Centrifugation is a method that uses high-speed spinning to separate molecules of different densities. It works on the principle of sedimentation under gravitational force. The objective is to purify components by removing impurities from the supernatant liquid or to separate crystalline drugs from the mother liquor. Common applications include extracting fat from milk to produce skimmed milk, removing water from lettuce in a salad spinner, and separating solid materials in blood and urine samples in forensic laboratories. Centrifugation is widely used in molecular biology to collect cells, precipitate DNA, and purify virus particles.