The Bio-Innovate Program is a regional initiative established in 2010 to promote biosciences innovations in Eastern Africa. It focuses on strengthening agriculture, developing innovative waste treatment technologies, and enhancing policy. The program comprises 9 projects across 6 countries involving 57 institutions. It has developed an integrated wastewater treatment system using anaerobic digesters, aerobic digesters, and constructed wetlands to produce biogas and biofertilizers. This system has been piloted successfully at industries in Ethiopia, Uganda, and Tanzania. Going forward, the Bio-Innovate Program aims to scale up promising innovations and deepen private sector partnerships.