Download as PDF, PPTX
Uploaded byInsideScientific
Peripheral and Cerebral Vascular Responses Following High-Intensity Interval Exercise
The document investigates the effects of high-intensity interval exercise on peripheral and cerebral vascular responses in healthy young adults. It aims to characterize the changes in brachial artery function and cerebral blood flow in response to varying exercise intensities. Results indicate that while peripheral vascular function improves after exercise, cerebrovascular reactivity remains unchanged.
More Related Content
Similar to Peripheral and Cerebral Vascular Responses Following High-Intensity Interval Exercise
Peripheral and Cerebral Vascular Responses Following High-Intensity Interval Exercise
- 1. Peripheral and Cerebral VascularResponses Following High-Intensity Interval Exercise Senior Lecturer Sport and Health Sciences University of Exeter Bert Bond, PhD Associate Lecturer Sport and Health Sciences University of Exeter Max Weston, PhD Candidate
- 2.
- 3. @maxeweston m.e.weston@exeter.ac.uk * b.bond@exeter.ac.uk @CHERC_UoE BertBond, PhD Senior Lecturer Public Health and Sport Science University of Exeter Medical School University of Exeter B.Bond@exeter.ac.uk Max Weston Associate Lecturer University of Exeter Medical School PhD Research Scholar QUEX institute M.E.Weston@exeter.ac.uk
- 4.
- 5. @maxeweston m.e.weston@exeter.ac.uk * b.bond@exeter.ac.uk @CHERC_UoE Alumni QaisAl-Alem (MSc), Rohit Banger (MSc), Sascha Kranen (PhD), Jodie Koep (PhD), Kate Sansum (MSc), Ollie Smail (MSc), Will Wallis(MSc) Postgraduate students Majed Alobaid Jacob Jack Petri Jalanko Rebecca Lear Alice Lester Jess Thomas Jessica Virgili Max Weston Alex Woodgates Vascular research in Public Health and Sport Sciences
- 6. @maxeweston m.e.weston@exeter.ac.uk * b.bond@exeter.ac.uk @CHERC_UoE Vascularresearch in Public Health and Sport Sciences
- 7. @maxeweston m.e.weston@exeter.ac.uk * b.bond@exeter.ac.uk @CHERC_UoE Vascularresearch in Public Health and Sport Sciences McGill et al. 2000 Am J Clin Nutr
- 8.
- 9.
- 10. @maxeweston m.e.weston@exeter.ac.uk * b.bond@exeter.ac.uk @CHERC_UoE FMD TCD Canexercise acutely alter cerebrovascular reactivity (CVR)? If so, is this intensity-dependent?
- 11. @maxeweston m.e.weston@exeter.ac.uk * b.bond@exeter.ac.uk @CHERC_UoE Highintensity interval exercise and the brain Cerebrovascular function?
- 12. @maxeweston m.e.weston@exeter.ac.uk * b.bond@exeter.ac.uk @CHERC_UoE 1)To investigate the effect of exercise intensity on peripheral vascular function Aims In healthy young adults: Brachial Artery FMD 2) To investigate the effect of exercise intensity on cerebrovascular function 3) To characterise the cerebral blood flow response during exercise
- 13. @maxeweston m.e.weston@exeter.ac.uk * b.bond@exeter.ac.uk @CHERC_UoE Methods •10 healthy adults – 6 females • 23 ± 4 years Intensity Time Exhaustion! Visit 1 • VO2max Visits 2-5 • 4 experimental trials • Completed in a different order
- 14. @maxeweston m.e.weston@exeter.ac.uk * b.bond@exeter.ac.uk @CHERC_UoE Time-matched Average-intensitymatched • Pre-exercise • 1h after exercise • 3h after exercise
- 15. @maxeweston m.e.weston@exeter.ac.uk * b.bond@exeter.ac.uk @CHERC_UoE Measurements– Peripheral Vascular Function Allometrically-scaled FMD Aim 1!
- 16. @maxeweston m.e.weston@exeter.ac.uk * b.bond@exeter.ac.uk @CHERC_UoE Measurements– Cerebral Blood Flow Transcranial Doppler ultrasound Middle cerebral artery blood velocity MCAv • At rest • During exercise • During other, whole-body dynamic movements Aim 3! Replicate scanning depth and position within + between visits! CV for baseline MCAv Within-day: 5.3% (95% CI: 3.8%–8.8%) Between-day: 9.3% (95% CI: 7.4%–13.2%)
- 17. @maxeweston m.e.weston@exeter.ac.uk * b.bond@exeter.ac.uk @CHERC_UoE Measurements– Cerebral Blood Flow Middle cerebral artery blood velocity MCAv Which side to measure? Inconsistencies in previous literature Weston et al., Under Review Practical Recommendations: Collect L & R if possible • If one signal is lost, use remaining Unilateral is okay on a group level • Need to be consistent within an individual Report how data are handled
- 18. @maxeweston m.e.weston@exeter.ac.uk * b.bond@exeter.ac.uk @CHERC_UoE Measurements– Cerebrovascular Function Smith & Ainslie (2017); Exp Physiol Cerebral autoregulation Cerebrovascular reactivity Aim 2!
- 19. @maxeweston m.e.weston@exeter.ac.uk * b.bond@exeter.ac.uk @CHERC_UoE Measurements– Cerebrovascular Reactivity Smith & Ainslie (2017); Exp Physiol Hypercapnia Hypocapnia 4 min 1 min Δ MCAv Δ PETCO2 = CVR 6%
- 20. @maxeweston m.e.weston@exeter.ac.uk * b.bond@exeter.ac.uk @CHERC_UoE Measurements TCD BloodPressure Expired gas PETCO2
- 21. @maxeweston m.e.weston@exeter.ac.uk * b.bond@exeter.ac.uk @CHERC_UoE Measurements FingerPressure, MAP, SBP, DBP, Q
- 22. @maxeweston m.e.weston@exeter.ac.uk * b.bond@exeter.ac.uk @CHERC_UoE Alldata is time-aligned Exported together
- 23. @maxeweston m.e.weston@exeter.ac.uk * b.bond@exeter.ac.uk @CHERC_UoE Results– Brachial Artery FMD
- 24. @maxeweston m.e.weston@exeter.ac.uk * b.bond@exeter.ac.uk @CHERC_UoE Results– Brachial Artery FMD HIIE 1(*) and HIIE 2(#) elevated FMD above baseline 1 and 3 hours post-exercise No difference between HIIE 1 vs 2 Shear Stress Interval Pattern
- 25. @maxeweston m.e.weston@exeter.ac.uk * b.bond@exeter.ac.uk @CHERC_UoE Results– Cerebrovascular Reactivity Hypercapnia Hypocapnia In contrast with previous work Protocol + measurement Vessel characteristics In contrast with FMD MCAv response during exercise…? Different mechanisms?
- 26. @maxeweston m.e.weston@exeter.ac.uk * b.bond@exeter.ac.uk @CHERC_UoE Results– MCAv during exercise Pattern of MCAv differed between trials But no difference in MCAv response to exercise: 1- Mean 2- Peak 3- AUC CON MOD HIIE 1 HIIE 2
- 27. @maxeweston m.e.weston@exeter.ac.uk * b.bond@exeter.ac.uk @CHERC_UoE Take-homemessages • HIIE performed at 75% and 90% VO2max improved peripheral vascular function 1 and 3 hours after exercise Greater brachial artery shear stress…? • CVR was unchanged following all conditions Peripheral ≠ Cerebral • exercise dose (intensity, duration) • measurement technique and timing • sample Access our paper:
- 28. @maxeweston m.e.weston@exeter.ac.uk * b.bond@exeter.ac.uk @CHERC_UoE Wherenext? Access our paper:
- 29.