The document discusses cleanroom protocols and procedures. It defines cleanrooms and their importance for minimizing contamination, especially in semiconductor manufacturing. It outlines cleanroom classifications, air filtration systems, environmental controls, and guidelines for cleaning, materials selection, and user behavior. Strict adherence to cleanroom protocols by all users is emphasized as essential for maintaining the clean environment.
This is the 1st part of our "All about cleanrooms". This presentation will take you through the history of cleanrooms, types and applications of cleanrooms.
This is the 1st part of our "All about cleanrooms". This presentation will take you through the history of cleanrooms, types and applications of cleanrooms.
Includes cleanroom rules, cleanroom techniques, cleanroom behavior, protocol and practices. Movement in cleanroom, handling in the cleanroom, nature of cleanroom personnel and wrong practices in the cleanroom.
Contamination Control in Cleanrooms_Dr.A. AmsavelDr. Amsavel A
Basic’s of Contamination
Sources of Contamination
Environment Specification
Elements of Cleanroom Design and Qualification
Definitions
Control of Contaminations
People, Cleaning, Environment & Material
Operation, Monitoring and Control
Documents and Records
Control on Cleanroom Environmental Monitoring (Pharmaceutical)Srinath Sasidharan
A general consideration of Environmental Monitoring in Pharmaceutical manufacturing area. Cleanroom Monitoring Tools and Utilities: Author Sreenath Sasidharan (Geltec Healthcare FZE)
To maintain the desired SAL at the plant is task which demands great care and control over Man, Machine & Method. This summarize work will definitely help you as hand note.
An introduction to the international cleanroom standard ISO 14644 and the 2015 revisions to Parts 1 and 2. The focus is on particulate and contamination control.
Includes cleanroom rules, cleanroom techniques, cleanroom behavior, protocol and practices. Movement in cleanroom, handling in the cleanroom, nature of cleanroom personnel and wrong practices in the cleanroom.
Contamination Control in Cleanrooms_Dr.A. AmsavelDr. Amsavel A
Basic’s of Contamination
Sources of Contamination
Environment Specification
Elements of Cleanroom Design and Qualification
Definitions
Control of Contaminations
People, Cleaning, Environment & Material
Operation, Monitoring and Control
Documents and Records
Control on Cleanroom Environmental Monitoring (Pharmaceutical)Srinath Sasidharan
A general consideration of Environmental Monitoring in Pharmaceutical manufacturing area. Cleanroom Monitoring Tools and Utilities: Author Sreenath Sasidharan (Geltec Healthcare FZE)
To maintain the desired SAL at the plant is task which demands great care and control over Man, Machine & Method. This summarize work will definitely help you as hand note.
An introduction to the international cleanroom standard ISO 14644 and the 2015 revisions to Parts 1 and 2. The focus is on particulate and contamination control.
Fascinating Guideline About range of Vial Capping MachineN.K Industries
Presentation describer fascinating guideline about the range of Vial capping machine. Vial Capping machine are imperative technology in injectable plant where they are use to seal the flip off cap or tear of cap on vial and bottle to give the perfect hermetic sealing .
for more information , please visit us http://www.nkcapingmachine.com/product/multi-head-rotary-vial-capping-machine.html
Available in various filling sizes, this machine has exclusive features and can be used in sterile areas where there is protection from laminar flow of air.
Source of contamination, Air flow system: conventional, Unidirectional, laminar air flow unit, Air filtration, mechanisms: Fibrous and HEPA filters, Temperature and humidity control, Building design, construction and use, personnel, Protective clothing, cleaning, and disinfecting, commissioning test of clean and aseptic rooms, routine monitoring tests, The operation of clean aseptic room, Key factors in clean room operations.
What is INFRARED? Explains the principle,uses and application of INFRARED in daily life. Technology of INFRARED in various fields like medical, archaeology,astronomy and many others.
Complying with 21 CFR Part 11 - Understanding the role of predicate ruleJasmin NUHIC
To obtain knowledge and understanding of 21 CFR Part 11 as how it applies to you as well as be advised of consequences which may result in failing to comply with this regulation.
21CFR regulations & its applicability in the industry and FDA perspective on the same and FDA check points on 21CFR regulations during their inspection.
This ppt explains in detail about the Behavior and Practices to be followed in Clean-rooms & Clean zones of an Orthopaedic Medical Device Mfg organization.
It explains what all the international standards to be followed, how the particle emission happens, how it can be avoided inside a cleanroom or Clean-zone etc. How the gowning or cleanroom garment should be worn, what activities should not be done while inside a cleanroom, what can be done etc.
It also mentions the effect of the implanted patient, if the sterile packaging was done in a contaminated cleanroom. All precautions to overcome the deficiencies have been explained.
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
Biological screening of herbal drugs: Introduction and Need for
Phyto-Pharmacological Screening, New Strategies for evaluating
Natural Products, In vitro evaluation techniques for Antioxidants, Antimicrobial and Anticancer drugs. In vivo evaluation techniques
for Anti-inflammatory, Antiulcer, Anticancer, Wound healing, Antidiabetic, Hepatoprotective, Cardio protective, Diuretics and
Antifertility, Toxicity studies as per OECD guidelines
Embracing GenAI - A Strategic ImperativePeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
Synthetic Fiber Construction in lab .pptxPavel ( NSTU)
Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
Operation “Blue Star” is the only event in the history of Independent India where the state went into war with its own people. Even after about 40 years it is not clear if it was culmination of states anger over people of the region, a political game of power or start of dictatorial chapter in the democratic setup.
The people of Punjab felt alienated from main stream due to denial of their just demands during a long democratic struggle since independence. As it happen all over the word, it led to militant struggle with great loss of lives of military, police and civilian personnel. Killing of Indira Gandhi and massacre of innocent Sikhs in Delhi and other India cities was also associated with this movement.
Instructions for Submissions thorugh G- Classroom.pptxJheel Barad
This presentation provides a briefing on how to upload submissions and documents in Google Classroom. It was prepared as part of an orientation for new Sainik School in-service teacher trainees. As a training officer, my goal is to ensure that you are comfortable and proficient with this essential tool for managing assignments and fostering student engagement.
Palestine last event orientationfvgnh .pptxRaedMohamed3
An EFL lesson about the current events in Palestine. It is intended to be for intermediate students who wish to increase their listening skills through a short lesson in power point.
The Roman Empire A Historical Colossus.pdfkaushalkr1407
The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
The empire's roots lie in the city of Rome, founded, according to legend, by Romulus in 753 BCE. Over centuries, Rome evolved from a small settlement to a formidable republic, characterized by a complex political system with elected officials and checks on power. However, internal strife, class conflicts, and military ambitions paved the way for the end of the Republic. Julius Caesar’s dictatorship and subsequent assassination in 44 BCE created a power vacuum, leading to a civil war. Octavian, later Augustus, emerged victorious, heralding the Roman Empire’s birth.
Under Augustus, the empire experienced the Pax Romana, a 200-year period of relative peace and stability. Augustus reformed the military, established efficient administrative systems, and initiated grand construction projects. The empire's borders expanded, encompassing territories from Britain to Egypt and from Spain to the Euphrates. Roman legions, renowned for their discipline and engineering prowess, secured and maintained these vast territories, building roads, fortifications, and cities that facilitated control and integration.
The Roman Empire’s society was hierarchical, with a rigid class system. At the top were the patricians, wealthy elites who held significant political power. Below them were the plebeians, free citizens with limited political influence, and the vast numbers of slaves who formed the backbone of the economy. The family unit was central, governed by the paterfamilias, the male head who held absolute authority.
Culturally, the Romans were eclectic, absorbing and adapting elements from the civilizations they encountered, particularly the Greeks. Roman art, literature, and philosophy reflected this synthesis, creating a rich cultural tapestry. Latin, the Roman language, became the lingua franca of the Western world, influencing numerous modern languages.
Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
2. Introduction
Cleanroom definitions
Parameters about clean room
Characteristics about clean room
Contamination & Measurement
Cleaning & Materials Selection
The user!!
Protocols to improve control
Conclusions
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3. MEMS is the acronym of Micro Electro Mechanical
Systems. It is a highly miniaturized device or an array of
devices combining electrical and mechanical
components that is fabricated using integrated circuit
(IC) batch processing techniques and can range in size
from micrometers to millimeters.
In Europe it is called Microsystems technology (MST).
4. It is important for users to understand concepts
behind clean processing
Benefit from the experiences of others (standards,
anecdotal information(reliable))
Impact that a single user can have on overall process
yield can be huge!
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5. Why Cleanrooms?
First cleanrooms were in hospitals to prevent disease
transmission and infection in operating rooms (over 100 years
ago!)
Valuable tool to prevent particulate and bio contamination
Most well known use is in semiconductor industry, but also
essential in pharmaceuticals, flat panel displays, space
program, photonics, life sciences, industrial (painting,
assembly), etc.
Essential for LCDs because of coating processes, small cell gaps
Cleanroom itself is only part of the solution
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6. Micro-fabrication needed a very clean environment to prevent dirt or
other particles from contamination the MEMS devices .
Two pictures in clean room.
7. Yellow room is a special area in CLEANROOM. It is used for
photolithograhpy process. Because of the sensitivity of PR,the wafers
covered by PR must be used in yellow room. Once such
wafers(substrates) are brought outside the yellow room, most of them
might be exposed by UV.
8. High Efficiency Particulate Air (HEPA) Filter:
–
–
–
–
Most common type of clean room air filter
High efficiency, low pressure drop, good loading characteristics
Uses glass fibers in a paper-like medium
Are rated by their particle retention:
• A true HEPA-rated filter will retain 99.97 % of incident particles of
0.3 mm or larger.
Ultra low particulate air (ULPA) Filter:
This filters are 99.9995% efficient in removing particles 0.12 µm and
larger.
ULPA filters are used in air filtration and purification systems to
control airborne
particulate levels and to stop the spread of
toxic agents and infectious diseases.
9. – Air is recirculated through HEPA filters with about 20 % make up.
• Vapors are entrained, so contamination potential is very high.
• Extensive gas detection and alarm systems are installed.
– Temperature is controlled to 68 - 72 °F.
– Humidity is controlled to 40 - 46 % RH.
– Room is held at positive pressure .
• Typically 0.1 in of H2O for Class 100, Class 1000, and Class 10,000
• Typically 0.3 - 0.4 in of H2O for Class 1 and Class 10
• Positive pressure constantly blows dust OUT
• (Biohazard rooms operate at negative pressure to keep bugs IN)
• Doors open inward, so room pressure closes them shut .
10. Positive Pressure / Airflow
Keeps contamination out of the work area
Depends on clean air input
Filtration
Development of effective filtration revolutionized industry
HEPA (High Efficiency Particulate Air) and ULPA (Ultra Low
Particulate Air) Filters
Materials Selection
User Protocols
Cleaning
All are very important!
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11. Particulate—encompasses most contamination
Chemical—films, vapors, etc.
Biological—bacteria, viruses, etc.; for our purposes,
treat as particles
Similar concerns for rooms & equipment as for
substrates
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12. Critical to remove contaminants that cannot be
removed by air handling
Important to follow procedures appropriate to your
application
What is appropriate for one industry may not be
appropriate for another
Most important thing is to develop standard
procedures and FOLLOW THEM
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13. The efficiency of these cleaning methods depends on
the surface being cleaned
Rough or pitted surfaces are more difficult to clean
Sharp corners are difficult to clean
Why are inside surfaces of cleanrooms smooth?
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14. Dry and wet
Dry has low (<25% ) efficiency for particles smaller than 10 microns
(about .0005 inches)
wet uses liquids which result in greater force on the particles and hence
better cleaning.
Most facilities use DI(Distilled Water) water or isopropyl alcohol with
disinfectant.
The choice depends on what works, cost, history, etc.
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15. Efficiency depends of tackiness of roller, cleanliness
of tacky surface and softness of roller are also very
important
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16. Choice of materials for supplies, equipment,
gowning, etc. is important
“Clean” materials can become dirty!!
Look for easy-to-clean materials
Triboelectricity can cause static problems, as can low
humidity—this exacerbates contamination problems
Biofilms!!(Biofilms form when single
microorganisms attach to a hydrated surface and
undergo a "lifestyle switch.“)
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17. Truth: Manufacturers can achieve similar yield results
using cost effective flow hoods and isolation chambers
as with full-blown central cleanrooms
BUT: user behavior is much more critical in these
areas!!!
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19. Before any work can be done in the cleanroom facility,
users must gown up in appropriate cleanroom garments.
These garments are located in a separate room at the top
of the ramp leading away from the entrance door to the
facility. Nothing should be taken into the gowning room.
All clothing and miscellaneous items (keys, cell phones,
sweaters, notebooks) that are not specifically qualified for
use inside a cleanroom must be left outside the entrance
to the facility, not in the gowning room. These items will
only contaminate the cleanroom garments which are hung
there. Please leave these extraneous items in your office
or car for the highest degree of safety. Items may be left
on the bench used for putting on shoe covers or on the
adjacent coat rack at your own risk.
21. Liquid Crystal Institute(LCI).
Pick up an appropriately sized coverall and put on, being
careful to avoid allowing coverall to touch floor
Put on plastic shoe covers (booties) over your shoes in
the hallway
If you wear boots or other heavy contaminating shoes,
consider keeping a pair of sneakers in your office for use
in the cleanroom.
Put on hairnet, Pick up an appropriately sized head
cover and put on.
Put on safety glasses and proceed to air shower
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22. Not wearing Safety Glasses
Improper gowning
zippers, snaps, masks
Non-cleanroom materials in cleanroom
paper, cardboard, personnel items
Not cleaning up after you are finished
General conduct
Fast motions, incorrect carrying of materials
Remember laminar flow; minimize turbulence
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23. Minimize sources of contaminants
No smoking
No cosmetics
Avoid high particulate clothing, such as wool sweaters
Cover up! Uncovered skin can lead to more
contamination
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24. Follow gowning procedures and restrict materials used
in cleanroom
An educated worker is essential to proper job
performance; workers should be well versed in the
how and why of their job
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25. Cleanroom environment is very fragile!(Easily broken or
damaged)
Your actions have impact on other users
Important to follow procedures EVERY TIME
Make sure fellow workers follow procedures as well;
nothing wrong with pointing out mistakes
Be an active participant: keep an eye out for areas
that can be improved
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26. Bring only required materials into cleanroom; if it is
not necessary to perform the task, it should not be
there
Personnel: only required personnel should be in the
clean space
Reduce clutter—do not store materials in clean areas
unless they have to be there!
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27. Follow exact procedures every time
Wipe down surfaces with cleanroom wipes before and
after every usage
Remember: this can seem tedious and unnecessary,
but is essential to keeping the cleanroom maintained
at its highest levels
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30. Contamination control is a continuous battle
User behavior has a critical impact on contamination
Proper procedures must be followed at all times
Think about your actions! Be an active participant
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