Clean room technology is used to control airborne particle concentrations and other parameters like temperature, humidity, and pressure. There are two main types of cleanrooms - turbulently ventilated and unidirectional flow. High efficiency particulate air (HEPA) and ultra low penetration air (ULPA) filters are used to filter air and control particle levels, working via mechanisms like diffusion, impaction, interception, and sieving. Proper clean room practices like changing gloves, wiping surfaces, and avoiding contaminants are important for maintaining cleanliness.
This is the 1st part of our "All about cleanrooms". This presentation will take you through the history of cleanrooms, types and applications of cleanrooms.
Source of contamination, Air flow system: conventional, Unidirectional, laminar air flow unit, Air filtration, mechanisms: Fibrous and HEPA filters, Temperature and humidity control, Building design, construction and use, personnel, Protective clothing, cleaning, and disinfecting, commissioning test of clean and aseptic rooms, routine monitoring tests, The operation of clean aseptic room, Key factors in clean room operations.
This is the 1st part of our "All about cleanrooms". This presentation will take you through the history of cleanrooms, types and applications of cleanrooms.
Source of contamination, Air flow system: conventional, Unidirectional, laminar air flow unit, Air filtration, mechanisms: Fibrous and HEPA filters, Temperature and humidity control, Building design, construction and use, personnel, Protective clothing, cleaning, and disinfecting, commissioning test of clean and aseptic rooms, routine monitoring tests, The operation of clean aseptic room, Key factors in clean room operations.
Validation Of System For Compressed Air Quality Imtiaz Rastgar
Food, Pharma and several other manufacturing industries need compressed air with precise control on oil-in-air, dust particles and moisture levels. Instruments and standards of compressed air quality are described by Imtiaz Rastgar, Chairman Rastgar Group and Ex CEO of Engineering Development Board, Ministry of Industries, Government of Pakistan, Islamabad.
Microbiological Environmental Monitoring in Pharmaceutical Facilitydelli_intralab
Merupakan jurnal tentang microbiological environment monitoring in pharma facility
Untuk informasi lebih lanjut atau diskusi mengenai environment monitoring, silahkan hubungi delli.intralab@gmail.com
How the concept was introduced by the astrophycists and examples that provide the base for the existence of dark matter. Basic introduction to types of dark matter according to standard cosmological theory.
Validation Of System For Compressed Air Quality Imtiaz Rastgar
Food, Pharma and several other manufacturing industries need compressed air with precise control on oil-in-air, dust particles and moisture levels. Instruments and standards of compressed air quality are described by Imtiaz Rastgar, Chairman Rastgar Group and Ex CEO of Engineering Development Board, Ministry of Industries, Government of Pakistan, Islamabad.
Microbiological Environmental Monitoring in Pharmaceutical Facilitydelli_intralab
Merupakan jurnal tentang microbiological environment monitoring in pharma facility
Untuk informasi lebih lanjut atau diskusi mengenai environment monitoring, silahkan hubungi delli.intralab@gmail.com
How the concept was introduced by the astrophycists and examples that provide the base for the existence of dark matter. Basic introduction to types of dark matter according to standard cosmological theory.
Cleanrooms | Minimizing Risk to ProcessesCleanrooms
The overarching objective of a cleanroom is to minimize risk to the process. The risk comes from a variety of pollutants such as dust, airborne microbes, aerosol particles and chemical vapors.
Blue Gene_SM
Introduction
The word "supercomputer" entered the mainstream lexicon in 1996 and 1997 when IBM's Deep Blue supercomputer challenged the world chess champion in two tournaments broadcast around the world.
Since then, IBM has been busy improving its supercomputer technology and tackling much deeper problems.
Their latest project, code named Blue Gene, is poised to shatter all records for computer and network performance.
What is a Super Computer
A supercomputer is a computer that is at the frontline of current processing capacity, particularly speed of calculation.
Today, supercomputers are typically one-of-a-kind custom designs produced by "traditional" companies such as Cray, IBM and Hewlett-Packard, who had purchased many of the 1980s companies to gain their experience.
Why we need Super Computers
Supercomputers are very useful in highly calculation-intensive tasks such as
Problems involving quantum physics,
Weather forecasting,
Climate research,
Molecular modeling (computing the structures and properties of chemical compounds, biological macromolecules, polymers, and crystals),
Physical simulations (such as simulation of airplanes in wind tunnels, simulation of the detonation of nuclear weapons, and research into nuclear fusion).
Why we need Super Computers
Also, they are useful for a particular class of problems, known as Grand Challenge problems, full solution for such problems require semi-infinite computing resources.
NASA™s Linux-based Super Computer
Why Supercomputers are Fast
Several elements of a supercomputer contribute to its high level of performance:
Numerous high-performance processors (CPUs) for parallel processing
Specially-designed high-speed internal networks
Specially-designed or tuned operating systems
What is Blue gene
Blue Gene is a computer architecture project designed to produce several supercomputers that are designed to reach operating speeds in the PFLOPS (petaFLOPS = 1015) range, and currently reaching sustained speeds of nearly 500 TFLOPS (teraFLOPS = 1012).
It is a cooperative project among IBM(particularly IBM Rochester and the Thomas J. Watson Research Center), the Lawrence Livermore National Laboratory, the United States Department of Energy (which is partially funding the project), and academia.
Why Blue Gene
Blue Gene is an IBM Research project dedicated to exploring the
frontiers in supercomputing:
in computer architecture,
in the software required to program and control massively parallel systems, and
in the use of computation to advance the understanding of important biological processes such as protein folding.
Learning more about biomolecular mechanisms is expected to give medical researchers better understanding of diseases, as well as potential cures.
Why the name Blue gene
Blue - The corporate color of IBM
Gene - The intended use of the Blue Gene clusters was for Computational biology.
Blue Gene Projects
There
This presentation is compiled from freely available resources like the websites of FDA, EMA ,WHO and research papers published by experts in this field like Sandle, T Reinmüller, B , Hyde, W,, Costello, E.K., Lauber, C. L., Hamady, M., Fierer, N., Gordon, J.I., Knight, R.
Paper published by T. Sandle on clean room contamination was referred extensively for this presentation. “Drug Regulations” is a non profit organization which provides free online resource to the Pharmaceutical Professional.
Visit http://www.drugregulations.org for latest information from the world of Pharmaceuticals.
- Raw material handling plant
- Dust generation
- Necessity of dust control
- Types of Dust Control system
- Wet Dust Suppression
- Dry fog Dust Suppression
- Types of Nozzle & Spray pattern
- Nozzle Maintenance & Performance Testing
Florida Indoor Air Quality, IAQ Indoor Air Quality Solutions, IAQS - John L...John P. Lapotaire, CIEC.
A presentation to help Floridians understand, improve and maintain their indoor air quality and the indoor environmental challenges in Florida. Presented by John Lapotaire, CIEC. Indoor Air Quality Solutions, IAQS
Air sanitation is the system of removing the impurities present in air inside buildings to protect people from infections. Sanitation of air is essential in enclosed places like hospitals and operation rooms.
the spray drying process involves the atomization of a solution ,slurry or emulsion containing one or more components of the desired product in to droplets by spraying followed by the rapid evaporation of the sprayed droplets in to solid powder by hot air at a certain temp and pressure.
Designing of aseptic area including design, construction, service, flow chart,source of contamination, method of prevention of it,clean area classification as per USPDA.
- Raw Material Handling Plant
- Dust Generation & Necessity of Control
- Types of Dust Control System
- Dust Collection System
- Air Cleaning Devices
- Bag House Dust Collector
Standard particulate matter
particle pollution
air pollution and control
particulate matter
Monitoring of Particulate matter
Monitoring of air pollutants
Design and Operations of Clean Room| Pharmacy. Design and Operations of Clean Room| Pharmacy. Design and Operations of Clean Room| Pharmacy. Design and Operations of Clean Room| Pharmacy. Design and Operations of Clean Room| Pharmacy. Design and Operations of Clean Room| Pharmacy. Design and Operations of Clean Room| Pharmacy. Design and Operations of Clean Room| Pharmacy. Design and Operations of Clean Room| Pharmacy. Design and Operations of Clean Room| Pharmacy. Design and Operations of Clean Room| Pharmacy. Design and Operations of Clean Room| Pharmacy. Design and Operations of Clean Room| Pharmacy. Design and Operations of Clean Room| Pharmacy. Design and Operations of Clean Room| Pharmacy. Design and Operations of Clean Room| Pharmacy. Design and Operations of Clean Room| Pharmacy. Design and Operations of Clean Room| Pharmacy. Design and Operations of Clean Room| Pharmacy. Design and Operations of Clean Room| Pharmacy.
The veda in its real and original meaning is "knowledge". All the knowledge collected by ancient sages was compiled into four books namely vedas. This book is a little attempt to reveal the knowledge hidden in them.
Industrial Training at Shahjalal Fertilizer Company Limited (SFCL)MdTanvirMahtab2
This presentation is about the working procedure of Shahjalal Fertilizer Company Limited (SFCL). A Govt. owned Company of Bangladesh Chemical Industries Corporation under Ministry of Industries.
Welcome to WIPAC Monthly the magazine brought to you by the LinkedIn Group Water Industry Process Automation & Control.
In this month's edition, along with this month's industry news to celebrate the 13 years since the group was created we have articles including
A case study of the used of Advanced Process Control at the Wastewater Treatment works at Lleida in Spain
A look back on an article on smart wastewater networks in order to see how the industry has measured up in the interim around the adoption of Digital Transformation in the Water Industry.
CW RADAR, FMCW RADAR, FMCW ALTIMETER, AND THEIR PARAMETERSveerababupersonal22
It consists of cw radar and fmcw radar ,range measurement,if amplifier and fmcw altimeterThe CW radar operates using continuous wave transmission, while the FMCW radar employs frequency-modulated continuous wave technology. Range measurement is a crucial aspect of radar systems, providing information about the distance to a target. The IF amplifier plays a key role in signal processing, amplifying intermediate frequency signals for further analysis. The FMCW altimeter utilizes frequency-modulated continuous wave technology to accurately measure altitude above a reference point.
About
Indigenized remote control interface card suitable for MAFI system CCR equipment. Compatible for IDM8000 CCR. Backplane mounted serial and TCP/Ethernet communication module for CCR remote access. IDM 8000 CCR remote control on serial and TCP protocol.
• Remote control: Parallel or serial interface.
• Compatible with MAFI CCR system.
• Compatible with IDM8000 CCR.
• Compatible with Backplane mount serial communication.
• Compatible with commercial and Defence aviation CCR system.
• Remote control system for accessing CCR and allied system over serial or TCP.
• Indigenized local Support/presence in India.
• Easy in configuration using DIP switches.
Technical Specifications
Indigenized remote control interface card suitable for MAFI system CCR equipment. Compatible for IDM8000 CCR. Backplane mounted serial and TCP/Ethernet communication module for CCR remote access. IDM 8000 CCR remote control on serial and TCP protocol.
Key Features
Indigenized remote control interface card suitable for MAFI system CCR equipment. Compatible for IDM8000 CCR. Backplane mounted serial and TCP/Ethernet communication module for CCR remote access. IDM 8000 CCR remote control on serial and TCP protocol.
• Remote control: Parallel or serial interface
• Compatible with MAFI CCR system
• Copatiable with IDM8000 CCR
• Compatible with Backplane mount serial communication.
• Compatible with commercial and Defence aviation CCR system.
• Remote control system for accessing CCR and allied system over serial or TCP.
• Indigenized local Support/presence in India.
Application
• Remote control: Parallel or serial interface.
• Compatible with MAFI CCR system.
• Compatible with IDM8000 CCR.
• Compatible with Backplane mount serial communication.
• Compatible with commercial and Defence aviation CCR system.
• Remote control system for accessing CCR and allied system over serial or TCP.
• Indigenized local Support/presence in India.
• Easy in configuration using DIP switches.
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NUMERICAL SIMULATIONS OF HEAT AND MASS TRANSFER IN CONDENSING HEAT EXCHANGERS...ssuser7dcef0
Power plants release a large amount of water vapor into the
atmosphere through the stack. The flue gas can be a potential
source for obtaining much needed cooling water for a power
plant. If a power plant could recover and reuse a portion of this
moisture, it could reduce its total cooling water intake
requirement. One of the most practical way to recover water
from flue gas is to use a condensing heat exchanger. The power
plant could also recover latent heat due to condensation as well
as sensible heat due to lowering the flue gas exit temperature.
Additionally, harmful acids released from the stack can be
reduced in a condensing heat exchanger by acid condensation. reduced in a condensing heat exchanger by acid condensation.
Condensation of vapors in flue gas is a complicated
phenomenon since heat and mass transfer of water vapor and
various acids simultaneously occur in the presence of noncondensable
gases such as nitrogen and oxygen. Design of a
condenser depends on the knowledge and understanding of the
heat and mass transfer processes. A computer program for
numerical simulations of water (H2O) and sulfuric acid (H2SO4)
condensation in a flue gas condensing heat exchanger was
developed using MATLAB. Governing equations based on
mass and energy balances for the system were derived to
predict variables such as flue gas exit temperature, cooling
water outlet temperature, mole fraction and condensation rates
of water and sulfuric acid vapors. The equations were solved
using an iterative solution technique with calculations of heat
and mass transfer coefficients and physical properties.
Sachpazis:Terzaghi Bearing Capacity Estimation in simple terms with Calculati...Dr.Costas Sachpazis
Terzaghi's soil bearing capacity theory, developed by Karl Terzaghi, is a fundamental principle in geotechnical engineering used to determine the bearing capacity of shallow foundations. This theory provides a method to calculate the ultimate bearing capacity of soil, which is the maximum load per unit area that the soil can support without undergoing shear failure. The Calculation HTML Code included.
Final project report on grocery store management system..pdfKamal Acharya
In today’s fast-changing business environment, it’s extremely important to be able to respond to client needs in the most effective and timely manner. If your customers wish to see your business online and have instant access to your products or services.
Online Grocery Store is an e-commerce website, which retails various grocery products. This project allows viewing various products available enables registered users to purchase desired products instantly using Paytm, UPI payment processor (Instant Pay) and also can place order by using Cash on Delivery (Pay Later) option. This project provides an easy access to Administrators and Managers to view orders placed using Pay Later and Instant Pay options.
In order to develop an e-commerce website, a number of Technologies must be studied and understood. These include multi-tiered architecture, server and client-side scripting techniques, implementation technologies, programming language (such as PHP, HTML, CSS, JavaScript) and MySQL relational databases. This is a project with the objective to develop a basic website where a consumer is provided with a shopping cart website and also to know about the technologies used to develop such a website.
This document will discuss each of the underlying technologies to create and implement an e- commerce website.
3. Definition
• A room in which the concentration of airborne particles is controlled,
and which is constructed and used in a manner to minimize the
introduction, generation, and retention of particles inside the room
and in which other relevant parameters, e.g. temperature, humidity,
and pressure, are controlled as necessary.
4. History
• Lord lister realized that elimination of bacteria can reduce infection.
• In 1860’s he used carbolic acid on instruments, wound and surgeons hands and prevent airborne
by spraying into air.
• The use of nuclear fission, as well as the biological and chemical warfare research carried out
during the 1939-1945 Second World War, were the driving forces for the production of High
Efficiency Particulate Air (HEPA) filters necessary to contain the dangerous microbial or
radioactive contaminants.
• In the early 1950s the Western Electric Company in Winston-Salem, NC, USA was having a major
problem in manufacturing missile gyroscopes. About 99 out of 100 gyroscopes were being
rejected, the problem being identified as dust.
5.
6. • Cleanroom technology can be divided into three parts: design, testing
and operation.
• Cleanrooms have to be first designed and constructed; they then have
to be tested to ensure they achieve their design specification and
continue to do so.
• Finally they have to be operated in such a way as to minimise
contamination.
7. Importance
• A major user of cleanrooms is the semiconductor fabrication industry,
where processors are produced for use in computers, cars and other
machines.
• Figure shows a photomicrograph of a semiconductor with a particle on it. Such particles can cause
an electrical short and ruin the semiconductor.
• To minimise contamination problems, semiconductors
Are manufactured in cleanrooms with very high
standards of cleanliness.
8. • Molecular contaminants (Out gassing, Oil vapour, Alcohols, Paints, glues, & epoxies, Aromatics; If
you can smell it, suspect it as a contaminant.
• Surface contaminants Finger prints - Oil & grease Skin oil Hand cream Wax
• Particulate contaminants
People (skin, scales, hair, clothing lint, etc.)
Particle shedding materials (cardboard boxes, paper)
Abrading actions (drilling, sawing, sanding, etc.)
12. Types of Cleanrooms
• Cleanrooms have evolved into two major types and they are
differentiated by their method of ventilation. These are turbulently
ventilated and unidirectional flow cleanrooms.
• Turbulently ventilated cleanrooms are also known as ‘non uni-
directional’. Unidirectional flow cleanrooms were originally known as
‘laminar flow’ cleanrooms.
• This air sweeps across the room in a unidirectional way at and exits
through the floor, thus removing the airborne contamination from the
room. This type of clean room uses very much more air than the
turbulently ventilated type, and gives superior cleanliness.
13.
14. • The type, number and placement of air supply diffusers, as well as the
extract grilles, is an important consideration in a turbulently
ventilated cleanroom.
• Air diffusers are used in many air conditioned rooms and situated
where the supply air enters a room; they are designed to minimize
the draught caused by high air velocities and ensure good air mixing.
• It is possible to supply the air to a cleanroom with, or without, a
diffuser.
16. • In some conventionally ventilated cleanrooms, diffusers are not used
and the supply air is ‘dumped’ down directly from the air filter into
the cleanroom.
• This method is chosen to obtain unidirectional flow and good
contamination control conditions under the filter
18. • ‘Dump’ methods will give enhanced conditions below the supply area,
but must therefore give poorer conditions elsewhere in the room.
• If enhanced conditions are required at critical areas, then it is better
to ensure good air mixing in the cleanroom by means of diffusers, and
use unidirectional cabinets or workstations at the critical areas.
• Diffusers should, however, be selected so that there are a sufficient
number and size to give good mixing and draught free conditions.
19. • If the ‘dump’ method is chosen then the filters should preferably be
distributed evenly about the room. There may be an advantage in
grouping the filters together to protect an area that must be kept
clean.
• However, if grouping is employed, it should be remembered that the
standard of the cleanroom is determined by the dirtiest part and this
may give a lower classification.
20. ISO classification
• Cn is the maximum permitted concentration (in particles/m3 of air) of airborne particles that are
equal to, or larger, than the considered particle size.
• Cn is rounded to the nearest whole number.
• N is the IS0 classification number, which shall not exceed the value of 9.
• Intermediate IS0 classification numbers may be specified, with 0.1 the smallest permitted
increment of N.
• D is the considered particle size in µm.
• 0.1 is a constant with a dimension of µm.
21. Room pressurisation and air movement
control between rooms
• A cleanroom must be designed to ensure that contaminated air does not come into the room
from dirtier adjacent areas.
• Air should therefore always move from the cleanroom to less-clean adjacent areas. This means
that the highest pressure should be in the production area
• If a cleanroom is at a higher pressure than an adjacent area then air will flow from the cleanroom
to the adjacent area. Differential pressures of 10 Pa between two cleanrooms, and 15 Pa between
a cleanroom and an unclassified area, are reasonable design pressures
22.
23. High efficiency FILTERS
• HEPA and ULPA
• High-Efficiency Particulate Air Filter
• Ultra Low Penetration Air Filter
• HEPA Collection Efficiency ≥ 99.97% (for 0.3 μm particles)
• ULPA Collection Efficiency ≥ 99.999%(for 0.1-0.2 μm particles)
• Paper-like mat of glass fibers perpendicular to airflow.
• Fibers randomly oriented in the mat.
• Organic binder is added for strength.
24.
25. Diffusion
• Diffusion works on the smallest particles. Small particles are not held in
place by the viscous fluid and diffuse(also known as Brownian movement) within
the flow stream. As the particles traverse the flow stream, they collide with the
fiber and are collected.
• It is interesting to note that high
efficiency filters are more efficient
against particles than are smaller than
the most penetrating size; this effect is
Caused by diffusion.
26. Inertial Impaction
Inertia works on large, heavy particles suspended in the flow stream. These
particles are heavier than the fluid surrounding them. As the fluid changes
direction to enter the fiber space, the particle continues in a straight line and
collides with the media fibers where it is trapped and held.
27. Interception
Direct interception works on particles in the mid-range size that are not
quite large enough to have inertia and not small enough to diffuse within the flow
stream. These mid-sized particles follow the flow stream as it bends through the
fiber spaces. Particles are intercepted or captured when they touch a fiber.
28. • Sieving
Sieving, the most common mechanism in filtration, occurs when
the particle is too large to fit between the fiber spaces.
Elecrostatic : when charged particles
29.
30.
31. Don’t:
– touch your face or skin with gloves
– touch building hardware, oily machinery, or wafer loading areas
– lean on equipment
– wear cosmetics, powders, or colognes
– wear anything on fingers-- remove all rings and bracelets
– use paper, pencils or markers that leave dust or lint
Do:
– change gloves whenever they get dirty or torn
– use a fresh pair of gloves whenever handling wafers
– wipe down wafer handling areas with isopropanol
– use clean room paper and dust-free ball point pens
32. REFERENCE:
• Cleanroom Technology: Fundamentals of Design, Testing and Operation, W.Whyte, Copyright 2001 John Wiley & Sons Ltd
Print ISBN 0-471-86842-6 Online ISBN 0--470-84777-8