Coronary angiography is the gold standard for detecting coronary artery disease. It was first performed by Dr. Mason Sones in 1958 at the Cleveland Clinic. It uses catheters to inject contrast dye into the coronary arteries so they can be visualized on x-ray imaging. The left main, left anterior descending, and left circumflex arteries are visualized from different angles, such as LAO caudal for the "spider view". Angiograms are also used to grade the severity of lesions, flow through blocked vessels (TIMI grade), and collateral vessel development (Rentrop grade).