This document discusses coordination and response biology. It defines key terms like stimuli, receptors, effectors, and responses. It explains that organisms detect both external stimuli from the environment and internal stimuli within the body. The nervous and endocrine systems allow organisms to coordinate responses. Detection of a stimulus involves receptors sending a signal to an integrating center like the brain, which then triggers an effector like muscles or glands to produce an appropriate response. Negative feedback loops help regulate internal environments to maintain homeostasis. Examples illustrate how temperature, sound, and glucose levels trigger detection and coordinated responses.