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CAR-T:
Market Perspectives
April 15, 2015
Brand Acumen
Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
CAR-T: Market Positioning
2	
  
The purpose of this presentation is
to examine the CAR-T market
landscape with an eye on brand
positioning, market messaging and
current external perceptions.
The contents include a high level
overview of the nomenclature and
nascent brand architecture of the
primary companies, a review of the
evolving CAR-T lexicon, and the
results of a CAR-T specific Brand
Equity Perception Study conducted
in March, 2015 with 83
professionals.
Differentiation Dimensions
Overview:
The CAR-T
Nomenclature and
Nascent Brand
Architecture
Brand Acumen’s
CAR-T
Brand Equity
Perception Study
March, 2015
A Review of the
Evolving
CAR-T Lexicon
Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
Celyad
Transposagen
Cellular Biomedicine
Carsgen
Unum
Caribou Biosciences
Xcyte
WuXi
Atara
CAR-T
émergent
nomenclature
corporatebrands
Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
CAR-T
anewlexicon
chimeric antigen receptor therapy
Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
CAR-T: Brand Equity Perception Study
In terms of Market Positioning,
we shaped our external
questionnaire to reflect each of
the company's 'overall clarity of
communication' and asked "What
were the key drivers that made
each respective company stand
out amongst their peers."
In this study we examined six (6) key
categories for assessment. They are
as follows:
Category Attributes Explained
For the Web Presence analysis,
we examined the inherent
associative brand (corporate)
characteristics as they related to
CAR-T. (This was particularly
important as Novartis is different
then the others as it is the only
'Big Pharma' player in the study).
Web
Presence
Market
Positioning
Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
CAR-T: Brand Equity Perception Study
Collateral Material incorporates a
review of the analog (print, etc.) and
digital materials available from each of
the companies. We looked at the ease
of access to materials, educational
offerings, range and scope of the
materials and commitment to continue
to educate at various different
communication junctions (Patient,
HCP, etc.).
In terms of Differentiation, we focused
our assessment on many of the
traditional market differentiators and
the ability for each company to
leverage their core brand today and in
the future. Gauging these attributes
included asking: "How do you perceive
this company’s ability to deliver on the
promise put forth in their
communication?". "Will their therapy
work?". "Will they be first to market?”
"Who is best? Second Best? etc.
Category Attributes Explained
Differentiation
Collateral
Material
Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
CAR-T: Brand Equity Perception Study
Category Attributes Explained
Depth. Here we examined each
company's respective pipelines and
how this resonates back to the
corporate brand identity. This was
more of a focus for Wall Street, VC's,
investors and peers. Questions
included: "Who has the deepest
minds?". "Who has the least likelihood
to suffer from brand technological
obsolescence?”
Analysts Perception asserts a battery
of questions for Wall Street Analysts,
VC's, biotech savvy investors and
hedge fund analysts who understand
and track/invest in the CAR-T space.
Depth
Analyst
Perception
Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”v
SurveyDesign
8	
  
To initiate the CAR-T Brand Equity
Study we surveyed five segments
of Key Innovation Leaders (KILs).
•  Bio Industry Writers (8)
•  Venture Capitalists (7)
•  Oncologists (35)
•  CAR-T Specific Researchers (21)
•  Market Makers/Analysts (12)
CAR-TBrandEquityPerceptionStudy
Brand Acumen’s CAR-T Brand Equity survey methodology brings together market,
brand, competitive, and technological attribute perceptions.
A corporate brand’s performance can be assessed allowing for a roadmap for
improvement to be identified in micro-niche biotech ecosystems.
samplesize/
numberofrespondents
Each of the six attribute
categories are scored from
0-100 with 0 being the lowest
and 100 the highest score.
The scores are weighted
based on respondents
answers to quantitative and
qualitative criteria.
Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
chimeric antigen receptor therapy
CAR-T:
The Main Players
A Review of Company Nomenclature and
Results of the Brand Acumen CAR-T Brand Equity Perception Study
Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
CAR-T
nomenclature
@NascentCAR-TNomenclature
tisagenlecleucel-T
Alternative Names:
•  Anti-CD19-CAR retroviral vector-transduced autologous T
cells - University of Pennsylvania
•  Anti-CD19-CAR transduced T cells - Novartis/University of
Pennsylvania
•  CART-019; CART-19; CART-19 cells
•  Chimeric antigen receptor-modified T cells against CD19 -
University of Pennsylvania/Novartis
•  CTL 019
•  LG-740
Most Recent Events
26 Feb 2015
Phase-II clinical trials in
Diffuse large B cell lymphoma
in USA (IV) (Novartis, pipeline,
February 2015)
08 Dec 2014 Efficacy data from
a pediatric study in Acute
lymphoblastic leukemia
presented at the 56th Annual
Meeting and Exposition of the
American Society of
Hematology (ASH-Hem-2014)
15 Oct 2014 Interim efficacy
and adverse events data from
two phase I trials in Acute
lymphoblastic leukemia
(second-line therapy or
greater) released by University
of Pennsylvania
tisa – gen – lec – leu – cel - T
generic name
•  MesoCART
•  huCART19
non-proprietary name
CRISPR/Cas9
Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
CAR-TBrandEquityPerceptionStudy
Each of the six attribute categories are scored from 0-100 with 0 being
the lowest and 100 the highest score.
Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
CAR-TBrandEquityPerceptionStudy
Each of the six
attribute
categories are
scored from 0-100
with 0 being the
lowest and 100 the
highest score.
The scores are
weighted based on
respondents
answers to
quantitative and
qualitative criteria.
Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
CAR-T
nomenclature
@NascentCAR-TNomenclature
Sleeping Beauty
RheoSwitch®
platformbrands
AttSite®
UltraVector®
LEAP®
Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
CAR-TBrandEquityPerceptionStudy
Each of the six attribute categories are scored from 0-100 with 0 being
the lowest and 100 the highest score.
Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
CAR-TBrandEquityPerceptionStudy
Each of the six
attribute
categories are
scored from 0-100
with 0 being the
lowest and 100 the
highest score.
The scores are
weighted based on
respondents
answers to
quantitative and
qualitative criteria.
Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
CAR-T
nomenclature
@NascentCAR-TNomenclature
Lentiglobin®
Lenti-D®
Starbeam Study
North Star Study
branded clinical studies
brands
Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
CAR-TBrandEquityPerceptionStudy
Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
CAR-TBrandEquityPerceptionStudy
Each of the six
attribute
categories are
scored from 0-100
with 0 being the
lowest and 100 the
highest score.
The scores are
weighted based on
respondents
answers to
quantitative and
qualitative criteria.
CAR-T
nomenclature
@NascentCAR-TNomenclature
eACT™
T-Cell Factory B.V.
acquisition
collaboration
platformbrand
Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
CAR-TBrandEquityPerceptionStudy
Each of the six attribute categories are scored from 0-100 with 0 being
the lowest and 100 the highest score.
Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
CAR-TBrandEquityPerceptionStudy
Each of the six
attribute
categories are
scored from 0-100
with 0 being the
lowest and 100 the
highest score.
The scores are
weighted based on
respondents
answers to
quantitative and
qualitative criteria.
Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
CAR-T
nomenclature
@NascentCAR-TNomenclature
CaspaCIDe™
CIDeCAR™
GoCAR-T™
DeCIDe™
brands
Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
CAR-TBrandEquityPerceptionStudy
Each of the six attribute categories are scored from 0-100 with 0 being
the lowest and 100 the highest score.
Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
CAR-TBrandEquityPerceptionStudy
Each of the six
attribute
categories are
scored from 0-100
with 0 being the
lowest and 100 the
highest score.
The scores are
weighted based on
respondents
answers to
quantitative and
qualitative criteria.
CAR-T
nomenclature
@NascentCAR-TNomenclature
Armored CAR technology
technology brand
Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
CAR-TBrandEquityPerceptionStudy
Each of the six attribute categories are scored from 0-100 with 0 being
the lowest and 100 the highest score.
Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
CAR-TBrandEquityPerceptionStudy
Each of the six
attribute
categories are
scored from 0-100
with 0 being the
lowest and 100 the
highest score.
The scores are
weighted based on
respondents
answers to
quantitative and
qualitative criteria.
Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
CAR-T
nomenclature
@NascentCAR-TNomenclature
pipeline identifier brand
UCART
Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
CAR-TBrandEquityPerceptionStudy
Each of the six attribute categories are scored from 0-100 with 0 being
the lowest and 100 the highest score.
Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
CAR-TBrandEquityPerceptionStudy
Each of the six
attribute
categories are
scored from 0-100
with 0 being the
lowest and 100 the
highest score.
The scores are
weighted based on
respondents
answers to
quantitative and
qualitative criteria.
Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
evolutionary.
revolutionary.
disruptive.
31	
  Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”

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CAR-T (Cell Therapy) Nomenclature Review & Brand Equity Study. April 15, 2015

  • 1. CAR-T: Market Perspectives April 15, 2015 Brand Acumen Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
  • 2. CAR-T: Market Positioning 2   The purpose of this presentation is to examine the CAR-T market landscape with an eye on brand positioning, market messaging and current external perceptions. The contents include a high level overview of the nomenclature and nascent brand architecture of the primary companies, a review of the evolving CAR-T lexicon, and the results of a CAR-T specific Brand Equity Perception Study conducted in March, 2015 with 83 professionals. Differentiation Dimensions Overview: The CAR-T Nomenclature and Nascent Brand Architecture Brand Acumen’s CAR-T Brand Equity Perception Study March, 2015 A Review of the Evolving CAR-T Lexicon Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
  • 4. CAR-T anewlexicon chimeric antigen receptor therapy Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
  • 5. CAR-T: Brand Equity Perception Study In terms of Market Positioning, we shaped our external questionnaire to reflect each of the company's 'overall clarity of communication' and asked "What were the key drivers that made each respective company stand out amongst their peers." In this study we examined six (6) key categories for assessment. They are as follows: Category Attributes Explained For the Web Presence analysis, we examined the inherent associative brand (corporate) characteristics as they related to CAR-T. (This was particularly important as Novartis is different then the others as it is the only 'Big Pharma' player in the study). Web Presence Market Positioning Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
  • 6. CAR-T: Brand Equity Perception Study Collateral Material incorporates a review of the analog (print, etc.) and digital materials available from each of the companies. We looked at the ease of access to materials, educational offerings, range and scope of the materials and commitment to continue to educate at various different communication junctions (Patient, HCP, etc.). In terms of Differentiation, we focused our assessment on many of the traditional market differentiators and the ability for each company to leverage their core brand today and in the future. Gauging these attributes included asking: "How do you perceive this company’s ability to deliver on the promise put forth in their communication?". "Will their therapy work?". "Will they be first to market?” "Who is best? Second Best? etc. Category Attributes Explained Differentiation Collateral Material Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
  • 7. CAR-T: Brand Equity Perception Study Category Attributes Explained Depth. Here we examined each company's respective pipelines and how this resonates back to the corporate brand identity. This was more of a focus for Wall Street, VC's, investors and peers. Questions included: "Who has the deepest minds?". "Who has the least likelihood to suffer from brand technological obsolescence?” Analysts Perception asserts a battery of questions for Wall Street Analysts, VC's, biotech savvy investors and hedge fund analysts who understand and track/invest in the CAR-T space. Depth Analyst Perception Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”v
  • 8. SurveyDesign 8   To initiate the CAR-T Brand Equity Study we surveyed five segments of Key Innovation Leaders (KILs). •  Bio Industry Writers (8) •  Venture Capitalists (7) •  Oncologists (35) •  CAR-T Specific Researchers (21) •  Market Makers/Analysts (12) CAR-TBrandEquityPerceptionStudy Brand Acumen’s CAR-T Brand Equity survey methodology brings together market, brand, competitive, and technological attribute perceptions. A corporate brand’s performance can be assessed allowing for a roadmap for improvement to be identified in micro-niche biotech ecosystems. samplesize/ numberofrespondents Each of the six attribute categories are scored from 0-100 with 0 being the lowest and 100 the highest score. The scores are weighted based on respondents answers to quantitative and qualitative criteria. Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
  • 9. chimeric antigen receptor therapy CAR-T: The Main Players A Review of Company Nomenclature and Results of the Brand Acumen CAR-T Brand Equity Perception Study Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
  • 10. CAR-T nomenclature @NascentCAR-TNomenclature tisagenlecleucel-T Alternative Names: •  Anti-CD19-CAR retroviral vector-transduced autologous T cells - University of Pennsylvania •  Anti-CD19-CAR transduced T cells - Novartis/University of Pennsylvania •  CART-019; CART-19; CART-19 cells •  Chimeric antigen receptor-modified T cells against CD19 - University of Pennsylvania/Novartis •  CTL 019 •  LG-740 Most Recent Events 26 Feb 2015 Phase-II clinical trials in Diffuse large B cell lymphoma in USA (IV) (Novartis, pipeline, February 2015) 08 Dec 2014 Efficacy data from a pediatric study in Acute lymphoblastic leukemia presented at the 56th Annual Meeting and Exposition of the American Society of Hematology (ASH-Hem-2014) 15 Oct 2014 Interim efficacy and adverse events data from two phase I trials in Acute lymphoblastic leukemia (second-line therapy or greater) released by University of Pennsylvania tisa – gen – lec – leu – cel - T generic name •  MesoCART •  huCART19 non-proprietary name CRISPR/Cas9 Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
  • 11. CAR-TBrandEquityPerceptionStudy Each of the six attribute categories are scored from 0-100 with 0 being the lowest and 100 the highest score. Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
  • 12. CAR-TBrandEquityPerceptionStudy Each of the six attribute categories are scored from 0-100 with 0 being the lowest and 100 the highest score. The scores are weighted based on respondents answers to quantitative and qualitative criteria. Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
  • 14. CAR-TBrandEquityPerceptionStudy Each of the six attribute categories are scored from 0-100 with 0 being the lowest and 100 the highest score. Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
  • 15. CAR-TBrandEquityPerceptionStudy Each of the six attribute categories are scored from 0-100 with 0 being the lowest and 100 the highest score. The scores are weighted based on respondents answers to quantitative and qualitative criteria. Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
  • 16. CAR-T nomenclature @NascentCAR-TNomenclature Lentiglobin® Lenti-D® Starbeam Study North Star Study branded clinical studies brands Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
  • 17. CAR-TBrandEquityPerceptionStudy Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
  • 18. CAR-TBrandEquityPerceptionStudy Each of the six attribute categories are scored from 0-100 with 0 being the lowest and 100 the highest score. The scores are weighted based on respondents answers to quantitative and qualitative criteria.
  • 19. CAR-T nomenclature @NascentCAR-TNomenclature eACT™ T-Cell Factory B.V. acquisition collaboration platformbrand Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
  • 20. CAR-TBrandEquityPerceptionStudy Each of the six attribute categories are scored from 0-100 with 0 being the lowest and 100 the highest score. Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
  • 21. CAR-TBrandEquityPerceptionStudy Each of the six attribute categories are scored from 0-100 with 0 being the lowest and 100 the highest score. The scores are weighted based on respondents answers to quantitative and qualitative criteria. Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
  • 23. CAR-TBrandEquityPerceptionStudy Each of the six attribute categories are scored from 0-100 with 0 being the lowest and 100 the highest score. Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
  • 24. CAR-TBrandEquityPerceptionStudy Each of the six attribute categories are scored from 0-100 with 0 being the lowest and 100 the highest score. The scores are weighted based on respondents answers to quantitative and qualitative criteria.
  • 25. CAR-T nomenclature @NascentCAR-TNomenclature Armored CAR technology technology brand Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
  • 26. CAR-TBrandEquityPerceptionStudy Each of the six attribute categories are scored from 0-100 with 0 being the lowest and 100 the highest score. Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
  • 27. CAR-TBrandEquityPerceptionStudy Each of the six attribute categories are scored from 0-100 with 0 being the lowest and 100 the highest score. The scores are weighted based on respondents answers to quantitative and qualitative criteria. Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
  • 28. CAR-T nomenclature @NascentCAR-TNomenclature pipeline identifier brand UCART Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
  • 29. CAR-TBrandEquityPerceptionStudy Each of the six attribute categories are scored from 0-100 with 0 being the lowest and 100 the highest score. Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
  • 30. CAR-TBrandEquityPerceptionStudy Each of the six attribute categories are scored from 0-100 with 0 being the lowest and 100 the highest score. The scores are weighted based on respondents answers to quantitative and qualitative criteria. Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”
  • 31. evolutionary. revolutionary. disruptive. 31  Brand Acumen. “The Global Leader in Pharmaceutical Name Development and Submissions”