Breathlessness, also known as dyspnea, is an unpleasant sensation of uncomfortable, difficult, or labored breathing. It has various potential causes, both acute and chronic, including conditions affecting the heart, lungs, and other systems. A medical history, physical exam, and tests can help identify potential differential diagnoses and assess severity. Treatment depends on the underlying cause but may involve oxygen supplementation, bronchodilators, opioids, anxiolytics, breathing exercises, and addressing any anxiety components.