The document describes various parts of cells and how substances move across cell membranes. It discusses the structures and functions of mitochondria, lysosomes, peroxisomes, centrioles, microtubules and other organelles. It also explains the three main ways that substances traverse the cell membrane: passive diffusion, active transport, and endocytosis/exocytosis. Specific transport mechanisms like osmosis, carrier-mediated transport, and receptor-mediated endocytosis are also outlined.
Austin Biomolecules: open access is a peer reviewed, scholarly journal dedicated to publish articles covering all areas of Biomolecules.
The journal aims to promote latest information and provide a forum for doctors, researchers, physicians, and healthcare professionals to find most recent advances in the areas of Biomolecules. Austin Biomolecules: open access accepts research articles, reviews, mini reviews, case reports and rapid communications covering all aspects of Biomolecules.
Austin Biomolecules: open access strongly supports the scientific up gradation and fortification in related scientific research community by enhancing access to peer reviewed scientific literary works. Austin Publishing Group also brings universally peer reviewed journals under one roof thereby promoting knowledge sharing, mutual promotion of multidisciplinary science.
Tissues, Organs and Systems: The images have big font size and reduced background color. Useful for smartphones, classroom and printouts. The rest is standard stuff.
Austin Biomolecules: open access is a peer reviewed, scholarly journal dedicated to publish articles covering all areas of Biomolecules.
The journal aims to promote latest information and provide a forum for doctors, researchers, physicians, and healthcare professionals to find most recent advances in the areas of Biomolecules. Austin Biomolecules: open access accepts research articles, reviews, mini reviews, case reports and rapid communications covering all aspects of Biomolecules.
Austin Biomolecules: open access strongly supports the scientific up gradation and fortification in related scientific research community by enhancing access to peer reviewed scientific literary works. Austin Publishing Group also brings universally peer reviewed journals under one roof thereby promoting knowledge sharing, mutual promotion of multidisciplinary science.
Tissues, Organs and Systems: The images have big font size and reduced background color. Useful for smartphones, classroom and printouts. The rest is standard stuff.
this presentation providing about the cell .Cell is the basic living, structural, and functional unit of the body.
Cells are grouped together to form tissues, each of which has a specialized function, e.g.- Bone and blood tissue.
Different tissues are grouped together to form a organs, e.g. liver, stomach, and kidney etc.
Organs are grouped together to form a system, each of which performs a particular function responsible for maintaining homeostasis .
e.g. Urinary system, Respiratory system etc.
Cell: The cell is the ultimate structural and functional unit of the body.
The three principal constituents of the cell are:
1. Cell membrane
2. Cytoplasm and its organelles
3. Nucleus
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
3. Cell Parts and Functions
Mitochondria – the powerhouse of the
cell. It converts the potential energy
of food molecules into ATP.
Microfilaments – also called actin
filaments that are found just beneath
the cell membrane providing support
and maintaining cell shape.
Lysosome- the suicidal bag of the cell
for it contains hydrolytic enzymes that
can break down large macromolecules
and also engulfs another organelle
specially the damaged ones.
4. Cell Parts and Functions
Peroxisome- contains enzymes that
can help detoxify alcohol and other
harmful substances and convert
poisonous peroxides to water. It also
plays an important role in the
hydrolysis of fatty acids into simple
units that can be utilized by the
mitochondria for the process of
cellular respiration.
Centrioles – associated with the
formation and anchoring of the
spindle fibers during cell division of
animal cell
5. Cell Parts and Functions
Microtubules – plays an important role
in intracellular transport, formation of
mitotic spindle fiber needed for the
cell division, and formation of cell wall
in plant cells.
Smooth Endoplasmic Reticulum –
performs functions like lipid synthesis,
carbohydrate metabolism, and help in
the detoxification of drug and poison.
6. Cell Parts and Functions
Golgi apparatus – performs unique
functions of manufacturing,
processing, and packaging
macromolecules like protein and other
products and secretions before they
are sent to their respective
destinations.
Cilia – structures for locomotion of
cell
Ribosomes- these are where proteins
are manufactured. They are the
protein factories of the cell.
7. Cell Parts and Functions
Rough Endoplasmic Reticulum-
provides surface for ribosomes where
synthesis of many secretory proteins
takes place.
Chromatin- to package DNA into a
smaller volume to fit in the cell, to
strengthen the DNA to allow mitosis,
to prevent DNA damage, and to
control gene expression. It contains
the gene as well.
8. Cell Parts and Functions
Nucleus- contains the genetic material
that directs the production of protein
and other many cellular processes. It
is the central command of the cell
center of the cell. Its main function is
to control gene expression and initiate
DNA replication.
Nuclear Envelope- protects the
nucleus.
9. Cell Parts and Functions
Nucleolus- it is where components of
ribosomes and Rrna are synthesized.
These components pass through the
nuclear membrane into the cytoplasm
where they are combined to form
ribosomes.
Nuclear Pores – allows the passage of
small water-soluble molecules in and
out of the nucleus.
10. Cell Parts and Functions
Cytoplasm/ Plasma Membrane- the
region found outside the nucleus
surrounded by cell membrane. This
contains semifluid translucent
substance called cytosol. Important
cellular processes such as cell division
take place in the cytoplasm.
Suspended in the cytoplasm are
membrane-bound organelles each
performing specific functions all
directed for the survival of the cell
and the cell and the individual as a
whole.
11. Cell Parts and Functions
Cell Membrane – a dynamic membrane
separating the interior of the cell from
the outside environment. Aside from
enclosing the cell, it gives form and
shape to the cell. It is semi-
permeable.
14. 2 Major Kinds of Cell Transport
1. Passive Transport – it is the
movement of molecules without the
expenditure of energy.
2. Active Transport - it is the movement
of molecules where energy is exerted
by the cell.
15. 3 Ways of Traversing the Cell Membrane
A substance may traverse the cell
membrane in three principal ways:
1. By Diffusion and Osmosis
2. By Carrie-Mediated Transport
System
3. By Endocytosis
I.DIFFUSION
The movement of particles from an
area of a higher concentration to an
area of lower concentration of the
particles or molecules, thus tending
16. 3 Ways of Traversing the Cell Membrane
to equalize the concentration
throughout the area of diffusion.
Simple Diffusion – the particle is
transported through the membrane
without the aid of permease and
without expenditure of energy by the
cell.
17. 3 Ways of Traversing the Cell Membrane
II. OSMOSIS
It is the movement of water molecules
or solvents through a semi-permeable
membrane from a lower osmotic
pressure to greater osmotic pressure
Osmotic Pressure – the physical
pressure that exactly balances the
osmosis of water due to the
concentration difference between a
solution and pure water.
18. 3 Ways of Traversing the Cell Membrane
“ OSMOSIS IN ANIMAL AND PLANT CELL
AND THE TYPES OF SOLUTION”
Turgor Pressure – the pressure that
tends to force water molecules out of
the cell.
Diffusion Pressure – the force or
pressure that causes water molecules
to diffuse into the cell.
19. 3 Ways of Traversing the Cell Membrane
THREE TYPES OF SOLUTION DURING
OSMOSIS
1. Isotonic Solution – a solution whose
osmotic pressure is equal top at of the
cell, no change will occur thus a
balance is maintained (equilibrium).
2. Hypertonic Solution- a solution
whose osmotic pressure is greater
than that of the cell.
- It will cause water to leave the cell,
thus the cell will shrink or crenate.
20. 3 Ways of Traversing the Cell Membrane
3. Hypotonic Solution – a solution
whose osmotic pressure is lower than
that of the cell
- It will cause water to enter the cell,
thus the cell will swell or hemolyze or
even burst in animal cell.
21. 3 Ways of Traversing the Cell Membrane
“ Diffusion Through Channels”
The diffusion of ions could be allowed
at all times or they may need signals
to open or close
* Chemically- Gated Ion Channels
- When a signalling molecule binds to
specific binding site on the
transmembrane protein
* Voltage- Gated Ion Channels
- When the ionic charge across a plasma
membrane changes
22. 3 Ways of Traversing the Cell Membrane
III. CARRIER-MEDIATED TRANSPORT
Carriers or Transporters- these are
special transmembrane proteins that
enable solute molecules to cross the
phospholipid bilayer
- They are usually quite specific,
recognizing and transporting only a
limited group of chemical substances or
perhaps even a single substance.
23. 3 Ways of Traversing the Cell Membrane
“FACILITATED DIFFUSION”
A transporter assists a molecule to
diffuse through the membrane that it
cannot otherwise penetrate
- Sponsors movement only in a
“downhill” movement, along a
concentration gradient where no
metabolic energy is required
- Example is the transport of GLUCOSE
(blood sugar) in cells
24. 3 Ways of Traversing the Cell Membrane
III. ENDOCYTOSIS
The ingestion of material by cells,
they are pathways for specifically
internalizing solid particles, small
molecules and ions, and
macromolecules, requires energy.
Examples are the following:
1. Phagocytosis- “cell eating”
- A common method among protozoa,
lower metazoan and white blood cells
25. 3 Ways of Traversing the Cell Membrane
- Digestion via lysosomal enzymes once
a phagosome detaches
2. Pinocytosis- small areas of the
surface membrane are invaginated in
cells to form tiny vesicles (aveolae)
- For the intake of vitamins,and similar
mechanisms may be important in
translocating substances from one
side of the cell to the other and
internalizing signal molecules
- Examples are hormones
26. 3 Ways of Traversing the Cell Membrane
3. Receptor-Mediated Endocytosis
Bring large molecules within the cell
A ligand (particular molecule) binds to
the plasma membrane.
Invaginations covered with the
protein clathrin are created (clathrin-
coated pits)
Invaginations uncoats, the receptor
and the ligand separates
Lysosome attacks the remaining
vesicle, the endosome
27. 3 Ways of Traversing the Cell Membrane
Contents are digested and absorbed in
the cytoplasm
EXOCYTOSIS
Extruding contents to the surrounding
medium
Removal of undigestible residues of
substances brought in by endocytosis,
to secrete substances such as
hormones and to transport a
substance completely across a cellular
28. 3 Ways of Traversing the Cell Membrane
barrier ( TRANSCYTOSIS)
Actin and actin- binding proteins are
essential cytoskeletal components in
the process of endocytosis and
exocytosis.