There are three main types of chemical bonds: ionic bonds, covalent bonds, and metallic bonds. Ionic bonds form when a metal transfers electrons to a nonmetal, creating positively charged ions and negatively charged ions. Covalent bonds form when atoms share electrons as either single, double or triple bonds. Metallic bonds form a "sea of electrons" that are shared between positive metal ions throughout a crystalline structure.
chemical bonding and molecular structure class 11sarunkumar31
hybridisation, bonding and antiboding, dipole moment, VSPER theory, Molecular orbital diagram, Phosphorous pentachloride, ionic bond, bond order, bond enthalpy, bond dissociation, sp and sp2hybridisation, hydrogen bonding,electron pair,lone pair repulsion, resonance structure of ozone, how to find electron pair and lone pair, sp3 hybridization of methane.
For Chem 1:
Significanceof the ELectron in Bonding
The Octet Rule
Lewis Symbol/Structures
Formal Charge
Polyatomic Ions
Types of Bonds (Ionic, Covalent, Coordinate Covalent, Metallic Bonds, Multiple Bonds)
Exceptions to the Octet Rules
Oxidation Number is not included in the class discussion and exam. ;D
The presentation "Chemical Bonding" is prepared for class IX. It contains a brief introduction to bonding and a detailed study of types of chemical bonds, basically ionic and covalent, along with the characteristics of compounds formed by these bonds.
All constructive comments are welcome.
chemical bonding and molecular structure class 11sarunkumar31
hybridisation, bonding and antiboding, dipole moment, VSPER theory, Molecular orbital diagram, Phosphorous pentachloride, ionic bond, bond order, bond enthalpy, bond dissociation, sp and sp2hybridisation, hydrogen bonding,electron pair,lone pair repulsion, resonance structure of ozone, how to find electron pair and lone pair, sp3 hybridization of methane.
For Chem 1:
Significanceof the ELectron in Bonding
The Octet Rule
Lewis Symbol/Structures
Formal Charge
Polyatomic Ions
Types of Bonds (Ionic, Covalent, Coordinate Covalent, Metallic Bonds, Multiple Bonds)
Exceptions to the Octet Rules
Oxidation Number is not included in the class discussion and exam. ;D
The presentation "Chemical Bonding" is prepared for class IX. It contains a brief introduction to bonding and a detailed study of types of chemical bonds, basically ionic and covalent, along with the characteristics of compounds formed by these bonds.
All constructive comments are welcome.
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
2. WHAT IS A CHEMICAL BOND?
‡ A chemical bond holds two atoms together.
‡ It is formed by the attraction of a positive and a
negative ion or by the attraction of a positive
nucleus to negative electrons.
‡ Atoms form chemical bonds to get eight valence
electrons, to complete the octet rule and to
become stable.
3. THERE ARE 3 TYPES OF
CHEMICAL BONDS
• Ionic
• Covalent
• Metallic
4. • Ionic bonds form between cations (metals)
and anions (nonmetals).
• The metal transfers its valence electron to
the nonmetal. The nonmetal accepts the
valence electrons and turns into a negative
ion, while the metal becomes a positive ion.
• Arranged in a pattern of a crystal lattice
• High melting and boiling points
• Hard, rigid, and brittle
5. IONIC BONDS: ENERGY
• The formation of ionic compounds is exothermic.
• The energy required to separate ions is called the lattice energy.
The more negative the lattice energy, the stronger the force of
attraction.
• Lattice energy of smaller compounds is more negative than that of
larger compounds because the nucleus holds the valence electrons
more closely together.
6. • Instead of transferring electrons, atoms share electrons.
• If one pair of electrons are shared, a single bond is formed
(Group 17 elements form single bonds).
• If multiple pairs of electrons are shared, double and triple
bonds can be formed (carbon, nitrogen, oxygen, and
sulfur usually form multiple bonds).
7. COVALENT BONDS: SIGMA VS. PI
• Single covalent bonds are called sigma bonds. Occurs
when the electron pair is shared in an area centered
between the two atoms. A sigma bond results if the
valence atomic orbitals overlap end to end.
• A pi bond is formed when parallel orbitals overlap to
share electrons. The shared electron pair occupies the
space above and below the place where the atoms are
joined.
• A double bond has one sigma and one pi bond. A
triple bond has one sigma bond and two pi bonds.
8. COVALENT BONDS: ENERGY
• Bond length: Distance between the atoms
• Bond dissociation energy: Amount of energy required to bread a
covalent bond
• The smaller the bond length, the greater the bond dissociation
energy, and vice versa.
10. • When metals bond together to
complete the octet rule.
• All metal atoms contribute their
valence electrons to form a sea of
electrons. Electrons are free to
move b/w the atoms.
11. METALLIC BONDING: ALLOYS
• An alloy is a mixture of elements that has metallic properties.
• Properties of alloys are different from those of the elements in it.
• Alloys most commonly forms when elements involved are similar
in size or the atoms of one element are considerably smaller than
the atoms of the other.
• There are two types of alloys, substitutional and interstitial.
12. METALLIC BONDS: ENERGY
• Metallic bonds are weak and little
energy is needed to break the bonds.
Therefore, they have high melting
points
• Because the electrons are mobile,
they transfer heat more efficiently
and, therefore, are better
conductors.
13. CONCLUSION
• Elements bond to become stable.
• Elements bond to have 8 valence electrons.
• 3 types of bonds: Ionic, Covalent, Metallic
• In ionic bonds, one element gives its electrons to another element.
• Covalent bonds are the strongest bonds. Elements share electrons.
• Metallic bonds are the weakest bonds. Elements are in a sea of
electrons