This document summarizes some key challenges for digital circuits related to process, voltage, and temperature variations. It discusses techniques to prevent latchup and electrostatic discharge issues in integrated circuits. It also describes simultaneous switching noise that can occur when large numbers of circuits switch simultaneously. The document proposes using adaptive body biasing techniques to compensate for PVT variations and control output slope under different conditions. Simulation results show this approach can adjust rising and falling times of an output buffer for different substrate bias voltage conditions.