Babesiosis is the diseased state caused by the protozoal (single celled) parasites of the genus Babesia. Infection in a dog may occur by tick transmission, direct transmission via blood transfer from dog bites, blood transfusions, or transplacental transmission.
www.petsgroomingtips.com is one of the front-runners in providing complete digital information to the pet owners, which would guide theme through various process of grooming their beloved kids. A shabby puppy or kitten not only appears dirty but soon infested with disease if not treated properly. Our various tutorials and free PDF guides cover every aspect of the grooming process.
Parvo virus infection in dog - preventive medicinerajboy19
Canine parvovirus is a highly contagious infection of dogs caused by a Parvovirus. This slide include virology,transmission,pathogenesis,clinical sign and symptoms,diagnosis, differential diagnosis,treatment, prevention and control.
etiology, local names, definition, transmission, source of infection, epidemiology, pathogenesis, clinical signs, diagnosis, differential diagnosis, treatment prevention and control
Lecturer notes for metabolic diseases in Cattle.which is benificial for student of BVSc& AH/DVM and MVsc student. It is My first presentation need your feedback for more presentation like this.
Whether your dog is a working companion, champion show animal, hunting partner, or just a best friend, the kindest and most responsible thing you can do for him is to provide proper health care.
Knowing about common dog diseases and being aware of appropriate prevention and treatment can better help you provide that care.
Many Diseases Can Be Prevented .Some of the most common and serious dog diseases have been made less common through vaccines: however, these diseases continue to threaten a dog that lacks proper immunization. Puppies many be vaccinated as early as 4-6 weeks depending on each situation and the veterinarian’s advice. Through mother’s milk, puppies receive disease fighting antibodies, which last 6-16 weeks. Vaccinations then take over.
Yearly boosters should be given throughout your dog’s life, including old age when your dog may become more susceptible to some diseases.
CONTACT: sayantand691@gmail.com
Superbugs are strains of bacteria, viruses, parasites and fungi that are resistant to most of the antibiotics and other medications commonly used to treat the infections they cause. A few examples of superbugs include resistant bacteria that can cause pneumonia, urinary tract infections and skin infections.
Drug resistance (antimicrobial resistance) is a naturally occurring phenomenon that can be slowed, but not stopped. Over time, germs such as bacteria, viruses, parasites and fungi adapt to the drugs that are designed to kill them and change to ensure their survival. This makes previously standard treatments for some infections less effective, and sometimes ineffective. Researchers continue to evaluate how these germs develop resistance. They also study how to diagnose, treat and prevent antimicrobial resistance.
Certain actions may step up the appearance and spread of antimicrobial-resistant germs, such as:
Using or misusing antibiotics
Having poor infection prevention and control practices
Living or working in unclean conditions
Mishandling food
To protect yourself from harmful germs and lower the risk of illnesses:
Wash your hands often with soap and water, or use an alcohol-based hand sanitizer
Handle food properly, such as separating raw and cooked food, cooking food thoroughly, and using clean water
Avoid close contact with people who are ill
Make sure your vaccinations are up to date
You can also help tackle antibiotic resistance by:
Using antibiotics as directed and only when needed
Completing the full treatment course, even if you feel better
Not sharing antibiotics with others
Not using leftover prescriptions.
www.petsgroomingtips.com is one of the front-runners in providing complete digital information to the pet owners, which would guide theme through various process of grooming their beloved kids. A shabby puppy or kitten not only appears dirty but soon infested with disease if not treated properly. Our various tutorials and free PDF guides cover every aspect of the grooming process.
Parvo virus infection in dog - preventive medicinerajboy19
Canine parvovirus is a highly contagious infection of dogs caused by a Parvovirus. This slide include virology,transmission,pathogenesis,clinical sign and symptoms,diagnosis, differential diagnosis,treatment, prevention and control.
etiology, local names, definition, transmission, source of infection, epidemiology, pathogenesis, clinical signs, diagnosis, differential diagnosis, treatment prevention and control
Lecturer notes for metabolic diseases in Cattle.which is benificial for student of BVSc& AH/DVM and MVsc student. It is My first presentation need your feedback for more presentation like this.
Whether your dog is a working companion, champion show animal, hunting partner, or just a best friend, the kindest and most responsible thing you can do for him is to provide proper health care.
Knowing about common dog diseases and being aware of appropriate prevention and treatment can better help you provide that care.
Many Diseases Can Be Prevented .Some of the most common and serious dog diseases have been made less common through vaccines: however, these diseases continue to threaten a dog that lacks proper immunization. Puppies many be vaccinated as early as 4-6 weeks depending on each situation and the veterinarian’s advice. Through mother’s milk, puppies receive disease fighting antibodies, which last 6-16 weeks. Vaccinations then take over.
Yearly boosters should be given throughout your dog’s life, including old age when your dog may become more susceptible to some diseases.
CONTACT: sayantand691@gmail.com
Superbugs are strains of bacteria, viruses, parasites and fungi that are resistant to most of the antibiotics and other medications commonly used to treat the infections they cause. A few examples of superbugs include resistant bacteria that can cause pneumonia, urinary tract infections and skin infections.
Drug resistance (antimicrobial resistance) is a naturally occurring phenomenon that can be slowed, but not stopped. Over time, germs such as bacteria, viruses, parasites and fungi adapt to the drugs that are designed to kill them and change to ensure their survival. This makes previously standard treatments for some infections less effective, and sometimes ineffective. Researchers continue to evaluate how these germs develop resistance. They also study how to diagnose, treat and prevent antimicrobial resistance.
Certain actions may step up the appearance and spread of antimicrobial-resistant germs, such as:
Using or misusing antibiotics
Having poor infection prevention and control practices
Living or working in unclean conditions
Mishandling food
To protect yourself from harmful germs and lower the risk of illnesses:
Wash your hands often with soap and water, or use an alcohol-based hand sanitizer
Handle food properly, such as separating raw and cooked food, cooking food thoroughly, and using clean water
Avoid close contact with people who are ill
Make sure your vaccinations are up to date
You can also help tackle antibiotic resistance by:
Using antibiotics as directed and only when needed
Completing the full treatment course, even if you feel better
Not sharing antibiotics with others
Not using leftover prescriptions.
Overview of scleroderma manifestations, organ involvement, brief classifications (limited, diffuse, sine scleroderma). Overview of current treatment options, need for additional therapies. Overview of plan for multi-disciplinary scleroderma center at the University of Chicago. Potential future therapies in the literature at large. Planned trials/future treatment options at the University of Chicago.
For more info about scleroderma and the foundation, head to www.stopscleroderma.org
This talk was presented at the Scleroderma Patient Education Conference on May 4, 2024, hosted by the Scleroderma Foundation of Greater Chicago.
Overview of scleroderma manifestations, organ involvement, brief classifications (limited, diffuse, sine scleroderma). Overview of current treatment options, need for additional therapies. Overview of plan for multi-disciplinary scleroderma center at the University of Chicago. Potential future therapies in the literature at large. Planned trials/future treatment options at the University of Chicago.
For more info about scleroderma and the foundation, head to www.stopscleroderma.org
This talk was presented at the Scleroderma Patient Education Conference on May 4, 2024, hosted by the Scleroderma Foundation of Greater Chicago.
Tick paralysis is a parasitic disease of dogs, neurotoxin causes ascending paralysis. An inspirational note for dog lovers and veterinarians.Also available video on youtube.
Glaucoma is a condition that causes a build-up of fluid and pressure in the eye. If too much fluid (called aqueous humor fluid) is made or too little fluid is drained, the pressure of the eye increases and causes damage to the retina and the optic nerve, which ultimately leads to blindness
Anaphylaxis shock due to penicillin-DR.Jibachha SahDr. Jibachha Sah
Anaphylaxis shock due to penicillin is a case study for practicing veterinarians and students, who will able to describe the mode of action of prescribing drugs.
The advantage of goal setting is an inspirational matter to the young generation. Teach how to goal setting in his life, a case study of Yale University 1952.
Ethno veterinary medicine or traditional animal health care is based on folk beliefs, traditional knowledge, skills, methods and practices used for curing diseases and maintaining health of animals.
Antiseptic and disinfectant-Dr.Jibachha Sah,M.V.Sc,Lecturer,NPIDr. Jibachha Sah
Antiseptics• These are chemical substances which inhibit the growth or kill micro- organisms on living surfaces such as skin & mucous membrane .Disinfectants are used to kill or eliminate microorganisms and/or inactivate viruses on inanimate objects and surfaces (medical devices, instruments, equipment, walls, floors).
Canine babesiosis is a tick-borne, protozoal, haemoparasitic disease that can cause varying degrees of haemolytic anaemia, splenomegaly, thrombocytopenia and fever. A lecture notes for B.V.Sc & A.H. Students.
This 7-second Brain Wave Ritual Attracts Money To You.!nirahealhty
Discover the power of a simple 7-second brain wave ritual that can attract wealth and abundance into your life. By tapping into specific brain frequencies, this technique helps you manifest financial success effortlessly. Ready to transform your financial future? Try this powerful ritual and start attracting money today!
1.Wireless Communication System_Wireless communication is a broad term that i...JeyaPerumal1
Wireless communication involves the transmission of information over a distance without the help of wires, cables or any other forms of electrical conductors.
Wireless communication is a broad term that incorporates all procedures and forms of connecting and communicating between two or more devices using a wireless signal through wireless communication technologies and devices.
Features of Wireless Communication
The evolution of wireless technology has brought many advancements with its effective features.
The transmitted distance can be anywhere between a few meters (for example, a television's remote control) and thousands of kilometers (for example, radio communication).
Wireless communication can be used for cellular telephony, wireless access to the internet, wireless home networking, and so on.
Multi-cluster Kubernetes Networking- Patterns, Projects and GuidelinesSanjeev Rampal
Talk presented at Kubernetes Community Day, New York, May 2024.
Technical summary of Multi-Cluster Kubernetes Networking architectures with focus on 4 key topics.
1) Key patterns for Multi-cluster architectures
2) Architectural comparison of several OSS/ CNCF projects to address these patterns
3) Evolution trends for the APIs of these projects
4) Some design recommendations & guidelines for adopting/ deploying these solutions.
ER(Entity Relationship) Diagram for online shopping - TAEHimani415946
https://bit.ly/3KACoyV
The ER diagram for the project is the foundation for the building of the database of the project. The properties, datatypes, and attributes are defined by the ER diagram.
1. CANINE BABESIOSIS
Dr. Jibachha Sah
M.V.Sc, Lecturer, College of Veterinary Science,
NPI, Bhojad, Chitwan, Nepal
jibachhashah@gmil.com,00977-9845024121
Welcome to my lecturer notes
2. Introduction
.
●Canine babesiosis is a worldwide, tick-borne, protozoal hemoparasitic disease caused
by hemoprotozoan parasites of the genus Babesia(Taboda and Merchant1991).
●It is characterized by haemolyticanemia, thrombocytopenia, fever, and
splenomegaly.
3. ETIOLOGY :
●The two predominant species capable of naturally infecting dogs are Babesia (B.) canis and B.
gibsoni. Babesia gibsoni (formerly called "the Asian strain") that affects dogs in the mostly Asian
countries.
INCUBATION PERIOD : about two weeks.
Vector:
Babesia canis and Babesia gibsoni are the
two organisms commonly known to infect the
dogs are transmitted by ixodid tick vectors
(Sunitha et al., 2011).
Ixodid tick●Babesia species affecting dogs and/or cats are not reported to be
of zoonotic importance.
4. ●A tick carrying B. canis sporozoites attaches to a dog, and feeds on its blood, releasing many
sporozoites into the dog's bloodstream. Each sporozoite attaches to a red blood cell, and moves
inside the cell. This transmission requires 2-3 days.
Lifecycle
5.
6. Pathogenesis
●Babesia spp. sporozoites are present in the salivary glands of the infected tick vector. They are
transmitted to the dog during feeding.
● This transmission requires 2-3 days. The sporozoites enter the red blood cells and multiply by binary
fission. Although dogs usually mount a good humoral immune response to infection, they are unable
to clear the parasitemia and become chronic carriers.
● The parasites induce FLP (fibrinogen like proteases) that cause the red blood cells to become sticky,
resulting in capillary sludging. Parasitized cells are sequestered in the spleen, and extravascular and
intavascular hemolysis occurs.
● The incubation period following tick transmission is 10-21 days.
7. Clinical sign
●Rise in body temperature (104.4ºF),
● Increased heart rate (122/min),
● Pale membranes,
● Dullness
● Peracute signs include acute onset of hypotensive shock, vasculitis, extensive tissue damage,
hypoxia, and death.
● Signs of acute disease include fever, lethargy, hemolytic anemia, thrombocytopenia,
splenomegaly, lymphadenopathy, icterus, and hemoglobinuria.
● Less common signs include ascites, peripheral edema, ulcerations, stomatitis, gastroenteritis, CNS
signs, acute renal failure, and rhabdomyolysis.
● Acute infections of virulent strains of Babesia canis have been associated with induction of the
systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS)
secondary to massive immunostimulation and cytokine release.
● Signs of MODS can include coagulopathies (DIC), adult respiratory distress syndrome (ARDS),
cerebral dysfunction, and acute renal failure.
11. ●Clinical signs are because of tissue hypoxia following anaemia and a concomitant systemic
inflammatory response syndrome caused by marked cytokine release [Lobetti RG.2006].
12.
13. Yellowish discoloration of the abdomen
●In the severe form of the disease
(case-can observe marked haemolytic
anaemia, severe
acidbaseabnormalities with frequent
secondary multiple organ failure and
complications such as acute renal
failure(ARF), hepatopathy with
marked icterus, hypoglycaemia
14.
15.
16.
17. Haemato-analyzer in Jibachha Veterinary hospital
Kathmandu
Haemato-analyzer in Jibachha Veterinary hospital
Chitwan
18. Ultra Sono Graphy(USG) of Babesia infected dog for diagnosis of spleenomegaly,
hepatomegaly at Jibachha Veterinary hospital, Kathmandu by Dr. Prabhakar K. Shah,
M.V.Sc ( Vet.Medicine)
19. Ulcerated skin lesions (A- Before treatment; B- After treatment).
Podo-dermatitis (A - Before treatment; B - After treatment).
Source:S. Sivajothi, B.and
Sudhakara Reddy Exploratory
Animal and Medical Research,
Vol.7, Issue 2, December, 2017
MANAGEMENT OF
DERMATOLOGICAL LESIONS
ASSOCIATED WITH BABESIA
GIBSONI IN DOGS
22. ● Increased urinary methemoglobinemia levels, as a result of hemoglobin oxidation followed by
hemolysis, have been found in dogs with naturally occurring B. canis infections.
●Hypotensive shock results from the release and production of vasoactive amines and cytokines
which produce vasodilation.
●Hemolysis may involve proteases produced by the invading parasite, an immune reaction to
parasitized cells, and/or oxidative damage to erythrocytes.
Clinico-pathology
●The reason for thrombocytopenia in babesiosis could be due to platelet sequestration in the spleen
or immune mediated platelet destruction and development of disseminated intravascular
coagulation(A. L. Boozer and D. K. Macintire,2003)
23. ●Babesia initiates a mechanism of antibody-mediated cytotoxic destruction of circulating erythrocytes.
●Auto-antibodies are directed against components of the membranes of infected and uninfected
erythrocytes. This causes intravascular and extravascular haemolysis, which leads to anaemia.
●The blood picture showed anaemic changes like anisocytosis, poikilocytosis, polychromasia, nucleated
RBCS and neutrophilic leucocytosis with left shift due to marked systemic inflammatory response.
●Chronic hepatic insufficiency in case of babesiosis could lead to hypoalbuminaemia
25. Babesia gibsoni species specific PCR assay.
Lane M: GeneRuler 100 bp Ladder; lane 1:
positive sample; lane 2: negative sample
control; lane 3: negative DNA
control.(Source:Suresh Gonde et al.,2014).
PCR (polymerase chain reaction) test
The PCR products were runon1.5%agarose gel and
stained with ethidium bromide.The size of the
amplified PCR product was 671 bp
26. ●The adverse effects of this medication include pain during injection and cholinergic effects such as
salivation, drooling, nasal drip or vomiting which can be mitigated by premedicating with atropine at
0.05 mg/kg.
● Additionally some less frequent adverse effects are panting, restlessness, diarrhoea, renal tubular or
hepatic necrosis and injection site inflammation and more rarely ulceration, which usually heals within
days to weeks.
Treatment
1.Imidocarb dipropionate(Imicarb): It is an aromatic diamidine
and is recommended to be used as 6.6 mg/kg intramuscularly
(IM) or subcutaneously (SC) with a repeated dose in 2 weeks
in dogs.(McHardy N et a.,1986).
Mechanism of action of imidocrab is interference with the
production and/or utilization of polyamines, or prevention of
entry of inositol into the erythrocyte containing the parasite.
The mechanism of Imidocarb includes nucleic acid damage
and inhibition of cellular repair and replication (Checa R, et
al.,20170
27. 2.Diminazene aceturate: It is 4,4′-(diazoamino) dibenzamidine diaceturate
which is widely used in tropical countries as a first-line agent for the treatment
of Babesia gibsoni infection of dogs, usually as an intramuscular injection of
3.5 mg/kg.
●Although diminazene aceturate has anti-Babesia activity, it often fails to
eliminate B. gibsoni from affected dogs and a relapse may occur.
intramuscularly,
●Mechanism o action of Diaminazine aceturate is acts by blocking the
replication of DNA of the parasite (Bhatt et al., 2005 and Bipin Kumar et al., 2008).
●Clinical signs associated with diminazene toxicity are depression or stupor,
continuous vocalisation, ataxia, opisthotonos, extensor rigidity, nystagmus and
seizures [Boozer AL et al.,2003].
●There are reported toxicity such as acute CNS signs including ataxia,
nystagmus and occasional seizures in dogs administered with one
recommended intramuscular dose (3.5 mg/kg) of diminazene for treatment of
babesiosis [Han D, et al.,2014].
28.
29. 3.Treatment with a combination therapy of Clindamycin(CLDM), @ 25mg/kg PO q 12h,
Metronidazole(MNZ) @ 15mg/kg PO q 12h and Doxycycline(DOXY) @ 5mg/kg PO q 12h for
10days(Nandini MK et al.,2016)
4. Oral administration of a doxycycline–enrofloxacin–metronidazole combination (Lin and Huang 2010)
with injections of diminazene aceturate was found to be very effective in the management of
paraplegia in naturally occurring canine babesiosis caused by B. gibsoni.
5. A combination of atovaquone (13.5 mg/kg PO q 8 h with a fatty meal) and azithromycin (10 mg/kg PO
q 24 hours) for 10 days effective treatment.
6 Other drugs that may be effective against babesiosis include clindamycin and metronidazole.
Clindamycin has been used to treat B microti in people, and metronidazole (25-65 mg/kg q 24 h for 10
days) resulted in clinical improvement in one group of dogs with B gibsoni.
7. Uneventful recovery was recorded after treatment with intra muscular administration of two doses
of diminazene aceturate @ 7.0 mg/kg body weight and oral administration of clindamycin @ 25 mg/kg
body weight twice in a day. Three days of therapy and complete dermatological clinical cure
was obtained after two months of therapy.(S. Sivajothi, B. Sudhakara Reddy ,2017).
30. 8.Supportive treatment is advisable, particularly in valuable animals, and may include the use of anti-
inflammatory drugs, corticosteroids, and fluid therapy and blood transfusions may be life-saving in
very anemic animals.
In Babesia-infected dogs, intravenous fluid therapy is required for patients in shock, old dogs with
history of renal disease, clinically dehydrated patients and dogs with intravascular haemolysis and
haemoglobinuria.
Mildly dehydrated patients (approximately 5%) require 50 ml/kg body weight, and moderately
dehydrated (approximately 10%) requires 100 ml/kg body weight, whereas severely dehydrated (15%)
dogs require about 150 ml/kg body weight of replacement fluid.
Usually intravenous crystalloid fluid is indicated with correction of electrolyte and acid–base
abnormalities. It is important to maintain blood volume and adequate end-organ perfusion diuresis
and prevention of red blood cell sludging in capillaries [Ayoob AL et al.,2010].
Hetastarch (10 to 20 ml/kg) causes greater plasma volumes expansion, its beneficial in resuscitative
fluid therapy.
31. Whole blood/ RBC/plasma transfusion: Need for blood
transfusion depends on magnitude of anaemia (haematocrit
≤15%) and clinical signs such as dyspnoea or tachypnoea.
Initially blood is transfused slowly at 2 ml/ kg/h for the first
30–60 min while observing for transfusion reactions, such as a
sudden rise in body temperature and/or respiratory rate and
lip and ear pinna swelling.
Blood transfusion at Jibachha
Veterinary hospital,Kathmandu
Immunosuppressants: The use of immunosuppressant drugs
in dogs with immune-mediated haemolytic anaemia (IMHA)
or thrombocytopenia is controversial because these
conditions are always associated with infectious disease.
But in cases of unresponsiveness to antiprotozoal
treatment, the use of 2 mg/kg/day of prednisone is
recommended in infected dogs with moderateto-severe
clinical signs [Grundy SA, Barton C. 2001].
32. Control:
●Regular control of the tick vectors by routinely dipping or spraying pets or using tick collars or
spot-on preparations.
●Vaccines against other Babesia species such as B. gibsoni are currently being developed
including recombinant antigen and DNA vaccines [Fukumoto S et al.,2009]