Dr. Naveen Verma presented on chemimmunotherapy for glanders. Glanders is a disease primarily affecting solipeds like horses and donkeys, caused by the bacterium Burkholderia mallei. It causes skin lesions, abscesses, and pneumonia. Historically it was investigated as a biological weapon. Treatment involves long-term antibiotic therapy over months. No vaccine currently exists for the disease in animals or humans. Control relies on identifying and eliminating infected herds through surveillance, slaughter of positive animals, and segregation and re-testing of exposed animals.
Francisella tularensis is a pathogenic species of Gram-negative coccobacillus, an aerobic bacterium. It is nonspore-forming, nonmotile, and the causative agent of tularemia, the pneumonic form of which is often lethal without treatment.
This ppt contains all the information about the epidemiology of lymphatic filariasis. It is useful for students of the medical field learning Preventive and social medicine, Swasthavritta (Ayurved), and everyone who is interested in knowing about it.
F. tularensis subspecies exhibit abroad host ranges. Diseases caused by this species is sub-divided into several forms, based on clinical presentation.
Objective :
Describe the morphology and structure of mycobacterial tuberculosis ?
What are the tests required for mycobacterial infection :
Mantoux skin test
Sputum examination using Ziehl-Neelsen staining
Sputum culture using lowenstein-jensen media
Discuss the clinical features and transmission of mycobacterial tuberculosis.
What are the pathological changes in mycobacterium tuberculosis?
How to control mycobacterial infection in the environment and vaccine available?
done by : asem shadid , college of medicine .
Francisella tularensis is a pathogenic species of Gram-negative coccobacillus, an aerobic bacterium. It is nonspore-forming, nonmotile, and the causative agent of tularemia, the pneumonic form of which is often lethal without treatment.
This ppt contains all the information about the epidemiology of lymphatic filariasis. It is useful for students of the medical field learning Preventive and social medicine, Swasthavritta (Ayurved), and everyone who is interested in knowing about it.
F. tularensis subspecies exhibit abroad host ranges. Diseases caused by this species is sub-divided into several forms, based on clinical presentation.
Objective :
Describe the morphology and structure of mycobacterial tuberculosis ?
What are the tests required for mycobacterial infection :
Mantoux skin test
Sputum examination using Ziehl-Neelsen staining
Sputum culture using lowenstein-jensen media
Discuss the clinical features and transmission of mycobacterial tuberculosis.
What are the pathological changes in mycobacterium tuberculosis?
How to control mycobacterial infection in the environment and vaccine available?
done by : asem shadid , college of medicine .
Epidemiology & Control Measures of Mumps.pptxAB Rajar
Mumps is best known for the puffy cheeks and tender, swollen jaw that it causes. This is a result of swollen salivary glands under the ears on one or both sides, often referred to as parotitis. Other symptoms that might begin a few days before parotitis include: Fever. Headache.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
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Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
3. Glanders
• It is an acute to chronic disease of mainly solipeds characterized
by pustular skin lesions , multiple abscess ,necrosis in
respiratory tract pneumonia and sepsis .
• It is called “glanders” when the principal lesions are seen in the
nostrils, submaxillary glands and lungs.
• &
• It is called “farcy” when lesions are on the surface of limbs or
body.
5. History
• World War I
• Suspected use as biological agent to infect Russian
horses and mules.
• Large number of human cases in Russia during
and after WWI.
6. History
• World War II
• Japanese handling infected horses, civilians, and POWs
• U.S. and Russia investigated use as biological weapon.
Center for Food Security and Public Health, Iowa State University, 2011
7.
8. The Organism
• Burkholderia mallei
• Gram negative bacillus
• Exists primarily in infected host
• Prolonged survival in favorable environments
• Inactivated by heat and sunlight
• Related to Burkholderia pseudomallei
• Cause of meliodosis
9. Epidemiology
• Endemic
• Africa, Asia, the Middle East and Central and South
America, Northern Australia specially during rainy
season.
• Sporadic cases
• Central America
• Once widespread, has been eradicated from many
countries
19. Diagnosis: Animals
• Isolation of Burkholderia mallei
• Blood, sputum, urine or skin lesions
• Mallein test
• Intrapalpebral or conjunctival injection
• Swelling 1 to 2 days later
• Serology
• Compliment fixation and ELISA
• Most reliable in horses
27. Ringer's-lactate-dextrose 500 ml + dimetyl-sulfoxide 60-80 ml
intravenously and Inj. Norfloxacin 5% 35-50 ml intramuscularly
(1st round of treatment).
(Ghulam mohammmed ,2001)
33. Prevention & Control
No vaccine is available for animal as well as human use.
Identification and elimination of foci of infection
Surveillance and monitoring of equine herds especially
in endemic areas
Positive animals should be slaughtered immediately &
carcass should be disposed off by incineration or deep
burial
In-contact & exposed animals should be segregated ,
Re- tested to detect and destroy the positives according
to The Glander & Farcy Act XIII, 1899
Editor's Notes
Animated pointer and light-up text
(Advanced)
To reproduce the background effects on this slide, do the following:
On the Home tab, in the Slides group, click Layout, and then click Blank.
Right-click the slide background area, and then click Format Background. In the Format Background dialog box, click Fill in the left pane, select Solid fill in the right pane, and select White, Background 1 (first row, first option from the left).
To reproduce the rectangle on this slide, do the following:
On the Home tab, in the Drawing group, click Shapes, and then under Rectangles click Rounded Rectangle (second option from the left). On the slide, drag to draw a rounded rectangle.
Select the rectangle. Drag the yellow diamond adjustment handle to the left to decrease the amount of rounding on the corners.
With the rounded rectangle still selected, under Drawing Tools, on the Format tab, in the Size group, do the following:
In the Shape Height box, enter 3.5”.
In the Shape Width box, enter 0.25”.
Under Drawing Tools, on the Format tab, in the bottom right corner of the Shape Styles group, click the Format Shape dialog box launcher. In the Format Shape dialog box, click Fill in the left pane. In the Fill pane, select Solid fill, click the button next to Color, and then under Theme Colors click White, Background 1, Darker 15% (third row, first option from the left).
Also in the Format Shape dialog box, click Line Color in the left pane. In the Line Color pane, select No line.
Also in the Format Shape dialog box, click Shadow in the left pane. In the Shadow pane, click the button next to Presets, under Outer select Offset Bottom (first row, second option from the left), and then do the following:
In the Transparency box, enter 0%.
In the Size box, enter 100%.
In the Blur box, enter 8.5 pt.
In the Angle box, enter 90°.
In the Distance box, enter 1 pt.
Also in the Format Shape dialog box, click 3-D Format in the left pane. In the 3-D Format tab, do the following:
Under Bevel, click the button next to Top, and then under Bevel click Circle (first row, first option from the left). Next to Top, in the Width box, enter 5 pt, and in the Height box, enter 5 pt.
Under Surface, click the button next to Material, and then under Standard click Matte (first row, first option from the left). Click the button next to Lighting, and then under Neutral click Soft (first row, third option from the left).
On the slide, select the rounded rectangle. On the Home tab, in the Clipboard group, click the arrow to the right of Copy, and then click Duplicate.
Select the duplicate rectangle. On the Home tab, in the Drawing group, do the following:
Click the arrow next to Shape Fill, and then click No Fill.
Click the arrow next to Shape Outline, and then click No Outline.
Drag the second rectangle above the first rectangle until the lower edge overlays the top edge of the first rectangle. (Note: When the spinning animation effect is created later for these rectangles, the spin will center where the edges of the rectangles meet.)
Press and hold CTRL, and then select both rectangles. On the Home tab, in the Drawing group, click Arrange, and do the following:
Point to Align, and then click Align Selected Objects.
Point to Align, and then click Align Center.
Click Group.
On the slide, drag the group until it is centered horizontally on the left edge of the slide (straddling the edge).
On the Home tab, in the Drawing group, click Arrange, point to Align, and then do the following:
Click Align to Slide.
Click Align Middle.
To reproduce the dashed arc on this slide, do the following:
On the Home tab, in the Drawing group, click Shapes, and then under Basic Shapes click Arc (third row, 12th option from the left). On the slide, drag to draw an arc.
Select the arc. Under Drawing Tools, on the Format tab, in the Size group, do the following:
In the Shape Height box, enter 7.5”.
In the Shape Width box, enter 7.5”.
With the arc still selected, on the Home tab, in the Drawing group, click the arrow next to Shape Outline and then do the following:
Under Theme Colors, click White, Background 1, Darker 15% (third row, first option from the left).
Point to Dashes, and then click Dash (fourth option from the top).
On the slide, drag the yellow diamond adjustment handle on the right side of the arc to the bottom of the arc to create a half circle.
Drag the arc until the yellow diamond adjustment handles are on the left edge of the slide.
With the arc still selected, on the Home tab, in the Drawing group, click the arrow under Arrange, point to Align, and then do the following:
Click Align to Slide.
Click Align Middle.
To reproduce the half circle on this slide, do the following:
On the slide, select the arc. On the Home tab, in the Clipboard group, click the arrow to the right of Copy, and then click Duplicate.
Select the duplicate arc. Under Drawing Tools, on the Format tab, in the Size group, do the following:
In the Shape Height box, enter 3.33”.
In the Shape Width box, enter 3.33”.
With the second arc still selected, under Drawing Tools, on the Format tab, in the Shape Styles group, click the arrow next to Shape Fill, and then under Theme Colors click White, Background 1, Darker 5% (second row, first option from the left).
Under Drawing Tools, on the Format tab, in the Shape Styles group, click the arrow next to Shape Outline, and then click No Outline.
Under Drawing Tools, on the Format tab, in the Shape Styles group, click Shape Effects, point to Shadow, and then click Shadow Options. In the Format Shape dialog box, click Shadow in the left pane. In the Shadow pane, click the button next to Presets , under Inner click Inside Right (second row, third option from the left), and then do the following:
In the Transparency box, enter 86%.
In the Blur box, enter 24 pt.
In the Angle box, enter 315°.
In the Distance box, enter 4 pt.
On the slide, drag the second arc until the yellow diamond adjustment handles are on the left edge of the slide. On the Home tab, in the Drawing group, click Arrange, and then do the following:
Point to Align, and then click Align to Slide.
Point to Align, and then click Align Middle.
Click Send to Back.
To reproduce the button shapes on this slide, do the following:
On the Home tab, in the Drawing group, click Shapes, and then under Basic Shapes click Oval (first row, second option from the left). On the slide, drag to draw an oval.
Select the oval. Under Drawing Tools, on the Format tab, in the Size group, do the following:
In the Shape Height box, enter 0.34”.
In the Shape Width box, enter 0.34”.
Under Drawing Tools, on the Format tab, in the Shape Styles group, click More, and then click Light 1 Outline, Colored Fill – Olive Green, Accent 3 (third row, first option from the left).
Under Drawing Tools, on the Format tab, in the bottom right corner of the Shape Styles group, click the Format Shape dialog box launcher. In the Format Shape dialog box, click Fill in the left pane. In the Fill pane, select Solid Fill. Click the button next to Color, and then under Theme Colors click Olive Green, Accent 3, Lighter 80° (second row, seventh option from the left).
Also in the Format Shape dialog box, click Line Color in the left pane. In the Line Color pane, select No line.
Also in the Format Shape dialog box, click Shadow in the left pane. In the Shadow pane, click the button next to Presets, under Outer click Offset Bottom (first row, second option from the left), and then do the following:
In the Transparency box, enter 0%.
In the Size box, enter 100%.
In the Blur box, enter 8.5 pt.
In the Angle box, enter 90°.
In the Distance box, enter 1 pt.
Also in the Format Shape dialog box, click 3-D Format in the left pane, and then do the following in the 3-D Format pane:
Under Bevel, click the button next to Top, and then under Bevel click Art Deco (third row, fourth option from the left). Next to Top, in the Width box, enter 5 pt, and in the Height box, enter 5 pt.
Under Contour, click the button next to Color, and then under Theme Colors click White, Background 1 (first row, first option from the left). In the Size box, enter 3.5 pt.
Under Surface, click the button next to Material, and then under Standard click Matte (first row, first option from the left). Click the button next to Lighting, and then under Neutral click Soft (first row, third option from the left).
On the slide, select the oval. Under Drawing Tools, on the Format tab, in the bottom right corner of the Size group, click the Size and Position dialog box launcher. In the Format Shape dialog box, click Position in the left pane, and in the Position pane, do the following to position the third and fourth ovals:
In the Horizontal box, enter 2.98”.
In the Vertical box, enter 1.5”.
Select the oval. On the Home tab, in the Clipboard group, click the arrow under Paste, and then click Duplicate.
Select the duplicate oval. Under Drawing Tools, on the Format tab, in the bottom right corner of the Size group, click the Size and Position dialog box launcher. In the Format Shape dialog box, click Position in the left pane, and in the Position pane, do the following to position the third and fourth ovals:
In the Horizontal box, enter 3.52”.
In the Vertical box, enter 2.98”.
Repeat step 9 two more times, for a total of four ovals. Under Drawing Tools, on the Format tab, in the bottom right corner of the Size group, click the Size and Position dialog box launcher. In the Format Shape dialog box, click Position in the left pane, and in the Position pane, do the following to position the third and fourth ovals:
Select the third oval on the slide, and then enter 3.52” in the Horizontal box and 4.27” in the Vertical box.
Select the fourth oval on the slide, and then enter 2.99” in the Horizontal box and 5.66” in the Vertical box.
To reproduce the text on this slide, do the following:
On the Insert tab, in the Text group, click Text Box, and then on the slide, drag to draw the text box.
Enter text in the text box and select the text. On the Home tab, in the Font group, do the following:
In the Font list, select Corbel.
In the Font Size list, select 22.
Click the arrow next to Font Color, and then under Theme Colors click White, Background 1, Darker 50% (sixth row, first option from the left).
On the Home tab, in the Paragraph group, click Align Text Left to align the text left in the text box.
On the slide, drag the text box to the right of the first oval.
Select the text box. On the Home tab, in the Clipboard group, click the arrow to the right of Copy, and then click Duplicate.
Click in the text box and edit the text.
Drag the second text box to the right of the second oval.
Repeat steps 5-7 to create the third and fourth text boxes, dragging them to the right of the third and fourth ovals.
To reproduce the animation effects on this slide, do the following:
On the Home tab, in the Editing group, click Select, and then click Selection Pane.
In the Selection and Visibility task pane, select the rectangle group.
On the Animations tab, in the Advanced Animation group, click Add Animation, and then under Emphasis click Spin.
Also on the Animations tab, in the Animation group, click the Effect Options dialog box launcher. In the Spin dialog box, do the following:
On the Effects tab, in the Amount list, in the Custom box, enter 123°, and then press ENTER. Also in the Amount list, click Counterclockwise.
On the Timing tab, in the Duration box, select 1.00.
On the Timing tab, in the Start list, select With Previous.
On the slide, select the first oval. On the Animations tab, in the Advanced Animation group, click Add Animation, and then click More Emphasis Effects. In the Add Emphasis Effect dialog box, under Basic, click Fill Color.
On the Animations tab, in the Animation group, click the Effect Options dialog box launcher. In Fill Color dialog box, the do the following:
On the Effects tab, in the Fill Color list, click More Colors. In the Colors dialog box, on the Custom tab, enter values for Red:130, Green:153, Blue: 117.
On the Timing tab, in the Duration box, , enter 0.50.
On the Timing tab, in the Start list, select After Previous.
On the slide, select the first text box. On the Animations tab, in the Advanced Animation group, click Add Animation, and then under Entrance click Fade.
Also on the Animations tab, in the Timing group, do the following:
In the Start list, select With Previous.
In the Duration box, enter 0.50.
In the Selection and Visibility task pane, select the rectangle group. On the Animations tab, in the Advanced Animation group, click Add Animation, and then under Emphasis click Spin.
Also on the Animations tab, in the Animation group, click the Effect Options dialog box launcher. In the Spin dialog box, do the following:
On the Effects tab, in the Amount list, in the Custom box, enter 22°, and then press ENTER. Also in the Amount list, click Clockwise.
On the Timing tab, in the Start list, select On Click.
On the Timing tab, in the Duration box, enter 0.50.
On the slide, select the second oval. On the Animations tab, in the Advanced Animation group, click Add Animation, and then click More Emphasis Effects. In the Add Emphasis Effect dialog box, under Basic, click Fill Color.
On the Animations tab, in the Animation group, click the Effect Options dialog box launcher. In the Fill Color dialog box, do the following:
On the Effects tab, in the Fill Color list, click More Colors. In the Colors dialog box, on the Custom tab, enter values for Red:130, Green:153, Blue: 117.
On the Timing tab, in the Start list, select After Previous.
On the Timing tab, in the Duration box, enter 0.50.
On the slide, select the second text box. On the Animations tab, in the Advanced Animation group, click Add Animation, and then under Entrance click Fade.
Also on the Animations tab, in the Timing group, do the following:
In the Start list, select With Previous.
In the Duration box, enter 0.50.
On the slide, select the third oval. On the Animations tab, in the Advanced Animation group, click Add Animation, and then click More Emphasis Effects. In the Add Emphasis Effect dialog box, under Basic, click Fill Color.
On the Animations tab, in the Animation group, click the Effect Options dialog box launcher. In the Fill Color dialog box, do the following:
On the Effects tab, in the Fill Color list, click More Colors. In the Colors dialog box, on the Custom tab, enter values for Red:130, Green:153, Blue: 117.
On the Timing tab, in the Start list, select After Previous.
On the Timing tab, in the Speed list, select Very Fast.
On the slide, select the third text box. On the Animations tab, in the Advanced Animation group, click Add Animation, and then under Entrance click Fade.
Also on the Animations tab, in the Timing group, do the following:
In the Start list, select With Previous.
In the Duration box, enter 0.50.
On the slide, select the fourth oval. On the Animations tab, in the Advanced Animation group, click Add Animation, and then click More Emphasis Effects. In the Add Emphasis Effect dialog box, under Basic, click Fill Color.
On the Animations tab, in the Animation group, click the Effect Options dialog box launcher. In the Fill Color dialog box, do the following:
On the Effects tab, in the Fill Color list, click More Colors. In the Colors dialog box, on the Custom tab, enter values for Red:130, Green:153, Blue: 117.
On the Timing tab, in the Start list, select After Previous.
On the Timing tab, in the Duration box, enter 0.50.
On the slide, select the fourth text box. On the Animations tab, in the Advanced Animation group, click Add Animation, and then under Entrance click Fade.
On the Animations tab, in the Timing group, do the following:
In the Start list, select With Previous.
In the Duration box, enter 0:50.
The first recorded description of glanders was in the third century by Aristotle. In 1664, glanders was recognized as a contagious organism, and in 1830 its zoonotic potential was suspected. In the late 1800s, the Mallein test was developed for the diagnosis of glanders. At the turn of the century, the U.S., Canada, and Great Britain all implemented glanders-control programs.
During World War I, glanders was believed to have been spread deliberately to infect large numbers of Russian horses and mules on the Eastern Front. This affected the troops and supply convoys, as well as artillery movement because of their dependence on horses and mules. Human cases of glanders also increased in Russia during and after WWI.
[Photo: Allied cavalries, such as this Belgian convoy, may have been the target of glanders attacks in World War I. Source: Nova Online, Iowa Public Television.]
It is widely held that the Japanese deliberately infected horses, civilians, and prisoners of war with glanders during World War II. The United States studied glanders as a possible biological weapon in 1943-44 but did not weaponize it. The former Soviet Union is also believed to have been interested in B. mallei as a potential biological weapon agent after World War II.
(Photos: Soldiers with their horses. Source: (Bottom right) www.civilwarhome.com/images/cavalry.jpg; www.continet.com/ppsh/cavalry.jpg; www.firstworldwar.com/diaries/ graphics/horsesdrinking.jpg)
Glanders is caused by the bacteria Burkholderia mallei. This organism has gone through several name changes, including Pseudomonas mallei, Malleomyces mallei, and Actinomyces mallei. It is a Gram negative bacillus and predominantly exists in infected hosts, but may remain viable for several months in warm moist environments. Although this organism is inactivated by heat and sunlight, its survival is prolonged in wet or humid environments. B. mallei remains viable in room temperature water for up to a month, and may be viable for more than a year in favorable environments. The organism is closely related to Burkholderia pseudomallei, the causative agent of melioidosis; the two are serologically indistinguishable in some cases. The genetic homology between the two organisms is great, and because of this, many consider them to be biotypes or isotypes of the same organism.
[Photo: Scanning electron micrograph of the bacillus shape of Burkholderia. Source: CDC Public Health Image Library]
Glanders is endemic in parts of Asia, Africa, the Middle East, South America and possibly the Balkan states, former Soviet republics, and Mexico. Sporadic cases occur in Central America. Between 1998 and 2007, cases were reported from Brazil, Turkey, the former U.S.S.R., Eritrea, Ethiopia, Iran, Iraq, United Arab Emirates, and Mongolia. This disease may also exist in Pakistan. The geographic distribution of B. mallei is difficult to determine precisely as cross reactions with serological tests for melioidosis (Burkholderia pseudomallei) most likely confound the true estimates of worldwide distribution. Although glanders was once widespread throughout the world, it has been eradicated from many countries by test and slaughter programs. In countries that have eradicated glanders, cases may occur in researchers who work with this agent.
Glanders is introduced into horse populations by diseased or latently infected animals. Ingestion of the organism is the major route of infection. Experimental evidence suggests that inhalation of the organism is less likely to result in typical cases of the disease. Acquiring the disease through skin or mucous membranes is possible but regarded as of minor importance in the natural spread of the disease. Close contact between animals alone does not usually result in transmission, but transmission is facilitated if animals share feeding or watering facilities. B. mallei is readily spread on fomites, including harnesses, grooming tools, and food and water troughs. Carnivores usually become infected when they eat contaminated meat.
[Photo: two horses sharing water. Source: Katie Lawless/nationalgeographic.com]
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Glanders is primarily a disease of solipeds – particularly horses, donkeys, and mules. Donkeys have been regarded as most likely to experience the acute form of the disease, while a more chronic form of the disease is common in horses. Sources disagree whether mules are more likely to develop acute or chronic disease. Carnivores are susceptible if they consume infected meat; felids appear to be more susceptible than canids. Several laboratory animals are susceptible to infection, including hamsters and guinea pigs. Humans also are susceptible to infection. Swine and cattle are resistant, but goats and sheep can be infected. Most domesticated animals other than cattle, pigs, and rats can be infected experimentally. Wildlife species, including bears, wolves, field mice, rabbits, and voles, have also been infected. Hamsters and guinea pigs are the most susceptible rodents. Mice are resistant to disease unless the dose of organisms is high.
[Photo: (Top) Horses. Source: U.S. Department of Agriculture. (Bottom): Donkey. Source: Wikimedia Commons]
Humans that have occupational exposure are at the highest risk for infection. This includes: workers in laboratory settings, veterinarians, grooms, horsemen, butchers, and any other people who work closely with horses.
[Photo: (Top) Veterinarian floating a horses teeth. Source: horsebackmagazine.com; (Middle) Grooming horse. Source: Michigan State University Extension; (Bottom) Laboratorian swabbing a petri dish. Source: www.labtestsonline.com]
At necropsy there may be ulcers, nodules, and stellate scars in the nasal cavity, trachea, pharynx, larynx, skin, and subcutaneous tissues. Catarrhal bronchopneumonia with enlarged bronchial lymph nodes may be present. The lungs, liver, spleen and kidneys may contain firm, rounded, encapsulated miliary gray nodules similar to tubercles. The lymphatic vessels may be swollen, the lymph nodes are typically enlarged and fibrotic and contain focal abscesses. In addition, necrosis may be noted in the internal organs and testes. The upper photo shows a granulomatous lesion in the lip of a donkey. Lower photo is an extensive pyogenic granulomatous pneumonia in a donkey.
(Photos: (Top) A granulomatous lesion in the lip of a donkey. (Bottom) Extensive pyogenic granulomatous pneumonia in a donkey. Source: USAHA Foreign Animal Diseases (The Gray Book) at http://www.aphis.usda.gov/emergency_response/downloads/nahems/fad.pdf]
Glanders can be diagnosed by bacteriologic isolation of B. mallei from skin lesions or blood samples. Inoculation into guinea pigs, the mallein test, and serology can also be used. With the mallein test, a positive reaction is indicated by eyelid swelling 1 to 2 days after intrapalpebral injection of a protein fraction of B. mallei, or by conjunctivitis after administration in eyedrops. This is similar to tuberculin testing. A variety of serologic tests are available, including complement fixation, ELISA, indirect hemagglutination, counter-immunoelectrophoresis and immunofluorescence. The most accurate and reliable tests in horses are complement fixation and ELISA. Agglutination and precipitin tests are unreliable for horses with chronic glanders and animals in poor condition. Serological tests cannot distinguish reactions to B. mallei from reactions to B. pseudomallei.
Signs of glanders must be distinguished from melioidosis, strangles, lymphangitis, ulcerative lymphangitis, and other forms of pneumonia. Purulent sinusitis, gutteral pouch empyema, and other causes of nasal catarrh should also be considered. Skin lesions may be similar to those of dermatophilosis or dermatomycoses, such as sporotrichosis.
Limited information exists regarding antibiotic treatment of glanders since the disease had largely disappeared by the time antibiotics became available. Long term treatment and multiple drugs may be necessary, up to 12 months for extrapulmonary suppurative disease. Few studies have been published on the antibiotic susceptibility of B. mallei, but some treatment recommendations are available. This organism is usually resistant to some classes of antibiotics. Abscesses may need to be drained.
In countries where glanders is endemic in animals, prevention of the disease in humans involves identification and elimination of the infection in animal populations. Within the health care setting, transmission can be prevented by using common blood and body fluid precautions. Biosafety level 3 containment practices are required for laboratory staff when working with glanders. Field veterinarians and veterinary pathologists must take strict precautions to prevent human infections by the cutaneous or respiratory route during clinical or post-mortem exams of suspected cases. Adequate protective clothing, including gloves and face masks, should be worn.