There are several types of bacterial vaccines that work through different mechanisms of the immune system. Active immunization stimulates the body's own immune response by introducing an antigen from the bacteria. This induces long-term immunity through memory B and T cells. Passive immunization provides immediate, short-term protection by transferring pre-formed antibodies. Common bacterial vaccines include those targeting Streptococcus pneumoniae, Neisseria meningitidis, Haemophilus influenzae, diphtheria, tetanus, pertussis, Lyme disease, anthrax, tuberculosis, and typhoid fever. These vaccines contain inactivated toxins, purified proteins, capsular polysaccharides, or live attenuated bacterial strains.
PREPARATION OF BACTERIAL VACCINES:
Steps involved in killed bacterial vaccine preparation:
1. Selection of an antigen:
The exact strain or strains to be incorporated for preparation of bacterial vaccine.
Eg. Cholera vaccine: smooth strains of the two serological types Inaba and Ogawa
TABC vaccine: O and H antigens in S. typhi and S. paratyphi microorganisms and these organisms also contains Vi antigen.
Each strain is carefully checked for freedom from variation and absence of contaminating organisms.
Toxoid vaccines refer to two vaccines contain toxoids as the immunogen, the vaccines against diphtheria and tetanus. A toxoid is an inactivated toxin that has lost its ability to cause disease but has retained its immunogenicity. (The pertussis vaccine also contains toxoid but contains other bacterial proteins as well.) https://www.creative-biolabs.com/vaccine/bacterial-vaccines.htm
PREPARATION OF BACTERIAL VACCINES:
Steps involved in killed bacterial vaccine preparation:
1. Selection of an antigen:
The exact strain or strains to be incorporated for preparation of bacterial vaccine.
Eg. Cholera vaccine: smooth strains of the two serological types Inaba and Ogawa
TABC vaccine: O and H antigens in S. typhi and S. paratyphi microorganisms and these organisms also contains Vi antigen.
Each strain is carefully checked for freedom from variation and absence of contaminating organisms.
Toxoid vaccines refer to two vaccines contain toxoids as the immunogen, the vaccines against diphtheria and tetanus. A toxoid is an inactivated toxin that has lost its ability to cause disease but has retained its immunogenicity. (The pertussis vaccine also contains toxoid but contains other bacterial proteins as well.) https://www.creative-biolabs.com/vaccine/bacterial-vaccines.htm
A introduction on Viral vaccine for medical students.Although most attenuated vaccines are viral, some are bacterial in nature. Examples include the viral diseases yellow fever, measles, rubella, and mumps, and the bacterial disease typhoid.
VIRAL VACCINES
Since viruses are intracellular parasites they will grow only within other living cells.
Methods of viral vaccine production:
Cultivation of virus using free living animals
Fertile eggs
Tissue cultures
Toxoid vaccines are vaccines that are made from the toxins (harmful chemicals) from bacteria. There are some bacteria that cause disease through releasing a protein called a toxin. Scientists can inactivate these toxins in the lab using a chemical called formalin (a solution of formaldehyde) and sterilized water, which are completely safe to use in small quantities in the human body. Once the toxin is inactivated, it’s called a toxoid, and it can no longer cause harm. The body learns how to fight off the bacteria’s natural toxin once exposed to the toxoid through producing antibodies that bind into the toxin like keys into a lock
A vaccine is a biological preparation of weakened or killed pathogen such as bacterium or virus that will improves immunity to a particular diseases.
The principle of immunization or vaccination is based on the property of ‘memory’ of the immune system.
The process of introduction of vaccine into an individual to provide protection against a disease called vaccination.
Viruses are small, acellular particles that can replicate only in a host cell. They are obligatory intracellular parasites.They
consist of a nucleic acid genome enclosed in a protective protein shell or capsidBacteriophage is the virus that infect bacteria.Bacteriophages were discovered by Frederick Twort(1915)and Felix d'Herelle(1917).
David Haselwood | How vaccines prevent diseasesDavid Haselwood
David Haselwood - Vaccines provide immunity that protects you from disease without the risk of the infection. It contains a small amount of the germs or parts of the germs that cause disease. The germs in vaccines are either killed or weakened so they can't make you sick. Therefore, vaccination plays an important role in one’s health. #DavidHaselwood
http://davidhaselwood.blogspot.in/
https://medium.com/@davidhaselwood
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A introduction on Viral vaccine for medical students.Although most attenuated vaccines are viral, some are bacterial in nature. Examples include the viral diseases yellow fever, measles, rubella, and mumps, and the bacterial disease typhoid.
VIRAL VACCINES
Since viruses are intracellular parasites they will grow only within other living cells.
Methods of viral vaccine production:
Cultivation of virus using free living animals
Fertile eggs
Tissue cultures
Toxoid vaccines are vaccines that are made from the toxins (harmful chemicals) from bacteria. There are some bacteria that cause disease through releasing a protein called a toxin. Scientists can inactivate these toxins in the lab using a chemical called formalin (a solution of formaldehyde) and sterilized water, which are completely safe to use in small quantities in the human body. Once the toxin is inactivated, it’s called a toxoid, and it can no longer cause harm. The body learns how to fight off the bacteria’s natural toxin once exposed to the toxoid through producing antibodies that bind into the toxin like keys into a lock
A vaccine is a biological preparation of weakened or killed pathogen such as bacterium or virus that will improves immunity to a particular diseases.
The principle of immunization or vaccination is based on the property of ‘memory’ of the immune system.
The process of introduction of vaccine into an individual to provide protection against a disease called vaccination.
Viruses are small, acellular particles that can replicate only in a host cell. They are obligatory intracellular parasites.They
consist of a nucleic acid genome enclosed in a protective protein shell or capsidBacteriophage is the virus that infect bacteria.Bacteriophages were discovered by Frederick Twort(1915)and Felix d'Herelle(1917).
David Haselwood | How vaccines prevent diseasesDavid Haselwood
David Haselwood - Vaccines provide immunity that protects you from disease without the risk of the infection. It contains a small amount of the germs or parts of the germs that cause disease. The germs in vaccines are either killed or weakened so they can't make you sick. Therefore, vaccination plays an important role in one’s health. #DavidHaselwood
http://davidhaselwood.blogspot.in/
https://medium.com/@davidhaselwood
https://davidhaselwood.wordpress.com/
https://gust.com/companies/david-haselwood
IMMUNIZATION
PASSIVE IMMUNIZATION
Passive Natural Immunization
Passive artificial immunization
2. ACTIVE IMMUNIZATION
Active Natural Immunization
Vaccine
Vaccination:
Types of vaccine
Routes of Administration
Scheme of immunization
Periods of maintained immunity due to vaccines
Toxoids
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
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Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
2. Immunity
•Sometimes called specific or adaptive
immunity, acquired immunity is those
features of the immune system that are
"learned" during a person's lifetime
rather than the ones the individual is
born with. This is the part of the
immune system that deals with specific
invaders and learns to recognise them
by exposure to them.
3. Immunity
•The other part of the immune
system, the one that we are born
with, is called the
innate immune system and consists
of many mechanisms which are all
nonspecific that is they are not
programmed to recognise any
particular invaders.
4. Acquired immunity
•Acquired immunity is further divided into
two parts:
•1-humoral immunitywhich
principally operates through a type
of lymphocyte called a B-cell
which originates in the
bone marrow and is matured both in
the marrow and thespleen.
5. •2-cell mediated immunity which
principally operates through a type
of lymphocyte called a T-cell which
also originates in the bone marrow
but is matured in an organ called
thethymus.
6. Immunization
•Historically, infectious disease has
been the leading cause of death in
the human population. Over the last
century, two important factors have
been developed to combat their
spread; Immunizations are
successful because they utilize the
immune system's natural specificity
as well as its inducibility.
8. •The principle behind immunization
is to introduce an antigen, derived
from a disease causing organism,
that stimulates the immune system
to develop protective immunity
against that organism, but which
does not itself cause the pathogenic
effects of that organism.
9. •An antigen (short for antibody
generator), is defined as any
substance that binds to a specific
antibody and elicits an
adaptive immune response.
10. •Most viral vaccines are based on
live attenuated viruses, while many
bacterial vaccines are based on
acellular components of micro-
organisms, including harmless toxin
components.
11. •Many antigens derived from
acellular vaccines do not strongly
induce an adaptive response, and
most bacterial vaccines require the
addition of adjuvants that activate
the antigen presenting cells of the
innate immune system to enhance
immunogenicity.
12. •The most important elements of the
immune system that are improved
by immunization are the B cells
(and the antibodies they produce)
and T cells. Memory B cell and
memory T cells are responsible for
a swift response to a second
encounter with a foreign molecule.
14. •Bacterial Vaccines Bacterial
diseases can be prevented by the
use of immunizations that induce
either active or passive immunity.
Active immunity is induced by
vaccines prepared from bacteria or
their products..
15. •Passive immunity is provided by
the administration of preformed
antibody in preparations called
immune globulins.
16. •The immune globulins usefil
against bacterial diseases. Passive-
active immunity involves giving
both immune globulins to provide
immediate protection and a vaccine
to provide longterm protection.
17. Passive immunization
•Passive immunization is where pre-
made elements of the immune
system are transferred to a person,
and the body doesn't have to create
these elements itself. Currently,
antibodies can be used for passive
immunization.
18. •This method of immunization
begins to work very quickly, but it
is short lasting, because the
antibodies are naturally broken
down, and if there are no B cells to
produce more antibodies, they will
disappear.
19. Passive immunization
•Passive immunization can be
naturally acquired when antibodies
are being transferred from mother
to fetus during pregnancy, to help
protect the fetus before and shortly
after birth.
20. •Artificial passive immunization is
normally given by injection and is
used if there has been a recent
outbreak of a particular disease or
as an emergency treatment to
poisons (for example, for tetanus).
The antibodies can be produced in
animals orin vitro.
21. Active immunization
•Active immunization entails the
introduction of a foreign molecule
into the body, which causes the
body itself to generate immunity
against the target. This immunity
comes from the T cells and the B
cells with their antibodies.
22. Active immunization
•Active immunization can occur
naturally when a person comes in
contact with, for example, a
microbe. If the person has not yet
come into contact with the microbe
and has no pre-made antibodies for
defense (like in passive
immunization),
23. Active immunization
•the person becomes immunized.
The immune system will eventually
create antibodies and other defenses
against the microbe. The next time,
the immune response against this
microbe can be very efficient; this
is the case in many of the childhood
infections that a person only
contracts once, but then is immune.
24. •Artificial active immunization is
where the microbe, or parts of it,
are injected into the person before
they are able to take it in naturally.
If whole microbes are used, they
are pre-treated. Depending on the
type of disease, this technique also
works with dead microbes, parts of
the microbe, or treated toxins from
the microbe.
29. A. CAPSULAR POLYSACCHARIDE
VACCINES:
•(1)streptococcus pneumoniae
vaccine contains the capsular
polysaccharides of the 23 most
prevalent types. It is recommended
for persons over 60 years of age
and patients of any age with such
chronic diseases as diabetes and
cirrhosis or with compromised
spleen function or splenectomy.
30. •A second vaccine containing the
capsular polysaccharide of 7
pneumococcal serotypes coupled to
a carrier protein (diphtheria toxoid)
is available for the protection of
young children who do not respond
well to the unconjugated vaccine.
31. •A potential problem regarding the
use of the pneumococcal vaccine
containing 7 serotypes is that of
serotype replacement. Will the
vaccine reduce the incidence of
disease caused by the serotypes in
the vaccine but not the overall
incidence of pneumococcal disease
because other serotypes that are not
in the vaccine will now cause
disease
32. •(2)Neisseria meningitidis vaccine
contains capsular polysaccharide of
four important types (A, C, W-135
and y) It is given when there is a
high risk of meningitis during an
outbreak, when military recruits
enter boot camp, or for travelers to
areas where meningitis is
hyperendemic.
33. •(3)Haemophilus influenzae
vaccine contains the type b
polysaccharide conjugated to
diphtheria toxoid or other carrier
protein. It is given to children
between the ages of 2 and 15
months to prevent meningitis.
34. •The capsular polysaccharide alone
is a poor immunogen in young
children, but coupling it to a carrier
protein greatly enhances its
immunogenicity. A combined
vaccine consisting of this vaccine
plus the diphtheria, pertussis, and
tetanus (DPT) vaccines is available.
35. •(4)One of the vaccines against
typhoid fever contains the capsular
polysaccharide of Salmonella typhi.
It is indicated for persons living or
traveling in areas where there is a
high risk of typhoid fever and for
persons in close contact with either
infected patients or chronic carriers.
36. B.Toxoid Vaccines:
(1)Corynebacterium diphtheriae vaccine
contains the toxoid (formaldehyde-
treated exotoxin).
Immunization against diphtheria is
indicated for every child and is given in
three doses at 2, 4, and 6 months of age,
with boosters given 1 year later and at
intervals thereafter.
•
39. C. PURIFIED PROTEIN
VACCINES:
)1(There are two types of B.
pertussis vaccines:
an acellular vaccine containing
purified proteins and a vaccine
containing whole killed
bacteria. The acellular vaccine is
now recommended in the
United States.
40. •The principal antigen in the
acellular vaccine is inactivated
pertussis toxin )pertussis
toxoid(, but other proteins, such
as filamentous hemagglutinin
and pertactin, are also required
for full protection.
41. •Pertussis toxin for the vaccine is
inactivated genetically by
introducing two amino acid
changes that eliminate its toxic
)ADP-ribo sylating( activity but
retain its antigenicity
42. •It is the first vaccine to contain
a genetically inactivated toxoid.
The vaccine is indicated for
every child as a protection
against whooping cough It is
usually given in combination with
diphtheria and tetanus toxoids )DPT
or DtaP vaccine(
43. •)2(The vaccine against Lyme
disease contains a purified outer
surface protein )OspA( of
Borrelia burgdorferi as the
immunogen. OspA is made by
recombinant DNA techniques.
44. •It is recommended for those
who live in areas of endemic
disease and whose occupation
or recreation makes them likely
to be exposed.
45. •)3(Bacillus anthracis vaccine
contains "protective antigen"
purified from the organism. It is
given to persons whose
occupations place them at risk
of exposure to the organism.
46. D. LIVE. ATTENUATED BACTERIAL
VACCINES:
)1(The vaccine against
tuberculosis contains a live,
attenuated strain of
Mycobacterium bovis called
BCG and is recommended for
children at high risk for
exposure to active tuberculosis
in some countries.
47. •)2(One of the vaccines against
typhoid fever contains live,
attenuated Salmonella typhi. It
is indicated for persons living or
traveling in areas where there is
a high risk of typhoid fever and
for persons in close contact with
either infected patients or
chronic carriers.
48. •)3(The vaccine against
tularemia contains live,
attenuated Francisella tularensis
organisms and is used primarily
in people who are exposed in
their occupation, such as
laboratory personnel,
veterinarians, and hunters.
52. •)3(The vaccine against typhus
contains killed Rickettsia
rickettsiae organisms and is
used primarily to immunize
members of the armed forces.
53. •)4(The vaccine against Q fever
contains killed Coxiella burnetii
organisms and is used to
immunize those who are at high
risk for being exposed to
animals infected with the
organism.
54. Passive immunity
•Antitoxins )immune globulins(
can be used for either the
treatment or prevention of
certain bacterial diseases. The
following preparations are
available.
55. •)1(Tetanus antitoxin is used in the
treatment of tetanus and in its
prevention )prophylaxis(. In
treatment, because the goal is to
neutralize any unbound toxin to
prevent the disease from getting
worse, the antitoxin should be given
promptly.
56. •In prevention, the antitoxin is given
to inadequately immunized persons
with contaminated )"dirty"(
wounds. The antitoxin is made in
humans to avoid hypersensitivity
reactions. In addition to the
antitoxin, these people should
receive tetanus toxoid.
57. •.The toxoid and the antitoxin
should be given at different
sites in the body to prevent
the antitoxin from
neutralizing the toxoid
58. •.)2(Botulinum antitoxin is used
in the treatment of botulism.
Because the antitoxin can
neutralize unbound toxin to
prevent the disease from
progressing, it should be given
promptly
59. •It contains antibodies against
botulinum toxins A, B, and E,
the most commonly occurring
types. The antitoxin is made in
horses, so hypersensitivity may
be a problem.
60. •)3(Diphtheria antitoxin is used
in the treatment of diphtheria.
The antitoxin can neutralize
unbound toxin to prevent the
disease from progressing;
therefore, the antitoxin should
be given promptly.
61. •The antitoxin is made in horses,
so hypersensitivity may be a
problem.
62.
63.
64. Bacterial vaccines - Gaza
At birthfirst registration
BCG Mycobacterium bovis .single dose
0.05 ml
Intradermal left upper arm
2month:
DPT first primary 0.5 ml intramuscular in
lateral aspect of thigh
4.6.12.month will give DPT
65. SCHOOL CHILDREN:
6years TD Tetanus Toxoid
0.5ml intramuscular left upper
arm
15years TD
0.5ml intramuscular left upper
arm
67. Cold chains
•Cold chains are common in the
food and pharmaceutical
industries and also some
chemical shipments. One
common temperature range for
a cold chain in pharmaceutical
industries is 2 to 8 °C.
68. but the specific temperature )and
time at temperature( tolerances
depend on the actual product
being shipped.
69. •This is important in the supply of
vaccines to distant clinics in hot
climates served by poorly
developed transport networks.
Disruption of a cold chain due to
war may produce consequences
similar to the Smallpox outbreaks in
the Philippines during the Spanish-
American war.
70. Cold chains need to be evaluated and
controlled.
Carriers and logistics providers can assist
shippers
The use of Refrigerator trucks,
Refrigerator cars, Reefer )ship(s, Reefer
)container(s, and refrigerated
warehouses is common.
71. Shipment in insulated shipping
containers or other specialised
packaging
Temperature data loggers help
monitor the temperature history of
the truck, warehouse, etc and the
temperature history of the product
being shipped.
Documentation is critical
72. Normal reaction
*Pain and tenderness at the injection site
but are mild and transient and end
within 2-3days
*Fever in 2%of cases
*Paracetamol may be needed for pain and
fever
*Mild skin rash
*Skin eruption ,consist of small red spots
73. DPT SIDE EFFECT
Injection site abscess and
neurological symptoms and
signs
)convulsions,encephalitis,encep
halopathy, should be
investigated
Pain
Fever