Dr. Ahmed M. Adawy, Professor Emeritus, Dep. Oral & Maxillofacial Surgery. Former Dean, Faculty of Dental Medicine, Al-Azhar University. Arthrocentesis of the temporomandibular joint refers to lavage of the upper joint space, hydraulic pressure and manipulation to release adhesions of the “anchored disc phenomenon” and improve motion. The technique of arthrocentesis is discussed together with the indications and contraindications of the procedure. Further, the presentation includes modifications of the standard technique.
Dr. Ahmed M. Adawy, Professor Emeritus, Dep. Oral & Maxillofacial Surgery. Former Dean, Faculty of Dental Medicine, Al-Azhar University. Mandibular angle fractures account for 23% to 42% of all facial fractures. Fracture of mandibular angle can be classified as (A) Vertical favorable or unfavorable, (B) Horizontally favorable of unfavorable. Traditionally, mandibular angle fractures have been treated with either closed reduction and inter-maxillary fixation or open reduction and internal fixation with or without inter-maxillary fixation. Patients treated with inter-maxillary fixation have a restricted airway and loose excess weight. Rigid internal fixation and early return to function have eliminated the use of wire osteosenthysis and prolonged use of inter-maxillary fixation. The principal of rigid fixation, however, have inherent set of disadvantages including damage to the inferior alveolar nerve and the marginal mandibular branch of facial nerve. Postoperative malocclusion rates are also high. With the introduction of semi-rigid technique fracture of the mandibular angle could be treated according to Champy’s Ideal lines of osteosenthysis. The technique involves placement of a single monocortial miniplate on the superior border of the mandible. However, some studies suggested using a second miniplate along the inferior border. Wether one or two miniplates should be used is still debatable. The application of 3D plates may provide additional stability in 3 dimension and good resistance against torque forces.
orthognathic surgery is very intresting and well knowing branch in oral surgery ....this presentation is dealing with jaw correction surgery in upper jaw.
This seminar explains about the development, relations, ligaments, various attachments, vascular and nervous supply and various surgical approaches and its modifications to TMJ
Dr. Ahmed M. Adawy, Professor Emeritus, Dep. Oral & Maxillofacial Surgery. Former Dean, Faculty of Dental Medicine, Al-Azhar University. Mandibular angle fractures account for 23% to 42% of all facial fractures. Fracture of mandibular angle can be classified as (A) Vertical favorable or unfavorable, (B) Horizontally favorable of unfavorable. Traditionally, mandibular angle fractures have been treated with either closed reduction and inter-maxillary fixation or open reduction and internal fixation with or without inter-maxillary fixation. Patients treated with inter-maxillary fixation have a restricted airway and loose excess weight. Rigid internal fixation and early return to function have eliminated the use of wire osteosenthysis and prolonged use of inter-maxillary fixation. The principal of rigid fixation, however, have inherent set of disadvantages including damage to the inferior alveolar nerve and the marginal mandibular branch of facial nerve. Postoperative malocclusion rates are also high. With the introduction of semi-rigid technique fracture of the mandibular angle could be treated according to Champy’s Ideal lines of osteosenthysis. The technique involves placement of a single monocortial miniplate on the superior border of the mandible. However, some studies suggested using a second miniplate along the inferior border. Wether one or two miniplates should be used is still debatable. The application of 3D plates may provide additional stability in 3 dimension and good resistance against torque forces.
orthognathic surgery is very intresting and well knowing branch in oral surgery ....this presentation is dealing with jaw correction surgery in upper jaw.
This seminar explains about the development, relations, ligaments, various attachments, vascular and nervous supply and various surgical approaches and its modifications to TMJ
Mandibular Third Molar Surgery in Patients with Oral Submucous Fibrosis: Mana...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Treatment of Extremely Displaced and Impacted Second Premolar in the MandibleAbu-Hussein Muhamad
The mandibular second premolar is one of the most frequently impacted teeth. The recommended treatment is to extract the second primary molar with or without removing the bone along the eruption path, to uncover the tooth surgically and move it into the arch by orthodontic treatment. The purpose of this article is to review the principles of case management of soft tissue impacted second premolars mandibular and to illustrate their potential to respond well to the treatment. Although the scope of treatment may depend on a varying range of factors, this case report demonstrates the inherent potential for good treatment outcome in cases of soft tissue impactions.
Nasal and nasoethmoidal fractures.
Dr. Ahmed M. Adawy
Professor Emeritus, Dept. Oral & Maxillofacial Surg.
Former Dean, Faculty of Dental Medicine
Al-Azhar University
Nasal bone fractures comprise up to 50% of all facial fractures. Nasal fractures can be classified in two broad categories based on impact force: lateral-type versus frontal-type injuries. Lateral-type injuries tend to be more common, have fewer residual anatomic and functional defects compared with frontal injuries, and are more amenable to closed reduction. Frontal injuries classically produce a posteriorly displaced fracture where the nasal septum is always involved. They have a higher risk of residual post-surgical deformity, and as the impact force increases, nasal, orbital, and ethmoidal fractures occur in combination. The extent of the septal injury determines the appropriate technique for septal correction. Closed reduction of fractured nasal bone can be performed by elevation of depressed bones or depression of elevated bones to restore the symmetry of the nasal aperture. Septal injuries that cannot be realigned with a closed reduction should be addressed with open techniques. Symmetrical fixation of the bones, restoration of orbital volume, globe position, frontonasal angle, and nasal projection are essential for a satisfactory cosmetic outcome.
The primary goal of the present book is to produce a comprehensive text that fully integrates the latest concepts and techniques in management of odontogenic infections. The main aim is to provide the readers with an update information regarding pathophysiology, clinical and radiographic presentation, microbiology, diagnosis, management, and complications of odontogenic infections. Accordingly, the text has been divided into six chapters. Chapter one is concerned with oral microbiology and immunology. Chapter two is dealing with the pathophysiology of odontogenic infections. In chapter three, management of odontogenic infections is presented. In chapter four, antibiotic therapy of odontogenic infections is given. Chapter five deals with life-threatening complications. In chapter six osteomyelitis of the jaws is discussed.
Facial trauma is without doubt a most challenging area within the specialty of oral and maxillofacial surgery. Trauma with all its aspects has great importance, being the main cause of morbidity and mortality with rising frequency worldwide, especially in recent decades. Traumatic facial injuries are often associated with high mortality and varying degrees of physical, functional, psychological damage, cosmetic disfigurement, and concomitant injuries to other organs that may be added complicating factors. Road traffic accidents represent the main cause of facial trauma. According to WHO, Egypt leads the Middle East when it comes to road accidents, with an average of 12,000 people killed annually. Interpersonal violence is the second most prevalent etiologic factor. Our society is progressively becoming more and more violent and impatient, perhaps due to overcrowding, so the frequency of patients reporting in emergency with facial bones fracture is increasing.
During the last three decades, significant advances have occurred in the methods of fixation used for facial bone fractures, resulting in improved functional and aesthetic outcomes. Surgical techniques have been moving away from delayed closed reduction with internal wires suspension to early open reduction and internal plate fixation. The transition from wire osteosynthesis to rigid internal fixation in facial bone fractures using different micro or mini-plates and screw systems is regarded as one of the greatest advances in the field of maxillofacial surgery. I hope this book reflects the latest trends, concepts and innovations in the care of patients with facial trauma.
For convenience, the text is divided into 3 sections. Section 1 deals with primary care of the patients. Section 2 is concerned with midface fractures. In section 3 management of trauma to the lower face is discussed. Upper face injuries are not included and the reader could find the subject elsewhere under the topic of craniofacial traumatology. From the basic to the most complex, readers will find that each chapter is sequentially organized to provide a concise, and practical description of the operative details. The goal was to provide the reader with a fully comprehensive, yet highly illustrated text on the subject of facial trauma.
Management of soft tissue injuries in facial traumaAhmed Adawy
Management of soft tissue injuries in facial trauma
Dr. Ahmed M. Adawy.
Professor Emeritus, Dept. Oral & Maxillofacial Surg.
Former Dean, Faculty of Dental Medicine, Al-Azhar University.
Soft-tissue injuries are the most common presentation following maxillofacial trauma. In general, injuries can initially be classified as open or closed wounds. A closed wound is one that damages underlying tissue and/or structures without breaking the skin. Examples of closed wounds include hematomas, contusions, and crush injuries. In contrast, open wounds involve a break in the skin, which exposes the underlying structures to the external environment. Open wounds include simple and complex lacerations, avulsions, punctures, abrasions, accidental tattooing, and retained foreign body. Detailed description of management is presented. The principles of repair is discussed.
Emergency management of patients with facial traumaAhmed Adawy
Emergency management of patients with facial trauma
Dr. Ahmed M. Adawy Professor Emeritus, Dept. Oral & Maxillofacial Surg. Former Dean, Faculty of Dental Medicine
Al-Azhar University.
Maxillofacial trauma is without doubt a most challenging area within the specialty of oral and maxillofacial surgery. As with all traumas, basic Advanced Trauma Life Support principles (ATLS) should be applied to the initial assessment of the casualty. The primary survey is given by the letters ABCDE.
• Airway maintenance with cervical spine protection.
• Breathing and ventilation.
• Circulation with hemorrhage control.
• Disability: neurological status.
• Exposure/environmental control - undress the patient but prevent hypothermia.
Each was explored and discussed.
Dr. Ahmed M. Adawy
Professor Emeritus, Dept. Oral & Maxillofacial Surg.
Former Dean, Faculty of Dental Medicine
Al-Azhar University
The term “blow out” refers to partial herniation of the orbital contents through one of its walls. This usually occurs via blunt force trauma to the eye. Most often, the orbital floor is fractured in conjunction with the inferior orbital rim “impure” blowout fracture, but “pure” orbital floor fractures, with intact orbital rim can be seen. An extensive and careful history, physical examination, together with CT scans is vital for the diagnosis of orbital floor fractures. The timing of treatment, surgical approaches, and reconstruction of the orbital floor are presented.
Zygomatic Complex Fractures
Dr. Ahmed M. Adawy
Professor Emeritus, Dept. Oral & Maxillofacial Surg.
Former Dean, Faculty of Dental Medicine
Al-Azhar University
The term “zygomatic complex” refers to zygomatic bone and parts of maxilla, frontal, temporal and sphenoid bone. Fracture of the zygomatic complex, also known as a quadripod fracture, and formerly referred to as a tripod fracture, varies in severity from a simple crack to major disruption. The etiology, clinical presentations, and radiographic findings are presented. Classification systems are mentioned. The management of zygomatic complex fracture depends on the degree of displacement and the resultant esthetical and functional deficit. As a general rule, non- displaced or minimal displaced fracture can usually be treated conservatively. On the other hand, open reduction and internal fixation is applied in all dislocated, instable, and comminuted fractures of the zygomatic bone. Different surgical approaches and fixation methods are discussed.
Mandibular fractures
Dr. Ahmed M. Adawy
Professor Emeritus, Dept. Oral & Maxillofacial Surg.
Former Dean, Faculty of Dental Medicine
Al-Azhar University
Fractures of the mandible are a common form of facial injury in adults and occur most frequently in males during the third decade of life. The main causes of mandibular fractures are road traffic accidents, interpersonal violence, falls and sport injuries. Mandibular fractures are classified according to various criteria. The three main factors to consider are the cause of the fracture, the type of fracture and the site of the fracture. Clinical diagnosis as well as radiographic examinations are presented. Treatment modalities are discussed. Moreover, treatment-related complications are given.
Facial bone fractures: an overview
Dr. Ahmed M. Adawy
Professor Emeritus, Dept. Oral & Maxillofacial Surg.
Former Dean, Faculty of Dental Medicine
Al-Azhar University
The bone and soft tissues of the face are able to absorb the energy from impact forces. Force to the bone in the elastic range causing the deformation and after force removal, bone returns to its previous state, but if the force be greater than the elasticity of bone, a permanent displacement occurs and be irreversible. Furthermore, when these forces exceed the strength of these tissues, a variety of fractures can occur. The buttress theory proposes that the midfacial region is like a framework that is stabilized by horizontal and vertical buttresses. The most common causes of maxillofacial trauma are traffic accidents, injuries from fights, sport accidents or falls. The Le Fort’s classification is based on low-velocity trauma, and does not completely reflect the breadth of high-velocity fractures encountered in modern practice. Currently, facial fractures are classified into central midface fractures, lateral midface fractures and mandibular fractures. Nasal, nasoethmoidal, Zygomatic bone, and orbital fractures are presented. Today, surgical techniques have been moving away from delayed closed reduction with internal wires suspension to early open reduction and internal plate fixation. Different treatment approaches exist to restore the facial skeleton using the different facial buttresses as landmarks.
Dr. Ahmed M. Adawy
Professor Emeritus, Dep. Oral & Maxillofacial Surg.
Former Dean, Faculty of Dental Medicine
Al-Azhar University
Salivary glands are exocrine glands that produce saliva through a series of ducts. The glands may be affected by a wide range of disorders. They can be involved with acute and chronic inflammatory processes, give rise to benign and malignant tumors, manifest congenital abnormalities or represent involvement of a systemic disorder. Further, partial or complete obstruction of the ductal element can occurs. Physical examination and diagnostic aids are presented. Current surgical managements of these disorders are discussed.
Oral surgery during pregnancy
Dr. Ahmed M. Adawy
Professor Emeritus, Dep. Oral & Maxillofacial Surg.
Former Dean, Faculty of Dental Medicine
Al-Azhar University
Pregnancy, also known as gestation, is the time during which a fetus develops inside a woman's uterus. Pregnancy is typically divided into three trimesters. The common belief has been that, if an oral surgery procedure is recommended, but it’s not an emergency, the second trimester is the ideal time. Pregnancy however, is not a disease and pregnant woman should not be treated differently than the general population. In short, it could be concluded that:
• Dental care is safe and essential during pregnancy
• Pregnancy is not a reason to defer routine dental care or treatment
• Diagnostic measures, including needed dental x-rays, can be undertaken safely
• Emergency care should be provided at any time during pregnancy
Diabetes mellitus is a group of metabolic diseases characterized by high blood glucose level caused by either absolute or relative deficiency of insulin. Classifications,sings and symptoms,complications,and prevalence of the disease particularly in Egypt are presented. Management of diabetic patients undergoing oral surgical procedures is discussed.
Differential diagnosis of oral and maxillofacial lesionsAhmed Adawy
A wide variety of lesions from the soft and hard tissues may arise in the orofacial region. Clinical diagnosis is a cognitive process of applying logic and knowledge in a series of step-by-step decisions, to create a list of possible diagnosis.
Dr. Ahmed M. Adawy
Professor Emeritus, Dep. Oral & Maxillofacial Surg.
Former Dean, Faculty of Dental Medicine
Al-Azhar University
The condition of being prognathic indicates abnormal forward projection of one or of both jaws beyond the established normal relationship with the cranial base. The skeletal manifestation can be due to mandibular anterior positioning (prognathism) or growth excess (macrognathia), maxillary posterior positioning (retrognathism) or growth deficiency (micrognathia), or a combination of both. The prevalence of mandibular prognathism, the etiologic factors, evaluation of patients, and treatment modalities are presented.
Dr. Ahmed M. Adawy
Professor Emeritus, Dep. Oral & Maxillofacial Surg.
Former Dean, Faculty of Dental Medicine
Al-Azhar UniversityOrthognathic surgery is the art and science of combining orthodontics and maxillofacial surgery to correct dento-facial deformities.The etiology, prevalence,diagnosis and preoperative planning,and Surgical procedures are presented.
Dr. Ahmed M. Adawy
Professor Emeritus, Dep. Oral & Maxillofacial Surg.
Former Dean, Faculty of Dental Medicine
Al-Azhar University. Numerous etiologies lie behind mandibular defects including pathologic lesions, trauma related, infectious diseases and congenital defects. At present, the methods to restore mandibular defects can be classified into four basic categories:
1.Autogenous bone grafts in the form of nonvascularized free bone transfer, or vascularized tissue transfer, either pedicled or based on microvascular anastomosis
2. Distraction osteogenesis
3. Alloplastic materials (with or without bone)
4. Tissue engineered grafts
Dr. Ahmed M. Adawy
Professor Emeritus, Dep. Oral & Maxillofacial Surg.
Former Dean, Faculty of Dental Medicine
Al-Azhar University. By definition, a cyst is a “pouch” or sac without an opening, provided with a distinct membrane, and containing fluid or semifluid material, abnormally developed in one of the natural cavities or in the substance of an organ. Cysts of the oral region may be epithelial or non-epithelial, odontogenic or non-odontogenic, developmental, or inflammatory in origin. The distribution of jaw cysts according to diagnosis in a general population is given. The treatment of choice is dependent on the size and localization of the lesion, the bone integrity of the cystic wall, its proximity to vital structures and patient age.Treatment modalities are discussed.
Teeth in The Line of Mandibular FracturesAhmed Adawy
Dr. Ahmed M. Adawy, Professor Emeritus, Dep. Oral & Maxillofacial Surgery. Former Dean, Faculty of Dental Medicine, Al-Azhar University. Approximately 60% of fractures of the mandible occur in the teeth bearing area. Incisors and third molars are the most commonly involved teeth on the fracture lines. The damaged to the tooth involved at the fracture site may include exposure of the root surface subluxation, avulsion or root fracture. This may lead to the vitalization, consequent infection and complicated healing of the fraction. Wether to remove or preserve the tooth in line of fraction is discussed. Certain guidelines have been suggested.
Mandibular Radiolucencies; A Systematic Approach to DiagnosisAhmed Adawy
Dr. Ahmed M. Adawy, Professor Emeritus, Dep. Oral & Maxillofacial Surgery. Former Dean, Faculty
of Dental Medicine, Al-Azhar University. Conventional radiography may revel a variety of
radiolucent legions in the mandible. Interpretation of such radiolucencies can be challenging either
because the clinical presentation may be non specific or because the ;legion is detected
incidentally. Further, interpretation may vary from one examiner to another. thus, systemic
approach is necessary to diagnose the legion or at least provide a meaningful deferential
diagnosis. This approach should focus on specific radiographic parameters. Initially, the legion
should be placed in the category of either normal or abnormal. The presented parameters includes
describing the legion in terms of: 1- Location, 2- Margins, 3- Size and shape, 4- Effect on
surrounding structures. Obviously, however diagnosis of a legion should never be made
exclusively on the bases of radiographic interpretation. Radiographic interpretation should be used
along with clinical information and other tests to formulate a deferential diagnosis.
Dr. Ahmed M. Adawy, Professor Emeritus, Dep. Oral & Maxillofacial Surgery. Former Dean, Faculty of Dental Medicine, Al-Azhar University. Ameloblastoma is benign slow-growing but locally invasive neoplasm of odontogenic origin. In 2005, the WHO has classified ameloblastomas into multi cystic, unicystic and peripheral subtypes. The clinical picture, radiographic findings and differential diagnosis are presented. Treatment of ameloblastomas is primarily surgical. There has been some debate regarding the most appropriate method for removing. These range from conservative to radical modes. Some authors advocate conservative approach and thought that ameloblastoma are essentially benign in nature and should be treated as such. However, this conservative approach result in recurrence rates of 55% to 90%of the cases. Currently, the standard of care for ameloblastoma includes en bloc resection with 1-2 combine margin and immediate bone reconstruction. Despite the medical nature of a surgical resection, it may actually involve less morbidity than extensive hard and soft tissue resection with associated extensive morbidity that may be warranted in case of recurrence following inadequate primary treatment.
Dr. Ahmed M. Adawy, Professor Emeritus, Dep. Oral & Maxillofacial Surgery. Former Dean, Faculty of Dental Medicine, Al-Azhar University. Condylar fractures represent one of the most controversial issues in maxillofacial traumatology regarding classification, diagnoses and therapeutic management. Classification systems of condylar fracture is discussed. Diagnosis is usually based on history clinical examination and radiographic finding. Treatment ranges from observation, jaw exercises to closed or opened interventions. For years closed reduction was thought to be essentially complication-free. Several serious complications however have been reported including temporomandibular joint ankyloses, malocclusion, mandibular deviation and the generative joint pathology. The absolute and relative indications for open reduction is given. The debate between supporters of open or closed reduction is still continuing and the issue has not been resolved. However, the final choice treatment modality should takes into account the location of the fracture, age of the patient, presence or absence of other associated injuries, cosmetic impact of the surgery and presence of other systemic medical conditions.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
2. Dr. Ahmed M. Adawy
Professor Emeritus, Dep. Oral & Maxillofacial Surg.
Former Dean, Faculty of Dental Medicine
Al-Azhar University
3. Arthrocentesis of the temporomandibular joint refers to
lavage of the upper joint space, hydraulic pressure and
manipulation to release adhesions of the “anchored disc
phenomenon” and improve motion. It was first described
by Nitzan and colleagues in 1991(1) to treat acute closed
lock jaw. Their study established that the treatment
decreased pain, increased maximal incisal opening and
showed prolonged relief of symptoms
4. Through arthrocentesis the microscopic tissue debris
resulting from the breakdown of the articular surfaces and
the pain mediators can be washed out, and normal
lubricating properties of synovial membrane can also be
stimulated. Today TMJ arthrocentesis is not only used in
the treatment of acute closed lock but in various other
temporomandibular joint disorders as well. It has been
considered as the first line of surgical treatment for patients
with TMJ disorders who do not respond to conservative
therapy such as interocclusal devices, physical therapy,
drugs, light diet, behavioral and lifestyle changes
5. Arthrocentesis is a minimally invasive procedure(2), that
can be performed under local anesthesia in an out-patient
basis. It consists in the lavage of the upper TMJ
compartment with a fluid, such as saline or lactated
Ringer’s solution, and/or anti-inflammatory, opioid and
steroid drugs
Arthrocentesis
6. Arthrocentesis is indicated for patients with anterior disc
displacement with and without reduction, for disc
adhesions, for early adhesiveness next to the fossa and/or
the upper aspect of the articular tubercle, with mouth
opening limitation, for cases of synovitis/capsulitis, as
palliation for acute degenerative rheumatoid arthritis,
patients with painful joint noises occurring during mouth
opening and/or closing and for hemarthrosis due to recent
trauma
7. Some contraindications for arthrocentesis have been
proposed including; psychiatric pathology, fibrous and
osseous ankylosis, multiply operated joints, regional
infectious disease and tumors of the joint
8. The technique starts by anaesthetizing the
auriculotemporal nerve followed by posterior deep
temporal and masseter nerves. This provides optimal
region analgesia, preventing the need for sedation. A
straight line is drawn from the medial portion of the ear
tragus to the lateral corner of the eye. In this line, two
needle insertion points are marked. The first, more
posterior point will be at a distance of 10 mm from the
tragus and 2 mm below the cantotragal line. This is the
approximate area of the maximum concavity of the
glenoid fossa. The distance is about 25mm from skin to
the centre of the joint space
10. The second point will be 20 mm in front of tragus and 10
mm below this same line. This marking indicates the site
of the eminence of the TMJ. After the points of insertion
for the two needles have been marked, local anaesthetic is
injected at the planned entrance points. Two 19 gauge
needles are inserted in the anterior and posterior recesses
of the upper joint space. Through one needle, Ringer’s
lactate 100–300 ml is injected into the superior joint
space. The second needle acts as an outflow portal, which
allows lavage of the joint cavity(3)
11.
12. Arthrocentesis changes synovial fluid viscosity, thus
contributing for the translation of the disc and mandible
head complex(4). In addition, when performed under
pressure and combined with shearing forces generated by
jaw manipulation it could break down early adhesions,
thus improving mouth opening(5). Pain is decreased or
eliminated possibly due to the wash-out of chemical pro-
inflammatory mediators(6), associated to the direct action
of instilled drugs on intracapsular pain receptors(7)
13. There may be zygomatic branch or facial nerve temporal
branch paresis caused by local anesthetic block or the
edema itself; zygomatic or buccal branch paralysis due
to needle trauma; postoperative edema caused by intra-
articular solution leakage; periauricular hematoma;
perioperative bleeding by vascular injury; and extradural
hematoma
14. In some cases, however, it is difficult to insert the second
needle. This means lavage failure, longer time operation ,
uncomfortable patients, and there may be increased
postoperative morbidity and possible damage to the facial
nerve(8). For this reason single needle arthrocentesis has
been proposed, in which inflow and out flow go through
the same cannula(8). The joint is lavaged with a single
needle used for injection and ejection resulting 40 ml of
irrigation. However, with a single needle the amount of
fluid may be inadequate and the pressure too low
15. Other modifications include the use of a single cannula
with two ports (9), and the use of the so called Shepard
cannula that holds two needles together (10). Nevertheless
the device that keeps two needles together seems to be
relatively thick, which has the potential to damage the
nerve. Repetitive use of the device may cause the tips of the
needles to blunt, and increase the risk of infection
18. 1.Nitzan DW, Dolwick MF, Martinez GA. Temporomandibular joint
arthrocentesis: a simplified treatment for severe, limited mouth opening.
J Oral Maxillofac Surg; 49:1163, 1991.
2. Nitzan DW. Arthrocentesis--incentives for using this minimally invasive
approach for temporomandibular disorders. Oral Maxillofac Surg Clin North
Am ; 18: 311, 2006.
3. Tozoglu S, Al-Belasy FA, Dolwick MF. A review of techniques of lysis
and lavage of the TMJ. Br J Oral Maxillofac Surg; 49: 302, 2011.
4.Nitzan DW, Etsion I: Adhesive force: the underlying cause of the disc
anchorage to the fossa and/or eminence in the temporomandibular joint. A
new concept. Int J Oral Maxillofac Surg; 31: 94, 2002.
5.Yura S, Totsuka Y, Yoshikawa T, et al. Can arthrocentesis release
intracapsular adhesions? Arthroscopic finding before and after irrigation
under sufficient hydraulic pressure. J Oral Maxillofac Surg; 61: 1253, 2003.
6. Kaneyama K, Segami N, Nishimura M, et al. The ideal lavage volume for
removing bradykinin, interleukin-6, and protein from the
temporomandibular joint by arthrocentesis. J Oral Maxillofac Surg; 62: 657,
2004.
19. 7. Kunjur J, Anand R, Brennan PA, et al. An audit of 405 temporomandibular
joint arthrocentesis with intra-articular morphinre infusion. Br J Oral
Maxillofac Surg; 41: 29, 2003.
8. Guarda-Nardini L, Manfredini D, Ferronato G. Arthrocentesis of the
temporomandibular joint: a proposal for a single-needle technique.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 106: 483, 2008.
9. Alkan A, Bas B. The use of double-needle canula method for
temporomandibular joint arthrocentesis: clinical report. Eur J Dent; 1:179,
2007.
10. Rehman KU, Hall T. Single needle arthrocentesis. Br J Oral Maxillofac
Surg; 47: 403, 2009.