CAR-T cell therapy involves genetically engineering T cells to express chimeric antigen receptors (CARs) that target specific tumor antigens. CARs consist of an antigen recognition domain from an antibody fused to T cell signaling domains. The first CAR was created in 1987 and the first successful cancer treatment with CAR-T therapy was reported in 2010. FDA approved the first CAR-T therapy tisagenlecleucel in 2017 for certain leukemias. CAR-T cell therapy shows promise for treating cancers but also risks like cytokine release syndrome and neurotoxicity require management.