maxillary osteotomies are the surgical procedure to correct dentofacial deformities of upper jaw. It includes Le Fort I, II & III, and subapical osteotomies.
maxillary osteotomies are the surgical procedure to correct dentofacial deformities of upper jaw. It includes Le Fort I, II & III, and subapical osteotomies.
Dr. Ahmed M. Adawy
Professor Emeritus, Dep. Oral & Maxillofacial Surg.
Former Dean, Faculty of Dental Medicine
Al-Azhar University. Numerous etiologies lie behind mandibular defects including pathologic lesions, trauma related, infectious diseases and congenital defects. At present, the methods to restore mandibular defects can be classified into four basic categories:
1.Autogenous bone grafts in the form of nonvascularized free bone transfer, or vascularized tissue transfer, either pedicled or based on microvascular anastomosis
2. Distraction osteogenesis
3. Alloplastic materials (with or without bone)
4. Tissue engineered grafts
orthognathic surgery is very intresting and well knowing branch in oral surgery ....this presentation is dealing with jaw correction surgery in upper jaw.
Arthrocentesis of the temporomandibular jointAhmed Adawy
Dr. Ahmed M. Adawy, Professor Emeritus, Dep. Oral & Maxillofacial Surgery. Former Dean, Faculty of Dental Medicine, Al-Azhar University. Arthrocentesis of the temporomandibular joint refers to lavage of the upper joint space, hydraulic pressure and manipulation to release adhesions of the “anchored disc phenomenon” and improve motion. The technique of arthrocentesis is discussed together with the indications and contraindications of the procedure. Further, the presentation includes modifications of the standard technique.
Clinical & surgical management of the mandibular condylar process fractures has generated a great deal of controversy in maxillofacial trauma and there are many various approaches to treat this injury. Before, many surgeons seem to favor closed treatment with maxillomandibular fixation (MMF), but recently open treatment of condylar fractures with rigid internal fixation (RIF) has become more common & acceptable. The objective of this presentation was to evaluate the factors that determine the choice of method for treatment of condylar fractures: open or closed, pointing out their indications, contra-indications, advantages and disadvantages.
Dr. Ahmed M. Adawy
Professor Emeritus, Dep. Oral & Maxillofacial Surg.
Former Dean, Faculty of Dental Medicine
Al-Azhar University. Numerous etiologies lie behind mandibular defects including pathologic lesions, trauma related, infectious diseases and congenital defects. At present, the methods to restore mandibular defects can be classified into four basic categories:
1.Autogenous bone grafts in the form of nonvascularized free bone transfer, or vascularized tissue transfer, either pedicled or based on microvascular anastomosis
2. Distraction osteogenesis
3. Alloplastic materials (with or without bone)
4. Tissue engineered grafts
orthognathic surgery is very intresting and well knowing branch in oral surgery ....this presentation is dealing with jaw correction surgery in upper jaw.
Arthrocentesis of the temporomandibular jointAhmed Adawy
Dr. Ahmed M. Adawy, Professor Emeritus, Dep. Oral & Maxillofacial Surgery. Former Dean, Faculty of Dental Medicine, Al-Azhar University. Arthrocentesis of the temporomandibular joint refers to lavage of the upper joint space, hydraulic pressure and manipulation to release adhesions of the “anchored disc phenomenon” and improve motion. The technique of arthrocentesis is discussed together with the indications and contraindications of the procedure. Further, the presentation includes modifications of the standard technique.
Clinical & surgical management of the mandibular condylar process fractures has generated a great deal of controversy in maxillofacial trauma and there are many various approaches to treat this injury. Before, many surgeons seem to favor closed treatment with maxillomandibular fixation (MMF), but recently open treatment of condylar fractures with rigid internal fixation (RIF) has become more common & acceptable. The objective of this presentation was to evaluate the factors that determine the choice of method for treatment of condylar fractures: open or closed, pointing out their indications, contra-indications, advantages and disadvantages.
[Dr. Suh's thesis in International journal SCI]
“A Novel technique for short nose correction”
The nominated thesis is about A Novel technique for short nose correction; Hybrid septal extension graft that have acquired the favorable reputation internationally based on the advanced clinical experiences.
Dedicated to my late professor safeer khalil whose guidance lives in our minds.professor late lady reading hospital peshawar and hayatabad medical complex peshawar
Dedicated to our late teacher professor dr umar khitab who taught us with full dedication .his legacy lives in the form of his students through out the world
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
3. Anatomical landmarks
• Anatomical landmarks considered for the
incision are medial axillary line,
• midclavicular line, and the
• relief of the 6th or 7th costal arch
5. Rib cartilages are identified on supine position. The clavicle
and xyphoid process is a key landmark and the first rib below
the clavicle is the second rib
6. Costochondral Graft (CCG) Harvest
Technique
1. The anterior chest wall is prepped and draped,
allowing for visualization of the sternum, clavicle,
nipple, and umbilicus
2.The ribs are counted and marked with a marking pen.
3. A sterile marking pen is used to outline a 6–8
cm line within the inframammary crease of
female patients or at the level of the sixth or
seventh rib in male patients. In pediatric
female patients, the incision is placed in the
anticipated future location of the
inframammary crease.
7. A 6 cm incision is marked corresponding to the anticipated
location of the inframammary crease, which corresponds
to rib #6.
8. Costochondral Graft (CCG) Harvest
Technique
4.Local anesthetic containing a vasoconstrictor is used to
infiltrate the subcutaneous tissue overlying the rib to be
harvested.
5. Digital pressure is used to identify the fifth,
sixth, or seventh rib and the costochondral
spaces. A 6–8 cm skin incision is made with a
#15 blade directly over the superior aspect of
the rib to be harvested. The incision transverses
skin, subcutaneous tissue, and pectoralis
muscle down to the perios- teum directly
overlying the rib.
9. Dissection directly over the superior aspect of the rib to be harvested.
The incision transverses skin, subcutaneous tissue, and pectoralis
muscle.
10. Costochondral Graft (CCG) Harvest
Technique
6. A #9 periosteal elevator is used to dissect circumfer-
entially around the rib. A tissue plane is developed
between the rib’s periosteum–perichondrium and
the thin parietal pleura . The subperiosteal dissection
continues laterally as far as is needed and medially
until the costochondral junction is reached. It is
important to stay subperiosteal in order to avoid
injury to the vascular bundle on the inferior portion
of the rib.
11. A #9 periosteal elevator is used to dissect circumferen- tially around the
rib. A tissue plane is developed between the rib's periosteum
perichondrium and the thin parietal pleura.
12. Costochondral Graft (CCG) Harvest
Technique
7)At the costochondral junction, dissection proceeds
in a supraperichondrial plane so as not to detach the
hyaline cartilaginous cap from the medial aspect of
the rib.
8)A guillotine rib cutter is used to transect the lateral
portion of the rib.
13. Costochondral Graft (CCG) Harvest
Technique
9) Either a Doyen retractor or a silk suture is used to elevate
the rib and to check the deep mar- gin for tissue–muscle
adherence.
14. A silk suture is used to elevate the rib and to check the deep
margin for tissue–muscle adherence after osteotomy of the
lateral margin.
15. Costochondral Graft (CCG) Harvest
Technique
10. A malleable retractor is placed deep to the medial
aspect of the rib. A #10 blade is used to cut the
medial aspect of the rib preserving a 5–10 mm
cartilaginous cap. The malleable retractor will
prevent the #10 blade from cutting into the
underlying parietal pleura.
16. Costochondral Graft (CCG) Harvest
Technique
11. The harvested costochondral graft is placed within a
sterile, saline‐soaked gauze until the recipient site is
prepared.
17. Costochondral Graft (CCG) Harvest
Technique
12. Once the rib or ribs are removed, sterile
water is placed over the anterior chest wall
defect, and the anesthesiologist is asked to
provide positive pressure in order to inspect
the harvest site for pleural perforations. If no
air bubbles are present, then the harvest site
is closed in layers. If minor air bubbles are
present, pleural tears can be closed primarily
with interrupted sutures. If large air bubbles
are present, then a thoracotomy tube is
placed
18. Once the rib is removed, the anterior chest wall cavity is inspected for
any bleeding or signs of pneumothorax. Sterile water can be placed over
the anterior chest wall defect, and positive pressure is provided in order
to inspect for pleural perforations.
19. Costochondral Graft (CCG) Harvest
Technique
13. After closure of the surgical site in a layered
fashion, steri-strips are applied to provide
additional skin ten- sion. Generally, a drain is not
required.
20. Indications of costochondral graft
1)Temporomandibular joint (TMJ) replacements in pediatric patients
with active growth centers to reconstruct condylar processes defects
caused by trauma, neoplasms, infections, congenital dysplasias,
growth abnormalities, ankyloses, and rheumatoid arthritis
2. TMJ reconstruction in adult patients due to idiopathic condylar
resorption, osteoarthritis, and rheumatoid arthritis when other
methods (alloplastic joint replacement) are contraindicated
3. Reconstruction of craniomaxillofacial defects caused by loss of hard
tissue
4. Reconstruction of skull defects or cranioplasty
5. Reconstruction of nasal dorsum defects or saddle nose deformities
(costochondral cartilage)
6. Reconstruction of the helical framework of the ear (costochondral
cartilage)
21. Contraindications
• History of restrictive lung disease
• History of recent pulmonary infection
• History of cardiopulmonary instability
22. Advantages
• biological compatibility
• workability
• functional adaptability
• minimal additional detriment to the patient
• The growth potential of the costochondral
graft makes it an ideal choice in children
24. Complications
• Immediate or Early Complications
1) Pleural tears, pneumothorax, and pleuritis
2) Infection
3) Hematoma or seroma formation
4) Injury to the intercostal neurovascular
5) Fracture at the bone–cartilage interface of the
CCG
25. Late Complications
• Chest concavity: Occurs when multiple, adjacent
ribs are harvested.
• Scar formation over the breast in female
patients: Incisions in female patients should be
placed in either the inframammary crease or in
the area of the antici- pated future
inframammary crease. At no point should the
incision be placed over the developing breast
mound or near the areolas.
• Areola retraction: Occurs when the incision is
placed near the areolas.