Dr. Dan Burkhoff joined InsideScientific for Part two of "Basic Hemodynamic Principles Viewed Through Pressure-Volume Relations". In this session, advanced PV Analysis concepts were discussed, along with best-practices during data acquisition and statistical analysis. An extended Q&A session includes detailed answers on subjects from seminar 1. Session 1: The goal of this webinar was to provide an overview of the fundamental principles of preload, afterload, contractility and lusitropy (diastolic properties), how these are quantified on the pressure-volume diagram, and how they are affected in heart failure. Measurement techniques were reviewed. Links were made to underlying properties of cardiac muscle and ventricular structure. After establishing basic concepts, it was demonstrated how pressure-volume analysis can lead to a quantitative understanding of how heart and vasculature interact to determine stroke volume, cardiac output and blood pressure. The implications for understanding therapeutic effects were also discussed. Key Concepts: - Preload, Afterload, Contractility and Lusitropy - Cardiac Muscle and Ventricular Structure - Understanding Heart-Vasculature Interactions - PV Loops in Heart Failure - Understanding Therapies and Their Effects on Cardiac Pump Performance