CAR-T (Cell Therapy) Nomenclature Review & Brand Equity Study. April 15, 2015.
Brand Acumen. The Global Leader in Pharmaceutical Name Development and Submission Strategy.
This PPT is about immune system and immune therapy, some basic knowledge about Chimeric Antigen Receptor or CAR technology and its application on tumor therapy.
chimeric antigen receptor, its structure and role in killing tumor cells,mechanism of antitumor killing, car's in clinic,evolution of cars and new chimeric antigen models
This PPT is about immune system and immune therapy, some basic knowledge about Chimeric Antigen Receptor or CAR technology and its application on tumor therapy.
chimeric antigen receptor, its structure and role in killing tumor cells,mechanism of antitumor killing, car's in clinic,evolution of cars and new chimeric antigen models
Two cases of Waldenstrӧm macroglobulinemia along with brief disease pathology. Waldenstrӧm macroglobulinemia is a rare B cell lymphoma involving bone marrow with IgM monoclonal gammopathy of any concentration
CAR-T cells (Chimeric Antigen Receptor- T cells) are T cells that have been genetically engineered to produce an artificial T cell receptor for use in immunotherapy. Chimeric antigen receptors are receptor proteins that have been engineered to give T cells the new ability to target a specific protein.
This therapy use to treat several type of cancer but significantly treat leukemia. And this therapy is very effective than other.
A treatment used to help the immune system fight diseases, such as cancer and infections with certain viruses. These T cells are given back to the patient to help the immune system fight disease" Also called cellular adoptive immunotherapy".
CAR T-cell Therapy_A New Era in Cancer ImmunotherapyTuhin Samanta
Illusory Antigen Receptor (CAR) T-cell treatment includes hereditary alteration of patient's autologous T-cells to express a CAR explicit for a tumor antigen, following by ex vivo cell extension and re-imbuement back to the patient. Vehicles are combination proteins of a chose single-chain section variable from a particular monoclonal immune response and at least one T-cell receptor intracellular flagging spaces. This T-cell hereditary change may happen either by means of viral-based quality exchange strategies or nonviral techniques, for example, DNA-based transposons, CRISPR/Cas9 innovation or direct exchange of in vitro deciphered mRNA by electroporation.
Car t cells - Chimeric antigen receptors (CARs)Qussai Abbas
Chimeric antigen receptors, Chimeric immunoreceptors, Chimeric T cell receptors, Artificial T cell receptors
How to produce CAR T-cells
The structure of CAR T-cells
Toxicity of CART-cell therapy
Management of chimeric antigen receptor (CAR) T-cell toxicity
Next generation CAR technology
Two cases of Waldenstrӧm macroglobulinemia along with brief disease pathology. Waldenstrӧm macroglobulinemia is a rare B cell lymphoma involving bone marrow with IgM monoclonal gammopathy of any concentration
CAR-T cells (Chimeric Antigen Receptor- T cells) are T cells that have been genetically engineered to produce an artificial T cell receptor for use in immunotherapy. Chimeric antigen receptors are receptor proteins that have been engineered to give T cells the new ability to target a specific protein.
This therapy use to treat several type of cancer but significantly treat leukemia. And this therapy is very effective than other.
A treatment used to help the immune system fight diseases, such as cancer and infections with certain viruses. These T cells are given back to the patient to help the immune system fight disease" Also called cellular adoptive immunotherapy".
CAR T-cell Therapy_A New Era in Cancer ImmunotherapyTuhin Samanta
Illusory Antigen Receptor (CAR) T-cell treatment includes hereditary alteration of patient's autologous T-cells to express a CAR explicit for a tumor antigen, following by ex vivo cell extension and re-imbuement back to the patient. Vehicles are combination proteins of a chose single-chain section variable from a particular monoclonal immune response and at least one T-cell receptor intracellular flagging spaces. This T-cell hereditary change may happen either by means of viral-based quality exchange strategies or nonviral techniques, for example, DNA-based transposons, CRISPR/Cas9 innovation or direct exchange of in vitro deciphered mRNA by electroporation.
Car t cells - Chimeric antigen receptors (CARs)Qussai Abbas
Chimeric antigen receptors, Chimeric immunoreceptors, Chimeric T cell receptors, Artificial T cell receptors
How to produce CAR T-cells
The structure of CAR T-cells
Toxicity of CART-cell therapy
Management of chimeric antigen receptor (CAR) T-cell toxicity
Next generation CAR technology
Final presentation for BIOL405, NSC, Spring 2014. Presented by Kevin Hugins and Duy-Khiem Chanh Pham. This presentation addressed the use of Chimeric Antigen Receptors for gene therapy for cancer. Gene therapy was first conceptualized to alter debilitating fates of genetic diseases. Gene therapy technology can help introduce new functional DNA to replace mutated genes. The idea first arose in 1972 when Friedmann and Roblin authored a paper, “Gene therapy for human genetic disease?”, demonstrating that exogenous DNA can be taken up by mammalian cells (1). They proposed that the same procedure could be done on humans to correct genetic defects by introducing therapeutic DNA. Currently, genetic modification of T lymphocytes has been the major area of research for treating malignant tumors. This technique seeks to create chimeric antigen receptor (CAR) in T cells by genetically modifying them in vitro and reintroduce them back into blood circulation. The T cells are unique to every patient and the chimeric antigen receptors are unique to the tumor that it is targeting.
Autologous and Allogeneic Cell Therapy Industrialisation – Overcoming Clinical Manufacturing Hurdles Early
A presentation by Chief Operating Officer, Dr Stephen Ward
Chimeric Antigen Receptors (paper with corresponding power point)Kevin B Hugins
Gene therapy was first conceptualized to alter debilitating fates of genetic diseases. Gene therapy technology can help introduce new functional DNA to replace mutated genes. The idea first arose in 1972 when Friedmann and Roblin authored a paper, “Gene therapy for human genetic disease?”, demonstrating that exogenous DNA can be taken up by mammalian cells (1). They proposed that the same procedure could be done on humans to correct genetic defects by introducing therapeutic DNA. Currently, genetic modification of T lymphocytes has been the major area of research for treating malignant tumors. This technique seeks to create chimeric antigen receptor (CAR) in T cells by genetically modifying them in vitro and reintroduce them back into blood circulation. The T cells are unique to every patient and the chimeric antigen receptors are unique to the tumor that it is targeting.
BIO Conference Upcoming Lecture" "The Case for Naming Sooner ...Than Later"Bill Smith
BIO Conference Upcoming Lecture" "The Case for Naming Sooner ...Than Later"
Bill Smith, CEO of Brand Acumen.
The global leader in pharmaceutical name development and submissions.
Myriad genetics, inc. product pipeline analysisraja1233
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Oncology Intelligence 2014 Report (Second Updated Edition)
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Outsourcing in Drug Development: The Contract Research (Clinical Trial) MarketMarketResearch.com
The cost and time of developing and bringing a drug to market is over $1.3 billion and often takes as long as 15 years, if not longer. Because of this, major pharmaceutical marketers continue to outsource stages of development, and over the years Kalorama Information has observed this process. In past editions of our outsourcing market studies, we found that outsourcing moved from "should" to "must." for manufacturers. This trend has only continued in the past two years. Contract Research Organizations (CROs) and other entities can expect growing demand for their services.
The demand for new drugs remains unabated, but the cost and need to bring those drugs to market is ever-increasing and intensifying. A key cost driver is the large number of failures during the expensive clinical trial phases. Driven by pressures to reduce costs, companies are increasingly implementing outsourcing strategies to increase revenues through faster drug development. By decreasing their in-house facilities and staff, and outsourcing more of their R&D functions, pharmaceutical and biotechnology companies are reshaping the drug development services industry.
Kalorama Information's Outsourcing in Drug Development: The Contract Research (Clinical Trial) Market is the third edition of this study of the drivers for outsourcing drug development, the companies involved in this market and the opportunity for revenues.
Global Markets Direct's, 'Carcinomas - Pipeline Review, H1 2013', provides an overview of the indication's therapeutic pipeline. This report provides information on the therapeutic development for Carcinomas, complete with latest updates, and special features on late-stage and discontinued projects.
https://www.reportscorner.com/reports/23246/Carcinomas-%E2%80%93-Pipeline-Review,-H1-2013/
This report provides comprehensive information on the therapeutic development for Brain Cancer, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Brain Cancer and special features on late-stage and discontinued projects.
http://www.researchmoz.us/brain-cancer-pipeline-review-h1-2015-report.html
Cook medical incorporated product pipeline analysisraja1233
Companyprofilesandconferences.com glad to promote a new report on "Cook Medical Incorporated - Product Pipeline Analysis" which is a source for data, analysis, and actionable intelligence on the company’s portfolio of pipeline products also provides key information about the company, its major products and brands.
Quantum genomics sa product pipeline review - 2015Ambikabasa
This report provides comprehensive information on the current therapeutic developmental pipeline of Quantum Genomics SAs, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. It also reviews latest updates, and featured news and press releases, along with special features on late-stage and discontinued projects.
http://www.researchmoz.us/quantum-genomics-sa-product-pipeline-review-2015-report.html
Global Markets Direct's, 'Esophageal Cancer - Pipeline Review, H1 2013', provides an overview of the indication's therapeutic pipeline. This report provides information on the therapeutic development for Esophageal Cancer, complete with latest updates, and special features on late-stage and discontinued projects.
https://www.reportscorner.com/reports/23243/Esophageal-Cancer-%E2%80%93-Pipeline-Review,-H1-2013/
Market Research Reports, Inc. has announced the addition of “Vulvar Cancer - Pipeline Insight, 2018” research report to their offering. See more at - http://mrr.cm/UBP
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2. CAR-T: Market Positioning
2
The purpose of this presentation is
to examine the CAR-T market
landscape with an eye on brand
positioning, market messaging and
current external perceptions.
The contents include a high level
overview of the nomenclature and
nascent brand architecture of the
primary companies, a review of the
evolving CAR-T lexicon, and the
results of a CAR-T specific Brand
Equity Perception Study conducted
in March, 2015 with 83
professionals.
Differentiation Dimensions
Overview:
The CAR-T
Nomenclature and
Nascent Brand
Architecture
Brand Acumen’s
CAR-T
Brand Equity
Perception Study
March, 2015
A Review of the
Evolving
CAR-T Lexicon
Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
5. CAR-T: Brand Equity Perception Study
In terms of Market Positioning,
we shaped our external
questionnaire to reflect each of
the company's 'overall clarity of
communication' and asked "What
were the key drivers that made
each respective company stand
out amongst their peers."
In this study we examined six (6) key
categories for assessment. They are
as follows:
Category Attributes Explained
For the Web Presence analysis,
we examined the inherent
associative brand (corporate)
characteristics as they related to
CAR-T. (This was particularly
important as Novartis is different
then the others as it is the only
'Big Pharma' player in the study).
Web
Presence
Market
Positioning
Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
6. CAR-T: Brand Equity Perception Study
Collateral Material incorporates a
review of the analog (print, etc.) and
digital materials available from each of
the companies. We looked at the ease
of access to materials, educational
offerings, range and scope of the
materials and commitment to continue
to educate at various different
communication junctions (Patient,
HCP, etc.).
In terms of Differentiation, we focused
our assessment on many of the
traditional market differentiators and
the ability for each company to
leverage their core brand today and in
the future. Gauging these attributes
included asking: "How do you perceive
this company’s ability to deliver on the
promise put forth in their
communication?". "Will their therapy
work?". "Will they be first to market?”
"Who is best? Second Best? etc.
Category Attributes Explained
Differentiation
Collateral
Material
Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
7. CAR-T: Brand Equity Perception Study
Category Attributes Explained
Depth. Here we examined each
company's respective pipelines and
how this resonates back to the
corporate brand identity. This was
more of a focus for Wall Street, VC's,
investors and peers. Questions
included: "Who has the deepest
minds?". "Who has the least likelihood
to suffer from brand technological
obsolescence?”
Analysts Perception asserts a battery
of questions for Wall Street Analysts,
VC's, biotech savvy investors and
hedge fund analysts who understand
and track/invest in the CAR-T space.
Depth
Analyst
Perception
Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”v
8. SurveyDesign
8
To initiate the CAR-T Brand Equity
Study we surveyed five segments
of Key Innovation Leaders (KILs).
• Bio Industry Writers (8)
• Venture Capitalists (7)
• Oncologists (35)
• CAR-T Specific Researchers (21)
• Market Makers/Analysts (12)
CAR-TBrandEquityPerceptionStudy
Brand Acumen’s CAR-T Brand Equity survey methodology brings together market,
brand, competitive, and technological attribute perceptions.
A corporate brand’s performance can be assessed allowing for a roadmap for
improvement to be identified in micro-niche biotech ecosystems.
samplesize/
numberofrespondents
Each of the six attribute
categories are scored from
0-100 with 0 being the lowest
and 100 the highest score.
The scores are weighted
based on respondents
answers to quantitative and
qualitative criteria.
Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
9. chimeric antigen receptor therapy
CAR-T:
The Main Players
A Review of Company Nomenclature and
Results of the Brand Acumen CAR-T Brand Equity Perception Study
Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
10. CAR-T
nomenclature
@NascentCAR-TNomenclature
tisagenlecleucel-T
Alternative Names:
• Anti-CD19-CAR retroviral vector-transduced autologous T
cells - University of Pennsylvania
• Anti-CD19-CAR transduced T cells - Novartis/University of
Pennsylvania
• CART-019; CART-19; CART-19 cells
• Chimeric antigen receptor-modified T cells against CD19 -
University of Pennsylvania/Novartis
• CTL 019
• LG-740
Most Recent Events
26 Feb 2015
Phase-II clinical trials in
Diffuse large B cell lymphoma
in USA (IV) (Novartis, pipeline,
February 2015)
08 Dec 2014 Efficacy data from
a pediatric study in Acute
lymphoblastic leukemia
presented at the 56th Annual
Meeting and Exposition of the
American Society of
Hematology (ASH-Hem-2014)
15 Oct 2014 Interim efficacy
and adverse events data from
two phase I trials in Acute
lymphoblastic leukemia
(second-line therapy or
greater) released by University
of Pennsylvania
tisa – gen – lec – leu – cel - T
generic name
• MesoCART
• huCART19
non-proprietary name
CRISPR/Cas9
Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
11. CAR-TBrandEquityPerceptionStudy
Each of the six attribute categories are scored from 0-100 with 0 being
the lowest and 100 the highest score.
Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
12. CAR-TBrandEquityPerceptionStudy
Each of the six
attribute
categories are
scored from 0-100
with 0 being the
lowest and 100 the
highest score.
The scores are
weighted based on
respondents
answers to
quantitative and
qualitative criteria.
Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
14. CAR-TBrandEquityPerceptionStudy
Each of the six attribute categories are scored from 0-100 with 0 being
the lowest and 100 the highest score.
Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
15. CAR-TBrandEquityPerceptionStudy
Each of the six
attribute
categories are
scored from 0-100
with 0 being the
lowest and 100 the
highest score.
The scores are
weighted based on
respondents
answers to
quantitative and
qualitative criteria.
Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
18. CAR-TBrandEquityPerceptionStudy
Each of the six
attribute
categories are
scored from 0-100
with 0 being the
lowest and 100 the
highest score.
The scores are
weighted based on
respondents
answers to
quantitative and
qualitative criteria.
20. CAR-TBrandEquityPerceptionStudy
Each of the six attribute categories are scored from 0-100 with 0 being
the lowest and 100 the highest score.
Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
21. CAR-TBrandEquityPerceptionStudy
Each of the six
attribute
categories are
scored from 0-100
with 0 being the
lowest and 100 the
highest score.
The scores are
weighted based on
respondents
answers to
quantitative and
qualitative criteria.
Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
23. CAR-TBrandEquityPerceptionStudy
Each of the six attribute categories are scored from 0-100 with 0 being
the lowest and 100 the highest score.
Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
24. CAR-TBrandEquityPerceptionStudy
Each of the six
attribute
categories are
scored from 0-100
with 0 being the
lowest and 100 the
highest score.
The scores are
weighted based on
respondents
answers to
quantitative and
qualitative criteria.
26. CAR-TBrandEquityPerceptionStudy
Each of the six attribute categories are scored from 0-100 with 0 being
the lowest and 100 the highest score.
Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
27. CAR-TBrandEquityPerceptionStudy
Each of the six
attribute
categories are
scored from 0-100
with 0 being the
lowest and 100 the
highest score.
The scores are
weighted based on
respondents
answers to
quantitative and
qualitative criteria.
Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
29. CAR-TBrandEquityPerceptionStudy
Each of the six attribute categories are scored from 0-100 with 0 being
the lowest and 100 the highest score.
Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
30. CAR-TBrandEquityPerceptionStudy
Each of the six
attribute
categories are
scored from 0-100
with 0 being the
lowest and 100 the
highest score.
The scores are
weighted based on
respondents
answers to
quantitative and
qualitative criteria.
Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”