This document discusses meningitis, including the different types (bacterial, viral, fungal), their causes and risk factors, how they spread, and details about lumbar puncture and CSF glucose testing. Bacterial meningitis is the most serious type and can be deadly if not treated promptly. Viral meningitis is the most common type and usually less severe. Fungal meningitis is rare and usually affects those with weakened immune systems. Lumbar puncture is used to collect CSF for glucose and other tests to help diagnose meningitis. Abnormal glucose levels in the CSF can indicate infection or other issues.
Encephalitis is a rare yet serious disease that can be life-threatening.
Encephalitis is an inflammation of the brain tissue.
The most common cause is viral infections.
In rare cases it can be caused by bacteria or even fungi.
Encephalitis is an inflammation of the brain tissue.
Primary encephalitis- It occurs when a virus directly infects the brain and spinal cord.
Secondary encephalitis- It occurs when an infection starts elsewhere in the body and then travels to your brain.
Older adults
Children under the age of 1 year
People with weak immune systems
Primary (infectious) encephalitis
Common viruses, including HSV (herpes simplex virus) and EBV (Epstein-Barr virus)
Childhood viruses, including measles and mumps
Arboviruses (spread by mosquitoes, ticks, and other insects), including Japanese encephalitis, West Nile encephalitis, and tick-borne encephalitis
Secondary encephalitis: could be caused by a complication of a viral infection.
Encephalitis is a rare yet serious disease that can be life-threatening.
Encephalitis is an inflammation of the brain tissue.
The most common cause is viral infections.
In rare cases it can be caused by bacteria or even fungi.
Encephalitis is an inflammation of the brain tissue.
Primary encephalitis- It occurs when a virus directly infects the brain and spinal cord.
Secondary encephalitis- It occurs when an infection starts elsewhere in the body and then travels to your brain.
Older adults
Children under the age of 1 year
People with weak immune systems
Primary (infectious) encephalitis
Common viruses, including HSV (herpes simplex virus) and EBV (Epstein-Barr virus)
Childhood viruses, including measles and mumps
Arboviruses (spread by mosquitoes, ticks, and other insects), including Japanese encephalitis, West Nile encephalitis, and tick-borne encephalitis
Secondary encephalitis: could be caused by a complication of a viral infection.
Glomerulonephritis is inflammation of the tiny filters in your kidneys (glomeruli). Glomeruli remove excess fluid, electrolytes and waste from your bloodstream and pass them into your urine.
Small intestine perforation- Easy ppt for student nurses
definition
causes
clinical manifestations
diagnostic tests
management of small intestine perforation
Glomerulonephritis is inflammation of the tiny filters in your kidneys (glomeruli). Glomeruli remove excess fluid, electrolytes and waste from your bloodstream and pass them into your urine.
Small intestine perforation- Easy ppt for student nurses
definition
causes
clinical manifestations
diagnostic tests
management of small intestine perforation
simplified Microbiological Approach to One of the most serious clinical situations worldwide .. with focused information about causes , diagnosis , treatment , prevention and epidemiology ..
making " meningitis " incredibly easy
Bacterial Meningitis in Paediatrics A Review.pdfPUBLISHERJOURNAL
Emmanuel Ifeanyi Obeagu1, Sowdo Abdirizak Mohamed2, Ugwu Okechukwu Paul-Chima3, Getrude Uzoma Obeagu4 and Chukwunalu Igbudu Umoke5
1Department of Medical Laboratory Science, Kampala International University, Uganda.
2Department of Pediatrics, Kampala International University, Uganda.
3Department of Publication and Extension, Kampala International University, Uganda.
4Department of Nursing Science, Kampala International University, Uganda.
5Department of Human Anatomy, Alex Ekwueme Federal University, Ndufu Alike, Ikwo, Ebonyi State, Nigeria.
Email:emmanuelobeagu@yahoo.com
________________________________________
ABSTRACT
Meningitis is a potentially life-threatening condition characterized by infection or inflammation of the central nervous system. It is classified as bacterial, viral, or aseptic. Delayed or untreated bacterial meningitis is associated with high morbidity and mortality. It is important to accurately distinguish between bacterial and nonbacterial meningitis. Most physicians will perform a lumbar puncture and consider antibiotics for all infants and children with suspected meningitis. Having a clinical prediction rule to determine the need for lumbar puncture and which patients need antibiotics could reduce morbidity and the cost associated with unnecessary procedures and treatment. Several clinical prediction rules to determine the risk of bacterial meningitis have been proposed. One clinical prediction rule, derived and validated from cohorts seen in pediatric hospitals in the Netherlands, found that altered consciousness, meningeal irritation, cyanosis, petechiae, vomiting, duration of main symptom, and an elevated C-reactive protein and Erythrocyte Sedimentation Rate level were independent predictors of bacterial meningitis. Patients below a predefined threshold on a risk score incorporating these elements could be safely considered as not having bacterial meningitis.
Keywords: Bacteria, Meningitis, petechiae, C - reactive protein, pediatrics, ESR
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
2. What is the meningitis and what are the
types?
Meningitis is an inflammation (swelling) of the protective membranes
covering the brain and spinal cord. A bacterial or viral infection of the fluid
surrounding the brain and spinal cord usually causes the swelling. However,
injuries, cancer, certain drugs, and other types of infections also can cause
meningitis. It is important to know the specific cause of meningitis because
the treatment differs depending on the cause.
3.
4. What is Bacterial Meningitis?
Bacterial meningitis is very serious and can be deadly.
Death can occur in as little as a few hours. Most people
recover from meningitis. However, permanent
disabilities (such as brain damage, hearing loss, and
learning disabilities) can result from the infection.
5. How B. Meningitis spread?
Generally, the germs that cause bacterial meningitis spread from one person to another. Certain
germs, such as Listeria monocytogenes, can spread through food.
How people spread the germs often depends on the type of bacteria. It is also important to know
that people can carry these bacteria in or on their bodies without being sick. These people are
“carriers.” Most carriers never become sick, but can still spread the bacteria to others.
Here are some of the most common examples of how people spread each type of bacteria to each
other:
Mothers can pass group B Streptococcus and Escherichia coli to their babies during labor and
birth.
People spread Hib and Streptococcus pneumoniae by coughing or sneezing while in close
contact with others, who breathe in the bacteria.
People spread Neisseria meningitidis by sharing respiratory or throat secretions (saliva or spit).
This typically occurs during close (coughing or kissing) or lengthy (living in the same
household) contact.
People can get Escherichia coli by eating food prepared by people who did not wash their hands
well after using the toilet.
People usually get sick from Escherichia coli and Listeria monocytogenes by eating contaminated
food
6. Risk factors of B. Meningitis
Age
Babies are at increased risk for bacterial meningitis compared to people in other
age groups. However, people of any age can develop bacterial meningitis. See
section above for which bacteria more commonly affect which age groups.
Community setting
Infectious diseases tend to spread where large groups of people gather together.
College campuses have reported outbreaks of meningococcal disease, caused by
N. meningitidis.
Certain medical conditions
There are certain medical conditions, medications, and surgical procedures that
put people at increased risk for meningitis.
Working with meningitis-causing pathogens
Microbiologists routinely exposed to meningitis-causing bacteria are at
increased risk for meningitis.
7.
8. What is Viral Meningitis? How it spread?
Viral meningitis causesd by viruses , it is the most common type of meningitis, an
inflammation of the tissue that covers the brain and spinal cord. It is often less
severe than bacterial meningitis, and most people get better on their own (without
treatment). However, it’s very important for anyone with symptoms of meningitis
to see a healthcare provider right away because some types of meningitis can be
very serious, and only a doctor can determine if you have the disease, the type of
meningitis, and the best treatment, which can sometimes be lifesaving.
If you have close contact with a person who has viral meningitis, you may become
infected with the virus that made that person sick. However, you are not likely to
develop meningitis. That’s because only a small number of people who get
infected with the viruses that cause meningitis will actually develop viral
meningitis.
9. Risk Factors of V. Meningitis
children younger than 5 years old, and
people with weakened immune systems caused by diseases,
medications (such as chemotherapy), and recent organ or bone
marrow transplantations.
Babies younger than 1 month old and people with weakened immune
systems are more likely to have severe illness.
10.
11. What is Fungal Meningitis ? How it spread?
Fungal meningitis is rare and usually caused by fungus spreading through
blood to the spinal cord. Although anyone can get fungal meningitis,
people with weakened immune systems, like those with an HIV infection
or cancer, are at increased risk.
The most common cause of fungal meningitis for people with weak
immune systems is Cryptococcus. This disease is one of the most common
causes of adult meningitis in Africa.
Fungal meningitis is not spread from person to person. Fungal
meningitis can develop after a fungus spreads through the bloodstream
from somewhere else in the body to the brain or spinal cord or from an
infection next to the brain or spinal cord.
12. Risk factors of F. Meningitis
Certain diseases (such as diabetes , cancer and HIV),
medications, and surgical procedures may weaken the
immune system and increase your risk of getting fungal
infection, which can lead to fungal meningitis. Premature
babies with very low birth weights are also at increased risk
for getting Candida blood stream infection, which may spread
to the brain.
13. CSF glucose test
A CSF glucose test measures the amount of sugar
(glucose) in the cerebrospinal fluid (CSF). CSF is a
clear fluid that flows in the space surrounding the
spinal cord and brain.
14. How the Test is Performed
LUMBAR PUNCTURE
A lumbar puncture is a medical procedure where a needle is
inserted into the lower part of the spine to test for conditions
affecting the brain, spinal cord or other parts of the nervous
system
15. CSF is collected by lumbar puncture
between third, fourth, fifth lumbar vertebrae.
It requires certain precautions and careful
technique to prevent the introduction of
infection or the damaging of neural tissue.
Lumbar puncture
17. CSF is collected in three sterile tubes
• Tube 1 – used for chemical and serologic test: centrifuge
and use supernatant for chemistry analysis (glucose, protein, enzymes and
chloride) kept in freezer till performed.
• Tube 2 – used for microbiology lab kept in room
temperature
• Tube 3 – used for hematology (cell count) Cell counts done
as soon as possible after the fluid is collected as cellular degradation occurs
rapidly. If postponed, refrigerate for up to one hour.
18. Normal Values
The glucose level in the CSF should be 50 - 80 mg/100 mL (or greater than
2/3 of the blood sugar level).
Note: Normal value ranges may vary slightly among different laboratories.
Talk to your doctor about the meaning of your specific test results
19. What abnormal results mean?
Abnormal results include increased and decreased glucose levels. Abnormal
results may be due to:
Infection (bacterial or fungus)
Inflammation of the central nervous system
Tumors
20.
21. CSF/blood glucose ratio
Normal CSF glucose/ plasma glucose ratio is
approximately 0.6-0.7
(N.B. Ratio is decreased if plasma glucose is more than 500
mg/dl
due to saturation of the glucose carrier system to CSF
CSF/blood glucose ratio may be a better single indicator for
bacterial meningitis. Since the CSF glucose and blood glucose
values are promptly and easily obtained from a lumbar puncture