Sellar, Suprasellar and Pineal tumor final pk .pptDr pradeep Kumar
this is very good presentation slide for radiologist and radiology resident. our references is authentic and most are from osborn brain imaging 2nd edition. This deal with sellar, suprasellar and pineal tumor . This help alot. thanks
Sellar, Suprasellar and Pineal tumor final pk .pptDr pradeep Kumar
this is very good presentation slide for radiologist and radiology resident. our references is authentic and most are from osborn brain imaging 2nd edition. This deal with sellar, suprasellar and pineal tumor . This help alot. thanks
Classification of stroke, clinical stages of stroke, types of imaging used for diagnosis with explanations on the findings.
Brief overview of ICP (increased intracranial pressure), causes, symptoms and management.
This presentation includes stroke and infarct latest defination an pathophysiology and CT MRI imaging features and management . This presntation help alot. Thanks
MRI in traumatic brain injury
Imaging is critical to both the diagnosis and management of TBI.
For diagnosis of TBI in the acute setting, noncontrast CT is the modality of choice as it quickly and accurately identifies intracranial hemorrhage that warrants neurosurgical evacuation. CT readily identifies both extra-axial hemorrhage (epidural, subdural, and subarachnoid/intraventricular hemorrhage) and intra-axial hemorrhage (cortical contusion, intraparenchymal hematoma, and TAI or shear injury).
While CT is the mainstay of TBI imaging in the acute setting, magnetic resonance imaging (MRI) has better diagnostic sensitivity for certain types of injuries that are not necessarily hemorrhagic, including cortical contusions and nonhemorrhagic traumatic axonal injuries.
Classification of stroke, clinical stages of stroke, types of imaging used for diagnosis with explanations on the findings.
Brief overview of ICP (increased intracranial pressure), causes, symptoms and management.
This presentation includes stroke and infarct latest defination an pathophysiology and CT MRI imaging features and management . This presntation help alot. Thanks
MRI in traumatic brain injury
Imaging is critical to both the diagnosis and management of TBI.
For diagnosis of TBI in the acute setting, noncontrast CT is the modality of choice as it quickly and accurately identifies intracranial hemorrhage that warrants neurosurgical evacuation. CT readily identifies both extra-axial hemorrhage (epidural, subdural, and subarachnoid/intraventricular hemorrhage) and intra-axial hemorrhage (cortical contusion, intraparenchymal hematoma, and TAI or shear injury).
While CT is the mainstay of TBI imaging in the acute setting, magnetic resonance imaging (MRI) has better diagnostic sensitivity for certain types of injuries that are not necessarily hemorrhagic, including cortical contusions and nonhemorrhagic traumatic axonal injuries.
Abnormalities of the placenta are important to recognize owing to the potential for maternal and fetal morbidity and mortality. Pathologic conditions of the placenta include
Placental causes of hemorrhage,
Gestational trophoblastic disease,
Retained products of conception,
Nontrophoblastic placental tumors, metastases, and
Cystic lesions..
glucagon secretion via the stimulation of pancreatic GLP‐1 receptors in beta and alpha cells and by increasing insulin sensitivity [5]. GLP-1 and its analogues can also amplify insulin signaling in brain cells, leading to increased insulin sensitivity in neurons [7, 8]. Within the cardiovascular system, GLP-1 receptors are expressed on endothelial cells, monocytes, macrophages, and vascular smooth muscle cells (VSMCs) [9]. GLP-1 receptors are also widely expressed in the central nervous system, including the brainstem, cerebellum, hippocampus, cortex, hypothalamus, and amygdala [7, 10, 11]. There, the cellular expression of GLP-1 receptors is predominantly confined to neurons and dendrites [11]. GLP-1RAs are overall well-tolerated, with their most common adverse effects being nausea, vomiting, and diarrhea [7]. It has been recently shown that there are cholecystokinin-expressing neurons in the caudal brainstem, which are activated postprandially and are responsive to GLP-1RAs, explaining in part the body weight-lowering effects of GLP-1RAs but also their ability to induce nausea [12]. Based on similarities in their amino acid sequence, GLP-1RAs are peptide derivatives of either exendin-4 (exenatide, lixisenatide, and efpeglenatide) or human GLP-1 (albiglutide, dulaglutide, liraglutide, and semaglutide). Moreover, based on their pharmacokinetic/pharmacodynamic profile, GLP-1RAs can be classified into short-acting (exenatide and lixisenatide) and long-acting (albiglutide, dulaglutide, exenatide extended-release, liraglutide, semaglutide, and efpeglenatide) [5, 6]. T he main pharmacokinetic difference between shortacting (half-life of 2–5 h) and long-acting (half-life > 12 h) GLP-1RAs is that short-acting GLP-1RAs are subject to wide fluctuations in the plasma concentration of the active compound, while long-acting GLP-1RAs exert a more constant effect on the GLP-1 receptor [13]. Furthermore, short-acting GLP-1RAs predominantly affect postprandial glucose levels, mainly by reducing
glucagon secretion via the stimulation of pancreatic GLP‐1 receptors in beta and alpha cells and by increasing insulin sensitivity [5]. GLP-1 and its analogues can also amplify insulin signaling in brain cells, leading to increased insulin sensitivity in neurons [7, 8]. Within the cardiovascular system, GLP-1 receptors are expressed on endothelial cells, monocytes, macrophages, and vascular smooth muscle cells (VSMCs) [9]. GLP-1 receptors are also widely expressed in the central nervous system, including the brainstem, cerebellum, hippocampus, cortex, hypothalamus, and amygdala [7, 10, 11]. There, the cellular expression of GLP-1 receptors is predominantly confined to neurons and dendrites [11]. GLP-1RAs are overall well-tolerated, with their most common adverse effects being nausea, vomiting, and diarrhea [7]. It has been recently shown that there are cholecystokinin-expressing neurons in the caudal brainstem, which are activated postprandially and are responsive to GLP
congenital vertebral anomaly. Congenital vertebral anomalies are a collection of malformations of the spine. Most, around 85%, are not clinically significant, but they can cause compression of the spinal cord by deforming the vertebral canal or causing instability. This condition occurs in the womb.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Cavum septum pellucidum (CSP), Cavum vergae and Cavum veli interpositi
1. Professor Yasser Metwally
www.yassermetwally.com
Cavum septum pellucidum (CSP), Cavum vergae and Cavum veli interpositi
The author: Professor Yasser Metwally
http://yassermetwally.com
INTRODUCTION
December 25, 2011 — As a single midline structure, the septum pellucidum separates the two
anterior horns of the lateral ventricles. The Cavum septum pellucidum (CSP) is demarcated by the
genu of the corpus callosum anteriorly , by the columns and body of the fornix posteriorly, by the
body of the corpus callosum superiorly, and by the rostrum of the corpus callosum inferiorly. It
consists of an ependymal lining toward the ventricles and contains neuronal and glial cell elements.
These cell elements have connections to the hypothalamus and the hippocampus. At birth, the two
layers of the septum pellucidum are separate and enclose a cavum. Later in life, these two layers
typically fuse into a single septum. Autopsy and imaging studies have shown that all premature
infants and 97% of term infants have a Cavum septum pellucidum (CSP), with the incidence dropping
to 41% by 3 months of age and to 15% by 6 months of age [1,2,3,4].
Figure 1. Cavum septum pellucidum (Click on figure to magnify..Online)
The Cavum septum pellucidum (CSP) may remain dilated in the context of some congenital disorders
with arrest of normal brain development or may secondarily enlarge with repetitive brain trauma,
such as in boxers. In such instances, obstructive hydrocephalus results from compression at the
foramina of Monro and may require neurosurgical treatment.
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2. Professor Yasser Metwally
www.yassermetwally.com
Figure 2. A, Cavum septum pellucidum (CVP) and cavum velum interpositum (CVI). (A) Axial T2-
weighted image demonstrates the CVP anteriorly (arrow) and CVI posteriorly (open arrow). (B) Sagittal
T1-weighted image demonstrates anterior and superior displacement of the fornix (open arrow)
distinguishing the CVI from the cavum vergae. Note characteristic inferior displacement of the
internal cerebral veins (arrow). (Click on figure to magnify..Online)
o Cavum vergae
If the layers of the septum pellucidum posterior to the columns of the fornix do not merge, they
leave a cavum vergae, which is commonly seen in combination with a Cavum septum pellucidum
(CSP) [2]. It is not clear whether the cavum vergae is the posterior portion of the Cavum septum
pellucidum (CSP) or whether it develops independently and communicates with the Cavum septum
pellucidum (CSP). The cavum vergae is bordered by the body of the corpus callosum superiorly, by
the hippocampal fissure inferiorly, by the crus of the fornices laterally, and by the splenium of the
corpus callosum posteriorly.
This anatomic variant is present in about one third of newborns and persists only rarely until
adulthood. Interestingly, the cavum vergae disappears before the Cavum septum pellucidum (CSP).
Cystic enlargement of the cavum vergae may cause hydrocephalus by obstruction of either the
foramen of Monro or the body of the lateral ventricle.
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3. Professor Yasser Metwally
www.yassermetwally.com
Figure 3. Cavum vergae (Click on figure to magnify..Online)
Cavum veli interpositi (Arachnoid cyst of the velum interpositum)
The velum interpositum is the potential subarachnoid space between the fornix and its attached
choroid above and the choroid forming the roof of the 3rd ventricle inferiorly, and is an anterior
extension of the quadrigeminal plate cistern just located superior to the pineal gland. If this
potential space is simply prominent, it is known as cavum velum interpositum. However, if there is
mass effect such as inferior displacement of the internal cerebral veins or the pineal gland,
arachnoid cyst is the most likely explanation. Arachnoid cysts are more commonly seen in boys and
may present with seizures, headache, or focal neurologic deficit. There is no enhancement in the
contents of arachnoid cysts and they follow CSF on all pulse sequences. Over half are located in the
middle cranial fossa while up to 10% are located in the suprasellar region and another 10% in the
quadrigeminal plate region.
The general differential of a non-enhancing CSF containing lesion in this location includes cavum
velum interpositum, arachnoid cyst, and epidermoid. Presence of mass effect mitigates strongly
against cavum velum interpositum. Likewise, epidermoids tend to engulf surrounding structures
rather than produce mass effect making it less likely as well.
Figure 4. Cavum veli interpositi (Click on figure to magnify..Online)
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4. Professor Yasser Metwally
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Cavum veli interpositi develops through an anterior extension of the pia-arachnoid membrane that
arises from the quadrigeminal plate cistern. The CVI is situated between the crus of the fornices and
lies inferior to the hippocampal commissure and the corpus callosum and superior to the roof of the
third ventricle [3]. The CVI may extend as far as the columns of the fornix. It is formed from a double
layer of pia mater, the tela choroidea, which covers the ependymal roof of the third ventricle, and
results in fluid accumulation within the potential space of these two layers when the posterior end of
the tela choroidea remains open. The internal cerebral veins and the medial posterior choroidal
artery lie within the two layers and can be displaced by cystic expansion of the CVI inferolaterally.
Cystic enlargement of the CVI requiring treatment is exceptional, with only a few case reports in the
literature [4,5].
Figure 5. Cavum veli interpositi (Click on figure to magnify..Online)
References
[1]. Shaw CM, Alvord Jr. EC. Cava septi pellucidi et vergae: their normal and pathological states.
Brain. 1969;92(1):213-223
[2]. Nakajima Y, Yano S, Kuramatsu T, Ichihashi K, Miyao M, Yanagisawa M, et al. Ultrasonographic
evaluation of cavum septi pellucidi and cavum vergae. Brain Dev. 1986;8(5):505-508
[3]. Kier LE. The evolutionary and embryologic basis for the development and anatomy of the cavum
veli interpositi. AJNR Am J Neuroradiol. 2000;21(3):612-614
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5. Professor Yasser Metwally
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[4]. Gangemi M, Donati P, Maiuri F, Sigona L. Cyst of the velum interpositum treated by endoscopic
fenestration. Surg Neurol. 1997;47(2):134-136
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