This document provides an overview of neonatal cranial sonography. It discusses the indications, acoustic windows, and limitations of neonatal cranial ultrasound. It describes normal ultrasound anatomy and measurements. It also reviews various pathologies that can be detected on neonatal cranial ultrasound such as intraventricular hemorrhage, periventricular leukomalacia, hydrocephalus, and posterior fossa abnormalities.
Radiology Spotters mixed Bag Collection for post graduates student .PPTDr pradeep Kumar
Radiology Spotters collection by Dr Pradeep. nice collection of radiology spotter made by or collected by Dr. Pradeep, this is a collection of confusing spotter and very important spotter commonly asked in exams, our references is radiopaedia, learning radiology and Aunt Minnie.. Thanks.
A brief overview of Imaging of urinary bladder and urethra for medical students and residents with commonly encountered benign and neoplastic conditions of lower urinary tract.
Description of various ultrasound features of benign and suspicious thyroid nodules with multiple ultrasound systems for risk stratification of malignancy.
Radiology Spotters mixed Bag Collection for post graduates student .PPTDr pradeep Kumar
Radiology Spotters collection by Dr Pradeep. nice collection of radiology spotter made by or collected by Dr. Pradeep, this is a collection of confusing spotter and very important spotter commonly asked in exams, our references is radiopaedia, learning radiology and Aunt Minnie.. Thanks.
A brief overview of Imaging of urinary bladder and urethra for medical students and residents with commonly encountered benign and neoplastic conditions of lower urinary tract.
Description of various ultrasound features of benign and suspicious thyroid nodules with multiple ultrasound systems for risk stratification of malignancy.
This lecture prides 8 easy steps of scanning the neonatal brain through anterior fontanelle ,followed by examples of most commonly encountered abnormalities.
With all of the focus on OOP and frameworks, sometimes the utilities get ignored. These modules provide us with lightweight, simple, effective solutions to everyday problems, saving us all from reinventing the wheel. This talk looks at a several of the utilities and shows some of the less common ways they can save a lot of time.
Nonparametric statistics show up in all sorts of places with fuzzy, ranked, or labeled data. The techniques allow handling messy data with more robust results than assuming normality. This talk describes the basics of nonparametric analysis and shows some examples with the Kolomogrov-Smirnov test, one of the most commonly used.
The $path to knowledge: What little it take to unit-test Perl.Workhorse Computing
Metadata-driven lazyness, Perl, and Jenkins provide a nice mix for automated testing. With Perl the only thing required to start testing is a files path, from there the possibilities are endless. Using Symbol's qualify_to_ref makes it easy to validate @EXPORT & @EXPORT_OK, knowing the path makes it easy to use "perl -wc" to get diagnostics.
The beautiful thing is all of it can be lazy... er, "automated". And repeatable. And simple.
perl often doesn't get updated because people don't have a way to know if their current code works with the new one. The problem is that they lack unit tests. This talk describes how simple it is to generate unit tests with Perl and shell, use them to automate solving problems like missing modules, and test a complete code base.
Using a base date, intervals, and ranges makes it easy to generate lookup tables for calendar intervals like annual or quarterly reports. The SQL for generating and searching the tables is made much easier using PG's built in range and interval types and more efficient with GiST indexes.
Face it, backticks are a pain. BASH $() construct provides a simpler, more effective approach. This talk uses examples from automating git branches and command line processing with getopt(1) to show how $() works in shell scripts.
This talk describes refactoring FindBin::libs from Perl5 to Raku: breaking the module up into functional pieces, writing the tests using Raku, testing and releasing the module with mi6.
Starting with the system calll "getrusage", this returns synchronous, process-level information, mainly max RSS used. This talk describes the output from getrusage, the rusage formatting utility in ProcStats, and several examples of using it to examine time and memory use.
Optional first & final outputs to give baseline and total status, differencing avoids extraneous output, and user messages allow arbitrary stat's and tracking content.
The combination makes this nice for tracking both long-lived and shorter, more intensive processing.
Variable interpolation is a standard way to BASH your head. This talk looks at interpolation, eval, ${} handling and "set -vx" to debug basic variable handling.
Performance benchmarks are all too often inaccurate. This talk introduces some things to look for in setting up and running benchmarks to make them effective.
A short description of the W-curve and its application to aligning genomic sequences. This includes a short introduction to the W-curve, example of SQL-based alignment of a crossover, suggestions for further work on its application.
We have all seen repetitive code, maintained by cut+paste, that creates an object, calls a method, checks a return, calls a method, checks a return... all of it difficult to maintain because of its sheer size.
Object::Exercise replaces the pasted loops with data-driven code, the operation controlled by a data structure of methods, arguments, and expected return values. This replaces cut+paste with declarative data.
This talk describes O::E and shows a few ways to apply it for testing the MadMongers' Adventure game.
Perl6 regular expression ("regex") syntax has a number of improvements over the Perl5 syntax. The inclusion of grammars as first-class entities in the language makes many uses of regexes clearer, simpler, and more maintainable. This talk looks at a few improvements in the regex syntax and also at how grammars can help make regex use cleaner and simpler.
Building a Perl5 smoketest environment in Docker using CPAN::Reporter::Smoker. Includes an overview of "smoke testing", shell commands to contstruct a hybrid environment with underlying O/S image and data volumes for /opt, /var/lib/CPAN. This allows maintaining the Perly smoke environemnt without having to rebuild it.
A few general pointers for Perl programmers starting out to write tests using Perl6. This describes a few of the differences in handling arrays vs. hashes, comparing objects, flattening, and value vs. immutable object contents.
This describes a Functional Programming approach to computing AWS Glacier "tree hash" values, hiding the tail-call elimination in Perl5 with a keyword and also shows how to accomplish the same result in Perl6.
This was the talk actually given at YAPC::NA 2016 by Dr. Conway and myself.
Implementing Glacier's Tree Hash using recursive, functional programming in Perl5. With Keyword::Declare we get clean syntax for tail-call elimination. Result is a simple, fast, functional solution.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
1. NEONATAL CRANIAL
SONOGRAPHY
Joan K. Zawin, M.D.
Cardinal Glennon Children’s Medical
Center
Saturday, April 21, 2012
2. Indications for HUS
• Prematurity • Hypoxia
• ↑ Head • FTT
circumference
• Mass
• Persistent large
fontanelle • Intracranial infection
• Craniosynostosis • Trauma
• ECMO
Saturday, April 21, 2012
3. Limitations of HUS
• Small acoustic window
• Cannot assess myelination
• Diffuse white matter injury
• Cerebellar lesions, infarctions, small isolated
IVH - can be missed
3
Saturday, April 21, 2012
21. Choroid Plexus
• Thin in roof of III vent and in temporal
horn
• “Split choroid” sign in trigone
• Present but not seen in roof of IV vent
• Never seen in occipital horn or anterior to
foramen Monroe
21
Saturday, April 21, 2012
28. Midline Cystic
Structures
• Communicate with each other
• Do not communicate with ventricular
system or subarachnoid spaces
• Obliterated from posterior ➞ anterior
Saturday, April 21, 2012
29. Cavum Septum
Pellucidum
• Between frontal
horns
• Anterior to foramen
of Monroe
• Usually closes 2-6
months after birth
Saturday, April 21, 2012
30. Cavum Septum Vergae
• Between bodies of
lateral ventricles
• Posterior to foramen
of Monroe
• Begins to close at 6
mos. gestation
• 97% closed at birth
Saturday, April 21, 2012
32. Cavum Veli Interpositi
• Posterior extension
of CSV
• Posterior to
quadrageminal plate
cistern - pineal gland
• Only seen in very
premature newborns
Saturday, April 21, 2012
37. Germinal Matrix
• Between ependyma lateral vent floor above
and caudate nucleus below
• Roof of III and IV ventricles
• Involution begins at 3 mos gestation
• complete involution by 36 wks
• NOT seen unless there is a bleed
37
Saturday, April 21, 2012
40. ICH and PVL
• Most common CNS pathologies in premies
• Risk factors:
• < 1500 gm (20 - 25% incd)
• < 30 wks. gestation
• 67% < 32 wks. will have ICH
40
Saturday, April 21, 2012
41. Intracranial
Hemorrhage
• 25 - 50% clinically silent
• Usually within first 3 days of life
• 50% Day 1
• 25% Day 2
• 80 - 90% occur by 3 - 4 days of age
41
Saturday, April 21, 2012
42. Intracranial
Hemorrhage in
Premature Newborns
• Impaired autoregulation ➟
pressure passive circulation
42
Saturday, April 21, 2012
43. Causes of ICH in
premies
• Systemic ↑ BP
• [↑P CO2, ↓Hb, ↑ intravascular vol]
• Increased CNS Venous Pressure
• asphyxia, tension PNTX, CHF, mechanical
ventilation, tracheal suctioning
• Decreased CNS Perfusion
• ↓ Hb, ↓PO2, systemic hypotension
43
Saturday, April 21, 2012
44. Screening
day 3-5
asx
day 10-14
<1,000 gm
day 28
asx
day 3-5
1,000 - 1250
day 28
gm
asx
day 3-5
1,251 - 1,500
Prior to discharge
gm
44
Saturday, April 21, 2012
45. Papile Classification
Grade I 40% GMH only
Grade II 25% GMH + IVH
Grade III 20% GMH + IVH + ↑Vents
GMH + IVH +
Grade IV 15% parenchymal blood
+/- ↑Vents
45
Saturday, April 21, 2012
46. Grade IV Hemorrhage
• Venous hemorrhagic infarction
secondary to venous outflow
compression
46
Saturday, April 21, 2012
68. Connatal Cysts
• Normal variant; incidence = 0.7%
• Superolateral to frontal horns
• Anterior to Foramen of Monroe
• “String of Pearls”
• Resolve spontaneously
Saturday, April 21, 2012
100. Posterior Fossa
• Cerebellar vermis = midline/echogenic
• Cerebellar hemispheres= hypoechoic
• Cisterna magna - posterior/ inferior to
vermis
• communicates with IV vent via vallecula
• ↑ in Dandy Walker, ↓ with Chiari
100
Saturday, April 21, 2012
109. Dandy Walker
Continuum
• Variant with vermis present and less
posterior fossa enlargement
• Persistent Blake Pouch Cyst
• looks like non-specific posterior fossa
cyst
• Mega Cisterna Magna
Saturday, April 21, 2012
153. Pilonidal Sinus
• aka sacral dimple; incd= 2-9%
• < 5 mm diameter, <2.5 cm from anus
• No cutaneous abnormalities
• Do not extend to neural structures
• Short hypoechoic tract from skin to coccyx
153
Saturday, April 21, 2012
196. Caput Succandeum
• Serosanguinous subcutaneous fluid
collection
• Below scalp and superficial to
periosteum
• Associated with moulding and over-
riding sutures
196
Saturday, April 21, 2012
199. Contact
• http://www.slideshare.net/lembark/
neonatal-cranial-spinal-sonography
• Joan K. Zawin
<bariumqueen1@yahoo.com>
199
Saturday, April 21, 2012