareness training course is aimed at raising awareness of the importance of the safe care and management of epilepsy. The course explores some of the common misconceptions about epilepsy and to care for someone who experiences seizures. On completion of this course staff will be aware of the clinical features of epilepsy and contribute to the care and wellbeing of patients who experience epileptic seizures.
Duration: 2 hours
Experience: None required.
This course is suitable for all staff currently working within health and social care settings in the United Kingdom who may come into contact with patients who experience epileptic seizures.
Number of Trainees: 16 maximum
Course Standard: Certificate of attendance
Equipment Needed: Hand-outs will be provided
Candidates will cover:
•Definitions, diagnosis and symptoms of epilepsy, including the nature and incidence of epilepsy
•Seizures and seizure types
•Care and treatment of epilepsy, including basic first aid and emergency care
•What to do when caring for a patient experiencing an epileptic seizure
•Care and management of patients who experience epileptic seizures
•Living with epilepsy
By the end of the course Candidates will be able to:
•Describe the diagnosis, symptoms and different types of epilepsy
•Understand and demonstrate the care and treatment of patients with epilepsy
•Understand the impact of epileptic seizures
•Contribute to the care-planning and safe management and care of patients who experience epileptic seizures, including basic first aid for epileptic sufferers
Through this project, we created a helpful resource for children diagnosed with epilepsy to bring with them to sleepovers or in instances where they are surrounded by people who are unfamiliar with epilepsy. We also covered the background of epilepsy as well as treatments and prognosis for this disorder.
The epilepsies are a spectrum of brain disorders ranging from severe,
life-threatening and disabling, to ones that are much
more benign. In epilepsy, the normal
pattern of neuronal activity becomes disturbed, causing strange
sensations, emotions,
and behavior or sometimes convulsions,
muscle spasms, and loss of consciousness. The epilepsies have many
possible causes
and there are several types of seizures.
Anything that disturbs the normal pattern of neuron activity—from
illness to brain
damage to abnormal brain development—can
lead to seizures.
Epilepsy may develop because of an abnormality in
brain wiring,
an imbalance of nerve signaling chemicals
called neurotransmitters, changes in important features of brain cells
called channels,
or some combination of these and other
factors. Having a single seizure as the result of a high fever (called
febrile seizure)
or head injury does not necessarily mean
that a person has epilepsy. Only when a person has had two or more
seizures is he
or she considered to have epilepsy. A
measurement of electrical activity in the brain and brain scans such as
magnetic resonance
imaging or computed tomography are common
diagnostic tests for epilepsy.
More than 10 million people suffer from epilepsy in India.Seizures impact the lives of people with epilepsy and their family in many ways including creating barriers to employment and education and facing a sense of discrimination and isolation from their peers who donʼt understand what happens when they see a seizure occur. In India, epilepsy is still thought of as mental illness mainly due to lack of information on the condition among the general public.
This presentation touches every aspect of epilepsy
1. Overview of Epilepsy;
2. Type of Seizures;
3. Diagnosis and Management;
4. Psychological Issues; and
5. Social Perspectives.
Epilepsy: A Neurological Condition Affecting the Nervous System. Epilepsy is also known as a seizure disorder. Here is a quick who, what, where, when, why, and how about epilepsy.
Neuropsychiatric aspects of hiv infection and aidsRobin Victor
HIV & AIDS are closely related to psychiatry with the infection giving rise to many psychiatric problems and psychiatric illnesses leading to risk of acquiring HIV. Hence the approach to such a situation must be holistic with good coordination between medical specialists and psychiatrists, psychologists to bring maximum possible benefit to people with such a difficult illness
HIV and Psychiatry , Neuropsychiatric aspects of HIV , AIDS , Breaking bad news in HIV , Psychiatric intervention in HIV , Neuropsychiatric complications of HIV and AIDS
Prof. Dr. Vladimir Trajkovski - Health issues and health care in ASD Vladimir Trajkovski
Prof. Dr. Vladimir Trajkovski presented topic: Health issues and health care in persons with autism spectrum disorders at international autism conference held in Krakow September 27th, 2018.
President of MSSA Prof. Dr. Vladimir Trajkovski prsented the his topic: "Association between cerebral palsy and autism spectrum disorders" at 8th interdisciplinary congress: "Cerebral palsy and other movement disorders" on 1-2 of November 2018 in Moscow, Russia.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
3. Pediatric Epilepsy Cognition Children with epilepsy have a disproportionate share of problems with learning and behavior As a group they have an average IQ that is 10 points below normal There is a 3-fold increase in mental retardation Even those without mental retardation are at risk of academic underachievement or school failure
4. Pediatric Epilepsy Cognition On the bright side Half of children with epilepsy have normal academic records Two-thirds are in regular classes More than 80% are working at grade level A majority of children with epilepsy develop normally and have normal cognitive abilities
5. Pediatric Epilepsy Cognition Perception and attention have been found to be two of the major factors associated with learning difficulties in children with epilepsy Boys have more problems than girls It is difficult to determine the cause for academic difficulties in children with epilepsy
7. Pediatric Epilepsy Cognition The underlying brain disease , not the seizures, is the most important factor contributing to subnormal intellect in children with epilepsy
8. Pediatric Epilepsy Cognition Epileptic syndrome and prognosis for cognitive function Unfavorable cognitive development West syndrome Lennox-Gastaut syndrome Doose’s syndrome Landau-Kleffner syndrome Rett syndrome
9. Pediatric Epilepsy Cognition Epileptic syndrome and prognosis for cognitive function Favorable cognitive development Febrile seizures Childhood absence epilepsy Benign partial epilepsy of childhood (Rolandic epilepsy) Juvenile myoclonic epilepsy
10. Pediatric EpilepsyAutism Neurodevelopmental disorder affecting primarily social communication but associated with language impairments and repetitive behaviors Autism spectrum disorders: a broader group of children including those with autism disorder, pervasive developmental disorders not otherwise specified, and those with Asperger’s syndrome
11. Pediatric EpilepsyAutism There is no clear evidence that epilepsy causes autism The contribution of epilepsy and interictal epileptiform discharges to ongoing cognitive deficits in children with autism remains poorly understood and controversial There is evidence that common shared anatomical and molecular mechanisms may account for both epilepsy and autism
12. Pediatric EpilepsyAutism Epilepsy and autism coexist in up to 20% of children with either disorder Intellectual disability show a very high prevalence in those with both autism and epilepsy Early onset seizures may be a factor in making infants at higher risk of autism
13. Pediatric EpilepsyAutism Epilepsy was noted in 21% of individuals with autism and intellectual disability versus 8% in individuals with autism without intellectual disability. There is consensus that there is a strong association between epilepsy, autism, intellectual and motor disability in infants with epileptic encephalopathy, the overall effect of both epilepsy and interictal epileptiform activity,
14. Pediatric EpilepsyAutism Mechanisms that lead to epilepsy may also affect the development of social cognition A recent study revealed malformations of cortical development in 12 of 13 autism brains and in only 1 of 14 control brains. Such malformations of cortical development are commonly found in children with epilepsy
15. Pediatric EpilepsyAutism Genome wide studies are demonstrating “copy number variants” or CNVs (deletions, duplications, and insertions) that are common to both epilepsy and autism.
16. Pediatric EpilepsyMedication Effects on Cognition Cognitive side effects are generally reported to be mild to moderate in magnitude compared with most of the other types of side effects. Some studies suggest such side effects have a greater impact on function and daily living than previously suspected.
17. Pediatric EpilepsyMedication Effects on Cognition Types of cognitive impairment Depressed capacity of the information-processing system by producing slowing Decreased the input of working memory Decreased mental flexibility
18. Pediatric EpilepsyMedication Effects on Cognition Many studies done only compare one agent with another that is thought to have a “favorable cognitive profile”
19. Pediatric EpilepsyMedication Effects on Cognition Phenobarbital Cognitive impairment including visual motor and memory tests Phenytoin (Dilantin) Attention, memory and memory speed Valproate (Depakote) Impairment of mental speed
20. Pediatric EpilepsyMedication Effects on Cognition Carbamazepine (Tegretol) Favorable compared with other “older” AED’s Lamotrigine (Lamictal) Does not impair cognition May benefit mental performance “Euphoria” secondary to impact of cognitive productivity Oxcarbazepine (Trileptal) No impairment/improved cognitive functioning
21. Pediatric EpilepsyMedication Effects on Cognition Topiramate Dose related slowing of mental speed and inattentiveness Word finding difficulty Felbatol (Felbamate) “Alerting” No formal studies have been done Gabapentin (Neurontin) Well tolerated cognitively
22. Pediatric EpilepsyMedication Effects on Cognition Vigabatrin (Sabril) Few cognitive side effects Zonisamide (Zonegran) Sedation Lacosamide (Vimpat) Sleepiness/fatigue Rufinamide (Banzel) Sleepiness/fatigue