Killed bacterial vaccines against cholera, plague, typhus, and Q fever contain whole killed bacteria and are used to protect those exposed. Live attenuated bacterial vaccines like BCG against tuberculosis use live but weakened Mycobacterium bovis. Toxoid vaccines for diphtheria and tetanus contain inactivated toxins that have lost disease-causing ability but retained immunogenicity. Purified protein vaccines such as the acellular pertussis vaccine recommended for all children contain purified bacterial proteins. Capsular polysaccharide vaccines for pneumonia, meningitis, and H. influenzae conjugate the polysaccharide to a carrier protein to enhance the antibody response.

1. KILLED BACTERIAL VACCINES
1
The vaccines against cholera, plague,
typhus, and Q fever contain whole killed
bacteria. These vaccines are used only to
protect those likely to be exposed.
BACTERIAL VACCINES
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LIVE, ATTENUATED BACTERIAL
VACCINES
2
The BCG vaccine against tuberculosis
contains live, attenuated Mycobacterium
bovis and is used in countries where the
disease is endemic.
TOXOID VACCINES
3
Two vaccines contain toxoids as the
immunogen, the vaccines against
diphtheria and tetanus. A toxoid is an
inactivated toxin that has lost its ability to
cause disease but has retained its
immunogenicity.
PURIFIED PROTEIN VACCINES
4
Two vaccines contain purified bacterial
proteins as the immunogen. The most
commonly used is the acellular pertussis
vaccine, which in combination with
diphtheria and tetanus toxoids is
recommended for all children.
CAPSULAR POLYSACCHARIDE
VACCINES
5
The capsular polysaccharide in the
pneumococcal vaccine, the meningococcal
vaccine, and the H. influenzae vaccine is
conjugated to a carrier protein to enhance
the antibody response.