This document discusses centrifugation and provides details about its history, basic principles, types of centrifuges and rotors, and applications. Centrifugation uses centrifugal force to separate mixtures based on density. It has been used since the 1400s and important developments include the first analytical ultracentrifuge in 1920. Common centrifuges include low-speed, high-speed, and ultracentrifuges, which separate particles based on mass and density. Rotors include swinging bucket, fixed angle, and vertical designs. Centrifugation has many clinical and laboratory applications, including separating blood components and subcellular particles.