The document describes the pectoralis major island flap technique. It can be used for reconstruction of the pharynx, tongue, face, neck, and skullbase defects. The flap has a large arc of rotation from the clavicle to the xiphoid process. It provides a single stage transfer with a muscle carrier but does not match the color and texture of facial skin. The document outlines the surgical technique including flap design, elevation of the vascular pedicle, and closure of the donor site. Variations including osteomyocutaneous flaps with rib bone and use of the flap as a free tissue transfer are also discussed. Complications, risk factors, and modifications to the technique are summarized.
This powerpoint describes the types of maxillectomy & operative steps for total maxillectomy. It also enumerates various flaps used for reconstruction of maxillectomy defect.
A flap is a unit of tissue that is transferred from one site (donor site) to another (recipient site) while maintaining its own blood supply or from a anastomised vessel.
Flaps come in many different shapes and forms. They range from simple advancements of skin to composites of many different types of tissue
Case Presentation On Reconstruction With Pectoralis Major Myocutanious FlapDrMahbub Hussain
Reconstruction after cancer surgery in the orofacial region is far the most important thing. hence Pectoralis Major Myocutanious Flap is termed as life boat flap.
This powerpoint describes the types of maxillectomy & operative steps for total maxillectomy. It also enumerates various flaps used for reconstruction of maxillectomy defect.
A flap is a unit of tissue that is transferred from one site (donor site) to another (recipient site) while maintaining its own blood supply or from a anastomised vessel.
Flaps come in many different shapes and forms. They range from simple advancements of skin to composites of many different types of tissue
Case Presentation On Reconstruction With Pectoralis Major Myocutanious FlapDrMahbub Hussain
Reconstruction after cancer surgery in the orofacial region is far the most important thing. hence Pectoralis Major Myocutanious Flap is termed as life boat flap.
Head and neck cancer reconstruction is arguably the
most challenging area of reconstruction for the reconstructive
surgeon. A clear understanding of the principles of use of local flaps and a comprehensive understanding of the anatomy of these flaps provides the head and neck surgeon with a plethora of local and regional options for primary and secondary reconstruction.
Flap coverage in upper extremities in trauma VishalPatil483
SEMINAR PRESENTED BY DR VISHAL PATIL ,IN THE DEPT OF TRAUMA SURGERY AND CRITICAL CARE, AIIMS RISHIKESH
INCLUDES-INTRODUCTION-CLASSIFICATIONS OF FLAP-COMPLICATIONS RELATED TO FLAP COVERAGE- FLAP USED IN HAND AND UPPER EXTREMITY SOFT TISSUE RECONSTRUCTION WITH PICTURES OF IT
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
2. Ariyan 1979
Work house flap for head and neck reconstruction
Regional pedicle flap
3. USES
The pectoralis major island flap can be used in reconstructions
1. Pharynx
2. Tongue
3. Face
4. Neck
5. To cover the carotid artery when this vessel is at risk due to prior
irradiation
6. Skullbase defects.
4. PREOPERATIVE CONSIDERATIONS
TIMING : trauma-related avulsive wound is delayed
ARC OF ROTATION :The arc of rotation extends in an oblique fashion from the
lateral head of the clavicle to the xiphoid process.
SIZE OF THE DEFECT : 6*6 cm without having to skin graft the chest wall
COLOR MATCH : does not provide tissue of similar color as the facial skin
TRAUMA TO THE THORACOACROMIAL AXIS-previous accidents,subclavian
vein puncture
5. ANATOMY
Insertion:Lateral lip of bicipital groove
of humerus
Origin: medial half od clavicle,upper six
costal cartilage,medial sternum,sheath
of abdominus rectus oblique
6.
7. NERVES AND VESSELS
Thoracoacromian artery,lateral thoracic
artery,superior thoracic artery,intercostal
perforators from internal mammary artery
medial (C5–C7) and lateral (C8-T1)
pectoral nerves
8.
9.
10.
11. Deep relations of pectoralis major
vascular pedicle, the pectoralis minor muscle,
the costal cartilages, and inferiorly the costal
attachments and the external oblique muscle
16. Positioning, prepping and draping
Supine position with the chest exposed and prepped up to the midline, and
inferiorly to the costal margin.
The upper arm is abducted slightly to expose the anterior axillary fold and
lateral chest wall.
17. Surface markings of vascular pedicle
Ariyan line:drawing a line
from the shoulder to the
xiphisternum and another line
vertically from the midpoint
of the clavicle to intersect the
1st line
18.
19. Skin paddle design
•Over the pectoralis major muscle along the
course of the pectoral branch of the
thoraco-acromial artery
•The distance between the top of the skin
paddle and the inferior edge of the clavicle
should equal or exceed the distance
between the recipient site for the flap and
the inferior edge of the clavicle
•Skin paddle should be
marked on the inferomedial portion of the
flap corresponding
to the size of the defect
22. Elevation of skin paddle
Bevel the dissection radially so
as to include as many
myocutaneous perforators as
possible that supply the skin
paddle
An incision is extended
laterally from the peripheral
margin of the skin paddle along
the anterior axillary fold, which
corre-sponds with the lateral
margin of the pec-toralis major
muscle
23. Exposure of pectoralis major muscle
The skin paddle is tacked to the
underlying pectoralis major muscle with a
few sutures so as to minimise the risk of
shearing injury to the myocutaneous per-
forators
The skin and breast tissue above the skin
paddle is then widely elevated from the
pectoralis major muscle with diathermy
up to the clavicle
24. Elevation of pedicle
•The dissection plane between the
pectoralis minor and major muscles
and the vascular pedicle is found by
dissecting along the lateral border
of the pectoralis major muscle
along the clavipectoral fascia
•The plane is avascular and can be
opened easily with blunt dissection
27. Rotated pmmc
Degree of rotation
The arc of rotation extends
in
an oblique fashion from the
lateral head of the
clavicle to the xiphoid
process
Improving arc of rotation-
1. Remove insertion part
into humerus
2. Sacrifice lateral and
medial pectoral nerves
28. Clinical Atlas Of Muscle And
Musculocutaneous Flaps
Mathes and Nahai
29. Gaining additional length
•The 1st is to transect the
pectoralis major muscle
just below the clavicle,
taking great care to
preserve the vascular
pedicle
•The 2nd maneuver to
gain additional length is
to pass the flap behind
the clavicle
30. Closure of donor site defect
The donor site is either closed primarily with a closed suction drain, or a
split skin graft is applied. Primary closure may be facilitated by
undermining the surrounding skin.
35. advantages
Single stage transfer
Insetting based on a muscle carrier
Improved bone vascularity
Less operating time as compared to free flap
36. disadvantages
Perforation of pleura
removal of the full thickness of the sternum is on the left side, the patient
has postoperative discomfort due to heart palpitations. Therefore only the
outer table of the sternum should be removed
Limited bone amount
Unwanted soft tissue bulk
38. Advantages
Large skin territory
Can be transferred without any delay
Large arc of rotation
If the muscle flap is used to cover intraoral defects, the muscular surface
mucosalizes even without the use of a skin paddle
39. Disadvantages :-
The loss of the skin paddle caused by possible shearing of the perforators
during surgery.
40. complication
Recipient site complication:
1. partial or total flap necrosis
2. wound infection
3. fistula formation
4. wound dehiscence
5. Muscle twitching
41. Donor site complication
1. Uncontrolled bleeding
2. Hematoma
3. Dehiscence
4. Infection
Rare complications
1. Rib osteomyelitis
2. Metastatic spread of tumour to base of flap
42. Risk factors
who are greater than 70 years of age, female, overweight were more likely at
risk to develop complications
who have albumin levels less than 4 g/dL;
presence of systemic diseases, such as diabetes mellitus, hypertension,
atherosclerotic heart disease, peripheral vascular disease,renal failure, and
collagen vascular disease
Previously irradiated patients
43. precautions
Take larger skin paddle
(lead to a greater capture of vessel perforators leading to decreased loss of
the skin paddle compared with smaller skin paddles that lead to vascular
insufficiency)
Suture the skin paddle to the muscle
(Prevents shearing of the perforators and, therefore, prevents loss of the
skin paddle)
Judicious use of the electrocautery
(excessive use can lead to coagulation of the vessels and compromising the
vascular pedicle through retrograde thrombosis)
44. contraindication
Prior radical axillary nodal dissection
Morbidly obese patients
Congenitally missing the pectoralis muscle,as patients with Poland
syndrome
Patients with previous trauma or surgery to the chest wall
Patients with vocations requiring full range of motion in their shoulders
and arms
45. Poland syndrome
underdevelopment or absence of the chest muscle
(pectoralis) on one side of the body, and usually also
webbing of the fingers (cutaneous syndactyly) of the hand
on the same side (the ipsilateral hand).
48. Free flap
Tissue along with its blood supply is completely detached from its original
location and then transferred to another location and circulation in the
tissue is re established by anastamosis of artery and vein.
49. references
Functional oromandibular reconstructionusing a sternum pectoralis
major osteomyoctaneous composite flap
Int. J. Oral Maxillofac. Surg. 1987: 16:604-608
Clinical Atlas Of Muscle And Musculocutaneous Flaps
Mathes and Nahai
Pectoralis major myocutaneous flap
Oral Maxillofacial Surg Clin N Am 15 (2003) 565–575
50. Pectoralis Major Myocutaneous Flap
Ketan Patel, DDS, PhDa,*, Diana Jee-Hyun Lyu, DDSb, Deepak Kademani,
DMD, Mda
Oral Maxillofacial Surg Clin N Am 26 (2014) 421–426
The pectoralis major flap
Johan Fagan
Otolaryngology, Head & Neck Operative Surgery
51. Two volume Petersons
Mathes volume 1 Plastic Surgery
53. Quazi Ghazwan Ahmad*, Suresh Navadgi, Ritu Agarwal, Harsh Kanhere,
Kanti P. Shetty, R. Prasad
Journal of Plastic, Reconstructive & Aesthetic Surgery (2006) 59, 166–173
54. Perforators of pectoralis major
P1: along the medial edge of the muscle, direct musculocutaneous
branches from the internal mammary artery
P2: 2–4 cm medial to the nipple, coming from the anterior intercostal
branch of internal mammary artery
P3: fine branches reaching the skin by curving around the lateral border
of the muscle.
Some branches of the lateral thoracic artery are found in the skin lateral
to the nipple at the level of 4th rib
55. rich anastomotic network within the muscle, blood supply from
acromiothoracic artery safely reaches the skin even after ligation of the
branches of the internal mammary and lateral thoracic artery
56. Flap design and operative technique
The paddle is placed horizontally, including the nipple, extending from
midline medially and crossing the lateral border of the muscle laterally
57. The lateral paddle bearing the areola is inset into the lining defect.
The paddle for the skin defect is placed on the medial edge of the muscle
based on P1 perforators.
58. An elliptical incision is then
made involving both paddles and deepened till the muscle.
If the nipple is prominent then it is excised
and closed with a single stitch
Then the skin between the paddles is
incised till the subcutaneous fat to facilitate inset of the
medial paddle into the cutaneous defect
59. advantage
As the paddle is placed along the transverse axis, the reach of flap is not
compromised
60. Material and methods
47 patients with full thickness cheek defects and segmental
mandibulectomy who underwent reconstruction with bipaddle PMMC
flaps between May 2000 and July 2004.
61. 24 patients had lesions involving left buccal mucosa, 19 with right buccal
mucosa, one involving the middle 1/3 of alveolus and floor of mouth, one
with left alveolar carcinoma, one with right alveolar carcinoma and one
patient had involvement of right buccal mucosa and cheek, extending to
infra temporal fossa.
62. All patients underwent composite resection (wide excision of the primary
tumour with segmental mandibulectomy and neck dissection in
continuity).
63.
64.
65. results
The size of the paddle used for mucosal defect cover ranged from 5*3 to 9*7
cm and the size of the paddle used for skin cover ranged from 4*4 to 9*8
cm. The total size of flap ranged from 10*5 to 17*7 cm.
66.
67. All patients were male.
One patient had complete loss of flap (2.12%). Sixteen patients had minor
complications all of which settled with conservative management. The
follow up period varied from 1 month to 4 years
68. CONCLUSION
Authors conclude that this method of bipaddling the
pectoralis major myocutaneous flap is a useful
technique for reconstruction of complex composite
cheek defects in male patients