This document provides an introduction to the One Health concept and integrated approaches to health. It discusses how global changes like climate change, globalization, and intensification of animal production are linked to threats to human, animal, and environmental health. The One Health concept positions human health at the center and recognizes the connections between human, animal, plant, and environmental health. Integrated approaches to health are based on systems thinking, interdisciplinarity, participation, sustainability, and bringing knowledge to action. For regions in Eastern and Southern Africa, integrated approaches must consider diverse cultures and socio-ecological systems like extensive pastoral and agro-pastoral production systems and wildlife economies. Specific needs in these regions that have been identified include addressing urban